Product References
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Nature immunology
Linnerbauer M,Lößlein L,Vandrey O,Peter A,Han Y,Tsaktanis T,Wogram E,Needhamsen M,Kular L,Nagel L,Zissler J,Andert M,Meszaros L,Hanspach J,Zuber F,Naumann UJ,Diebold M,Wheeler MA,Beyer T,Nirschl L,Cirac A,Laun FB,Günther C,Winkler J,Bäuerle T,Jagodic M,Hemmer B,Prinz M,Quintana FJ,Rothhammer V
211-11B was used in Cell Culture to identify astrocyte-derived HB-EGF and its epigenetic regulation as a modulator of autoimmune CNS inflammation and potential therapeutic target in MS.
Fri Mar 01 00:00:00 EST 2024
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
211-11B was used in In vitro experiments to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 EST 2024
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation.
Nature communications
Linnerbauer M,Beyer T,Nirschl L,Farrenkopf D,Lößlein L,Vandrey O,Peter A,Tsaktanis T,Kebir H,Laplaud D,Oellinger R,Engleitner T,Alvarez JI,Rad R,Korn T,Hemmer B,Quintana FJ,Rothhammer V
211-11B was used in Cell Culture to suggest the glial PD-L1/PD-1 axis as a potential therapeutic target for both acute and progressive MS stages.
Sat Sep 09 00:00:00 EDT 2023
IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss.
Bone research
Kim H,Takegahara N,Choi Y
211-11B was used in In vitro experiments to show that IgSF11 controls osteoclast differentiation through PKM2 activity, which is a metabolic switch necessary for optimal osteoclast maturation.
Thu Mar 16 00:00:00 EDT 2023
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
The Journal of experimental medicine
Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C
Mon Feb 07 00:00:00 EST 2022
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer.
The Journal of experimental medicine
Masetti M,Carriero R,Portale F,Marelli G,Morina N,Pandini M,Iovino M,Partini B,Erreni M,Ponzetta A,Magrini E,Colombo P,Elefante G,Colombo FS,den Haan JMM,Peano C,Cibella J,Termanini A,Kunderfranco P,Brummelman J,Chung MWH,Lazzeri M,Hurle R,Casale P,Lugli E,DePinho RA,Mukhopadhyay S,Gordon S,Di Mitri D
Mon Feb 07 00:00:00 EST 2022
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
The Journal of experimental medicine
Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T
Mon Jan 03 00:00:00 EST 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
211-11B was used in Sample Preparation (Western Blotting) to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 EDT 2022
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.
Cell reports
Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ
211-11B was used in In vivo experiments to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.
Tue Jan 25 00:00:00 EST 2022
Glycogen Synthase Kinase 3β inhibits BMSCs Chondrogenesis in Inflammation via the Cross-Reaction between NF-κB and β-Catenin in the Nucleus.
Stem cells international
Wang Z,He Z,Zhang W,Liang S,Chen K,Xu S,Zhang Y,Cheng P
211-11B was used in Cell Culture to demonstrate that GSK-3β regulates the chondrogenesis via the NF-κB and Wnt/β-catenin signaling pathways and possibly mediates the cross-reaction between NF-κB and β-catenin in the nucleus.
Sat Sep 24 00:00:00 EDT 2022
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
iScience
Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR
211-11B was used in Sample Preparation to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.
Fri Jul 15 00:00:00 EDT 2022
NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism.
ImmunoHorizons
Hamilton C,Olona A,Leishman S,MacDonald-Ramsahai K,Cockcroft S,Larrouy-Maumus G,Anand PK
211-11B was used in In vitro experiments to reveal a novel metabolic-inflammatory circuit that contributes to calibrating immune responses.
Mon Aug 29 00:00:00 EDT 2022
Glutamine metabolism modulates chondrocyte inflammatory response.
eLife
Arra M,Swarnkar G,Adapala NS,Naqvi SK,Cai L,Rai MF,Singamaneni S,Mbalaviele G,Brophy R,Abu-Amer Y
211-11B was used in Cell Culture to show that glutamine deprivation itself causes metabolic reprogramming and decreases the inflammatory response of chondrocytes through inhibition of NF-κB activity.
Tue Aug 02 00:00:00 EDT 2022
Pioglitazone attenuates ischaemic stroke aggravation by blocking PPARγ reduction and inhibiting chronic inflammation in diabetic mice.
The European journal of neuroscience
Guo Y,Zuo W,Yin L,Gu T,Wang S,Fang Z,Wang B,Dong H,Hou W,Zuo Z,Deng J
211-11B was used in In vivo experiments to study whether pioglitazone use before ischaemia could reduce brain ischaemic injury.
Thu Sep 01 00:00:00 EDT 2022
The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury.
Nature communications
Bretheau F,Castellanos-Molina A,Bélanger D,Kusik M,Mailhot B,Boisvert A,Vallières N,Lessard M,Gunzer M,Liu X,Boilard É,Quan N,Lacroix S
211-11B was used in In vivo experiments to report that the alarmin interleukin (IL)-1α is produced by damaged microglia after SCI.
Sun Oct 02 00:00:00 EDT 2022
P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold.
Neurobiology of disease
Dutta SS,Andonova AA,Wöellert T,Hewett SJ,Hewett JA
211-11B was used in In vitro experiments to support the notion that constitutive P2X7-dependent Interleukin-1β (IL-1β) release from hippocampal pyramidal neurons contributes to maintenance of the seizure threshold (ST) in the normal brain, perhaps by modulating neuronal excitability.
Wed Jun 15 00:00:00 EDT 2022
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Nature
Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA
211-11B was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
211-11B was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
211-11B was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
211-11B was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 EDT 2021
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.
Cell research
Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B
Fri Oct 01 00:00:00 EDT 2021
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair.
Immunity
Wang X,Cai J,Lin B,Ma M,Tao Y,Zhou Y,Bai L,Jiang W,Zhou R
Tue Jun 08 00:00:00 EDT 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 EST 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 EST 2021
Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease.
Immunity
Huang LJ,Mao XT,Li YY,Liu DD,Fan KQ,Liu RB,Wu TT,Wang HL,Zhang Y,Yang B,Ye CQ,Zhong JY,Chai RJ,Cao Q,Jin J
Tue Aug 10 00:00:00 EDT 2021
SPLUNC1: a novel marker of cystic fibrosis exacerbations.
The European respiratory journal
Khanal S,Webster M,Niu N,Zielonka J,Nunez M,Chupp G,Slade MD,Cohn L,Sauler M,Gomez JL,Tarran R,Sharma L,Dela Cruz CS,Egan M,Laguna T,Britto CJ
211-11B was used in Cell Culture to show that in acute CF care, low SPLUNC1 levels could support a decision to increase airway clearance or to initiate pharmacological interventions.
Mon Nov 01 00:00:00 EDT 2021
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.
Nature immunology
Fiancette R,Finlay CM,Willis C,Bevington SL,Soley J,Ng STH,Baker SM,Andrews S,Hepworth MR,Withers DR
Fri Oct 01 00:00:00 EDT 2021
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Cellular & molecular immunology
Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R
Mon Feb 01 00:00:00 EST 2021
PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.
The Journal of experimental medicine
Chavez JS,Rabe JL,Loeffler D,Higa KC,Hernandez G,Mills TS,Ahmed N,Gessner RL,Ke Z,Idler BM,Niño KE,Kim H,Myers JR,Stevens BM,Davizon-Castillo P,Jordan CT,Nakajima H,Ashton J,Welner RS,Schroeder T,DeGregori J,Pietras EM
Mon Jun 07 00:00:00 EDT 2021
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy.
The Journal of experimental medicine
Pei S,Huang M,Huang J,Zhu X,Wang H,Romano S,Deng X,Wang Y,Luo Y,Hao S,Xu J,Yu T,Zhu Q,Yuan J,Shen K,Liu Z,Hu G,Peng C,Luo Q,Wen Z,Dai D,Xiao Y
Mon Jul 05 00:00:00 EDT 2021
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
The Journal of experimental medicine
Kiuchi M,Onodera A,Kokubo K,Ichikawa T,Morimoto Y,Kawakami E,Takayama N,Eto K,Koseki H,Hirahara K,Nakayama T
Mon Apr 05 00:00:00 EDT 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 EST 2021
HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis.
