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Invitrogen
Human MAPK10 (JNK3), GST Tag Recombinant Protein
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Product Details
PV4563
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
Full length
Tag
GST-tag
Molecular weight
76.6 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Amount
10 µg
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 0.02% Triton X-100, 0.5mM EDTA, 150mM NaCl, 50% glycerol, 2mM DTT
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). MAPK10 is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Jun N-terminal kinase 3; JNK3 alpha protein kinase; MAP kinase 10; MAP kinase p49 3F12; Mitogen-activated protein kinase 10; OTTHUMP00000161181; OTTHUMP00000161183; OTTHUMP00000218718; SAPK1b; stress activated protein kinase beta; Stress-activated protein kinase 1b; Stress-activated protein kinase JNK3; unnamed protein product
Gene Aliases: JNK3; JNK3A; MAPK10; p493F12; p54bSAPK; PRKM10; SAPK1B
UniProt ID: (Human) P53779
Entrez Gene ID: (Human) 5602
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