Product References
Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells.
Cell reports. Medicine
Sprooten J,Vanmeerbeek I,Datsi A,Govaerts J,Naulaerts S,Laureano RS,Borràs DM,Calvet A,Malviya V,Kuballa M,Felsberg J,Sabel MC,Rapp M,Knobbe-Thomsen C,Liu P,Zhao L,Kepp O,Boon L,Tejpar S,Borst J,Kroemer G,Schlenner S,De Vleeschouwer S,Sorg RV,Garg AD
210-12 was used in Cell Culture to propose that a multimodal immunotherapy and vaccination regimen is mandatory to overcome T cell-depleted tumors.
Tue Jan 16 00:00:00 UTC 2024
Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis.
Hepatology (Baltimore, Md.)
Crespo M,Nikolic I,Mora A,Rodríguez E,Leiva-Vega L,Pintor-Chocano A,Horrillo D,Hernández-Cosido L,Torres JL,Novoa E,Nogueiras R,Medina-Gómez G,Marcos M,Leiva M,Sabio G
210-12 was used in In vivo experiments to report that lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis.
Wed Mar 01 00:00:00 UTC 2023
High glucose promotes regulatory T cell differentiation.
PloS one
Pitmon E,Meehan EV,Ahmadi E,Adler AJ,Wang K
210-12 was used in Cell Culture to culture naïve CD4+ T cells with different concentrations of glucose, and examined their differentiation into effector versus regulatory lineages.
Mon Feb 06 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
210-12 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences.
Nature immunology
Cheng MI,Li JH,Riggan L,Chen B,Tafti RY,Chin S,Ma F,Pellegrini M,Hrncir H,Arnold AP,O'Sullivan TE,Su MA
210-12 was used in Enzyme-linked immunosorbent assay to demonstrate that while numbers of NK cells are increased in male mice, they display decreased effector function compared to females in mice and humans.
Mon May 01 00:00:00 UTC 2023
Identification of novel lactic acid bacteria with enhanced protective effects against influenza virus.
PloS one
Sugimoto A,Numaguchi T,Chihama R,Takenaka Y,Sato Y
210-12 was used in Enzyme-linked immunosorbent assay to suggest that D279 administration confers beneficial effects by regulating innate immunity and that it may be relevant for commercial use in the future. isolate lactic acid bacteria (LAB) strain D279 from among 741 LAB strains that were analyzed for their ability to induce interleukin 12 (IL-12) production and was subsequently characterized.
Fri Aug 11 00:00:00 UTC 2023
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Immunity
Kiss MG,Mindur JE,Yates AG,Lee D,Fullard JF,Anzai A,Poller WC,Christie KA,Iwamoto Y,Roudko V,Downey J,Chan CT,Huynh P,Janssen H,Ntranos A,Hoffmann JD,Jacob W,Goswami S,Singh S,Leppert D,Kuhle J,Kim-Schulze S,Nahrendorf M,Kleinstiver BP,Probert F,Roussos P,Swirski FK,McAlpine CS
210-12 was used in Cell Culture to establish IL-3:IL-3RA as a glial-peripheral immune network that prompts immune cell recruitment to the CNS and worsens MS.
Tue Jul 11 00:00:00 UTC 2023
Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
Signal transduction and targeted therapy
Wang Z,Zeng FL,Hu YW,Wang XY,Zhao FL,Zhou P,Hu J,Xiao YY,Hu ZL,Guo MF,Wei XQ,Liu X,Huang NY,Zhang J,Chen SW,Cheng J,Zheng HP,Zhou H,Zhao QX,Zhang C,Hao Y,Zou S,Gui YY,Yu JD,Gu LN,Yue CC,Zhang HZ,Wu WL,Zhou YF,Zhou XK,Shen GB,Teng X,Li J
Thu Jan 20 00:00:00 UTC 2022
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
The Journal of experimental medicine
Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C
Mon Feb 07 00:00:00 UTC 2022
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
The Journal of experimental medicine
Krzywinska E,Sobecki M,Nagarajan S,Zacharjasz J,Tambuwala MM,Pelletier A,Cummins E,Gotthardt D,Fandrey J,Kerdiles YM,Peyssonnaux C,Taylor CT,Sexl V,Stockmann C
Mon Feb 07 00:00:00 UTC 2022
Store-operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease.
EMBO molecular medicine
Letizia M,Wang YH,Kaufmann U,Gerbeth L,Sand A,Brunkhorst M,Weidner P,Ziegler JF,Böttcher C,Schlickeiser S,Fernández C,Yamashita M,Stauderman K,Sun K,Kunkel D,Prakriya M,Sanders A,Siegmund B,Feske S,Weidinger C
210-12 was used in Sample Preparation (FC/FACS) to indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.
Wed Sep 07 00:00:00 UTC 2022
The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors.
Nature immunology
Nie J,Carpenter AC,Chopp LB,Chen T,Balmaceno-Criss M,Ciucci T,Xiao Q,Kelly MC,McGavern DB,Belkaid Y,Bosselut R
210-12 was used in Cell Culture to identify LRF as an essential transcriptional regulator of IELp maturation in the thymus and subsequent migration to the intestinal epithelium.
Fri Apr 01 00:00:00 UTC 2022
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming.
Cell metabolism
Hochrein SM,Wu H,Eckstein M,Arrigoni L,Herman JS,Schumacher F,Gerecke C,Rosenfeldt M,Grün D,Kleuser B,Gasteiger G,Kastenmüller W,Ghesquière B,Van den Bossche J,Abel ED,Vaeth M
210-12 was used in In vitro experiments to show that GLUT3-dependent glucose uptake controls a metabolic-transcriptional circuit that regulates the pathogenicity of Th17 cells.
Tue Apr 05 00:00:00 UTC 2022
CNS Pericytes Modulate Local T Cell Infiltration in EAE.
International journal of molecular sciences
Koch K,Lindner M,Fleck AK,Liebmann M,Eschborn M,Zondler L,Diéguez-Hurtado R,Adams RH,Meyer Zu Hörste G,Zarbock A,Kuhlmann T,Wiendl H,Klotz L
210-12 was used in In vitro experiments to find that pericytes present antigen in vitro to induce T cell activation and proliferation.
Fri Oct 28 00:00:00 UTC 2022
Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection.
PLoS pathogens
Lee AJ,Feng E,Chew MV,Balint E,Poznanski SM,Giles E,Zhang A,Marzok A,Revill SD,Vahedi F,Dubey A,Ayaub E,Jimenez-Saiz R,McGrath JJC,Ritchie TM,Jordana M,Jonigk DD,Ackermann M,Ask K,Miller M,Richards CD,Ashkar AA
210-12 was used in In vivo experiments to demonstrate that IFNs inhibit macrophage-mediated MMP production to prevent virus-induced immunopathology and uncover MMPs as a therapeutic target towards viral infections.
Sun May 01 00:00:00 UTC 2022
Evaluation of Glutaminolysis in T Cells.
Current protocols
Tajima M,Strober W
210-12 was used in Cell Culture to provide one element of such tracking by describing protocols for the assessment of the contribution of glutaminolysis to overall ATP production within different T cell subsets.
Thu Sep 01 00:00:00 UTC 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
210-12 was used in In vitro experiments to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.
Wed Feb 16 00:00:00 UTC 2022
ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.
The Journal of general physiology
Wang L,Noyer L,Wang YH,Tao AY,Li W,Zhu J,Saavedra P,Hoda ST,Yang J,Feske S
210-12 was used in In vitro experiments to investigate the plasma membrane protein ORAI3 function in immune cells in mice.
Mon Oct 03 00:00:00 UTC 2022
Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy.
Nature communications
Yu Y,Wu X,Wang M,Liu W,Zhang L,Zhang Y,Hu Z,Zhou X,Jiang W,Zou Q,Cai F,Ye H
210-12 was used in In vivo experiments to show that FLICs-loaded hydrogel implants placed at the surgical wound site achieve sustainable release of immunomodulatory cytokines, leading to prevention of tumor recurrence and increased animal survival.
Wed Oct 26 00:00:00 UTC 2022
Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Cell
Puleston DJ,Baixauli F,Sanin DE,Edwards-Hicks J,Villa M,Kabat AM,Kamiński MM,Stanckzak M,Weiss HJ,Grzes KM,Piletic K,Field CS,Corrado M,Haessler F,Wang C,Musa Y,Schimmelpfennig L,Flachsmann L,Mittler G,Yosef N,Kuchroo VK,Buescher JM,Balabanov S,Pearce EJ,Green DR,Pearce EL
210-12 was used in Cell Culture to conclude that polyamine metabolism is critical for maintaining the epigenome to focus TH cell subset fidelity.
Thu Aug 05 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Tue Jan 12 00:00:00 UTC 2021
Cold exposure protects from neuroinflammation through immunologic reprogramming.
Cell metabolism
Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M
Tue Nov 02 00:00:00 UTC 2021
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity.
Nature immunology
Fiancette R,Finlay CM,Willis C,Bevington SL,Soley J,Ng STH,Baker SM,Andrews S,Hepworth MR,Withers DR
Fri Oct 01 00:00:00 UTC 2021
Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool.
Cellular & molecular immunology
Permanyer M,Bošnjak B,Glage S,Friedrichsen M,Floess S,Huehn J,Patzer GE,Odak I,Eckert N,Zargari R,Ospina-Quintero L,Georgiev H,Förster R
Mon Feb 01 00:00:00 UTC 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Mon Jun 07 00:00:00 UTC 2021
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
The Journal of experimental medicine
Xiao Y,Qureischi M,Dietz L,Vaeth M,Vallabhapurapu SD,Klein-Hessling S,Klein M,Liang C,König A,Serfling E,Mottok A,Bopp T,Rosenwald A,Buttmann M,Berberich I,Beilhack A,Berberich-Siebelt F
Mon Jan 04 00:00:00 UTC 2021
BFAR coordinates TGFβ signaling to modulate Th9-mediated cancer immunotherapy.
The Journal of experimental medicine
Pei S,Huang M,Huang J,Zhu X,Wang H,Romano S,Deng X,Wang Y,Luo Y,Hao S,Xu J,Yu T,Zhu Q,Yuan J,Shen K,Liu Z,Hu G,Peng C,Luo Q,Wen Z,Dai D,Xiao Y
Mon Jul 05 00:00:00 UTC 2021
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
The Journal of experimental medicine
Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M
Mon Jul 05 00:00:00 UTC 2021
Arkadia-SKI/SnoN signaling differentially regulates TGF-β-induced iTreg and Th17 cell differentiation.
The Journal of experimental medicine
Xu H,Wu L,Nguyen HH,Mesa KR,Raghavan V,Episkopou V,Littman DR
Mon Nov 01 00:00:00 UTC 2021
Mechanical force-driven TNFα endocytosis governs stem cell homeostasis.
Bone research
Yu W,Chen C,Kou X,Sui B,Yu T,Liu D,Wang R,Wang J,Shi S
Fri Jan 01 00:00:00 UTC 2021
Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
Proceedings of the National Academy of Sciences of the United States of America
Ducimetière L,Lucchiari G,Litscher G,Nater M,Heeb L,Nuñez NG,Wyss L,Burri D,Vermeer M,Gschwend J,Moor AE,Becher B,van den Broek M,Tugues S
Tue Jul 06 00:00:00 UTC 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
Fri Jan 01 00:00:00 UTC 2021
miR-99a regulates CD4+ T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis.
Molecular therapy. Nucleic acids
Gu Y,Zhou H,Yu H,Yang W,Wang B,Qian F,Cheng Y,He S,Zhao X,Zhu L,Zhang Y,Jin M,Lu E
Fri Dec 03 00:00:00 UTC 2021
Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
Journal of immunology (Baltimore, Md. : 1950)
Jang YS,Song HE,Seo GY,Jo HJ,Park S,Park HW,Kim TG,Kang SG,Yoon SI,Ko HJ,Lee GS,Park SR,Kim PH
Mon Nov 15 00:00:00 UTC 2021
Purinergic Receptor P2Y6 Is a Negative Regulator of NK Cell Maturation and Function.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Gao Y,He C,Wei H,Zhang J,Zhang H,Hu L,Jiang W
Wed Sep 15 00:00:00 UTC 2021
The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis.