Proceedings of the National Academy of Sciences of the United States of America
Senda N,Yanai H,Hibino S,Li L,Mizushima Y,Miyagaki T,Saeki M,Kishi Y,Hangai S,Nishio J,Sugaya M,Taniguchi T,Sato S
Tue Jan 05 00:00:00 EST 2021
D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner.
Cell proliferation
Zhou X,Zheng Y,Sun W,Zhang Z,Liu J,Yang W,Yuan W,Yi Y,Wang J,Liu J
Mon Nov 01 00:00:00 EDT 2021
Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis.
Journal of leukocyte biology
Kwon MY,Ghanta S,Ng J,Castano AP,Han J,Ith B,Lederer JA,El-Chemaly S,Chung SW,Liu X,Perrella MA
Fri Oct 01 00:00:00 EDT 2021
Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH
Mon Nov 15 00:00:00 EST 2021
Galectin-9 Targets NLRP3 for Autophagic Degradation to Limit Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Wang W,Qin Y,Song H,Wang L,Jia M,Zhao C,Gong M,Zhao W
Tue Jun 01 00:00:00 EDT 2021
Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wang L,Cao L,Li T,Li Z,Sun Y,Ding J,Zhou C,Xie Y,Yue N,Nan J,Jia XM,Peng C,Li H,Yang J,Xiao H
Sat May 01 00:00:00 EDT 2021
VEGF Contributes to Mesenchymal Stem Cell-Mediated Reversion of Nor1-Dependent Hypertrophy in iPS Cell-Derived Cardiomyocytes.
Stem cells international
Philipp D,Holthaus M,Basoah V,Pfannkuche K,Suhr L,Wahlers T,Paunel-Görgülü A
Sun May 02 00:00:00 EDT 2021
The Antioxidant Resveratrol Protects against Chondrocyte Apoptosis by Regulating the COX-2/NF-κB Pathway in Created Temporomandibular Osteoarthritis.
BioMed research international
Li W,Hu S,Chen X,Shi J
Wed Sep 22 00:00:00 EDT 2021
Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Cell death & disease
Buffolo F,Petrosino V,Albini M,Moschetta M,Carlini F,Floss T,Kerlero de Rosbo N,Cesca F,Rocchi A,Uccelli A,Benfenati F
Mon Feb 15 00:00:00 EST 2021
Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy.
Nature communications
Bian Z,Shi L,Kidder K,Zen K,Garnett-Benson C,Liu Y
Fri May 28 00:00:00 EDT 2021
Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.
Cell reports
Marks KE,Flaherty S,Patterson KM,Stratton M,Martinez GJ,Reynolds JM
Tue Jun 29 00:00:00 EDT 2021
Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.
Redox biology
Pescador N,Francisco V,Vázquez P,Esquinas EM,González-Páramos C,Valdecantos MP,García-Martínez I,Urrutia AA,Ruiz L,Escalona-Garrido C,Foretz M,Viollet B,Fernández-Moreno MÁ,Calle-Pascual AL,Obregón MJ,Aragonés J,Valverde ÁM
211-11B was used in Cell Culture to find the impact of metformin on macrophages by suppressing a HIF1α-dependent proinflammatory program is likely responsible for a secondary beneficial effect on insulin-mediated glucose uptake and β-adrenergic responses in brown adipocytes.
Tue Oct 19 00:00:00 EDT 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 EST 2021
RORα is critical for mTORC1 activity in T cell-mediated colitis.
Cell reports
Chi X,Jin W,Bai X,Zhao X,Shao J,Li J,Sun Q,Su B,Wang X,Yang XO,Dong C
Tue Sep 14 00:00:00 EDT 2021
Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.
Nature communications
Tao H,Pan Y,Chu S,Li L,Xie J,Wang P,Zhang S,Reddy S,Sleasman JW,Zhong XP
211-11B was used in In vivo experiments to demonstrate that IL-2/IL-15 receptor β chain and inducible costimulatory (ICOS) not only serve as lineage-specific markers for IFN-γ-producing MAIT1 and IL-17A-producing MAIT17 cells, but are also important for their differentiation, respectively.
Thu Apr 01 00:00:00 EDT 2021
Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids.
Scientific reports
Allaire JM,Poon A,Crowley SM,Han X,Sharafian Z,Moore N,Stahl M,Bressler B,Lavoie PM,Jacobson K,Li X,Vallance BA
Thu Apr 15 00:00:00 EDT 2021
Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide.
Scientific reports
Ueno T,Yamamoto Y,Kawasaki K
Wed Mar 24 00:00:00 EDT 2021
The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.
Immunity
Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C
Tue Sep 15 00:00:00 EDT 2020
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
Immunity
Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G
Tue Oct 13 00:00:00 EDT 2020
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Blood
He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J
Thu Jul 09 00:00:00 EDT 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.
The Journal of clinical investigation
Matthias J,Heink S,Picard F,Zeiträg J,Kolz A,Chao YY,Soll D,de Almeida GP,Glasmacher E,Jacobsen ID,Riedel T,Peters A,Floess S,Huehn J,Baumjohann D,Huber M,Korn T,Zielinski CE
Tue Sep 01 00:00:00 EDT 2020
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis.
The Journal of clinical investigation
Hyun J,Sun Z,Ahmadi AR,Bangru S,Chembazhi UV,Du K,Chen T,Tsukamoto H,Rusyn I,Kalsotra A,Diehl AM
Wed Apr 01 00:00:00 EDT 2020
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
The Journal of experimental medicine
Bogie JFJ,Grajchen E,Wouters E,Corrales AG,Dierckx T,Vanherle S,Mailleux J,Gervois P,Wolfs E,Dehairs J,Van Broeckhoven J,Bowman AP,Lambrichts I,Gustafsson JÅ,Remaley AT,Mulder M,Swinnen JV,Haidar M,Ellis SR,Ntambi JM,Zelcer N,Hendriks JJA
Mon May 04 00:00:00 EDT 2020
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
The Journal of experimental medicine
Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C
Mon Apr 06 00:00:00 EDT 2020
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.
EMBO molecular medicine
Kahlfuss S,Kaufmann U,Concepcion AR,Noyer L,Raphael D,Vaeth M,Yang J,Pancholi P,Maus M,Muller J,Kozhaya L,Khodadadi-Jamayran A,Sun Z,Shaw P,Unutmaz D,Stathopulos PB,Feist C,Cameron SB,Turvey SE,Feske S
Fri Aug 07 00:00:00 EDT 2020
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.
Proceedings of the National Academy of Sciences of the United States of America
Morianos I,Trochoutsou AI,Papadopoulou G,Semitekolou M,Banos A,Konstantopoulos D,Manousopoulou A,Kapasa M,Wei P,Lomenick B,Belaidi E,Kalamatas T,Karageorgiou K,Doskas T,Sallusto F,Pan F,Garbis SD,Quintana FJ,Xanthou G
Tue Jun 02 00:00:00 EDT 2020
Intracellular IL-1 Receptor Antagonist Isoform 1 Released from Keratinocytes upon Cell Death Acts as an Inhibitor for the Alarmin IL-1α.
Journal of immunology (Baltimore, Md. : 1950)
Martin P,Palmer G,Rodriguez E,Palomo J,Lemeille S,Goldstein J,Gabay C
Sat Feb 15 00:00:00 EST 2020
Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.
Journal of immunology (Baltimore, Md. : 1950)
Vyas SP,Hansda AK,Kaplan MH,Goswami R
Sun Mar 01 00:00:00 EST 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Yan J,Hedl M,Abraham C
Sat Aug 15 00:00:00 EDT 2020
TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
Journal of immunology (Baltimore, Md. : 1950)
Yi FS,Zhang X,Zhai K,Huang ZY,Wu XZ,Wu MT,Shi XY,Pei XB,Dong SF,Wang W,Yang Y,Du J,Luo ZT,Shi HZ
Sun Nov 15 00:00:00 EST 2020
Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism.
American journal of physiology. Cell physiology
Liu F,Wang X,Geng H,Bu HF,Wang P,De Plaen IG,Yang H,Qian J,Tan XD
Wed Apr 01 00:00:00 EDT 2020
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.
