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Invitrogen
Mouse EphA2 His-tag Recombinant Protein
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Product Details
RP-88230
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Expression System
HEK293 cells
Amino acid sequence
Mouse EPHA2, amino acids Met1-Asn535 (Accession # NP_034269.2) with a C-terminal His-tag
Tag
His-tag
Molecular weight
65 kDa
Class
Recombinant
Type
Protein
Purity
>98% as determined by SDS-PAGE.
Endotoxin concentration
<1.0 EU/µg
Activity
Measured by its binding ability in a functional ELISA. 1. Immobilized mouse EphA2 at 2 µg/ml (100 µL/well) can bind mouse EphrinA1 with a linear range of 0.16-20 ng/mL. 2. Immobilized mouse EphA2 at 2 µg/ml (100 µL/well) can bind human EphrinA1 with a linear range of 0.8-20 ng/mL.
Conjugate
Form
Lyophilized
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (400 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2
Gene Aliases: AW545284; Eck; Epha2; Myk2; Sek-2; Sek2
UniProt ID: (Mouse) Q03145
Entrez Gene ID: (Mouse) 13836
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