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Product Details
PEP-1469
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 15 amino acid peptide near the center of human SCUBE3.
PEP-1469 can be used as a blocking peptide with polyclonal antibody PA5-34427.
Target Information
SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-Beta receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-Beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-Beta1, VEGF, Snail, and Slug.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUB domain and EGF-like repeat containing 3; signal peptide; Signal peptide, CUB and EGF-like domain-containing protein 3
Gene Aliases: CEGF3; SCUBE3
UniProt ID: (Human) Q8IX30
Entrez Gene ID: (Human) 222663
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