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Invitrogen
Human MATN3 Synthetic Peptide
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Product Details
PEP-0840
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human MATN3.
PEP-0840 can be used as a blocking peptide with polyclonal antibody PA5-20726.
Target Information
Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B14.5b; CI-B14.5b; Matrilin-3; matrilin-3 lacking EGF-1 domain; NADHDH2; NDUFC2; unnamed protein product
Gene Aliases: DIPOA; EDM5; HOA; MATN3; OADIP; OS2; SEMDBCD
UniProt ID: (Human) O15232
Entrez Gene ID: (Human) 4148
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