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Invitrogen
Human RAD51 Recombinant Protein
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Product Details
RP-4964
Product Specifications
Expression System
E. coli
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
20 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-4964 has been successfully used in Western blot proceedures. It is specific for the ~35 kDa Rad51 protein.
The Human gene Rad51 is homologous to the highly conserved bacterial gene RecA.
RP-4964 is highly purified from E. coli over-expressing human Rad51 protein as a recombinant protein. The tag was removed from the recombinant protein (though it still contains Gly-Ser-His at the N-terminal). The protein has been shown to retain nuclear filament forming and strand-exchange activity as well as interaction with Rad52. RP-4964 was confirmed to possess single strand DNA stimulated ATPase activity.
Target Information
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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