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Invitrogen
Human PRDM16 Synthetic Peptide
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Product Details
PEP-0986
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human PRDM16.
PEP-0986 can be used as a blocking peptide with polyclonal antibody PA5-20872.
Target Information
PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone-lysine N-methyltransferase PRDM16; MDS1/EVI1-like gene 1; PR domain containing 16; PR domain zinc finger protein 16; PR domain-containing protein 16; Transcription factor MEL1
Gene Aliases: CMD1LL; KIAA1675; LVNC8; MEL1; PFM13; PRDM16
UniProt ID: (Human) Q9HAZ2
Entrez Gene ID: (Human) 63976
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