Nature communications
Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T
Fri Mar 20 00:00:00 EDT 2020
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Scientific reports
Lu J,Lu L,Yu Y,Baranowski J,Claud EC
Mon May 18 00:00:00 EDT 2020
CD4+ T-Cell Differentiation In Vitro.
Methods in molecular biology (Clifton, N.J.)
Yang W,Chen X,Hu H
211-11B was used in In vitro experiments to study the regulating mechanism and function of Th cells, dependent on in vitro CD4+ T-cell differentiation.
Tue Jan 26 00:00:00 EST 2021
Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps.
Cancers
Li M,Lin C,Leso A,Nefedova Y
211-11B was used in In vitro experiments to investigate NET formation in cancer.
Wed Nov 18 00:00:00 EST 2020
Organotypic Culture of Mouse Meibomian Gland: A Novel Model to Study Meibomian Gland Dysfunction In Vitro.
Investigative ophthalmology & visual science
Xu KK,Huang YK,Liu X,Zhang MC,Xie HT
211-11B was used in In vitro experiments to establish a novel in vitro model for investigating the role of inflammation in the process of Meibomian gland dysfunction.
Thu Apr 09 00:00:00 EDT 2020
Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis.
FEBS open bio
Guan M,Zhu Y,Liao B,Tan Q,Qi H,Zhang B,Huang J,Du X,Bai D
Sun Mar 01 00:00:00 EST 2020
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.
Nature communications
Arra M,Swarnkar G,Ke K,Otero JE,Ying J,Duan X,Maruyama T,Rai MF,O'Keefe RJ,Mbalaviele G,Shen J,Abu-Amer Y
Thu Jul 09 00:00:00 EDT 2020
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Nature communications
Mayr L,Grabherr F,Schwärzler J,Reitmeier I,Sommer F,Gehmacher T,Niederreiter L,He GW,Ruder B,Kunz KTR,Tymoszuk P,Hilbe R,Haschka D,Feistritzer C,Gerner RR,Enrich B,Przysiecki N,Seifert M,Keller MA,Oberhuber G,Sprung S,Ran Q,Koch R,Effenberger M,Tancevski I,Zoller H,Moschen AR,Weiss G,Becker C,Rosenstiel P,Kaser A,Tilg H,Adolph TE
Tue Apr 14 00:00:00 EDT 2020
Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Scientific reports
Rambousek L,Gschwind T,Lafourcade C,Paterna JC,Dib L,Fritschy JM,Fontana A
Fri Feb 28 00:00:00 EST 2020
Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.
Scientific reports
Wang J,Ortiz C,Fontenot L,Mukhopadhyay R,Xie Y,Law IKM,Shih DQ,Mattai SA,Li Z,Koon HW
Thu Jul 30 00:00:00 EDT 2020
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
Thu Oct 31 00:00:00 EDT 2019
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.
Cell
Mogilenko DA,Haas JT,L'homme L,Fleury S,Quemener S,Levavasseur M,Becquart C,Wartelle J,Bogomolova A,Pineau L,Molendi-Coste O,Lancel S,Dehondt H,Gheeraert C,Melchior A,Dewas C,Nikitin A,Pic S,Rabhi N,Annicotte JS,Oyadomari S,Velasco-Hernandez T,Cammenga J,Foretz M,Viollet B,Vukovic M,Villacreces A,Kranc K,Carmeliet P,Marot G,Boulter A,Tavernier S,Berod L,Longhi MP,Paget C,Janssens S,Staumont-Sallé D,Aksoy E,Staels B,Dombrowicz D
Thu May 16 00:00:00 EDT 2019
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.
Immunity
Burzynski LC,Humphry M,Pyrillou K,Wiggins KA,Chan JNE,Figg N,Kitt LL,Summers C,Tatham KC,Martin PB,Bennett MR,Clarke MCH
Tue Apr 16 00:00:00 EDT 2019
Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β.
Immunity
Komuczki J,Tuzlak S,Friebel E,Hartwig T,Spath S,Rosenstiel P,Waisman A,Opitz L,Oukka M,Schreiner B,Pelczar P,Becher B
Tue May 21 00:00:00 EDT 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
Tue Jan 15 00:00:00 EST 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
211-11B was used in Flow cytometry/Cell sorting to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 EDT 2019
A role for macrophages in hematopoiesis in the embryonic head.
Blood
Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E
Thu Nov 28 00:00:00 EST 2019
Type I interferon induces CXCL13 to support ectopic germinal center formation.
The Journal of experimental medicine
Denton AE,Innocentin S,Carr EJ,Bradford BM,Lafouresse F,Mabbott NA,Mörbe U,Ludewig B,Groom JR,Good-Jacobson KL,Linterman MA
Mon Mar 04 00:00:00 EST 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
The Journal of experimental medicine
Sun X,Cui Y,Feng H,Liu H,Liu X
Mon Dec 02 00:00:00 EST 2019
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
The EMBO journal
Fossati G,Pozzi D,Canzi A,Mirabella F,Valentino S,Morini R,Ghirardini E,Filipello F,Moretti M,Gotti C,Annis DS,Mosher DF,Garlanda C,Bottazzi B,Taraboletti G,Mantovani A,Matteoli M,Menna E
Thu Jan 03 00:00:00 EST 2019
Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset.
Aging cell
Martini H,Iacovoni JS,Maggiorani D,Dutaur M,Marsal DJ,Roncalli J,Itier R,Dambrin C,Pizzinat N,Mialet-Perez J,Cussac D,Parini A,Lefevre L,Douin-Echinard V
Tue Oct 01 00:00:00 EDT 2019
Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells.
Genome research
Miraldi ER,Pokrovskii M,Watters A,Castro DM,De Veaux N,Hall JA,Lee JY,Ciofani M,Madar A,Carriero N,Littman DR,Bonneau R
211-11B was used in Sample Preparation to study TRN inference in a mammalian setting by developing methods in the context of T Helper Cell Type 17 (Th17) differentiation, generating new ATAC-seq data to complement existing Th17 genomic resources. This study provides quantitative, genome-scale evaluation of TRN inference, combining ATAC-seq and RNA-seq data.
Fri Mar 01 00:00:00 EST 2019
Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities.
Journal of neurochemistry
Bosch ME,Kielian T
211-11B was used in Cell Culture to investigate astrocyte glutamate toxicity in neuronal loss of juvenile neuronal ceroid lipofuscinosis.
Fri Mar 01 00:00:00 EST 2019
USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.
Journal of immunology (Baltimore, Md. : 1950)
Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB
211-11B was used in In vitro experiments to investigate ubiquitination of TAK1.
Mon Jul 01 00:00:00 EDT 2019
USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.
Journal of immunology (Baltimore, Md. : 1950)
Lei CQ,Wu X,Zhong X,Jiang L,Zhong B,Shu HB
211-11B was used in In vitro experiments to investigate ubiquitination of TAK1.
Mon Jul 01 00:00:00 EDT 2019
Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Barman PK,Pang J,Urao N,Koh TJ
211-11B was used in Cell Culture to investigate whether skin wounding induces monocyte expansion in bone marrow and if IL-1R1 signalling regulates this process.
Wed May 01 00:00:00 EDT 2019
Gamma-secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF-κB signaling pathway induced by IL-1β and TNF-α in nucleus pulposus cells.
Journal of cellular biochemistry
Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J
Fri Feb 01 00:00:00 EST 2019
Gamma-secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF-κB signaling pathway induced by IL-1β and TNF-α in nucleus pulposus cells.
Journal of cellular biochemistry
Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J
Fri Feb 01 00:00:00 EST 2019
Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.
Scientific reports
Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR
Wed Nov 20 00:00:00 EST 2019
Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation.
Scientific reports
Dai D,Yuan J,Wang Y,Xu J,Mao C,Xiao Y
Wed May 29 00:00:00 EDT 2019
Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells.
Nature communications
Rosenbaum M,Gewies A,Pechloff K,Heuser C,Engleitner T,Gehring T,Hartjes L,Krebs S,Krappmann D,Kriegsmann M,Weichert W,Rad R,Kurts C,Ruland J
Tue May 28 00:00:00 EDT 2019
Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.
The Journal of biological chemistry
Yin W,Song Y,Chang X
Fri Jan 04 00:00:00 EST 2019
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.