Journal of immunology (Baltimore, Md. : 1950)
Inoue T,Omori-Miyake M,Maruyama S,Okabe M,Kuwahara M,Honda H,Miura H,Yamashita M
Mon Nov 01 00:00:00 UTC 2021
Reevaluation of NOD/SCID Mice as NK Cell-Deficient Models.
BioMed research international
Miao M,Masengere H,Yu G,Shan F
Thu Jan 20 00:00:00 UTC 2022
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
210-12 was used in In vitro experiments to demonstrate HDAC3 is essential during CD4+ T-cell activation to repress cholesterol efflux.
Thu Dec 02 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Nature communications
He J,Shangguan X,Zhou W,Cao Y,Zheng Q,Tu J,Hu G,Liang Z,Jiang C,Deng L,Wang S,Yang W,Zuo Y,Ma J,Cai R,Chen Y,Fan Q,Dong B,Xue W,Tan H,Qi Y,Gu J,Su B,Eugene Chin Y,Chen G,Wang Q,Wang T,Cheng J
Fri Jul 16 00:00:00 UTC 2021
Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape.
Nature communications
Hicks KC,Chariou PL,Ozawa Y,Minnar CM,Knudson KM,Meyer TJ,Bian J,Cam M,Schlom J,Gameiro SR
Thu Aug 26 00:00:00 UTC 2021
Chronic stress physically spares but functionally impairs innate-like invariant T cells.
Cell reports
Rudak PT,Choi J,Parkins KM,Summers KL,Jackson DN,Foster PJ,Skaro AI,Leslie K,McAlister VC,Kuchroo VK,Inoue W,Lantz O,Haeryfar SMM
Tue Apr 13 00:00:00 UTC 2021
Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice.
Nature communications
Papaioannou NE,Salei N,Rambichler S,Ravi K,Popovic J,Küntzel V,Lehmann CHK,Fiancette R,Salvermoser J,Gajdasik DW,Mettler R,Messerer D,Carrelha J,Ohnmacht C,Haller D,Stumm R,Straub T,Jacobsen SEW,Schulz C,Withers DR,Schotta G,Dudziak D,Schraml BU
Tue Jan 19 00:00:00 UTC 2021
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells.
Nature communications
Song H,Song J,Cheng M,Zheng M,Wang T,Tian S,Flavell RA,Zhu S,Li HB,Ding C,Wei H,Sun R,Peng H,Tian Z
Fri Sep 17 00:00:00 UTC 2021
A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation.
eLife
Kiritsy MC,Ankley LM,Trombley J,Huizinga GP,Lord AE,Orning P,Elling R,Fitzgerald KA,Olive AJ
210-12 was used in Cell Culture to demonstrate regulation of MHCII expression that is required to control CD4+ T cell responses.
Mon Nov 08 00:00:00 UTC 2021
Endothelial STING controls T cell transmigration in an IFNI-dependent manner.
JCI insight
Anastasiou M,Newton GA,Kaur K,Carrillo-Salinas FJ,Smolgovsky SA,Bayer AL,Ilyukha V,Sharma S,Poltorak A,Luscinskas FW,Alcaide P
210-12 was used in In vitro experiments to investigate IFN signalling effect on T cell transdoepithelial infiltration.
Mon Aug 09 00:00:00 UTC 2021
In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim GR,Kim WJ,Lim S,Lee HG,Koo JH,Nam KH,Kim SM,Park SD,Choi JM
Thu Jul 01 00:00:00 UTC 2021
"γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy.
Frontiers in immunology
Zhang Z,Yang C,Li L,Zhu Y,Su K,Zhai L,Wang Z,Huang J
210-12 was used in Sample Preparation (FC/FACS) to study cancer cell resistance to anti-VEGFR2 therapy to illustrate the potential mechanism of antiangiogenic therapy resistance in breast cancer for treatment of cancer.
Mon Dec 13 00:00:00 UTC 2021
STAT4 is expressed in neutrophils and promotes antimicrobial immunity.
JCI insight
Mehrpouya-Bahrami P,Moriarty AK,De Melo P,Keeter WC,Alakhras NS,Nelson AS,Hoover M,Barrios MS,Nadler JL,Serezani CH,Kaplan MH,Galkina EV
210-12 was used in Sample Preparation (Western Blotting)g to investigate STAT4 on the differentiation of T helper 1 cells.
Thu Jul 22 00:00:00 UTC 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 UTC 2021
Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation.
eLife
Russler-Germain EV,Yi J,Young S,Nutsch K,Wong HS,Ai TL,Chai JN,Durai V,Kaplan DH,Germain RN,Murphy KM,Hsieh CS
210-12 was used in In vitro experiments to suggest a model where DC-mediated effector T cell differentiation is 'dominant', necessitating that all DC subsets presenting antigen are permissive for pTreg cell induction to maintain gut tolerance.
Wed Feb 03 00:00:00 UTC 2021
Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion.
Cell reports
Mah-Som AY,Keppel MP,Tobin JM,Kolicheski A,Saucier N,Sexl V,French AR,Wagner JA,Fehniger TA,Cooper MA
Tue Jun 01 00:00:00 UTC 2021
CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter.
Cell reports
Prizant H,Patil N,Negatu S,Bala N,McGurk A,Leddon SA,Hughson A,McRae TD,Gao YR,Livingstone AM,Groom JR,Luster AD,Fowell DJ
Tue Aug 10 00:00:00 UTC 2021
High-Dimensional T Helper Cell Profiling Reveals a Broad Diversity of Stably Committed Effector States and Uncovers Interlineage Relationships.
Immunity
Tortola L,Jacobs A,Pohlmeier L,Obermair FJ,Ampenberger F,Bodenmiller B,Kopf M
Tue Sep 15 00:00:00 UTC 2020
The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.
Immunity
Chang D,Xing Q,Su Y,Zhao X,Xu W,Wang X,Dong C
Tue Sep 15 00:00:00 UTC 2020
Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity.
Immunity
Ni J,Wang X,Stojanovic A,Zhang Q,Wincher M,Bühler L,Arnold A,Correia MP,Winkler M,Koch PS,Sexl V,Höfer T,Cerwenka A
Tue Jun 16 00:00:00 UTC 2020
Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Immunity
Kim D,Nguyen QT,Lee J,Lee SH,Janocha A,Kim S,Le HT,Dvorina N,Weiss K,Cameron MJ,Asosingh K,Erzurum SC,Baldwin WM,Lee JS,Min B
Tue Sep 15 00:00:00 UTC 2020
Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.
Cell metabolism
Roy DG,Chen J,Mamane V,Ma EH,Muhire BM,Sheldon RD,Shorstova T,Koning R,Johnson RM,Esaulova E,Williams KS,Hayes S,Steadman M,Samborska B,Swain A,Daigneault A,Chubukov V,Roddy TP,Foulkes W,Pospisilik JA,Bourgeois-Daigneault MC,Artyomov MN,Witcher M,Krawczyk CM,Larochelle C,Jones RG
210-12 was used in In vitro experiments to investigate the role of methionine on CD4+ T helper cells.
Tue Feb 04 00:00:00 UTC 2020
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.
Blood
Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR
Thu Dec 24 00:00:00 UTC 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 UTC 2020
Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation.
The Journal of experimental medicine
Gao Y,Deason K,Jain A,Irizarry-Caro RA,Dozmorov I,Coughlin LA,Rauch I,Evers BM,Koh AY,Wakeland EK,Pasare C
Mon Apr 06 00:00:00 UTC 2020
Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells.
Proceedings of the National Academy of Sciences of the United States of America
Chaudhry MZ,Casalegno-Garduno R,Sitnik KM,Kasmapour B,Pulm AK,Brizic I,Eiz-Vesper B,Moosmann A,Jonjic S,Mocarski ES,Cicin-Sain L
Tue Jun 09 00:00:00 UTC 2020
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation.
Proceedings of the National Academy of Sciences of the United States of America
Mikami N,Kawakami R,Chen KY,Sugimoto A,Ohkura N,Sakaguchi S
Tue Jun 02 00:00:00 UTC 2020
IQGAP1 restrains T-cell cosignaling mediated by OX40.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Okuyama Y,Nagashima H,Ushio-Fukai M,Croft M,Ishii N,So T
Wed Jan 01 00:00:00 UTC 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
210-12 was used in In vitro experiments to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 UTC 2020
Calcitriol Regulates the Differentiation of IL-9-Secreting Th9 Cells by Modulating the Transcription Factor PU.1.
Journal of immunology (Baltimore, Md. : 1950)
Vyas SP,Hansda AK,Kaplan MH,Goswami R
Sun Mar 01 00:00:00 UTC 2020
Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs.
Journal of immunology (Baltimore, Md. : 1950)
Tani-Ichi S,Wagatsuma K,Hara T,Cui G,Abe S,Miyachi H,Kitano S,Ikuta K
Fri May 15 00:00:00 UTC 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 UTC 2020
CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation.
Journal of immunology (Baltimore, Md. : 1950)
Alam F,Singh A,Flores-Malavet V,Sell S,Cooper AM,Swain SL,McKinstry KK,Strutt TM
Mon Jun 15 00:00:00 UTC 2020
P2Y6 Deficiency Enhances Dendritic Cell-Mediated Th1/Th17 Differentiation and Aggravates Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,He C,Zhang J,Zhang H,Wei H,Wu S,Jiang W
Wed Jul 15 00:00:00 UTC 2020
Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D
Mon Jun 01 00:00:00 UTC 2020
Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis.
Nature communications
Azizov V,Dietel K,Steffen F,Dürholz K,Meidenbauer J,Lucas S,Frech M,Omata Y,Tajik N,Knipfer L,Kolenbrander A,Seubert S,Lapuente D,Sokolova MV,Hofmann J,Tenbusch M,Ramming A,Steffen U,Nimmerjahn F,Linker R,Wirtz S,Herrmann M,Temchura V,Sarter K,Schett G,Zaiss MM
Fri Apr 24 00:00:00 UTC 2020
Characterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter Mice.
Current protocols in immunology
Laumonnier Y,Karsten CM,Köhl G,Köhl J
Tue Sep 01 00:00:00 UTC 2020
CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response.
Cell reports
Bromley SK,Akbaba H,Mani V,Mora-Buch R,Chasse AY,Sama A,Luster AD
210-12 was used in In vitro experiments to study the requirement for CD49a in the formation, localization, persistence, and function of cutaneous CD8+ tissue-resident memory T cells.
Tue Sep 01 00:00:00 UTC 2020
Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells.
Cell reports
Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA
210-12 was used in In vitro experiments to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.
Tue Feb 04 00:00:00 UTC 2020
PU.1 regulates Ccr7 gene expression by binding to its promoter in naïve CD4+ T cells.
FEBS open bio
Yashiro T,Takeuchi H,Kasakura K,Nishiyama C
Mon Jun 01 00:00:00 UTC 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
Tue Jan 14 00:00:00 UTC 2020
Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Scientific reports
Svendsen P,Etzerodt A,Deleuran BW,Moestrup SK
Fri Jul 24 00:00:00 UTC 2020
Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.
Scientific reports
Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F
Thu Dec 10 00:00:00 UTC 2020
Transcription factor p73 regulates Th1 differentiation.
Nature communications
Ren M,Kazemian M,Zheng M,He J,Li P,Oh J,Liao W,Li J,Rajaseelan J,Kelsall BL,Peltz G,Leonard WJ
Thu Mar 19 00:00:00 UTC 2020
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.
Nature communications
Chen J,He R,Sun W,Gao R,Peng Q,Zhu L,Du Y,Ma X,Guo X,Zhang H,Tan C,Wang J,Zhang W,Weng X,Man J,Bauer H,Wang QK,Martin BN,Zhang CJ,Li X,Wang C
Mon Apr 20 00:00:00 UTC 2020
Valproic acid inhibits interferon-γ production by NK cells and increases susceptibility to Listeria monocytogenes infection.
