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Invitrogen
Human ZMIZ1 Synthetic Peptide
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Product Details
PEP-1247
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human ZIMP10.
PEP-1247 can be used as a blocking peptide with polyclonal antibody PA5-21133.
Target Information
Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PIAS-like protein Zimp10; retinoic acid induced 17; Retinoic acid-induced protein 17; unnamed protein product; Zinc finger MIZ domain-containing protein 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Gene Aliases: KIAA1224; MIZ; NEDDFSA; RAI17; TRAFIP10; ZIMP10; ZMIZ1
UniProt ID: (Human) Q9ULJ6
Entrez Gene ID: (Human) 57178
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