Cell reports
Koliaraki V,Chalkidi N,Henriques A,Tzaferis C,Polykratis A,Waisman A,Muller W,Hackam DJ,Pasparakis M,Kollias G
211-11B was used in Cell Culture to investigate the role of MyD88 in sporadic intestinal carcinogenesis.
Tue Jan 15 00:00:00 EST 2019
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 EST 2018
Vitamin D Switches BAF Complexes to Protect β Cells.
Cell
Wei Z,Yoshihara E,He N,Hah N,Fan W,Pinto AFM,Huddy T,Wang Y,Ross B,Estepa G,Dai Y,Ding N,Sherman MH,Fang S,Zhao X,Liddle C,Atkins AR,Yu RT,Downes M,Evans RM
Thu May 17 00:00:00 EDT 2018
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Cell
Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T
Thu Jan 11 00:00:00 EST 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 EST 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 EDT 2018
Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.
Immunity
Barbet G,Sander LE,Geswell M,Leonardi I,Cerutti A,Iliev I,Blander JM
Tue Mar 20 00:00:00 EDT 2018
Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.
Immunity
Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X
Tue Jul 17 00:00:00 EDT 2018
Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis.
Immunity
Castellanos JG,Woo V,Viladomiu M,Putzel G,Lima S,Diehl GE,Marderstein AR,Gandara J,Perez AR,Withers DR,Targan SR,Shih DQ,Scherl EJ,Longman RS
Tue Dec 18 00:00:00 EST 2018
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling.
Molecular cell
Zhao Y,Mudge MC,Soll JM,Rodrigues RB,Byrum AK,Schwarzkopf EA,Bradstreet TR,Gygi SP,Edelson BT,Mosammaparast N
211-11B was used in In vitro experiments to study how the deubiquitinase OTUD4, which nominally encodes a K48-specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63-specific deubiquitinase to show how deubiquitinase may modulate diverse processes through post-translational modification.
Thu Feb 01 00:00:00 EST 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
Mon Sep 03 00:00:00 EDT 2018
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.
The Journal of experimental medicine
Hogstad B,Berres ML,Chakraborty R,Tang J,Bigenwald C,Serasinghe M,Lim KPH,Lin H,Man TK,Remark R,Baxter S,Kana V,Jordan S,Karoulia Z,Kwan WH,Leboeuf M,Brandt E,Salmon H,McClain K,Poulikakos P,Chipuk J,Mulder WJM,Allen CE,Merad M
Tue Jan 02 00:00:00 EST 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 EDT 2018
Contextual control of skin immunity and inflammation by Corynebacterium.
The Journal of experimental medicine
Ridaura VK,Bouladoux N,Claesen J,Chen YE,Byrd AL,Constantinides MG,Merrill ED,Tamoutounour S,Fischbach MA,Belkaid Y
Mon Mar 05 00:00:00 EST 2018
Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling.
Experimental & molecular medicine
Baek JM,Cheon YH,Kwak SC,Jun HY,Yoon KH,Lee MS,Kim JY
Fri Apr 27 00:00:00 EDT 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 EDT 2018
Single cell analysis of kynurenine and System L amino acid transport in T cells.
Nature communications
Sinclair LV,Neyens D,Ramsay G,Taylor PM,Cantrell DA
Thu May 17 00:00:00 EDT 2018
GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.
Scientific reports
Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S
Tue Apr 03 00:00:00 EDT 2018
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Frontiers in pharmacology
Liang S,Lv ZT,Zhang JM,Wang YT,Dong YH,Wang ZG,Chen K,Cheng P,Yang Q,Guo FJ,Lu WW,Zhu WT,Chen AM
211-11B was used in In vitro experiments to study the effects of necrostatin-1 (Nec-1) on interleukin (IL)-1β-induced inflammation in mouse chondrocytes and the destabilised medial meniscus (DMM) mouse model.
Tue Sep 29 00:00:00 EDT 2020
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
The Journal of biological chemistry
Wang Z,Huang J,Zhou S,Luo F,Tan Q,Sun X,Ni Z,Chen H,Du X,Xie Y,Chen L
Fri Jun 08 00:00:00 EDT 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
Nature communications
Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C
Thu Apr 12 00:00:00 EDT 2018
Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization.
Stem cell research & therapy
Philipp D,Suhr L,Wahlers T,Choi YH,Paunel-Görgülü A
Thu Oct 25 00:00:00 EDT 2018
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment.
Cell death & disease
Ruiz L,Gurlo T,Ravier MA,Wojtusciszyn A,Mathieu J,Brown MR,Broca C,Bertrand G,Butler PC,Matveyenko AV,Dalle S,Costes S
Tue May 22 00:00:00 EDT 2018
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage.
Nature
Naik S,Larsen SB,Gomez NC,Alaverdyan K,Sendoel A,Yuan S,Polak L,Kulukian A,Chai S,Fuchs E
Thu Oct 26 00:00:00 EDT 2017
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 EDT 2017
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.
Cell
Moretti J,Roy S,Bozec D,Martinez J,Chapman JR,Ueberheide B,Lamming DW,Chen ZJ,Horng T,Yeretssian G,Green DR,Blander JM
Thu Nov 02 00:00:00 EDT 2017
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Cell
Dang EV,McDonald JG,Russell DW,Cyster JG
Thu Nov 16 00:00:00 EST 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
Tue Dec 19 00:00:00 EST 2017
IL-22 Upregulates Epithelial Claudin-2 to Drive Diarrhea and Enteric Pathogen Clearance.
Cell host & microbe
Tsai PY,Zhang B,He WQ,Zha JM,Odenwald MA,Singh G,Tamura A,Shen L,Sailer A,Yeruva S,Kuo WT,Fu YX,Tsukita S,Turner JR
211-11B was used in Cell Culture to investigate the pathogenic effects of diarrhea.
Wed Jun 14 00:00:00 EDT 2017
The islet-resident macrophage is in an inflammatory state and senses microbial products in blood.
The Journal of experimental medicine
Ferris ST,Zakharov PN,Wan X,Calderon B,Artyomov MN,Unanue ER,Carrero JA
Mon Aug 07 00:00:00 EDT 2017
Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome.
Journal of immunology (Baltimore, Md. : 1950)
Xing Y,Yao X,Li H,Xue G,Guo Q,Yang G,An L,Zhang Y,Meng G
Fri Sep 01 00:00:00 EDT 2017
IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Vazquez-Lombardi R,Luong JK,Warren J,Stolp J,Christ D,King C,Brink R,Sprent J,Webster KE
Sun Oct 01 00:00:00 EDT 2017
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y
Sun Oct 15 00:00:00 EDT 2017
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.
Oncoimmunology
Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE
211-11B was used in In vivo experiments to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17-neutrophil axis.
Sat Jan 29 00:00:00 EST 2022
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
NPJ Parkinson's disease
Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG
Wed Sep 30 00:00:00 EDT 2020
A high-fat diet impairs reproduction by decreasing the IL1β level in mice treated at immature stage.
Scientific reports
Zhang J,Li K,Yuan M,Zhang J,Huang G,Ao J,Tan H,Li Y,Gong D,Li J,Kang L,An N,Li F,Lin P,Huang L
211-11B was used in Cell Culture to investigate a high-fat diet in mice on Interleukin 1 beta.
Mon Apr 03 00:00:00 EDT 2017
Implication of REDD1 in the activation of inflammatory pathways.
Scientific reports
Pastor F,Dumas K,Barthélémy MA,Regazzetti C,Druelle N,Peraldi P,Cormont M,Tanti JF,Giorgetti-Peraldi S
Tue Aug 01 00:00:00 EDT 2017
IL-15 sustains IL-7R-independent ILC2 and ILC3 development.
Nature communications
Robinette ML,Bando JK,Song W,Ulland TK,Gilfillan S,Colonna M
Fri Mar 31 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
211-11B was used in Cell Culture to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.
Tue Jan 12 00:00:00 EST 2021
The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction.
Scientific reports
Nagasaka A,Mogi C,Ono H,Nishi T,Horii Y,Ohba Y,Sato K,Nakaya M,Okajima F,Kurose H
Thu Aug 10 00:00:00 EDT 2017
The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis.
