Gibco

Human PlGF-1 Recombinant Protein, PeproTech®

Human PlGF-1 Protein in Functional Assay (FN)

FIGURE: 1 / 1

Human PlGF-1 Protein (100-06-100UG) in FN

Bioassay analysis of Human PlGF-1 Recombinant Protein, PeproTech® (Product # 100-06-1MG).

Product Image Gallery

Product Details

100-06-100UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

ELISA (ELISA)

Assay-dependent

View 2 publications 2 publications

Functional Assay (FN)

Assay-dependent

In vitro Assay (IV)

View 8 publications 8 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

MLPAVPPQQW ALSAGNGSSE VEVVPFQEVW GRSYCRALER LVDVVSEYPS EVEHMFSPSC VSLLRCTGCC GDENLHCVPV ETANVTMQLL KIRSGDRPSY VELTFSQHVR CECRPLREKM KPERCGDAVP RR

Molecular weight

29.7 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human monocytes of using a concentration range of 1.0-10.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human PlGF-1 is a 29.7 kDa disulfide-linked homodimeric protein of two 132 amino acid polypeptide chains.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

PlGF-1 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-1 is expressed in placental tissues, the colon, and mammary carcinomas. It signals through the VEGFR-1/FLT1 receptor, and stimulates endothelial cell proliferation and migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer.

American journal of cancer research

Xie SY,Shi DB,Ouyang Y,Lin F,Chen XY,Jiang TC,Xia W,Guo L,Lin HX

100-06 was used in In vitro experiments to indicate that SHMT2 plays a critical role in regulating breast cancer growth through MAPK, and VEGF signaling pathways.

Tue Aug 16 00:00:00 EDT 2022

Role of Elevated SFLT-1 on the Regulation of Placental Transporters in Women With Pre-Eclampsia.

Clinical and translational science

Kojovic D,V Workewych N,Piquette-Miller M

Fri May 01 00:00:00 EDT 2020

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.

Nature communications

Lechertier T,Reynolds LE,Kim H,Pedrosa AR,Gómez-Escudero J,Muñoz-Félix JM,Batista S,Dukinfield M,Demircioglu F,Wong PP,Matchett KP,Henderson NC,D'Amico G,Parsons M,Harwood C,Meier P,Hodivala-Dilke KM

Thu Jun 04 00:00:00 EDT 2020

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.

Nature communications

Thu Jun 04 00:00:00 EDT 2020

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 EDT 2018

Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing.

Nature communications

Ishihara J,Ishihara A,Fukunaga K,Sasaki K,White MJV,Briquez PS,Hubbell JA

Mon Jun 04 00:00:00 EDT 2018

Computer-assisted quantification of motile and invasive capabilities of cancer cells.

Scientific reports

Kumar KS,Pillong M,Kunze J,Burghardt I,Weller M,Grotzer MA,Schneider G,Baumgartner M

Wed Oct 21 00:00:00 EDT 2015

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Proceedings of the National Academy of Sciences of the United States of America

Chen PY,Qin L,Zhuang ZW,Tellides G,Lax I,Schlessinger J,Simons M

Tue Apr 15 00:00:00 EDT 2014

Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α.

The Journal of biological chemistry

Li C,Mpollo MS,Gonsalves CS,Tahara SM,Malik P,Kalra VK

Fri Dec 26 00:00:00 EST 2014

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.

Proceedings of the National Academy of Sciences of the United States of America

Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA

Tue Mar 19 00:00:00 EDT 2013

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

The Journal of clinical investigation

Argaw AT,Asp L,Zhang J,Navrazhina K,Pham T,Mariani JN,Mahase S,Dutta DJ,Seto J,Kramer EG,Ferrara N,Sofroniew MV,John GR

Sun Jul 01 00:00:00 EDT 2012

Cyclic stretch induces PlGF expression in bronchial airway epithelial cells via nitric oxide release.

American journal of physiology. Lung cellular and molecular physiology

Mohammed KA,Nasreen N,Tepper RS,Antony VB

Thu Feb 01 00:00:00 EST 2007

Bioinformatics

Protein Aliases: Placenta Growth Factor; Placenta Growth Factor-1; placental growth factor, vascular endothelial growth factor-related protein; PlGF

Human PlGF-1 Recombinant Protein, PeproTech®

Human PlGF-1 Protein (100-06-100UG) in FN

Product Details

100-06-100UG

Western Blot (WB)

ELISA (ELISA)

Functional Assay (FN)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Activity

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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