Scientific reports
Soria-Castro R,Chávez-Blanco AD,García-Pérez BE,Wong-Baeza I,Flores-Mejía R,Flores-Borja F,Estrada-Parra S,Estrada-García I,Serafín-López J,Chacón-Salinas R
Tue Oct 20 00:00:00 UTC 2020
Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing.
Scientific reports
Shen H,Gu C,Liang T,Liu H,Guo F,Liu X
Tue Nov 10 00:00:00 UTC 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
Thu Jul 11 00:00:00 UTC 2019
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
Thu Jan 24 00:00:00 UTC 2019
Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants.
Immunity
Bachus H,Kaur K,Papillion AM,Marquez-Lago TT,Yu Z,Ballesteros-Tato A,Matalon S,León B
Tue Jan 15 00:00:00 UTC 2019
A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Immunity
Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R
Tue Sep 17 00:00:00 UTC 2019
High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
Immunity
Zhang D,Jin W,Wu R,Li J,Park SA,Tu E,Zanvit P,Xu J,Liu O,Cain A,Chen W
Tue Oct 15 00:00:00 UTC 2019
Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.
Immunity
Gaylo-Moynihan A,Prizant H,Popović M,Fernandes NRJ,Anderson CS,Chiou KK,Bell H,Schrock DC,Schumacher J,Capece T,Walling BL,Topham DJ,Miller J,Smrcka AV,Kim M,Hughson A,Fowell DJ
Tue Aug 20 00:00:00 UTC 2019
The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.
Immunity
Xu W,Zhao X,Wang X,Feng H,Gou M,Jin W,Wang X,Liu X,Dong C
Tue Nov 19 00:00:00 UTC 2019
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
Immunity
Schmidleithner L,Thabet Y,Schönfeld E,Köhne M,Sommer D,Abdullah Z,Sadlon T,Osei-Sarpong C,Subbaramaiah K,Copperi F,Haendler K,Varga T,Schanz O,Bourry S,Bassler K,Krebs W,Peters AE,Baumgart AK,Schneeweiss M,Klee K,Schmidt SV,Nüssing S,Sander J,Ohkura N,Waha A,Sparwasser T,Wunderlich FT,Förster I,Ulas T,Weighardt H,Sakaguchi S,Pfeifer A,Blüher M,Dannenberg AJ,Ferreirós N,Muglia LJ,Wickenhauser C,Barry SC,Schultze JL,Beyer M
Tue May 21 00:00:00 UTC 2019
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
Immunity
Tibbitt CA,Stark JM,Martens L,Ma J,Mold JE,Deswarte K,Oliynyk G,Feng X,Lambrecht BN,De Bleser P,Nylén S,Hammad H,Arsenian Henriksson M,Saeys Y,Coquet JM
Tue Jul 16 00:00:00 UTC 2019
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity
Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA
Tue Sep 17 00:00:00 UTC 2019
Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.
The Journal of clinical investigation
Kaushik DK,Bhattacharya A,Mirzaei R,Rawji KS,Ahn Y,Rho JM,Yong VW
Tue May 21 00:00:00 UTC 2019
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
The Journal of experimental medicine
Vetters J,van Helden MJ,Wahlen S,Tavernier SJ,Martens A,Fayazpour F,Vergote K,Vanheerswynghels M,Deswarte K,Van Moorleghem J,De Prijck S,Takahashi N,Vandenabeele P,Boon L,van Loo G,Vivier E,Lambrecht BN,Janssens S
Mon Sep 02 00:00:00 UTC 2019
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.
The Journal of experimental medicine
Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S
Mon Aug 05 00:00:00 UTC 2019
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
The Journal of experimental medicine
Sun X,Cui Y,Feng H,Liu H,Liu X
Mon Dec 02 00:00:00 UTC 2019
Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.
The Journal of experimental medicine
Tanaka H,Arima Y,Kamimura D,Tanaka Y,Takahashi N,Uehata T,Maeda K,Satoh T,Murakami M,Akira S
Mon Jun 03 00:00:00 UTC 2019
Boosting Interleukin-12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR-Tagged Nanogold.
Small (Weinheim an der Bergstrasse, Germany)
Gasparri AM,Sacchi A,Basso V,Cortesi F,Freschi M,Rrapaj E,Bellone M,Casorati G,Dellabona P,Mondino A,Corti A,Curnis F
Fri Nov 01 00:00:00 UTC 2019
Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America
DeLaney AA,Berry CT,Christian DA,Hart A,Bjanes E,Wynosky-Dolfi MA,Li X,Tummers B,Udalova IA,Chen YH,Hershberg U,Freedman BD,Hunter CA,Brodsky IE
Tue Jun 11 00:00:00 UTC 2019
Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.
Mucosal immunology
Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y
Fri Mar 01 00:00:00 UTC 2019
Proteomic Profiling of Mouse Helper T Cell Differentiation.
Proteomics
van den Ham HJ,Binai NA,Zaaraoui-Boutahar F,Heck AJR,Andeweg AC
Mon Apr 01 00:00:00 UTC 2019
Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma.
Frontiers in genetics
Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M
210-12 was used in Cell Culture to explore the lncRNAs profile in the CD4+T cells from the mouse model of acute asthma.
Fri Apr 08 00:00:00 UTC 2022
EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming.
Nature communications
Istaces N,Splittgerber M,Lima Silva V,Nguyen M,Thomas S,Le A,Achouri Y,Calonne E,Defrance M,Fuks F,Goriely S,Azouz A
Wed Jul 24 00:00:00 UTC 2019
Single-cell RNA-Seq analysis identifies a noncoding interleukin 4 (IL-4) RNA that post-transcriptionally up-regulates IL-4 production in T helper cells.
The Journal of biological chemistry
Yin W,Song Y,Chang X
Fri Jan 04 00:00:00 UTC 2019
Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters.
Frontiers in immunology
Li W,Qu G,Choi SC,Cornaby C,Titov A,Kanda N,Teng X,Wang H,Morel L
210-12 was used in Cell Culture to suggest that blocking glucose uptake with a small molecule inhibitor ameliorates autoimmune activation, at least partially due to its inhibition of glycolysis in CD4+ T cells.
Thu Sep 24 00:00:00 UTC 2020
IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.
Cell reports
Elsner RA,Shlomchik MJ
210-12 was used in In vivo experiments to investigate the mechanisms of Salmonella enterica serovar Typhimurium (STm) that driving germinal centers suppression.
Tue Nov 26 00:00:00 UTC 2019
Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.
Cell reports
Myers DR,Norlin E,Vercoulen Y,Roose JP
210-12 was used in Cell Culture to investigate the role of Rasgrp1 in selective and robust tonic mTORC1 signals in CD4+ T cells.
Tue May 07 00:00:00 UTC 2019
Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells.
eLife
Park E,Patel S,Wang Q,Andhey P,Zaitsev K,Porter S,Hershey M,Bern M,Plougastel-Douglas B,Collins P,Colonna M,Murphy KM,Oltz E,Artyomov M,Sibley LD,Yokoyama WM
210-12 was used in In vitro experiments to explore apparently permanent transformation of NK cells into ILC1-like cells in the Toxoplasma gondii infection.
Thu Aug 08 00:00:00 UTC 2019
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
Tue Feb 12 00:00:00 UTC 2019
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.
Nature
Xu M,Pokrovskii M,Ding Y,Yi R,Au C,Harrison OJ,Galan C,Belkaid Y,Bonneau R,Littman DR
Thu Feb 15 00:00:00 UTC 2018
Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection.
Cell
Smith NL,Patel RK,Reynaldi A,Grenier JK,Wang J,Watson NB,Nzingha K,Yee Mon KJ,Peng SA,Grimson A,Davenport MP,Rudd BD
Thu Jun 28 00:00:00 UTC 2018
Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection.
Cell
Smith NL,Patel RK,Reynaldi A,Grenier JK,Wang J,Watson NB,Nzingha K,Yee Mon KJ,Peng SA,Grimson A,Davenport MP,Rudd BD
Thu Jun 28 00:00:00 UTC 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 UTC 2018
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Immunity
Herndler-Brandstetter D,Ishigame H,Shinnakasu R,Plajer V,Stecher C,Zhao J,Lietzenmayer M,Kroehling L,Takumi A,Kometani K,Inoue T,Kluger Y,Kaech SM,Kurosaki T,Okada T,Flavell RA
Tue Apr 17 00:00:00 UTC 2018
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Immunity
Garris CS,Arlauckas SP,Kohler RH,Trefny MP,Garren S,Piot C,Engblom C,Pfirschke C,Siwicki M,Gungabeesoon J,Freeman GJ,Warren SE,Ong S,Browning E,Twitty CG,Pierce RH,Le MH,Algazi AP,Daud AI,Pai SI,Zippelius A,Weissleder R,Pittet MJ
Tue Dec 18 00:00:00 UTC 2018
Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.
Immunity
Wang Z,Yin W,Zhu L,Li J,Yao Y,Chen F,Sun M,Zhang J,Shen N,Song Y,Chang X
Tue Jul 17 00:00:00 UTC 2018
Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.
Immunity
Shimba A,Cui G,Tani-Ichi S,Ogawa M,Abe S,Okazaki F,Kitano S,Miyachi H,Yamada H,Hara T,Yoshikai Y,Nagasawa T,Schütz G,Ikuta K
Tue Feb 20 00:00:00 UTC 2018
Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells.
Immunity
Page N,Klimek B,De Roo M,Steinbach K,Soldati H,Lemeille S,Wagner I,Kreutzfeldt M,Di Liberto G,Vincenti I,Lingner T,Salinas G,Brück W,Simons M,Murr R,Kaye J,Zehn D,Pinschewer DD,Merkler D
Tue May 15 00:00:00 UTC 2018
Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.
Cell metabolism
Cong J,Wang X,Zheng X,Wang D,Fu B,Sun R,Tian Z,Wei H
210-12 was used in Cell Culture to identify novel mechanisms in natural killer cell dysfunction.
Tue Aug 07 00:00:00 UTC 2018
BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
The Journal of experimental medicine
Deason K,Troutman TD,Jain A,Challa DK,Mandraju R,Brewer T,Ward ES,Pasare C
Mon Sep 03 00:00:00 UTC 2018
The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.
The Journal of experimental medicine
Yu F,Sharma S,Jankovic D,Gurram RK,Su P,Hu G,Li R,Rieder S,Zhao K,Sun B,Zhu J
Mon Jul 02 00:00:00 UTC 2018
USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.
The Journal of experimental medicine
Chen S,Yun F,Yao Y,Cao M,Zhang Y,Wang J,Song X,Qian Y
Mon Nov 05 00:00:00 UTC 2018
Trim33 mediates the proinflammatory function of Th17 cells.
The Journal of experimental medicine
Tanaka S,Jiang Y,Martinez GJ,Tanaka K,Yan X,Kurosaki T,Kaartinen V,Feng XH,Tian Q,Wang X,Dong C
210-12 was used in In vitro experiments to study the mechanism by which transforming growth factor-β regulates reciprocal regulatory T cell and T helper 17 differentiation.
Mon Jul 02 00:00:00 UTC 2018
CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.
Proceedings of the National Academy of Sciences of the United States of America
Stanko K,Iwert C,Appelt C,Vogt K,Schumann J,Strunk FJ,Ahrlich S,Schlickeiser S,Romagnani C,Jürchott K,Meisel C,Willimsky G,Kühl AA,Sawitzki B
Tue Mar 27 00:00:00 UTC 2018
Naive CD4+ T Cells Carrying a TLR2 Agonist Overcome TGF-β-Mediated Tumor Immune Evasion.
Journal of immunology (Baltimore, Md. : 1950)
Ibrahim M,Scozzi D,Toth KA,Ponti D,Kreisel D,Menna C,De Falco E,D'Andrilli A,Rendina EA,Calogero A,Krupnick AS,Gelman AE
Mon Jan 15 00:00:00 UTC 2018
Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor.