The Journal of biological chemistry
Vaamonde-Garcia C,Courties A,Pigenet A,Laiguillon MC,Sautet A,Houard X,Kerdine-Römer S,Meijide R,Berenbaum F,Sellam J
Fri Sep 01 00:00:00 EDT 2017
DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas.
Cell
Herrtwich L,Nanda I,Evangelou K,Nikolova T,Horn V,Erny D,Stefanowski J,Rogell L,Klein C,Gharun K,Follo M,Seidl M,Kremer B,Münke N,Senges J,Fliegauf M,Aschman T,Pfeifer D,Sarrazin S,Sieweke MH,Wagner D,Dierks C,Haaf T,Ness T,Zaiss MM,Voll RE,Deshmukh SD,Prinz M,Goldmann T,Hölscher C,Hauser AE,Lopez-Contreras AJ,Grün D,Gorgoulis V,Diefenbach A,Henneke P,Triantafyllopoulou A
Thu Nov 17 00:00:00 EST 2016
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Immunity
Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C
Tue Jun 21 00:00:00 EDT 2016
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 EDT 2016
Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.
Immunity
Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O
Tue Jul 19 00:00:00 EDT 2016
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
The Journal of clinical investigation
Fritz M,Klawonn AM,Nilsson A,Singh AK,Zajdel J,Wilhelms DB,Lazarus M,Löfberg A,Jaarola M,Kugelberg UÖ,Billiar TR,Hackam DJ,Sodhi CP,Breyer MD,Jakobsson J,Schwaninger M,Schütz G,Parkitna JR,Saper CB,Blomqvist A,Engblom D
Mon Feb 01 00:00:00 EST 2016
Donor dendritic cell-derived exosomes promote allograft-targeting immune response.
The Journal of clinical investigation
Liu Q,Rojas-Canales DM,Divito SJ,Shufesky WJ,Stolz DB,Erdos G,Sullivan ML,Gibson GA,Watkins SC,Larregina AT,Morelli AE
Mon Aug 01 00:00:00 EDT 2016
Recent thymic emigrants are tolerized in the absence of inflammation.
The Journal of experimental medicine
Friesen TJ,Ji Q,Fink PJ
Mon May 30 00:00:00 EDT 2016
GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.
The Journal of experimental medicine
Littlewood-Evans A,Sarret S,Apfel V,Loesle P,Dawson J,Zhang J,Muller A,Tigani B,Kneuer R,Patel S,Valeaux S,Gommermann N,Rubic-Schneider T,Junt T,Carballido JM
Mon Aug 22 00:00:00 EDT 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
Tue Feb 09 00:00:00 EST 2016
Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque.
Stem cells (Dayton, Ohio)
Leszczynska A,O'Doherty A,Farrell E,Pindjakova J,O'Brien FJ,O'Brien T,Barry F,Murphy M
Fri Apr 01 00:00:00 EDT 2016
Lack of IL-1 Receptor-Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection.
Journal of immunology (Baltimore, Md. : 1950)
Marinho FV,Fahel JS,Scanga CA,Gomes MT,Guimarães G,Carvalho GR,Morales SV,Báfica A,Oliveira SC
Thu Sep 01 00:00:00 EDT 2016
Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Journal of immunology (Baltimore, Md. : 1950)
Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K
Sun May 01 00:00:00 EDT 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 EDT 2016
Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Su P,Chen S,Zheng YH,Zhou HY,Yan CH,Yu F,Zhang YG,He L,Zhang Y,Wang Y,Wu L,Wu X,Yu B,Ma LY,Yang Z,Wang J,Zhao G,Zhu J,Wu ZY,Sun B
Mon Aug 15 00:00:00 EDT 2016
Broad Infiltration of Macrophages Leads to a Proinflammatory State in Streptozotocin-Induced Hyperglycemic Mice.
Journal of immunology (Baltimore, Md. : 1950)
Niu S,Bian Z,Tremblay A,Luo Y,Kidder K,Mansour A,Zen K,Liu Y
Sat Oct 15 00:00:00 EDT 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
Fri Jul 15 00:00:00 EDT 2016
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Journal of immunology (Baltimore, Md. : 1950)
Boucard-Jourdin M,Kugler D,Endale Ahanda ML,This S,De Calisto J,Zhang A,Mora JR,Stuart LM,Savill J,Lacy-Hulbert A,Paidassi H
Thu Sep 01 00:00:00 EDT 2016
Peroxiredoxin 1 Contributes to Host Defenses against Mycobacterium tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Matsumura K,Iwai H,Kato-Miyazawa M,Kirikae F,Zhao J,Yanagawa T,Ishii T,Miyoshi-Akiyama T,Funatogawa K,Kirikae T
Sat Oct 15 00:00:00 EDT 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
Mon Apr 18 00:00:00 EDT 2016
Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.
Scientific reports
Liu J,Copland DA,Theodoropoulou S,Chiu HA,Barba MD,Mak KW,Mack M,Nicholson LB,Dick AD
Fri Feb 05 00:00:00 EST 2016
Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.
Nature communications
Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S
Tue Mar 22 00:00:00 EDT 2016
Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.
Nature communications
Martino MM,Maruyama K,Kuhn GA,Satoh T,Takeuchi O,Müller R,Akira S
Tue Mar 22 00:00:00 EDT 2016
Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.
The Journal of biological chemistry
Luo MC,Zhou SY,Feng DY,Xiao J,Li WY,Xu CD,Wang HY,Zhou T
Fri Oct 14 00:00:00 EDT 2016
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Nature communications
Zhao Y,Chu X,Chen J,Wang Y,Gao S,Jiang Y,Zhu X,Tan G,Zhao W,Yi H,Xu H,Ma X,Lu Y,Yi Q,Wang S
Fri Aug 05 00:00:00 EDT 2016
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
The Journal of biological chemistry
Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y
Fri Aug 26 00:00:00 EDT 2016
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Scientific reports
Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ
Mon May 23 00:00:00 EDT 2016
Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.
Scientific reports
Song S,Faleo G,Yeung R,Kant R,Posselt AM,Desai TA,Tang Q,Roy S
Thu Mar 24 00:00:00 EDT 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Fri Jun 03 00:00:00 EDT 2016
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
Scientific reports
Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D
Thu Jan 07 00:00:00 EST 2016
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.
Scientific reports
Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D
Thu Jan 07 00:00:00 EST 2016
Macrophage-mediated inflammatory response decreases mycobacterial survival in mouse MSCs by augmenting NO production.
Scientific reports
Yang K,Wu Y,Xie H,Li M,Ming S,Li L,Li M,Wu M,Gong S,Huang X
Thu Jun 02 00:00:00 EDT 2016
A Novel Protective Function of 5-Methoxytryptophan in Vascular Injury.
Scientific reports
Ho YC,Wu ML,Su CH,Chen CH,Ho HH,Lee GL,Lin WS,Lin WY,Hsu YJ,Kuo CC,Wu KK,Yet SF
Thu May 05 00:00:00 EDT 2016
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Immunity
Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C
Tue Apr 21 00:00:00 EDT 2015
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair.
The Journal of clinical investigation
Leoni G,Neumann PA,Kamaly N,Quiros M,Nishio H,Jones HR,Sumagin R,Hilgarth RS,Alam A,Fredman G,Argyris I,Rijcken E,Kusters D,Reutelingsperger C,Perretti M,Parkos CA,Farokhzad OC,Neish AS,Nusrat A
Mon Mar 02 00:00:00 EST 2015
The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
The Journal of experimental medicine
Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG
Mon Jun 29 00:00:00 EDT 2015
IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer.
The Journal of experimental medicine
Koliaraki V,Pasparakis M,Kollias G
Mon Dec 14 00:00:00 EST 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
Wed Apr 01 00:00:00 EDT 2015
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.
European journal of immunology
Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S
Fri May 01 00:00:00 EDT 2015
Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.
Stem cells (Dayton, Ohio)
Kavanagh DP,Suresh S,Newsome PN,Frampton J,Kalia N
Tue Sep 01 00:00:00 EDT 2015
Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease.
