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This peptide corresponds to 17 amino acids near the carboxy terminus of human WIPI1.
PEP-1494 can be used as a blocking peptide with polyclonal antibody PA5-34452.
WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.
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Protein Aliases: Atg18 protein homolog; WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha
Gene Aliases: ATG18; ATG18A; WIPI1; WIPI49
UniProt ID: (Human) Q5MNZ9
Entrez Gene ID: (Human) 55062
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