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Invitrogen
Human MAPK3 (ERK1), GST Tag Recombinant Protein
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Product Details
PR5254B
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Full length
Tag
GST-tag
Molecular weight
70.8 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 50% glycerol, 0.05% Triton X-100, 0.5mM EDTA, 2mM DTT, 150mM NaCl
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERK; ERK-1; Erk1; cancer susceptibility protein; ERK1b; ERK1c; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK2; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 3; p44-ERK1; p44-MAPK; unnamed protein product
Gene Aliases: ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; MAPK3; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3
UniProt ID: (Human) P27361
Entrez Gene ID: (Human) 5595
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