Journal of immunology (Baltimore, Md. : 1950)
Ladell K,Hazenberg MD,Fitch M,Emson C,McEvoy-Hein Asgarian BK,Mold JE,Miller C,Busch R,Price DA,Hellerstein MK,McCune JM
Sun Nov 01 00:00:00 EDT 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
Wed Apr 01 00:00:00 EDT 2015
Composition, Development, and Function of Uterine Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Balmas E,Boulenouar S,Gaynor LM,Kieckbusch J,Gardner L,Hawkes DA,Barbara CF,Sharkey AM,Brady HJ,Brosens JJ,Moffett A,Colucci F
Thu Oct 15 00:00:00 EDT 2015
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB
Tue Dec 15 00:00:00 EST 2015
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
PloS one
Bremser A,Brack M,Izcue A
211-11B was used in Cell Culture to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.
Tue May 24 00:00:00 EDT 2016
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.
The Journal of biological chemistry
Fujimaki K,Ogihara T,Morris DL,Oda H,Iida H,Fujitani Y,Mirmira RG,Evans-Molina C,Watada H
Fri Jul 03 00:00:00 EDT 2015
Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.
Scientific reports
Yamamoto S,Niida S,Azuma E,Yanagibashi T,Muramatsu M,Huang TT,Sagara H,Higaki S,Ikutani M,Nagai Y,Takatsu K,Miyazaki K,Hamashima T,Mori H,Matsuda N,Ishii Y,Sasahara M
Tue Feb 17 00:00:00 EST 2015
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Nature communications
Yoon JH,Sudo K,Kuroda M,Kato M,Lee IK,Han JS,Nakae S,Imamura T,Kim J,Ju JH,Kim DK,Matsuzaki K,Weinstein M,Matsumoto I,Sumida T,Mamura M
Tue Jul 21 00:00:00 EDT 2015
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
Thu Oct 16 00:00:00 EDT 2014
Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
The Journal of clinical investigation
Westphalen CB,Asfaha S,Hayakawa Y,Takemoto Y,Lukin DJ,Nuber AH,Brandtner A,Setlik W,Remotti H,Muley A,Chen X,May R,Houchen CW,Fox JG,Gershon MD,Quante M,Wang TC
Sat Mar 01 00:00:00 EST 2014
Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
The Journal of clinical investigation
Choi SH,Kim BG,Robinson J,Fink S,Yan M,Sporn MB,Markowitz SD,Letterio JJ
Sun Jun 01 00:00:00 EDT 2014
Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3.
The Journal of experimental medicine
Tanaka S,Suto A,Iwamoto T,Kashiwakuma D,Kagami S,Suzuki K,Takatori H,Tamachi T,Hirose K,Onodera A,Suzuki J,Ohara O,Yamashita M,Nakayama T,Nakajima H
Mon Aug 25 00:00:00 EDT 2014
Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.
Proceedings of the National Academy of Sciences of the United States of America
Watanabe Y,Onodera A,Kanai U,Ichikawa T,Obata-Ninomiya K,Wada T,Kiuchi M,Iwamura C,Tumes DJ,Shinoda K,Yagi R,Motohashi S,Hirahara K,Nakayama T
Tue Sep 02 00:00:00 EDT 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
Tue Aug 26 00:00:00 EDT 2014
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
Proceedings of the National Academy of Sciences of the United States of America
Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS
Tue Jul 29 00:00:00 EDT 2014
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Roulis M,Nikolaou C,Kotsaki E,Kaffe E,Karagianni N,Koliaraki V,Salpea K,Ragoussis J,Aidinis V,Martini E,Becker C,Herschman HR,Vetrano S,Danese S,Kollias G
Tue Oct 28 00:00:00 EDT 2014
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition.
Proceedings of the National Academy of Sciences of the United States of America
Kaiser WJ,Daley-Bauer LP,Thapa RJ,Mandal P,Berger SB,Huang C,Sundararajan A,Guo H,Roback L,Speck SH,Bertin J,Gough PJ,Balachandran S,Mocarski ES
Tue May 27 00:00:00 EDT 2014
TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state.
Oncogene
Mori T,Sato Y,Miyamoto K,Kobayashi T,Shimizu T,Kanagawa H,Katsuyama E,Fujie A,Hao W,Tando T,Iwasaki R,Kawana H,Morioka H,Matsumoto M,Saya H,Toyama Y,Miyamoto T
Thu Aug 14 00:00:00 EDT 2014
NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.
Mucosal immunology
Nordlander S,Pott J,Maloy KJ
211-11B was used in Enzyme-linked immunosorbent assay to study how early NLRC4 sensing in intestinal epithelial cells regulates colonization by an extracellular bacterial pathogen and limits subsequent intestinal damage.
Tue Jul 01 00:00:00 EDT 2014
Nlrp3 activation in the intestinal epithelium protects against a mucosal pathogen.
Mucosal immunology
Song-Zhao GX,Srinivasan N,Pott J,Baban D,Frankel G,Maloy KJ
211-11B was used in Enzyme-linked immunosorbent assay to investigate how protection from disease is mediated through Nlrp3 activation in nonhematopoietic cells and is initiated very early after infection.
Tue Jul 01 00:00:00 EDT 2014
Excess IL-1 signaling enhances the development of Th17 cells by downregulating TGF-β-induced Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ikeda S,Saijo S,Murayama MA,Shimizu K,Akitsu A,Iwakura Y
Sat Feb 15 00:00:00 EST 2014
The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
Journal of immunology (Baltimore, Md. : 1950)
Severa M,Islam SA,Waggoner SN,Jiang Z,Kim ND,Ryan G,Kurt-Jones E,Charo I,Caffrey DR,Boyartchuk VL,Luster AD,Fitzgerald KA
Sat Mar 01 00:00:00 EST 2014
Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.
Journal of immunology (Baltimore, Md. : 1950)
Sriskantharajah S,Gückel E,Tsakiri N,Kierdorf K,Brender C,Ben-Addi A,Veldhoen M,Tsichlis PN,Stockinger B,O'Garra A,Prinz M,Kollias G,Ley SC
Tue Apr 15 00:00:00 EDT 2014
A novel TLR2-triggered signalling crosstalk synergistically intensifies TNF-mediated IL-6 induction.
Journal of cellular and molecular medicine
Chang YL,Chen TH,Wu YH,Chen GA,Weng TH,Tseng PH,Hsieh SL,Fu SL,Lin CH,Chen CJ,Chu CL,Chio II,Mak TW,Chen NJ
Tue Jul 01 00:00:00 EDT 2014
Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation.
Cell death & disease
Huang RL,Yuan Y,Tu J,Zou GM,Li Q
Thu Apr 17 00:00:00 EDT 2014
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.
Scientific reports
Tilstra JS,Gaddy DF,Zhao J,Davé SH,Niedernhofer LJ,Plevy SE,Robbins PD
Fri Jan 10 00:00:00 EST 2014
Tumor necrosis factor and transforming growth factor β regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP).
The Journal of biological chemistry
Lopez M,Meier D,Müller A,Franken P,Fujita J,Fontana A
Fri Jan 31 00:00:00 EST 2014
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.
The Journal of clinical investigation
Ye P,Chen W,Wu J,Huang X,Li J,Wang S,Liu Z,Wang G,Yang X,Zhang P,Lv Q,Xia J
Wed May 01 00:00:00 EDT 2013
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Masuda K,Ripley B,Nishimura R,Mino T,Takeuchi O,Shioi G,Kiyonari H,Kishimoto T
Tue Jun 04 00:00:00 EDT 2013
Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Lamagna C,Scapini P,van Ziffle JA,DeFranco AL,Lowell CA
Tue Aug 27 00:00:00 EDT 2013
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH
Tue Feb 05 00:00:00 EST 2013
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T
Mon Jul 15 00:00:00 EDT 2013
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH
Mon Jul 15 00:00:00 EDT 2013
The role of IL-1β in the early tumor cell-induced angiogenic response.
