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Thermo Scientific
LRRK2 [G2019S] Recombinant Protein
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Product Details
A15200
Product Specifications
Species
Human
Expression System
proprietary
Amino acid sequence
Full length
Tag
DYKDDDDK-tag
Molecular weight
288 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 0.5mM EDTA, 150mM NaCl, 50% glycerol, 0.02% Triton X-100, 2mM DTT
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
•Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
•Uncover novel compounds or hits specific to the full-length form
•Advance Parkinson's research using the full-length protein and validated assays
Related Links:
•LRRK2 tools for advancing Parkinson's disease research
•Kinase protein portfolio
•LanthaScreen™ Eu Kinase Binding Assay
•LanthaScreen™ TR-FRET Kinase Activity Assay
Protein Form: Recombinant, Full Length, Mutant
Target Information
LRRK2 (Leucine Rich Repeat Kinase 2) is a Protein Coding gene. Diseases associated with LRRK2 include Parkinson Disease 8, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. Among its related pathways are Signaling by PTK6 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma. Gene Ontology (GO) annotations related to LRRK2 (G2019S Mutant) include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of LRRK2 (G2019S Mutant) is TNNI3K. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: augmented in rheumatoid arthritis 17; Dardarin; leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRRK2
Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2
UniProt ID: (Human) Q5S007
Entrez Gene ID: (Human) 120892
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