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Invitrogen
Human ZIP1 Synthetic Peptide
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Product Details
PEP-1180
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human ZIP1.
PEP-1180 can be used as a blocking peptide with polyclonal antibody PA5-21066.
Target Information
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: solute carrier family 39 (zinc transporter), member 1; solute carrier family 39 (zinc transporter), member 3; Solute carrier family 39 member 1; Zinc transporter ZIP1; Zinc-iron-regulated transporter-like; ZIP-1; Zrt- and Irt-like protein 1
Gene Aliases: CGI-08; CGI-71; IRT1; SLC39A1; ZIP1; ZIRTL
UniProt ID: (Human) Q9NY26
Entrez Gene ID: (Human) 27173
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