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          • Proteins & Peptides ›
          • TBK1 Proteins

          Invitrogen

          Human TBK1, GST Tag Recombinant Protein

          View all (4) TBK1 proteins

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          Cite Human TBK1, GST Tag Recombinant Protein

          Product Details

          A31520

          Applications
          Tested Dilution
          Publications

          Kinase Assay (KA)

          Assay-dependent
          -
          Product Specifications

          Species

          Human

          Expression System

          Insect cells

          Amino acid sequence

          Full length

          Tag

          GST-tag

          Molecular weight

          109.9 kDa

          Class

          Recombinant

          Type

          Protein

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          See Label

          Purification

          purified

          Storage buffer

          50mM tris HCl, pH 7.5, with 10mM glutathione, 25% glycerol, 0.1mM EDTA, 0.25mM DTT, 150mM NaCl, 0.1mM PMSF

          Contains

          no preservative

          Storage conditions

          -80°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Dry ice

          Product Specific Information

          For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.

          This purified recombinant full-length protein can be used in a number of different applications, but it has been specifically validated for use with both the LanthaScreen™ & Z'-LYTE™ assay technologies to identify novel kinase inhibitors. TBL1 is also available in our SelectScreen™ Kinase Profiling Service.

          • Validated for use with the LanthaScreen & Z'-LYTE assay technology
          • Available in multiple pack sizes for convenient use
          • Also available in our SelectSceen Kinase Profiling Service

          Protein Form: Full Length, Recombinant, Active

          Target Information

          TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk

          View more View less

          Gene Aliases: FTDALS4; NAK; T2K; TBK1

          View more View less

          UniProt ID: (Human) Q9UHD2

          View more View less

          Entrez Gene ID: (Human) 29110

          View more View less

          It has to be done as per old AB suggested Products section.
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