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Invitrogen
Human UBE4B (aa 2-67) Control Fragment Recombinant Protein
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Product Details
RP-92041
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
EELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAASAPGPSQSLGLNVHNMTPATSPI
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-53958. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; RING-type E3 ubiquitin transferase E4 B; similar to Saccharomyces cerevisiae Ufd2p; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitin-fusion degradation protein 2; ubiquitination factor E4B (UFD2 homolog, yeast); UFD2; Ufd2a/Ube4B; ubiquitin ligase E3 and E4 activity; alternative splice form specific for striated muscle cells; unnamed protein product
Gene Aliases: E4; HDNB1; KIAA0684; UBE4B; UBOX3; UFD2; UFD2A
UniProt ID: (Human) O95155
Entrez Gene ID: (Human) 10277
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