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Invitrogen
Human PIK3CD/PIK3R1 (p110 delta/p85 alpha), His Tag Recombinant Protein
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Product Details
PV6452
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
Full length
Tag
His-tag
Molecular weight
84.7-120.6 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM sodium phosphate, pH 7, with 150mM Imidazole, 25% glycerol, 0.25mM DTT, 0.1mM PMSF, 300mM NaCl
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
PIK3CD/PIK3R1 (p110-delta/p85-alpha) recombinant human protein is:
• Available in 3 convenient sizes
• Validated in our Adapta™ and Kinase Binding assays
• A full length protein that can help advance your research when used with validated assays
Related assay platforms:
LanthaScreen™ Kinase Binding Assay
Adapta™ Kinase Activity Assay
Protein Form: Full Length
The gene accession number for PIK3CD (p110δ) is NP_005017.3 and for PIK3R1 (p85α) is NP_852664.1.
Target Information
Phosphatidylinositol 3-kinase (PI3K) is composed of a catalytic subunit (p110-delta) and a regulatory subunit (p85-alpha in this case), which are encoded by the PIK3CD and PIK3R1 genes. PI3K phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It plays a role in oncogenic transformation and is consistently expressed at a high level in AML blast cells. PI3K can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that leads to neutrophil polarization, and regulates directional migration, but not random locomotion. The PI3K signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3-kinase p110 subunit delta; PI3-kinase regulatory subunit alpha; PI3-kinase subunit delta; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3Kdelta; PIK3CD; PIK3R1; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase subunit p110-delta
Gene Aliases: AGM7; APDS; GRB1; IMD14; IMD36; p110D; P110DELTA; p85; p85-ALPHA; PI3K; PIK3CD; PIK3R1
UniProt ID: (Human) O00329, (Human) P27986
Entrez Gene ID: (Human) 5293, (Human) 5295
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