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Recombinant Human Neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino-acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp781N13156; Neuroserpin; Peptidase inhibitor 12; PI-12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; Serpin I1; serpin peptidase inhibitor clade I member 1; serpin peptidase inhibitor, clade I (neuroserpin), member 1
Gene Aliases: neuroserpin; PI12; SERPINI1
UniProt ID: (Human) Q99574
Entrez Gene ID: (Human) 5274
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