Journal of immunology (Baltimore, Md. : 1950)
Friede ME,Leibelt S,Dudziak D,Steinle A
Thu Feb 01 00:00:00 UTC 2018
IVIg Promote Cross-Tolerance against Inflammatory Stimuli In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Domínguez-Soto Á,Simón-Fuentes M,de Las Casas-Engel M,Cuevas VD,López-Bravo M,Domínguez-Andrés J,Saz-Leal P,Sancho D,Ardavín C,Ochoa-Grullón J,Sánchez-Ramón S,Vega MA,Corbí AL
Sun Jul 01 00:00:00 UTC 2018
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Steinbuck MP,Arakcheeva K,Winandy S
Thu Feb 01 00:00:00 UTC 2018
Relative Contributions of B Cells and Dendritic Cells from Lupus-Prone Mice to CD4+ T Cell Polarization.
Journal of immunology (Baltimore, Md. : 1950)
Choi SC,Xu Z,Li W,Yang H,Roopenian DC,Morse HC,Morel L
Tue May 01 00:00:00 UTC 2018
Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Dabitao D,Hedrich CM,Wang F,Vacharathit V,Bream JH
Thu Mar 15 00:00:00 UTC 2018
Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Mathies F,Steffens N,Kleinschmidt D,Stuhlmann F,Huber FJ,Roy U,Meyer T,Luetgehetmann M,von Petersdorff M,Seiz O,Herkel J,Schramm C,Flavell RA,Gagliani N,Krebs C,Panzer U,Abdullah Z,Strowig T,Bedke T,Huber S
Sat Dec 15 00:00:00 UTC 2018
Amplifying IFN-γ Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Alice AF,Kramer G,Bambina S,Baird JR,Bahjat KS,Gough MJ,Crittenden MR
Mon Jan 01 00:00:00 UTC 2018
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5.
Journal of immunology (Baltimore, Md. : 1950)
Sen S,He Z,Ghosh S,Dery KJ,Yang L,Zhang J,Sun Z
Sun Jul 15 00:00:00 UTC 2018
Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.
Scientific reports
Abrahamsen G,Sundvold-Gjerstad V,Habtamu M,Bogen B,Spurkland A
Thu Sep 06 00:00:00 UTC 2018
A conserved enhancer regulates Il9 expression in multiple lineages.
Nature communications
Koh B,Abdul Qayum A,Srivastava R,Fu Y,Ulrich BJ,Janga SC,Kaplan MH
Thu Nov 15 00:00:00 UTC 2018
Glycolysis promotes caspase-3 activation in lipid rafts in T cells.
Cell death & disease
Secinaro MA,Fortner KA,Dienz O,Logan A,Murphy MP,Anathy V,Boyson JE,Budd RC
Fri Jan 19 00:00:00 UTC 2018
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.
Nature communications
Meng X,Grötsch B,Luo Y,Knaup KX,Wiesener MS,Chen XX,Jantsch J,Fillatreau S,Schett G,Bozec A
Wed Jan 17 00:00:00 UTC 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.
Nature communications
Jiang Y,Liu Y,Lu H,Sun SC,Jin W,Wang X,Dong C
Thu Apr 12 00:00:00 UTC 2018
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 UTC 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
210-12 was used in In vitro experiments to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 UTC 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
Tue Dec 19 00:00:00 UTC 2017
miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity.
The Journal of clinical investigation
Li B,Wang X,Choi IY,Wang YC,Liu S,Pham AT,Moon H,Smith DJ,Rao DS,Boldin MP,Yang L
Mon Oct 02 00:00:00 UTC 2017
Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.
Immunology and cell biology
Alberdi M,Iglesias M,Tejedor S,Merino R,López-Rodríguez C,Aramburu J
210-12 was used in Cell Culture to show that NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context.
Sun Jan 01 00:00:00 UTC 2017
SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.
Journal of immunology (Baltimore, Md. : 1950)
Takahashi R,Nakatsukasa H,Shiozawa S,Yoshimura A
Sat Jul 01 00:00:00 UTC 2017
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Ulrich BJ,Hummel SA,Khan I,Meuris B,Cherukuri Y,Dent AL,Janga SC,Kaplan MH
Thu Jun 01 00:00:00 UTC 2017
Cell penetrable-mouse forkhead box P3 suppresses type 1 T helper cell-mediated immunity in a murine model of delayed-type hypersensitivity.
Experimental and therapeutic medicine
Liu X,Wang J,Wang H,Zhou C,Yu Q,Yin L,Wu W,Xia S,Shao Q
210-12 was used in Sample Preparation (FC/FACS) to study the role and mechanism of PTD-mFOXP3, shown to alleviate experimental arthritis in mice, in type 1 T helper (Th1) cell-mediated immunity to show that PTD-mFOXP3 may attenuate delayed type hypersensitivity (DTH) reactions by suppressing the infiltration and activity of Th1 cells.
Wed Feb 01 00:00:00 UTC 2017
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
NPJ Parkinson's disease
Sarkar S,Malovic E,Harishchandra DS,Ghaisas S,Panicker N,Charli A,Palanisamy BN,Rokad D,Jin H,Anantharam V,Kanthasamy A,Kanthasamy AG
Wed Sep 30 00:00:00 UTC 2020
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
Wed Mar 15 00:00:00 UTC 2017
A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.
Scientific reports
Korthals M,Langnaese K,Smalla KH,Kähne T,Herrera-Molina R,Handschuh J,Lehmann AC,Mamula D,Naumann M,Seidenbecher C,Zuschratter W,Tedford K,Gundelfinger ED,Montag D,Fischer KD,Thomas U
Mon Aug 21 00:00:00 UTC 2017
IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.
Scientific reports
Mitchell RE,Hassan M,Burton BR,Britton G,Hill EV,Verhagen J,Wraith DC
Tue Sep 12 00:00:00 UTC 2017
Non-thermal atmospheric plasma ameliorates imiquimod-induced psoriasis-like skin inflammation in mice through inhibition of immune responses and up-regulation of PD-L1 expression.
Scientific reports
Lee YS,Lee MH,Kim HJ,Won HR,Kim CH
Tue Nov 14 00:00:00 UTC 2017
Innate CD8αα+ lymphocytes enhance anti-CD40 antibody-mediated colitis in mice.
Immunity, inflammation and disease
Kumar AA,Delgado AG,Piazuelo MB,Van Kaer L,Olivares-Villagómez D
Thu Jun 01 00:00:00 UTC 2017
Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice.
Immunology
Pedrotti LP,Sena AA,Rodriguez Galán MC,Cejas H,Correa SG
210-12 was used in Flow cytometry/Cell sorting to address whether the burst of systemic interleukin-12 (IL-12) influences intestinal inflammation elicited by luminal stimuli, we induced IL-12 release by cDNA injection in C57BL/6 mice and simultaneously started dextran sulphate sodium administration.
Wed Mar 01 00:00:00 UTC 2017
The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.
Immunity
Ichiyama K,Gonzalez-Martin A,Kim BS,Jin HY,Jin W,Xu W,Sabouri-Ghomi M,Xu S,Zheng P,Xiao C,Dong C
Tue Jun 21 00:00:00 UTC 2016
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Immunity
Delconte RB,Shi W,Sathe P,Ushiki T,Seillet C,Minnich M,Kolesnik TB,Rankin LC,Mielke LA,Zhang JG,Busslinger M,Smyth MJ,Hutchinson DS,Nutt SL,Nicholson SE,Alexander WS,Corcoran LM,Vivier E,Belz GT,Carotta S,Huntington ND
Tue Jan 19 00:00:00 UTC 2016
Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.
Immunity
Bhattacharya N,Yuan R,Prestwood TR,Penny HL,DiMaio MA,Reticker-Flynn NE,Krois CR,Kenkel JA,Pham TD,Carmi Y,Tolentino L,Choi O,Hulett R,Wang J,Winer DA,Napoli JL,Engleman EG
Tue Sep 20 00:00:00 UTC 2016
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands.
Immunity
Cortez VS,Cervantes-Barragan L,Robinette ML,Bando JK,Wang Y,Geiger TL,Gilfillan S,Fuchs A,Vivier E,Sun JC,Cella M,Colonna M
Tue May 17 00:00:00 UTC 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
210-12 was used in In vivo experiments to investigate the developmental stage of tumour-associated NK cells, showing that the tumour microenvironment alters the phenotype and function of NK cells.
Thu Sep 01 00:00:00 UTC 2016
Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.
The Journal of experimental medicine
Guo H,Cranert SA,Lu Y,Zhong MC,Zhang S,Chen J,Li R,Mahl SE,Wu N,Davidson D,Waggoner SN,Veillette A
Mon Sep 19 00:00:00 UTC 2016
miR-23∼27∼24 clusters control effector T cell differentiation and function.
The Journal of experimental medicine
Cho S,Wu CJ,Yasuda T,Cruz LO,Khan AA,Lin LL,Nguyen DT,Miller M,Lee HM,Kuo ML,Broide DH,Rajewsky K,Rudensky AY,Lu LF
Mon Feb 08 00:00:00 UTC 2016
A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells.
The Journal of experimental medicine
Liu WH,Kang SG,Huang Z,Wu CJ,Jin HY,Maine CJ,Liu Y,Shepherd J,Sabouri-Ghomi M,Gonzalez-Martin A,Xu S,Hoffmann A,Zheng Y,Lu LF,Xiao N,Fu G,Xiao C
Mon Aug 22 00:00:00 UTC 2016
NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics.
Proceedings of the National Academy of Sciences of the United States of America
Kiniwa T,Enomoto Y,Terazawa N,Omi A,Miyata N,Ishiwata K,Miyajima A
Tue Sep 06 00:00:00 UTC 2016
Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.
Proceedings of the National Academy of Sciences of the United States of America
Rabacal W,Pabbisetty SK,Hoek KL,Cendron D,Guo Y,Maseda D,Sebzda E
Tue May 10 00:00:00 UTC 2016
Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.
Proceedings of the National Academy of Sciences of the United States of America
Liu CF,Brandt GS,Hoang QQ,Naumova N,Lazarevic V,Hwang ES,Dekker J,Glimcher LH,Ringe D,Petsko GA
Tue Oct 25 00:00:00 UTC 2016
Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
Brucklacher-Waldert V,Ferreira C,Innocentin S,Kamdar S,Withers DR,Kullberg MC,Veldhoen M
Wed Jun 15 00:00:00 UTC 2016
IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Journal of immunology (Baltimore, Md. : 1950)
Goplen NP,Saxena V,Knudson KM,Schrum AG,Gil D,Daniels MA,Zamoyska R,Teixeiro E
Thu Sep 15 00:00:00 UTC 2016
Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Journal of immunology (Baltimore, Md. : 1950)
Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K
Sun May 01 00:00:00 UTC 2016
The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Koh B,Hufford MM,Pham D,Olson MR,Wu T,Jabeen R,Sun X,Kaplan MH
Thu Sep 15 00:00:00 UTC 2016
Differential Role of Hematopoietic and Nonhematopoietic Cell Types in the Regulation of NK Cell Tolerance and Responsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Shifrin NT,Kissiov DU,Ardolino M,Joncker NT,Raulet DH
Tue Nov 15 00:00:00 UTC 2016
NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Iraolagoitia XL,Spallanzani RG,Torres NI,Araya RE,Ziblat A,Domaica CI,Sierra JM,Nuñez SY,Secchiari F,Gajewski TF,Zwirner NW,Fuertes MB
Mon Aug 01 00:00:00 UTC 2016
A Simple, Versatile Antibody-Based Barcoding Method for Flow Cytometry.
Journal of immunology (Baltimore, Md. : 1950)
Akkaya B,Miozzo P,Holstein AH,Shevach EM,Pierce SK,Akkaya M
Thu Sep 01 00:00:00 UTC 2016
Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
McArdel SL,Brown DR,Sobel RA,Sharpe AH
Sat Oct 15 00:00:00 UTC 2016
Selective ORAI1 Inhibition Ameliorates Autoimmune Central Nervous System Inflammation by Suppressing Effector but Not Regulatory T Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Kaufmann U,Shaw PJ,Kozhaya L,Subramanian R,Gaida K,Unutmaz D,McBride HJ,Feske S
Fri Jan 15 00:00:00 UTC 2016
TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.
