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Invitrogen
Human TACR3 Synthetic Peptide
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Product Details
PEP-0509
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human NK3R.
PEP-0509 can be used as a blocking peptide with polyclonal antibody PA5-20392.
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; Neuromedin-K receptor; NK-3 receptor; NK-3R; NK3R TAC3R; NKR; Nmk-r; Tachykinin receptor 3
Gene Aliases: HH11; NK-3R; NK3R; NKR; TAC3R; TAC3RL; TACR3
UniProt ID: (Human) P29371
Entrez Gene ID: (Human) 6870
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