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Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-58998. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; protein kinase MUK; ZPK
Gene Aliases: DLK; MAP3K12; MEKK12; MUK; ZPK; ZPKP1
UniProt ID: (Human) Q12852
Entrez Gene ID: (Human) 7786
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