Journal of immunology (Baltimore, Md. : 1950)
Kourepini E,Paschalidis N,Simoes DC,Aggelakopoulou M,Grogan JL,Panoutsakopoulou V
Sun May 01 00:00:00 UTC 2016
Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Radtke D,Lacher SM,Szumilas N,Sandrock L,Ackermann J,Nitschke L,Zinser E
Fri Apr 01 00:00:00 UTC 2016
ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Simoes DC,Kalavrizioti D,Dimisianos N,Papathanasopoulos P,Mouzaki A,Panoutsakopoulou V
Sat Oct 01 00:00:00 UTC 2016
ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Aggelakopoulou M,Kourepini E,Paschalidis N,Panoutsakopoulou V
Wed Jun 15 00:00:00 UTC 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
Mon Apr 18 00:00:00 UTC 2016
Bone-protective Functions of Netrin 1 Protein.
The Journal of biological chemistry
Maruyama K,Kawasaki T,Hamaguchi M,Hashimoto M,Furu M,Ito H,Fujii T,Takemura N,Karuppuchamy T,Kondo T,Kawasaki T,Fukasaka M,Misawa T,Saitoh T,Suzuki Y,Martino MM,Kumagai Y,Akira S
Fri Nov 11 00:00:00 UTC 2016
Interleukin 12 shows a better curative effect on lung cancer than paclitaxel and cisplatin doublet chemotherapy.
BMC cancer
Yue T,Zheng X,Dou Y,Zheng X,Sun R,Tian Z,Wei H
210-12 was used in In vivo experiments to show that Interleukin 12 treatment inhibits lung tumour growth, resulting in the long-term survival of lung cancer-bearing mice.
Mon Aug 22 00:00:00 UTC 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
Wed May 18 00:00:00 UTC 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
Tue May 17 00:00:00 UTC 2016
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
Scientific reports
Drujont L,Lemoine A,Moreau A,Bienvenu G,Lancien M,Cens T,Guillot F,Bériou G,Bouchet-Delbos L,Fehling HJ,Chiffoleau E,Nicot AB,Charnet P,Martin JC,Josien R,Cuturi MC,Louvet C
Thu Mar 24 00:00:00 UTC 2016
Assessment of NK Cell Metabolism.
Methods in molecular biology (Clifton, N.J.)
Keppel MP,Cooper MA
210-12 was used in In vitro experiments to present methods for using inhibitors to alter cellular metabolism, measurement of intracellular ATP in NK cells, assessment of real-time glycolysis and oxidative phosphorylation by an extracellular flux assay from Seahorse Biosciences, and some basic protocols for stimulation of NK cells via cytokines and receptors.
Mon Dec 25 00:00:00 UTC 2017
Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.
Scientific reports
Kawalkowska J,Quirke AM,Ghari F,Davis S,Subramanian V,Thompson PR,Williams RO,Fischer R,La Thangue NB,Venables PJ
Mon May 23 00:00:00 UTC 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Fri Jun 03 00:00:00 UTC 2016
TNFR2 expression by CD4 effector T cells is required to induce full-fledged experimental colitis.
Scientific reports
Chen X,Nie Y,Xiao H,Bian Z,Scarzello AJ,Song NY,Trivett AL,Yang D,Oppenheim JJ
Wed Sep 07 00:00:00 UTC 2016
T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.
Nature communications
Krausgruber T,Schiering C,Adelmann K,Harrison OJ,Chomka A,Pearson C,Ahern PP,Shale M,Oukka M,Powrie F
Thu May 19 00:00:00 UTC 2016
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses.
The Journal of biological chemistry
Akhter N,Takeda Y,Nara H,Araki A,Ishii N,Asao N,Asao H
Fri Nov 04 00:00:00 UTC 2016
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
Tue Dec 15 00:00:00 UTC 2015
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Immunity
Ichiyama K,Chen T,Wang X,Yan X,Kim BS,Tanaka S,Ndiaye-Lobry D,Deng Y,Zou Y,Zheng P,Tian Q,Aifantis I,Wei L,Dong C
Tue Apr 21 00:00:00 UTC 2015
Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells.
The Journal of experimental medicine
Sekiya T,Kondo T,Shichita T,Morita R,Ichinose H,Yoshimura A
Mon Sep 21 00:00:00 UTC 2015
The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
The Journal of experimental medicine
Barnes MJ,Li CM,Xu Y,An J,Huang Y,Cyster JG
Mon Jun 29 00:00:00 UTC 2015
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
The Journal of experimental medicine
Lim HW,Kang SG,Ryu JK,Schilling B,Fei M,Lee IS,Kehasse A,Shirakawa K,Yokoyama M,Schnölzer M,Kasler HG,Kwon HS,Gibson BW,Sato H,Akassoglou K,Xiao C,Littman DR,Ott M,Verdin E
Mon May 04 00:00:00 UTC 2015
PTEN regulates natural killer cell trafficking in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Leong JW,Schneider SE,Sullivan RP,Parikh BA,Anthony BA,Singh A,Jewell BA,Schappe T,Wagner JA,Link DC,Yokoyama WM,Fehniger TA
Tue Feb 17 00:00:00 UTC 2015
T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Baumann C,Bonilla WV,Fröhlich A,Helmstetter C,Peine M,Hegazy AN,Pinschewer DD,Löhning M
Tue Mar 31 00:00:00 UTC 2015
T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
del Blanco B,Angulo Ú,Krangel MS,Hernández-Munain C
Tue Apr 07 00:00:00 UTC 2015
The aged nonhematopoietic environment impairs natural killer cell maturation and function.
Aging cell
Shehata HM,Hoebe K,Chougnet CA
Wed Apr 01 00:00:00 UTC 2015
Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter.
European journal of immunology
Hill EV,Ng TH,Burton BR,Oakley CM,Malik K,Wraith DC
Wed Apr 01 00:00:00 UTC 2015
NFATc1 deficiency in T cells protects mice from experimental autoimmune encephalomyelitis.
European journal of immunology
Reppert S,Zinser E,Holzinger C,Sandrock L,Koch S,Finotto S
Fri May 01 00:00:00 UTC 2015
Activation-specific metabolic requirements for NK Cell IFN-γ production.
Journal of immunology (Baltimore, Md. : 1950)
Keppel MP,Saucier N,Mah AY,Vogel TP,Cooper MA
Sun Feb 15 00:00:00 UTC 2015
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.
Journal of immunology (Baltimore, Md. : 1950)
Sakala IG,Kjer-Nielsen L,Eickhoff CS,Wang X,Blazevic A,Liu L,Fairlie DP,Rossjohn J,McCluskey J,Fremont DH,Hansen TH,Hoft DF
Wed Jul 15 00:00:00 UTC 2015
Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ding X,Yan Y,Li X,Li K,Ciric B,Yang J,Zhang Y,Wu S,Xu H,Chen W,Lovett-Racke AE,Zhang GX,Rostami A
Fri May 01 00:00:00 UTC 2015
IFN-γ production by memory helper T cells is required for CD40-independent alloantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Gorbacheva V,Fan R,Wang X,Baldwin WM,Fairchild RL,Valujskikh A
Sun Feb 01 00:00:00 UTC 2015
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK.
Journal of immunology (Baltimore, Md. : 1950)
Ebel ME,Awe O,Kaplan MH,Kansas GS
Mon Jun 15 00:00:00 UTC 2015
Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.
Journal of immunology (Baltimore, Md. : 1950)
Chen P,Aguilar OA,Rahim MM,Allan DS,Fine JH,Kirkham CL,Ma J,Tanaka M,Tu MM,Wight A,Kartsogiannis V,Gillespie MT,Makrigiannis AP,Carlyle JR
Sun Mar 15 00:00:00 UTC 2015
Deficiency of CD40 Reveals an Important Role for LIGHT in Anti-Leishmania Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Okwor I,Xu G,Tang H,Liang Y,Fu YX,Uzonna JE
Wed Jul 01 00:00:00 UTC 2015
Flt3 Ligand Is Essential for Survival and Protective Immune Responses during Toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950)
Dupont CD,Harms Pritchard G,Hidano S,Christian DA,Wagage S,Muallem G,Tait Wojno ED,Hunter CA
Sun Nov 01 00:00:00 UTC 2015
Composition, Development, and Function of Uterine Innate Lymphoid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Doisne JM,Balmas E,Boulenouar S,Gaynor LM,Kieckbusch J,Gardner L,Hawkes DA,Barbara CF,Sharkey AM,Brady HJ,Brosens JJ,Moffett A,Colucci F
Thu Oct 15 00:00:00 UTC 2015
Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance.
Journal of immunology (Baltimore, Md. : 1950)
Seregin SS,Chen GY,Laouar Y
Sat Aug 01 00:00:00 UTC 2015
IRAK1 Drives Intestinal Inflammation by Promoting the Generation of Effector Th Cells with Optimal Gut-Homing Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Heiseke AF,Jeuk BH,Markota A,Straub T,Lehr HA,Reindl W,Krug AB
Tue Dec 15 00:00:00 UTC 2015
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.
Scientific reports
Guo A,He D,Xu HB,Geng CA,Zhao J
Tue Sep 15 00:00:00 UTC 2015
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.
Nature communications
Matsuda T,Murao N,Katano Y,Juliandi B,Kohyama J,Akira S,Kawai T,Nakashima K
Mon Mar 09 00:00:00 UTC 2015
Tristetraprolin regulation of interleukin-22 production.
Scientific reports
Härdle L,Bachmann M,Bollmann F,Pautz A,Schmid T,Eberhardt W,Kleinert H,Pfeilschifter J,Mühl H
Wed Oct 21 00:00:00 UTC 2015
Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations.
Scientific reports
Lesterhuis WJ,Rinaldi C,Jones A,Rozali EN,Dick IM,Khong A,Boon L,Robinson BW,Nowak AK,Bosco A,Lake RA
Tue Jul 21 00:00:00 UTC 2015
A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells.
Nature communications
Cook PC,Owen H,Deaton AM,Borger JG,Brown SL,Clouaire T,Jones GR,Jones LH,Lundie RJ,Marley AK,Morrison VL,Phythian-Adams AT,Wachter E,Webb LM,Sutherland TE,Thomas GD,Grainger JR,Selfridge J,McKenzie AN,Allen JE,Fagerholm SC,Maizels RM,Ivens AC,Bird A,MacDonald AS
Fri Apr 24 00:00:00 UTC 2015
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Cell
Klose CSN,Flach M,Möhle L,Rogell L,Hoyler T,Ebert K,Fabiunke C,Pfeifer D,Sexl V,Fonseca-Pereira D,Domingues RG,Veiga-Fernandes H,Arnold SJ,Busslinger M,Dunay IR,Tanriver Y,Diefenbach A
Thu Apr 10 00:00:00 UTC 2014
Function of a Foxp3 cis-element in protecting regulatory T cell identity.
Cell
Li X,Liang Y,LeBlanc M,Benner C,Zheng Y
Thu Aug 14 00:00:00 UTC 2014
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
Thu Oct 16 00:00:00 UTC 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
210-12 was used in In vitro experiments to identify TRAF5 as a negative regulator of the IL-6 receptor signalling pathway that limits the induction of proinflammatory CD4(+) T cells.
Thu May 01 00:00:00 UTC 2014
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Blood
Masson F,Ghisi M,Groom JR,Kallies A,Seillet C,Johnstone RW,Nutt SL,Belz GT
Thu May 29 00:00:00 UTC 2014
Cytokine therapy reverses NK cell anergy in MHC-deficient tumors.
The Journal of clinical investigation
Ardolino M,Azimi CS,Iannello A,Trevino TN,Horan L,Zhang L,Deng W,Ring AM,Fischer S,Garcia KC,Raulet DH
Sat Nov 01 00:00:00 UTC 2014
CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.
The Journal of experimental medicine
Cortez VS,Cervantes-Barragan L,Song C,Gilfillan S,McDonald KG,Tussiwand R,Edelson BT,Murakami Y,Murphy KM,Newberry RD,Sibley LD,Colonna M
Mon Apr 07 00:00:00 UTC 2014
Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease.
