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Product Details
RP-109539
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SLQDLCCRAVVSCTPVHLVDKLPL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (92%), Rat (92%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-140185. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Rab 40B is a 278 amino acid protein that belongs to the small GTPase superfamily and the Rab family. Rab 40B contains a SOCS box domain that mediates interactions with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. Rab 40B shares similarity with a yeast protein, suggesting a role in regulation of secretory vesicles. The Rab 40B gene is conserved in chimpanzee, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 17q25.3. It has been suggested that there is a major gene locus on chromosome 17q25.3 for autosomal dominant moyamoya disease (MMD), which is an idiopathic steno-occlusive cerebrovascular disease that represents an important cause of stroke.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein homologous to Saccharomyces cerevisiae SEC4; Protein Rar; Ras-related protein Rab-40B; sec4; SOCS box-containing protein RAR
Gene Aliases: RAB40B; RAR; SEC4L
UniProt ID: (Human) Q12829
Entrez Gene ID: (Human) 10966
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