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Invitrogen
Human MPP5 (aa 567-643) Control Fragment Recombinant Protein
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Product Details
RP-108493
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
INSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is crucial for establishing and maintaining cell polarity in epithelial cells and neurons. It is involved in the Par-3 complex, which contributes to maintaining tight junctions in epithelial cells. Mutations in MPP5 have been associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is highly involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, primarily in myeloid and lymphoid cells. MPP5 variants disrupt normal cellular function, leading to profound developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ12615; MAGUK p55 subfamily member 5; Membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); palmitoylated 5; protein associated with lin seven 1; Protein associated with Lin-7 1; Protein PALS1; stardust
Gene Aliases: MPP5; PALS1
UniProt ID: (Human) Q8N3R9
Entrez Gene ID: (Human) 64398
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