Gibco

Human Prokineticin-2 Recombinant Protein, PeproTech®

Product Details

100-46-100UG

Applications

Tested Dilution

Publications

Functional Assay (FN)

Assay-dependent

In vitro Assay (IV)

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K

Molecular weight

8.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.

Scientific reports

Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH

Wed Sep 15 00:00:00 EDT 2021

A Prokineticin-Driven Epigenetic Switch Regulates Human Epicardial Cell Stemness and Fate.

Stem cells (Dayton, Ohio)

Qureshi R,Kindo M,Boulberdaa M,von Hunolstein JJ,Steenman M,Nebigil CG

Mon Oct 01 00:00:00 EDT 2018

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

The Journal of biological chemistry

Xin H,Lu R,Lee H,Zhang W,Zhang C,Deng J,Liu Y,Shen S,Wagner KU,Forman S,Jove R,Yu H

Fri May 10 00:00:00 EDT 2013

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

The Journal of biological chemistry

Xin H,Lu R,Lee H,Zhang W,Zhang C,Deng J,Liu Y,Shen S,Wagner KU,Forman S,Jove R,Yu H

Fri May 10 00:00:00 EDT 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 EDT 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 EDT 2013

A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis.

PloS one

McDowell EN,Kisielewski AE,Pike JW,Franco HL,Yao HH,Johnson KJ

Tue May 07 00:00:00 EDT 2013

A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis.

PloS one

McDowell EN,Kisielewski AE,Pike JW,Franco HL,Yao HH,Johnson KJ

Tue May 07 00:00:00 EDT 2013

Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

Diabetes

Gardiner JV,Bataveljic A,Patel NA,Bewick GA,Roy D,Campbell D,Greenwood HC,Murphy KG,Hameed S,Jethwa PH,Ebling FJ,Vickers SP,Cheetham S,Ghatei MA,Bloom SR,Dhillo WS