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          • Proteins & Peptides ›
          • SEMA3A Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Human Semaphorin 3A Fc Recombinant Protein, PeproTech®

          3 References
          View all (3) SEMA3A proteins

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          Datasheet
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          Cite Human Semaphorin 3A Fc Recombinant Protein, PeproTech®

          • Testing Data (1)
          Human Semaphorin 3A Fc Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.
          Human Semaphorin 3A Fc Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Human Semaphorin 3A Fc Protein (150-17H-100UG) in Functional

          Bioassay analysis of Human Semaphorin 3A Fc Recombinant Protein, PeproTech® (Product # 150-17H-1MG). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          View Product

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          Human Semaphorin 3A Fc Protein in Functional Assay (Functional)

          Product Details

          150-17H-100UG

          Applications
          Tested Dilution
          Publications

          ELISA (ELISA)

          Assay-dependent
          View 1 publication 1 publication

          Functional Assay (Functional)

          Assay-dependent
          -

          In vitro Assay (IV)

          -
          View 1 publication 1 publication

          Miscellaneous PubMed (Misc)

          -
          View 1 publication 1 publication
          Product Specifications

          Species

          Human

          Published species

          Human, Mouse

          Expression System

          CHO cells

          Amino acid sequence

          HHHHHHHHGK NNVPRLKLSY KEMLESNNVI TFNGLANSSS YHTFLLDEER SRLYVGAKDH IFSFDLVNIK DFQKIVWPVS YTRRDECKWA GKDILKECAN FIKVLKAYNQ THLYACGTGA FHPICTYIEI GHHPEDNIFK LENSHFENGR GKSPYDPKLL TASLLIDGEL YSGTAADFMG RDFAIFRTLG HHHPIRTEQH DSRWLNDPKF ISAHLISESD NPEDDKVYFF FRENAIDGEH SGKATHARIG QICKNDFGGH RSLVNKWTTF LKARLICSVP GPNGIDTHFD ELQDVFLMNF KDPKNPVVYG VFTTSSNIFK GSAVCMYSMS DVRRVFLGPY AHRDGPNYQW VPYQGRVPYP RPGTCPSKTF GGFDSTKDLP DDVITFARSH PAMYNPVFPM NNRPIVIKTD VNYQFTQIVV DRVDAEDGQY DVMFIGTDVG TVLKVVSIPK ETWYDLEEVL LEEMTVFREP TAISAMELST KQQQLYIGST AGVAQLPLHR CDIYGKACAE CCLARDPYCA WDGSACSRYF PTAKRATRAQ DIRNGDPLTH CSDLHHDNHH GHSPEERIIY GVENSSTFLE CSPKSQRALV YWQFQRRNEE RKEEIRVDDH IIRTDQGLLL RSLQQKDSGN YLCHAVEHGF IQTLLKVTLE VIDTEHLEEL LHKDDDGDGS KTKEMSNSMT PSQKVWYRDF MQLINHPNLN TMDEFCEQVW KRDRKQRRQR PGHTPGNSNK WKHLQENKKG RNRRTHEFER APRSVGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK

          Tag

          Fc-tag, His-tag

          Molecular weight

          226.2 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥ 95% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Determined by its ability to bind recombinant rat Neuropilin-1 Fc Chimera in a functional ELISA assay.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          150-17H-1MG will be provided as 10 x 100 µg (150-17H-100UG).

          150-17H-500UG will be provided as 5 x 100 µg (150-17H-100UG).

          Recombinant Human Semaphorin 3A Fc has a calculated molecular weight of 226.2 kDa and therefore runs above the 200kDa marker by SDS-PAGE analysis under nonreducing conditions. When run under reducing conditions, this protein migrates as three distinct bands that, due to glycosylation, run higher than expected at apparent molecular weights of approximately 120-130 kDa, 90-100 kDa, and 35-40 kDa.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: collapsin 1; MGC133243; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Sema III; semaphorin D; Semaphorin III; semaphorin L; Semaphorin-3A

          View more View less

          Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMA3A; SEMAD; SEMAIII; SEMAL; SemD

          View more View less

          UniProt ID: (Human) Q14563

          View more View less

          Entrez Gene ID: (Human) 10371

          View more View less

          It has to be done as per old AB suggested Products section.
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