EMBO molecular medicine
Bilbao D,Luciani L,Johannesson B,Piszczek A,Rosenthal N
Sat Nov 01 00:00:00 UTC 2014
Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity.
Proceedings of the National Academy of Sciences of the United States of America
Okoye IS,Czieso S,Ktistaki E,Roderick K,Coomes SM,Pelly VS,Kannan Y,Perez-Lloret J,Zhao JL,Baltimore D,Langhorne J,Wilson MS
Tue Jul 29 00:00:00 UTC 2014
Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Kissick HT,Sanda MG,Dunn LK,Pellegrini KL,On ST,Noel JK,Arredouani MS
Tue Jul 08 00:00:00 UTC 2014
CD1d-unrestricted NKT cells are endowed with a hybrid function far superior than that of iNKT cells.
Proceedings of the National Academy of Sciences of the United States of America
Farr AR,Wu W,Choi B,Cavalcoli JD,Laouar Y
Tue Sep 02 00:00:00 UTC 2014
Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
Stem cells (Dayton, Ohio)
Glenn JD,Smith MD,Calabresi PA,Whartenby KA
Wed Oct 01 00:00:00 UTC 2014
IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals.
Journal of immunology (Baltimore, Md. : 1950)
Walsh MC,Pearce EL,Cejas PJ,Lee J,Wang LS,Choi Y
Wed Oct 15 00:00:00 UTC 2014
Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mori T,Iwasaki Y,Seki Y,Iseki M,Katayama H,Yamamoto K,Takatsu K,Takaki S
Fri Aug 15 00:00:00 UTC 2014
CCAAT/enhancer-binding protein α negatively regulates IFN-γ expression in T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Tanaka K,Magnusson F,Chung Y,Martinez GJ,Wang YH,Nurieva RI,Kurosaki T,Dong C
Mon Dec 15 00:00:00 UTC 2014
Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi T,Oyamada A,Sakuraba K,Shimoda K,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H
Thu May 15 00:00:00 UTC 2014
Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Pawaria S,Ramani K,Maers K,Liu Y,Kane LP,Levesque MC,Biswas PS
Wed Oct 01 00:00:00 UTC 2014
The inhibitory effect of IFN-γ on protease HTRA1 expression in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Hou Y,Lin H,Zhu L,Liu Z,Hu F,Shi J,Yang T,Shi X,Guo H,Tan X,Zhang L,Wang Q,Li Z,Zhao Y
Tue Jul 01 00:00:00 UTC 2014
Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Oksanen A,Aittomäki S,Jankovic D,Ortutay Z,Pulkkinen K,Hämäläinen S,Rokka A,Corthals GL,Watford WT,Junttila I,O'Shea JJ,Pesu M
Mon Dec 01 00:00:00 UTC 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
Wed Jan 01 00:00:00 UTC 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
Tue Jul 15 00:00:00 UTC 2014
Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Spooner E,Kessler BM,Radaev S,Lantz L,Xiao TS,Matzinger P,Sun PD,Ploegh HL
Sun Jun 15 00:00:00 UTC 2014
Th17 cells demonstrate stable cytokine production in a proallergic environment.
Journal of immunology (Baltimore, Md. : 1950)
Glosson-Byers NL,Sehra S,Stritesky GL,Yu Q,Awe O,Pham D,Bruns HA,Kaplan MH
Mon Sep 15 00:00:00 UTC 2014
Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection.
Journal of immunology (Baltimore, Md. : 1950)
Davila SJ,Olive AJ,Starnbach MN
Thu May 01 00:00:00 UTC 2014
CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-γ production in response to mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Stojanovic A,Fiegler N,Brunner-Weinzierl M,Cerwenka A
Thu May 01 00:00:00 UTC 2014
Type 2 innate lymphoid cells drive CD4+ Th2 cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Mirchandani AS,Besnard AG,Yip E,Scott C,Bain CC,Cerovic V,Salmond RJ,Liew FY
Sat Mar 01 00:00:00 UTC 2014
Defining the functional boundaries of the murine α1,3-fucosyltransferase Fut7 reveals a remarkably compact locus.
The Journal of biological chemistry
Ebel ME,Kansas GS
Fri Mar 07 00:00:00 UTC 2014
Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy.
Nature communications
Burton BR,Britton GJ,Fang H,Verhagen J,Smithers B,Sabatos-Peyton CA,Carney LJ,Gough J,Strobel S,Wraith DC
Wed Sep 03 00:00:00 UTC 2014
STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells.
JAK-STAT
Glosson-Byers NL,Sehra S,Kaplan MH
210-12 was used in In vitro experiments to define populations of T cells that are STAT4-dependent in response to IL-23.
Mon Sep 28 00:00:00 UTC 2015
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.
Immunity
Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M
Thu Apr 18 00:00:00 UTC 2013
Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.
Blood
Tinsley KW,Hong C,Luckey MA,Park JY,Kim GY,Yoon HW,Keller HR,Sacks AJ,Feigenbaum L,Park JH
Thu Oct 03 00:00:00 UTC 2013
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
The Journal of clinical investigation
Peng H,Jiang X,Chen Y,Sojka DK,Wei H,Gao X,Sun R,Yokoyama WM,Tian Z
Mon Apr 01 00:00:00 UTC 2013
Dynamic visualization of RANKL and Th17-mediated osteoclast function.
The Journal of clinical investigation
Kikuta J,Wada Y,Kowada T,Wang Z,Sun-Wada GH,Nishiyama I,Mizukami S,Maiya N,Yasuda H,Kumanogoh A,Kikuchi K,Germain RN,Ishii M
Fri Feb 01 00:00:00 UTC 2013
Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.
The Journal of experimental medicine
Sitrin J,Ring A,Garcia KC,Benoist C,Mathis D
Mon Jun 03 00:00:00 UTC 2013
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex.
The Journal of experimental medicine
Liu X,Li H,Zhong B,Blonska M,Gorjestani S,Yan M,Tian Q,Zhang DE,Lin X,Dong C
Mon Jul 29 00:00:00 UTC 2013
Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
The Journal of experimental medicine
Bouchlaka MN,Sckisel GD,Chen M,Mirsoian A,Zamora AE,Maverakis E,Wilkins DE,Alderson KL,Hsiao HH,Weiss JM,Monjazeb AM,Hesdorffer C,Ferrucci L,Longo DL,Blazar BR,Wiltrout RH,Redelman D,Taub DD,Murphy WJ
Mon Oct 21 00:00:00 UTC 2013
Deficiency of β-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Li J,Wei B,Guo A,Liu C,Huang S,Du F,Fan W,Bao C,Pei G
Tue Apr 30 00:00:00 UTC 2013
MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Chang J,Burkett PR,Borges CM,Kuchroo VK,Turka LA,Chang CH
Tue Feb 05 00:00:00 UTC 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
Mon Apr 01 00:00:00 UTC 2013
Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction.
Journal of immunology (Baltimore, Md. : 1950)
Tamiya T,Ichiyama K,Kotani H,Fukaya T,Sekiya T,Shichita T,Honma K,Yui K,Matsuyama T,Nakao T,Fukuyama S,Inoue H,Nomura M,Yoshimura A
Sun Sep 01 00:00:00 UTC 2013
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Yamashita J,Iwamura C,Ito T,Narita M,Hara Y,Sasaki T,Masuda D,Takahashi M,Tsuchiya M,Hada K,Ishikawa M,Matsuo T,Ohno Y,Tanaka H,Maruyama H,Ogawa Y,Nakayama T
Mon Jul 15 00:00:00 UTC 2013
Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease.
Journal of immunology (Baltimore, Md. : 1950)
Sugita S,Kawazoe Y,Imai A,Kawaguchi T,Horie S,Keino H,Takahashi M,Mochizuki M
Sat Jun 01 00:00:00 UTC 2013
Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.
Journal of immunology (Baltimore, Md. : 1950)
Knudson KM,Hamilton SE,Daniels MA,Jameson SC,Teixeiro E
Sun Dec 15 00:00:00 UTC 2013
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Yu Q,Walline CC,Muthukrishnan R,Blum JS,Kaplan MH
Mon Jul 15 00:00:00 UTC 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
Fri Feb 01 00:00:00 UTC 2013
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
Sun Dec 01 00:00:00 UTC 2013
Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Keppel MP,Yang L,Cooper MA
Wed May 01 00:00:00 UTC 2013
TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.
Journal of immunology (Baltimore, Md. : 1950)
Heidegger S,Kirchner SK,Stephan N,Bohn B,Suhartha N,Hotz C,Anz D,Sandholzer N,Stecher B,Rüssmann H,Endres S,Bourquin C
Wed May 15 00:00:00 UTC 2013
MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA
Sun Dec 15 00:00:00 UTC 2013
Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn.
Journal of immunology (Baltimore, Md. : 1950)
Hoeman CM,Dhakal M,Zaghouani AA,Cascio JA,Wan X,Khairallah MT,Chen W,Zaghouani H
Sat Jun 15 00:00:00 UTC 2013
CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.
Journal of immunology (Baltimore, Md. : 1950)
Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G
Sun Dec 01 00:00:00 UTC 2013
CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Frazer LC,Sullivan JE,Zurenski MA,Mintus M,Tomasak TE,Prantner D,Nagarajan UM,Darville T
Tue Oct 15 00:00:00 UTC 2013
Tumor-derived vascular pericytes anergize Th cells.
Journal of immunology (Baltimore, Md. : 1950)
Bose A,Barik S,Banerjee S,Ghosh T,Mallick A,Bhattacharyya Majumdar S,Goswami KK,Bhuniya A,Banerjee S,Baral R,Storkus WJ,Dasgupta PS,Majumdar S
Mon Jul 15 00:00:00 UTC 2013
IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier.
Journal of immunology (Baltimore, Md. : 1950)
Zeng Z,Kong X,Li F,Wei H,Sun R,Tian Z
Tue Oct 15 00:00:00 UTC 2013
CD62L is critical for maturation and accumulation of murine hepatic NK cells in response to viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Peng H,Sun R,Tang L,Wei H,Tian Z
Mon Apr 15 00:00:00 UTC 2013
Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
Journal of immunology (Baltimore, Md. : 1950)
Mishra R,Polic B,Welsh RM,Szomolanyi-Tsuda E
Mon Jul 15 00:00:00 UTC 2013
Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kawashima H,Takatori H,Suzuki K,Iwata A,Yokota M,Suto A,Minamino T,Hirose K,Nakajima H
Tue Oct 01 00:00:00 UTC 2013
Nuclear receptor NR4A2 orchestrates Th17 cell-mediated autoimmune inflammation via IL-21 signalling.
PloS one
Raveney BJ,Oki S,Yamamura T
Tue Sep 10 00:00:00 UTC 2013
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
The Journal of biological chemistry
Pham D,Walline CC,Hollister K,Dent AL,Blum JS,Firulli AB,Kaplan MH
Fri Sep 20 00:00:00 UTC 2013
Compensatory dendritic cell development mediated by BATF-IRF interactions.
Nature
Tussiwand R,Lee WL,Murphy TL,Mashayekhi M,KC W,Albring JC,Satpathy AT,Rotondo JA,Edelson BT,Kretzer NM,Wu X,Weiss LA,Glasmacher E,Li P,Liao W,Behnke M,Lam SS,Aurthur CT,Leonard WJ,Singh H,Stallings CL,Sibley LD,Schreiber RD,Murphy KM
Thu Oct 25 00:00:00 UTC 2012
Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy.
Blood
Tietze JK,Wilkins DE,Sckisel GD,Bouchlaka MN,Alderson KL,Weiss JM,Ames E,Bruhn KW,Craft N,Wiltrout RH,Longo DL,Lanier LL,Blazar BR,Redelman D,Murphy WJ
Thu Mar 29 00:00:00 UTC 2012
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.