Journal of immunology (Baltimore, Md. : 1950)
Carmi Y,Dotan S,Rider P,Kaplanov I,White MR,Baron R,Abutbul S,Huszar M,Dinarello CA,Apte RN,Voronov E
Mon Apr 01 00:00:00 EDT 2013
CD47 deficiency does not impede polymorphonuclear neutrophil transmigration but attenuates granulopoiesis at the postacute stage of colitis.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Luo Y,Tremblay A,Zhang X,Dharma S,Mishra A,Liu Y
Tue Jan 01 00:00:00 EST 2013
IL-23-independent induction of IL-17 from γδT cells and innate lymphoid cells promotes experimental intraocular neovascularization.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa E,Sonoda KH,Shichita T,Morita R,Sekiya T,Kimura A,Oshima Y,Takeda A,Yoshimura T,Yoshida S,Ishibashi T,Yoshimura A
Fri Feb 15 00:00:00 EST 2013
Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
Journal of immunology (Baltimore, Md. : 1950)
Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E
Mon Jul 15 00:00:00 EDT 2013
Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Bassity E,Flies A,Strutt TM,Garcia-Hernandez Mde L,McKinstry KK,Zou T,Swain SL,Dutton RW
Tue Jan 01 00:00:00 EST 2013
Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-α.
Journal of immunology (Baltimore, Md. : 1950)
Duhart JM,Leone MJ,Paladino N,Evans JA,Castanon-Cervantes O,Davidson AJ,Golombek DA
Fri Nov 01 00:00:00 EDT 2013
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.
Journal of translational medicine
Przybyt E,Krenning G,Brinker MG,Harmsen MC
Wed Feb 13 00:00:00 EST 2013
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.
Journal of translational medicine
Przybyt E,Krenning G,Brinker MG,Harmsen MC
Wed Feb 13 00:00:00 EST 2013
Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2.
Journal of translational medicine
Przybyt E,Krenning G,Brinker MG,Harmsen MC
Wed Feb 13 00:00:00 EST 2013
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
The Journal of biological chemistry
Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH
Fri Sep 20 00:00:00 EDT 2013
Do β-cells generate peroxynitrite in response to cytokine treatment?
The Journal of biological chemistry
Broniowska KA,Mathews CE,Corbett JA
Fri Dec 20 00:00:00 EST 2013
Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression.
Blood
Adhikary S,Kocieda VP,Yen JH,Tuma RF,Ganea D
Thu Nov 01 00:00:00 EDT 2012
SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.
Cellular & molecular immunology
Zhang X,Han S,Kang Y,Guo M,Hong S,Liu F,Fu S,Wang L,Wang QX
Sat Sep 01 00:00:00 EDT 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 EST 2012
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.
The Journal of clinical investigation
Koliaraki V,Roulis M,Kollias G
Thu Nov 01 00:00:00 EDT 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
Mon Oct 22 00:00:00 EDT 2012
High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
The Journal of experimental medicine
Yang D,Postnikov YV,Li Y,Tewary P,de la Rosa G,Wei F,Klinman D,Gioannini T,Weiss JP,Furusawa T,Bustin M,Oppenheim JJ
Mon Jan 16 00:00:00 EST 2012
Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.
Proceedings of the National Academy of Sciences of the United States of America
Descamps D,Le Gars M,Balloy V,Barbier D,Maschalidi S,Tohme M,Chignard M,Ramphal R,Manoury B,Sallenave JM
Tue Jan 31 00:00:00 EST 2012
Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.
Cellular and molecular life sciences : CMLS
Wann AK,Knight MM
Sat Sep 01 00:00:00 EDT 2012
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Schiffmann S,Ferreiros N,Birod K,Eberle M,Schreiber Y,Pfeilschifter W,Ziemann U,Pierre S,Scholich K,Grösch S,Geisslinger G
Fri Jun 01 00:00:00 EDT 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 EST 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 EDT 2012
Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
The Journal of biological chemistry
Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N
Fri Sep 21 00:00:00 EDT 2012
Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.
The Journal of biological chemistry
Paget C,Ivanov S,Fontaine J,Renneson J,Blanc F,Pichavant M,Dumoutier L,Ryffel B,Renauld JC,Gosset P,Gosset P,Si-Tahar M,Faveeuw C,Trottein F
Fri Mar 16 00:00:00 EDT 2012
In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.
PloS one
Coppola A,Tomasello L,Pizzolanti G,Pucci-Minafra I,Albanese N,Di Cara G,Cancemi P,Pitrone M,Bommarito A,Carissimi E,Zito G,Criscimanna A,Galluzzo A,Giordano C
Mon Jul 23 00:00:00 EDT 2012
Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735.
PloS one
Hall KC,Blobel CP
Mon Aug 27 00:00:00 EDT 2012
MicroRNA-124 as a novel treatment for persistent hyperalgesia.
Journal of neuroinflammation
Willemen HL,Huo XJ,Mao-Ying QL,Zijlstra J,Heijnen CJ,Kavelaars A
Mon Jun 25 00:00:00 EDT 2012
Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.
PloS one
Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL
Thu Sep 27 00:00:00 EDT 2012
Comparison of the virulence potential of Acinetobacter strains from clinical and environmental sources.
PloS one
Tayabali AF,Nguyen KC,Shwed PS,Crosthwait J,Coleman G,Seligy VL
Thu Sep 27 00:00:00 EDT 2012
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.
Nature
Sander LE,Davis MJ,Boekschoten MV,Amsen D,Dascher CC,Ryffel B,Swanson JA,Müller M,Blander JM
Sun May 22 00:00:00 EDT 2011
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
Fri Mar 25 00:00:00 EDT 2011
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.
Immunity
Kuroda E,Ishii KJ,Uematsu S,Ohata K,Coban C,Akira S,Aritake K,Urade Y,Morimoto Y
Fri Apr 22 00:00:00 EDT 2011
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.
Nature immunology
Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP
Sun May 01 00:00:00 EDT 2011
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A.
Blood
Joyal JS,Sitaras N,Binet F,Rivera JC,Stahl A,Zaniolo K,Shao Z,Polosa A,Zhu T,Hamel D,Djavari M,Kunik D,Honoré JC,Picard E,Zabeida A,Varma DR,Hickson G,Mancini J,Klagsbrun M,Costantino S,Beauséjour C,Lachapelle P,Smith LE,Chemtob S,Sapieha P
Thu Jun 02 00:00:00 EDT 2011
TAK1 in brain endothelial cells mediates fever and lethargy.
The Journal of experimental medicine
Ridder DA,Lang MF,Salinin S,Röderer JP,Struss M,Maser-Gluth C,Schwaninger M
Mon Dec 19 00:00:00 EST 2011
Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature.
Journal of immunology (Baltimore, Md. : 1950)
Brancaleone V,Dalli J,Bena S,Flower RJ,Cirino G,Perretti M
Fri Apr 15 00:00:00 EDT 2011
Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Soulard V,Bécourt C,Amniai L,Henrot P,Havenar-Daughton C,Blanchet C,Zitvogel L,Ryffel B,Cavaillon JM,Marie JC,Couillin I,Benlagha K
Sat Jan 15 00:00:00 EST 2011
Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis.
Journal of immunology (Baltimore, Md. : 1950)
Carmi Y,Rinott G,Dotan S,Elkabets M,Rider P,Voronov E,Apte RN
Tue Mar 15 00:00:00 EDT 2011
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Wang L,Du C,Lv J,Wei W,Cui Y,Xie X
Thu Sep 01 00:00:00 EDT 2011
The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.
Journal of immunology (Baltimore, Md. : 1950)
Möser CV,Kynast K,Baatz K,Russe OQ,Ferreirós N,Costiuk H,Lu R,Schmidtko A,Tegeder I,Geisslinger G,Niederberger E
Thu Sep 01 00:00:00 EDT 2011
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.
Clinical & experimental metastasis
Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M
Sat Jan 01 00:00:00 EST 2011
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis.
Clinical & experimental metastasis
Seike T,Fujita K,Yamakawa Y,Kido MA,Takiguchi S,Teramoto N,Iguchi H,Noda M
Sat Jan 01 00:00:00 EST 2011
Influence of synthetic superparamagnetic iron oxide on dendritic cells.
International journal of nanomedicine
Mou Y,Chen B,Zhang Y,Hou Y,Xie H,Xia G,Tang M,Huang X,Ni Y,Hu Q
Wed Feb 08 00:00:00 EST 2012
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 EST 2011
In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide.
International journal of nanomedicine
Mou Y,Hou Y,Chen B,Hua Z,Zhang Y,Xie H,Xia G,Wang Z,Huang X,Han W,Ni Y,Hu Q
Tue Mar 27 00:00:00 EDT 2012
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
Thu Sep 29 00:00:00 EDT 2011
Early effects of lipopolysaccharide-induced inflammation on foetal brain development in rat.
