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Invitrogen
Human ZNF281 Synthetic Peptide
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Product Details
PEP-1235
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 19 amino acids near the carboxy terminus of human ZFP281.
PEP-1235 can be used as a blocking peptide with polyclonal antibody PA5-21121.
Target Information
ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression. ZFP281 also interacts with many other other transcription factors, such as Sp1 to repress vimentin gene transcription. ZFP281 has also been shown to control embryonic stem cell pluripotency by direct regulating specific target genes. ZFP281 phyically interacts with the transcription factos POU5F1, Sox2, and NANOG. Gene expression microarray anlysis indicated that some ZFP281 target genes were activated, while others were repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifuctinal roles in regulating gene expression in stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GC-box-binding zinc finger protein 1; Transcription factor ZBP-99; unnamed protein product; Zinc finger DNA-binding protein 99; Zinc finger protein 281; ZNP-99 transcription factor
Gene Aliases: GZP1; ZBP-99; ZBP99; ZNF281; ZNP-99
UniProt ID: (Human) Q9Y2X9
Entrez Gene ID: (Human) 23528
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