The Journal of clinical investigation
Yiakouvaki A,Dimitriou M,Karakasiliotis I,Eftychi C,Theocharis S,Kontoyiannis DL
Sun Jan 01 00:00:00 UTC 2012
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
The Journal of clinical investigation
Brüstle A,Brenner D,Knobbe CB,Lang PA,Virtanen C,Hershenfield BM,Reardon C,Lacher SM,Ruland J,Ohashi PS,Mak TW
Sat Dec 01 00:00:00 UTC 2012
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
The Journal of experimental medicine
Ni J,Miller M,Stojanovic A,Garbi N,Cerwenka A
Mon Dec 17 00:00:00 UTC 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
Tue Oct 02 00:00:00 UTC 2012
Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Journal of immunology (Baltimore, Md. : 1950)
Cedeno-Laurent F,Opperman M,Barthel SR,Kuchroo VK,Dimitroff CJ
Sun Apr 01 00:00:00 UTC 2012
Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Eberle ME,Dalpke AH
Fri Jun 01 00:00:00 UTC 2012
Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Bian Z,Guo Y,Ha B,Zen K,Liu Y
Sun Jan 15 00:00:00 UTC 2012
CD4+ T cells are necessary and sufficient to confer protection against Chlamydia trachomatis infection in the murine upper genital tract.
Journal of immunology (Baltimore, Md. : 1950)
Gondek DC,Olive AJ,Stary G,Starnbach MN
Sat Sep 01 00:00:00 UTC 2012
Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Poovassery JS,Bishop GA
Wed Aug 15 00:00:00 UTC 2012
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.
Journal of immunology (Baltimore, Md. : 1950)
Pham D,Vincentz JW,Firulli AB,Kaplan MH
Sun Jul 15 00:00:00 UTC 2012
NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950)
Souza-Fonseca-Guimaraes F,Parlato M,Fitting C,Cavaillon JM,Adib-Conquy M
Fri Jun 15 00:00:00 UTC 2012
Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950)
Zhao YG,Wang Y,Guo Z,Gu AD,Dan HC,Baldwin AS,Hao W,Wan YY
Thu Nov 01 00:00:00 UTC 2012
Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
Journal of immunology (Baltimore, Md. : 1950)
Abdi K,Singh NJ,Matzinger P
Fri Jun 15 00:00:00 UTC 2012
MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Leong JW,Schneider SE,Keppel CR,Germino E,French AR,Fehniger TA
Sun Apr 01 00:00:00 UTC 2012
CD23+ CD21(high) CD1d(high) B cells in inflamed lymph nodes are a locally differentiated population with increased antigen capture and activation potential.
Journal of immunology (Baltimore, Md. : 1950)
Moshkani S,Kuzin II,Adewale F,Jansson J,Sanz I,Schwarz EM,Bottaro A
Fri Jun 15 00:00:00 UTC 2012
NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.
Journal of immunology (Baltimore, Md. : 1950)
Wortham BW,Eppert BL,Motz GT,Flury JL,Orozco-Levi M,Hoebe K,Panos RJ,Maxfield M,Glasser SW,Senft AP,Raulet DH,Borchers MT
Tue May 01 00:00:00 UTC 2012
Fyn promotes Th17 differentiation by regulating the kinetics of RORγt and Foxp3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Ueda A,Zhou L,Stein PL
Fri Jun 01 00:00:00 UTC 2012
TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.
PloS one
Ohnishi H,Tochio H,Kato Z,Kawamoto N,Kimura T,Kubota K,Yamamoto T,Funasaka T,Nakano H,Wong RW,Shirakawa M,Kondo N
Fri Dec 07 00:00:00 UTC 2012
p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.
The Journal of biological chemistry
Hu P,Nebreda AR,Liu Y,Carlesso N,Kaplan M,Kapur R
Fri Sep 28 00:00:00 UTC 2012
Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.
PloS one
Caserta S,Nausch N,Sawtell A,Drummond R,Barr T,Macdonald AS,Mutapi F,Zamoyska R
Thu Aug 23 00:00:00 UTC 2012
HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates.
PloS one
Basile LA,Ellefson D,Gluzman-Poltorak Z,Junes-Gill K,Mar V,Mendonca S,Miller JD,Tom J,Trinh A,Gallaher TK
Mon Aug 27 00:00:00 UTC 2012
Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities.
PloS one
Chan T,Back TC,Subleski JJ,Weiss JM,Ortaldo JR,Wiltrout RH
Mon Aug 20 00:00:00 UTC 2012
Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression.
PloS one
Redmond WL,Triplett T,Floyd K,Weinberg AD
Tue Aug 21 00:00:00 UTC 2012
De novo DNA methylation is required to restrict T helper lineage plasticity.
The Journal of biological chemistry
Thomas RM,Gamper CJ,Ladle BH,Powell JD,Wells AD
Fri Jun 29 00:00:00 UTC 2012
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.
Immunity
Mashayekhi M,Sandau MM,Dunay IR,Frickel EM,Khan A,Goldszmid RS,Sher A,Ploegh HL,Murphy TL,Sibley LD,Murphy KM
Fri Aug 26 00:00:00 UTC 2011
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
Thu Feb 03 00:00:00 UTC 2011
CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.
Blood
Noda M,Omatsu Y,Sugiyama T,Oishi S,Fujii N,Nagasawa T
Thu Jan 13 00:00:00 UTC 2011
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice.
Blood
Hao Y,O'Neill P,Naradikian MS,Scholz JL,Cancro MP
Thu Aug 04 00:00:00 UTC 2011
SMAD3 prevents graft-versus-host disease by restraining Th1 differentiation and granulocyte-mediated tissue damage.
Blood
Giroux M,Delisle JS,Gauthier SD,Heinonen KM,Hinsinger J,Houde B,Gaboury L,Brochu S,Wu J,Hébert MJ,Perreault C
Thu Feb 03 00:00:00 UTC 2011
Development of thymic NK cells from double negative 1 thymocyte precursors.
Blood
Vargas CL,Poursine-Laurent J,Yang L,Yokoyama WM
Thu Sep 29 00:00:00 UTC 2011
CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.
Blood
Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G
Thu Apr 28 00:00:00 UTC 2011
Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
The Journal of clinical investigation
Ma H,Lu C,Ziegler J,Liu A,Sepulveda A,Okada H,Lentzsch S,Mapara MY
Fri Jul 01 00:00:00 UTC 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
Mon Apr 11 00:00:00 UTC 2011
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
The Journal of experimental medicine
Knosp CA,Carroll HP,Elliott J,Saunders SP,Nel HJ,Amu S,Pratt JC,Spence S,Doran E,Cooke N,Jackson R,Swift J,Fitzgerald DC,Heaney LG,Fallon PG,Kissenpfennig A,Johnston JA
Mon Jul 04 00:00:00 UTC 2011
Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.
The Journal of experimental medicine
Brigl M,Tatituri RV,Watts GF,Bhowruth V,Leadbetter EA,Barton N,Cohen NR,Hsu FF,Besra GS,Brenner MB
Mon Jun 06 00:00:00 UTC 2011
Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections.
PLoS pathogens
Coers J,Gondek DC,Olive AJ,Rohlfing A,Taylor GA,Starnbach MN
Wed Jun 01 00:00:00 UTC 2011
Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
PLoS pathogens
Ingram JT,Yi JS,Zajac AJ
Thu Sep 01 00:00:00 UTC 2011
Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.
Journal of immunology (Baltimore, Md. : 1950)
Koguchi Y,Gardell JL,Thauland TJ,Parker DC
Fri Jul 15 00:00:00 UTC 2011
TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Subleski JJ,Hall VL,Wolfe TB,Scarzello AJ,Weiss JM,Chan T,Hodge DL,Back TC,Ortaldo JR,Wiltrout RH
Sat Jan 15 00:00:00 UTC 2011
Retinal self-antigen induces a predominantly Th1 effector response in Axl and Mertk double-knockout mice.
Journal of immunology (Baltimore, Md. : 1950)
Ye F,Han L,Lu Q,Dong W,Chen Z,Shao H,Kaplan HJ,Li Q,Lu Q
Sat Oct 15 00:00:00 UTC 2011
Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Newland S,Krejcí A,Phillips JM,Bray S,Cooke A
Tue Mar 15 00:00:00 UTC 2011
MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Zhang F,Chen F,Liu D,Zheng Y,Zhang Y,Dong C,Su B
Sun May 15 00:00:00 UTC 2011
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Obar JJ,Jellison ER,Sheridan BS,Blair DA,Pham QM,Zickovich JM,Lefrançois L
Tue Nov 15 00:00:00 UTC 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
Thu Dec 15 00:00:00 UTC 2011
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells.
Journal of immunology (Baltimore, Md. : 1950)
Mattapallil MJ,Silver PB,Mattapallil JJ,Horai R,Karabekian Z,McDowell JH,Chan CC,James EA,Kwok WW,Sen HN,Nussenblatt RB,David CS,Caspi RR
Mon Aug 15 00:00:00 UTC 2011
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Ishizaki M,Akimoto T,Muromoto R,Yokoyama M,Ohshiro Y,Sekine Y,Maeda H,Shimoda K,Oritani K,Matsuda T
Fri Jul 01 00:00:00 UTC 2011
Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.
Journal of immunology (Baltimore, Md. : 1950)
Galitovskiy V,Qian J,Chernyavsky AI,Marchenko S,Gindi V,Edwards RA,Grando SA
Thu Sep 01 00:00:00 UTC 2011
A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Zhou R,Horai R,Mattapallil MJ,Caspi RR
Sat Oct 15 00:00:00 UTC 2011
A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Zhou R,Horai R,Mattapallil MJ,Caspi RR
Sat Oct 15 00:00:00 UTC 2011
Elf3 regulates allergic airway inflammation by controlling dendritic cell-driven T cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Kushwah R,Oliver JR,Wu J,Chang Z,Hu J
Tue Nov 01 00:00:00 UTC 2011
IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production.
Journal of immunology (Baltimore, Md. : 1950)
Jung MY,Son MH,Kim SH,Cho D,Kim TS
Wed Jun 15 00:00:00 UTC 2011
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Wang L,Du C,Lv J,Wei W,Cui Y,Xie X
Thu Sep 01 00:00:00 UTC 2011
Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa R,Yoshida H,Asakawa M,Tamiya T,Inoue N,Morita R,Inoue H,Nakao A,Yoshimura A
Tue Nov 01 00:00:00 UTC 2011
IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Silver JS,Stumhofer JS,Passos S,Ernst M,Hunter CA
Fri Jul 01 00:00:00 UTC 2011
Resident peritoneal NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Gonzaga R,Matzinger P,Perez-Diez A
Thu Dec 15 00:00:00 UTC 2011
Overexpression of a minimal domain of calpastatin suppresses IL-6 production and Th17 development via reduced NF-κB and increased STAT5 signals.
PloS one
Iguchi-Hashimoto M,Usui T,Yoshifuji H,Shimizu M,Kobayashi S,Ito Y,Murakami K,Shiomi A,Yukawa N,Kawabata D,Nojima T,Ohmura K,Fujii T,Mimori T
Mon Mar 26 00:00:00 UTC 2012
Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production.
The Journal of biological chemistry
Fujita-Sato S,Ito S,Isobe T,Ohyama T,Wakabayashi K,Morishita K,Ando O,Isono F
Fri Sep 09 00:00:00 UTC 2011
Cyp26b1 regulates retinoic acid-dependent signals in T cells and its expression is inhibited by transforming growth factor-β.
PloS one
Takeuchi H,Yokota A,Ohoka Y,Iwata M
Fri Jan 07 00:00:00 UTC 2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
Thu Sep 29 00:00:00 UTC 2011
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.
Nature communications
Sekiya T,Kashiwagi I,Inoue N,Morita R,Hori S,Waldmann H,Rudensky AY,Ichinose H,Metzger D,Chambon P,Yoshimura A
Fri Jul 22 00:00:00 UTC 2011
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.
PloS one
Eto D,Lao C,DiToro D,Barnett B,Escobar TC,Kageyama R,Yusuf I,Crotty S
Mon Mar 14 00:00:00 UTC 2011
Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling.
