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Invitrogen
Human TLX1 Synthetic Peptide
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Product Details
PEP-1596
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acid peptide near the amino terminus of human TLX1.
PEP-1596 can be used as a blocking peptide with polyclonal antibody PA5-34553. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37ºC.
Target Information
The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch); Homeobox protein Hox-11; MGC163402; Proto-oncogene TCL-3; T-cell leukemia homeobox protein 1; T-cell leukemia/lymphoma protein 3
Gene Aliases: HOX11; TCL3; TLX1
UniProt ID: (Human) P31314
Entrez Gene ID: (Human) 3195
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