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The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex.
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The protein encoded by this gene is a member of the bone morphogenetic protein family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
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Protein Aliases: compact; GDF-8; growth differentiation factor 8; Growth/differentiation factor 8; H-Myo-Propeptide; H-Myostatin; Myostatin
Gene Aliases: Cmpt; GDF8; MSLHP; MSTN
UniProt ID: (Human) O14793, (Rat) O35312, (Mouse) O08689
Entrez Gene ID: (Human) 2660, (Rat) 29152, (Mouse) 17700
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