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Invitrogen
LexA Recombinant Protein
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Product Details
RP-4904
Product Specifications
Expression System
E. coli
Class
Recombinant
Type
Protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Amount
20 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-4904 can be used as a positive control in Western blotting to confirm that the Bait construct is expressed stably in the nucleus, as well as in studies on the mechanism of E. coli SOS response.
RP-4904 calculated molecular weight is ~23 kDa. Purity is 90%.
Target Information
E. coli LexA protein inhibits the transcription of the genes belonging to the SOS regulon that are related to DNA repair and cell division by recognizing and binding to the SOS-box sequence. LexA‘s self-protease activity is promoted by RecA protein which, responding to DNA damage, is activated by its binding to single-strand DNA accumulated in the cells. It is cleaved into two fragments and loses its function as a repressor. As the result, the expression of genes belonging to the SOS regulon is induced, and mutagenic activity in the cells are enhanced.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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