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Invitrogen
Human PD-L1 (B7-H1) Fc Chimera Recombinant Protein
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Product Details
A42498
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human B7-H1, amino acids Met1-Thr239 (Accession # NP_054862.1) with a C-terminal human IgG1 Fc-tag
Tag
Fc-tag
Molecular weight
52 kDa
Class
Recombinant
Type
Protein
Purity
≥95 % as determined by SDS-PAGE. ≥90 % as determined by SEC-HPLC.
Endotoxin concentration
<1.0 EU/µg
Activity
1.Immobilized Recombinant Human PD1/PDCD1 Protein (His Tag) at 2 µg/mL (100 µL/well) can bind Human PD-L1 (B7-H1) Fc Chimera Recombinant Protein, the EC50 is 220-660 ng/mL.
2.Immobilized Human PD-L1 (B7-H1) Fc Chimera Recombinant Protein at µg/mL (100 µL/well) can bind Recombinant Human PD1/PDCD1 Protein (Fc & AVI Tag), Biotinylated, the EC50 is 5-15 ng/m(Routinely tested).
2.Immobilized Human PD-L1 (B7-H1) Fc Chimera Recombinant Protein at µg/mL (100 µL/well) can bind Recombinant Human PD1/PDCD1 Protein (Fc & AVI Tag), Biotinylated, the EC50 is 5-15 ng/m(Routinely tested).
Conjugate
Form
Lyophilized
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B7 homolog 1; B7-H1; B7-H1,PD-L1; CD274; CD274 antigen; costimulatory molecule; PD-L1; PDCD1 ligand 1; pdl-1; Programmed cell death 1 ligand 1; programmed death-1 ligand 1; sCD274; similar to Homo sapiens B7-1 and B7-2; soluble CD274; soluble PD L1; soluble PD-L1; B7-H1; sPD L1; unnamed protein product
Gene Aliases: B7-H; B7H1; CD274; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
UniProt ID: (Human) Q9NZQ7
Entrez Gene ID: (Human) 29126
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