ASN neuro
Ghiani CA,Mattan NS,Nobuta H,Malvar JS,Boles J,Ross MG,Waschek JA,Carpenter EM,Fisher RS,de Vellis J
Thu Nov 17 00:00:00 EST 2011
Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells.
PloS one
Bess E,Fisslthaler B,Frömel T,Fleming I
Fri Sep 30 00:00:00 EDT 2011
The non-phagocytic route of collagen uptake: a distinct degradation pathway.
The Journal of biological chemistry
Madsen DH,Ingvarsen S,Jürgensen HJ,Melander MC,Kjøller L,Moyer A,Honoré C,Madsen CA,Garred P,Burgdorf S,Bugge TH,Behrendt N,Engelholm LH
Fri Jul 29 00:00:00 EDT 2011
A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli.
Journal of neuroinflammation
Welser-Alves JV,Crocker SJ,Milner R
Wed Jun 01 00:00:00 EDT 2011
MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts.
PloS one
Chen Z,Phillips LK,Gould E,Campisi J,Lee SW,Ormerod BK,Zwierzchoniewska M,Martinez OM,Palmer TD
Wed Mar 30 00:00:00 EDT 2011
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
PloS one
Siegert S,Huang HY,Yang CY,Scarpellino L,Carrie L,Essex S,Nelson PJ,Heikenwalder M,Acha-Orbea H,Buckley CD,Marsland BJ,Zehn D,Luther SA
Mon Mar 26 00:00:00 EDT 2012
Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature.
Blood
Pederzoli-Ribeil M,Maione F,Cooper D,Al-Kashi A,Dalli J,Perretti M,D'Acquisto F
Thu Nov 18 00:00:00 EST 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 EDT 2010
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
The Journal of clinical investigation
Melton AC,Bailey-Bucktrout SL,Travis MA,Fife BT,Bluestone JA,Sheppard D
Wed Dec 01 00:00:00 EST 2010
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine.
Journal of immunology (Baltimore, Md. : 1950)
Wang C,Kang SG,HogenEsch H,Love PE,Kim CH
Sat May 15 00:00:00 EDT 2010
Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1.
Journal of immunology (Baltimore, Md. : 1950)
Furuya M,Kirschbaum SB,Paulovich A,Pauli BU,Zhang H,Alexander JS,Farr AG,Ruddell A
Mon Nov 15 00:00:00 EST 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 EST 2010
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.
Journal of immunology (Baltimore, Md. : 1950)
Horrillo R,González-Périz A,Martínez-Clemente M,López-Parra M,Ferré N,Titos E,Morán-Salvador E,Deulofeu R,Arroyo V,Clària J
Thu Apr 01 00:00:00 EDT 2010
5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.
Journal of immunology (Baltimore, Md. : 1950)
Horrillo R,González-Périz A,Martínez-Clemente M,López-Parra M,Ferré N,Titos E,Morán-Salvador E,Deulofeu R,Arroyo V,Clària J
Thu Apr 01 00:00:00 EDT 2010
Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Dufton N,Hannon R,Brancaleone V,Dalli J,Patel HB,Gray M,D'Acquisto F,Buckingham JC,Perretti M,Flower RJ
Mon Mar 01 00:00:00 EST 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.
Journal of immunology (Baltimore, Md. : 1950)
Yen JH,Kong W,Ganea D
Thu Apr 01 00:00:00 EDT 2010
MEKK3 overexpression contributes to the hyperresponsiveness of IL-12-overproducing cells and CD4+ T conventional cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,Zhu N,Wang Q,Wang J,Ma Y,Qiao C,Li Y,Li X,Su B,Shen B
Wed Sep 15 00:00:00 EDT 2010
SMAD2 is essential for TGF beta-mediated Th17 cell generation.
The Journal of biological chemistry
Malhotra N,Robertson E,Kang J
Fri Sep 17 00:00:00 EDT 2010
CCL2 modulates cytokine production in cultured mouse astrocytes.
Journal of neuroinflammation
Semple BD,Frugier T,Morganti-Kossmann MC
Thu Oct 14 00:00:00 EDT 2010
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).
The Journal of biological chemistry
Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM
Fri Jul 09 00:00:00 EDT 2010
Central control of fever and female body temperature by RANKL/RANK.
Nature
Hanada R,Leibbrandt A,Hanada T,Kitaoka S,Furuyashiki T,Fujihara H,Trichereau J,Paolino M,Qadri F,Plehm R,Klaere S,Komnenovic V,Mimata H,Yoshimatsu H,Takahashi N,von Haeseler A,Bader M,Kilic SS,Ueta Y,Pifl C,Narumiya S,Penninger JM
Thu Nov 26 00:00:00 EST 2009
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity
Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL
Fri Oct 16 00:00:00 EDT 2009
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations.
Blood
Carlson MJ,West ML,Coghill JM,Panoskaltsis-Mortari A,Blazar BR,Serody JS
Thu Feb 05 00:00:00 EST 2009
Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.
Blood
Yen JH,Ganea D
Thu Aug 13 00:00:00 EDT 2009
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers.
The Journal of experimental medicine
Kubo A,Nagao K,Yokouchi M,Sasaki H,Amagai M
Mon Dec 21 00:00:00 EST 2009
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates.
The EMBO journal
Pelegrin P,Surprenant A
Wed Jul 22 00:00:00 EDT 2009
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Ben-Sasson SZ,Hu-Li J,Quiel J,Cauchetaux S,Ratner M,Shapira I,Dinarello CA,Paul WE
Tue Apr 28 00:00:00 EDT 2009
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.
Proceedings of the National Academy of Sciences of the United States of America
Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul W
Tue Aug 11 00:00:00 EDT 2009
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K
Mon Jun 15 00:00:00 EDT 2009
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Journal of immunology (Baltimore, Md. : 1950)
Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW
Sun Mar 15 00:00:00 EDT 2009
IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia.
Journal of immunology (Baltimore, Md. : 1950)
Ueda Y,Cain DW,Kuraoka M,Kondo M,Kelsoe G
Fri May 15 00:00:00 EDT 2009
A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.
Journal of immunology (Baltimore, Md. : 1950)
Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N
Wed Jul 01 00:00:00 EDT 2009
Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Fiorina P,Jurewicz M,Augello A,Vergani A,Dada S,La Rosa S,Selig M,Godwin J,Law K,Placidi C,Smith RN,Capella C,Rodig S,Adra CN,Atkinson M,Sayegh MH,Abdi R
Wed Jul 15 00:00:00 EDT 2009
Smad3 differentially regulates the induction of regulatory and inflammatory T cell differentiation.
The Journal of biological chemistry
Martinez GJ,Zhang Z,Chung Y,Reynolds JM,Lin X,Jetten AM,Feng XH,Dong C
Fri Dec 18 00:00:00 EST 2009
Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo.
Blood
Orelio C,Haak E,Peeters M,Dzierzak E
Mon Dec 15 00:00:00 EST 2008
CD40 mediates retinal inflammation and neurovascular degeneration.
Journal of immunology (Baltimore, Md. : 1950)
Portillo JA,Van Grol J,Zheng L,Okenka G,Gentil K,Garland A,Carlson EC,Kern TS,Subauste CS
Mon Dec 15 00:00:00 EST 2008
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
The Journal of biological chemistry
Shibata H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandenabeele P,Aggarwal BB,Nakamura T,Yamagata Y,Tsunoda S,Kamada H,Tsutsumi Y
Fri Jan 11 00:00:00 EST 2008
Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist.
The Journal of biological chemistry
Shibata H,Yoshioka Y,Ohkawa A,Minowa K,Mukai Y,Abe Y,Taniai M,Nomura T,Kayamuro H,Nabeshi H,Sugita T,Imai S,Nagano K,Yoshikawa T,Fujita T,Nakagawa S,Yamamoto A,Ohta T,Hayakawa T,Mayumi T,Vandenabeele P,Aggarwal BB,Nakamura T,Yamagata Y,Tsunoda S,Kamada H,Tsutsumi Y
Fri Jan 11 00:00:00 EST 2008
Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.
Blood
Khanna-Gupta A,Sun H,Zibello T,Lee HM,Dahl R,Boxer LA,Berliner N
Tue May 15 00:00:00 EDT 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 EST 2007