The Journal of biological chemistry
Maier E,Hebenstreit D,Posselt G,Hammerl P,Duschl A,Horejs-Hoeck J
Fri Jan 14 00:00:00 UTC 2011
Deletion of the aryl hydrocarbon receptor enhances the inflammatory response to Leishmania major infection.
International journal of biological sciences
Elizondo G,Rodríguez-Sosa M,Estrada-Muñiz E,Gonzalez FJ,Vega L
Tue May 29 00:00:00 UTC 2012
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature
Okamoto K,Iwai Y,Oh-Hora M,Yamamoto M,Morio T,Aoki K,Ohya K,Jetten AM,Akira S,Muta T,Takayanagi H
Thu Apr 29 00:00:00 UTC 2010
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.
Nature
Ghoreschi K,Laurence A,Yang XP,Tato CM,McGeachy MJ,Konkel JE,Ramos HL,Wei L,Davidson TS,Bouladoux N,Grainger JR,Chen Q,Kanno Y,Watford WT,Sun HW,Eberl G,Shevach EM,Belkaid Y,Cua DJ,Chen W,O'Shea JJ
Thu Oct 21 00:00:00 UTC 2010
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
Blood
Cejas PJ,Walsh MC,Pearce EL,Han D,Harms GM,Artis D,Turka LA,Choi Y
Thu Jun 10 00:00:00 UTC 2010
mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS.
Blood
Turnquist HR,Cardinal J,Macedo C,Rosborough BR,Sumpter TL,Geller DA,Metes D,Thomson AW
Thu Jun 10 00:00:00 UTC 2010
Effect of diet-induced obesity on acute pancreatitis induced by administration of interleukin-12 plus interleukin-18 in mice.
Obesity (Silver Spring, Md.)
Pini M,Sennello JA,Cabay RJ,Fantuzzi G
Mon Mar 01 00:00:00 UTC 2010
FoxP3+RORgammat+ T helper intermediates display suppressive function against autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Tartar DM,VanMorlan AM,Wan X,Guloglu FB,Jain R,Haymaker CL,Ellis JS,Hoeman CM,Cascio JA,Dhakal M,Oukka M,Zaghouani H
Thu Apr 01 00:00:00 UTC 2010
CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B.
Journal of immunology (Baltimore, Md. : 1950)
Jimenez F,Quinones MP,Martinez HG,Estrada CA,Clark K,Garavito E,Ibarra J,Melby PC,Ahuja SS
Sat May 15 00:00:00 UTC 2010
Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.
Journal of immunology (Baltimore, Md. : 1950)
Takimoto T,Wakabayashi Y,Sekiya T,Inoue N,Morita R,Ichiyama K,Takahashi R,Asakawa M,Muto G,Mori T,Hasegawa E,Saika S,Hara T,Nomura M,Yoshimura A
Thu Jul 15 00:00:00 UTC 2010
CD30 ligand is a target for a novel biological therapy against colitis associated with Th17 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Iwakura Y,Yoshikai Y
Wed Dec 15 00:00:00 UTC 2010
Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.
Journal of immunology (Baltimore, Md. : 1950)
Johannsen A,Genolet R,Legler DF,Luther SA,Luescher IF
Wed Sep 15 00:00:00 UTC 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
Sun Aug 15 00:00:00 UTC 2010
Lck mediates Th2 differentiation through effects on T-bet and GATA-3.
Journal of immunology (Baltimore, Md. : 1950)
Kemp KL,Levin SD,Bryce PJ,Stein PL
Thu Apr 15 00:00:00 UTC 2010
Synergistic effect of IL-6 and IL-4 in driving fate revision of natural Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kastner L,Dwyer D,Qin FX
Mon Nov 15 00:00:00 UTC 2010
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA
Sun Aug 01 00:00:00 UTC 2010
Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.
PloS one
Domingues HS,Mues M,Lassmann H,Wekerle H,Krishnamoorthy G
Mon Nov 29 00:00:00 UTC 2010
Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.
Lipids in health and disease
Kong W,Yen JH,Vassiliou E,Adhikary S,Toscano MG,Ganea D
Mon Feb 01 00:00:00 UTC 2010
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment.
Immunity
Delgoffe GM,Kole TP,Zheng Y,Zarek PE,Matthews KL,Xiao B,Worley PF,Kozma SC,Powell JD
Fri Jun 19 00:00:00 UTC 2009
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase.
Immunity
Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL
Fri Oct 16 00:00:00 UTC 2009
Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10-secreting Th1 cells.
The Journal of experimental medicine
Gabrysová L,Nicolson KS,Streeter HB,Verhagen J,Sabatos-Peyton CA,Morgan DJ,Wraith DC
Mon Aug 03 00:00:00 UTC 2009
Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.
The Journal of experimental medicine
McCartney S,Vermi W,Gilfillan S,Cella M,Murphy TL,Schreiber RD,Murphy KM,Colonna M
Mon Dec 21 00:00:00 UTC 2009
Cytokine-induced memory-like natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM
Tue Feb 10 00:00:00 UTC 2009
Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Verhagen J,Gabrysová L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC
Tue Mar 03 00:00:00 UTC 2009
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity.
Proceedings of the National Academy of Sciences of the United States of America
Komatsu N,Mariotti-Ferrandiz ME,Wang Y,Malissen B,Waldmann H,Hori S
Tue Feb 10 00:00:00 UTC 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
Tue Dec 15 00:00:00 UTC 2009
Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Mikhak Z,Farsidjani A,Luster AD
Mon Jun 15 00:00:00 UTC 2009
Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule-dependent and -independent pathways.
Journal of immunology (Baltimore, Md. : 1950)
Aleyas AG,George JA,Han YW,Rahman MM,Kim SJ,Han SB,Kim BS,Kim K,Eo SK
Sat Aug 15 00:00:00 UTC 2009
Regulation of DNA demethylation during maturation of CD4+ naive T cells by the conserved noncoding sequence 1.
Journal of immunology (Baltimore, Md. : 1950)
Aoki K,Sato N,Yamaguchi A,Kaminuma O,Hosozawa T,Miyatake S
Mon Jun 15 00:00:00 UTC 2009
Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V
Mon Jun 01 00:00:00 UTC 2009
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A
Sat Aug 01 00:00:00 UTC 2009
MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Chang X,Facchinetti V,Zhuang Y,Su B
Sun Mar 15 00:00:00 UTC 2009
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Yoshimi R,Chang TH,Wang H,Atsumi T,Morse HC,Ozato K
Mon Jun 15 00:00:00 UTC 2009
Ikaros is a regulator of Il10 expression in CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Umetsu SE,Winandy S
Sun Nov 01 00:00:00 UTC 2009
Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Oyamada A,Ikebe H,Itsumi M,Saiwai H,Okada S,Shimoda K,Iwakura Y,Nakayama KI,Iwamoto Y,Yoshikai Y,Yamada H
Tue Dec 01 00:00:00 UTC 2009
Cutting edge: Ikaros is a regulator of Th2 cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Quirion MR,Gregory GD,Umetsu SE,Winandy S,Brown MA
Thu Jan 15 00:00:00 UTC 2009
4-1BB functions as a survival factor in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS
Wed Apr 01 00:00:00 UTC 2009
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Perona-Wright G,Jenkins SJ,O'Connor RA,Zienkiewicz D,McSorley HJ,Maizels RM,Anderton SM,MacDonald AS
Sun Mar 01 00:00:00 UTC 2009
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis.
Journal of immunology (Baltimore, Md. : 1950)
Gondek DC,Roan NR,Starnbach MN
Wed Jul 15 00:00:00 UTC 2009
Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock.
Journal of immunology (Baltimore, Md. : 1950)
Jung ID,Lee MG,Chang JH,Lee JS,Jeong YI,Lee CM,Park WS,Han J,Seo SK,Lee SY,Park YM
Sun Mar 01 00:00:00 UTC 2009
PU.1 regulates TCR expression by modulating GATA-3 activity.
Journal of immunology (Baltimore, Md. : 1950)
Chang HC,Han L,Jabeen R,Carotta S,Nutt SL,Kaplan MH
Thu Oct 15 00:00:00 UTC 2009
ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes.
Immunology letters
Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Nagahira A,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T
Sat Feb 21 00:00:00 UTC 2009
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
Immunity
Meylan F,Davidson TS,Kahle E,Kinder M,Acharya K,Jankovic D,Bundoc V,Hodges M,Shevach EM,Keane-Myers A,Wang EC,Siegel RM
Fri Jul 18 00:00:00 UTC 2008
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease.
The Journal of experimental medicine
Chong MM,Rasmussen JP,Rudensky AY,Littman DR
Mon Sep 01 00:00:00 UTC 2008
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Proceedings of the National Academy of Sciences of the United States of America
Zhou D,Medoff BD,Chen L,Li L,Zhang XF,Praskova M,Liu M,Landry A,Blumberg RS,Boussiotis VA,Xavier R,Avruch J
Tue Dec 23 00:00:00 UTC 2008
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Proceedings of the National Academy of Sciences of the United States of America
Zhu Q,Egelston C,Vivekanandhan A,Uematsu S,Akira S,Klinman DM,Belyakov IM,Berzofsky JA
Tue Oct 21 00:00:00 UTC 2008
Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases.
Journal of immunology (Baltimore, Md. : 1950)
Liu X,Lee YS,Yu CR,Egwuagu CE
Thu May 01 00:00:00 UTC 2008
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4.
Journal of immunology (Baltimore, Md. : 1950)
Kurowska-Stolarska M,Kewin P,Murphy G,Russo RC,Stolarski B,Garcia CC,Komai-Koma M,Pitman N,Li Y,Niedbala W,McKenzie AN,Teixeira MM,Liew FY,Xu D
Wed Oct 01 00:00:00 UTC 2008
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.
Journal of immunology (Baltimore, Md. : 1950)
Kamimura D,Bevan MJ
Wed Oct 15 00:00:00 UTC 2008
SOCS1 regulates CCR7 expression and migration of CD4+ T cells into peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950)
Yu CR,Mahdi RM,Liu X,Zhang A,Naka T,Kishimoto T,Egwuagu CE
Tue Jul 15 00:00:00 UTC 2008
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A
Sat Nov 01 00:00:00 UTC 2008
Herpes virus oncolytic therapy reverses tumor immune dysfunction and facilitates tumor antigen presentation.
Cancer biology & therapy
Benencia F,Courrèges MC,Fraser NW,Coukos G
210-12 was used in Enzyme-linked immunosorbent assay to show how oncolytic HSV-1716 generates vaccination effects and that that oncolytic therapy with HSV-1716 facilitates antitumor immune responses.
Fri Aug 01 00:00:00 UTC 2008
Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells.
Genes and immunity
Grant LR,Yao ZJ,Hedrich CM,Wang F,Moorthy A,Wilson K,Ranatunga D,Bream JH
Sun Jun 01 00:00:00 UTC 2008
CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.
Journal of immune based therapies and vaccines
Sakthivel SK,Singh UP,Singh S,Taub DD,Novakovic KR,Lillard JW
Tue Oct 28 00:00:00 UTC 2008
Immunomodulatory effects of aqueous birch pollen extracts and phytoprostanes on primary immune responses in vivo.
The Journal of allergy and clinical immunology
Gutermuth J,Bewersdorff M,Traidl-Hoffmann C,Ring J,Mueller MJ,Behrendt H,Jakob T
Wed Aug 01 00:00:00 UTC 2007
IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Kreymborg K,Etzensperger R,Dumoutier L,Haak S,Rebollo A,Buch T,Heppner FL,Renauld JC,Becher B
Sat Dec 15 00:00:00 UTC 2007
Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Shimaoka T,Seino K,Kume N,Minami M,Nishime C,Suematsu M,Kita T,Taniguchi M,Matsushima K,Yonehara S
Sat Dec 15 00:00:00 UTC 2007
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature
Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ
Thu Aug 31 00:00:00 UTC 2006
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Blood
Mathur AN,Chang HC,Zisoulis DG,Kapur R,Belladonna ML,Kansas GS,Kaplan MH
Fri Sep 01 00:00:00 UTC 2006
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.
The Journal of experimental medicine
Usui T,Preiss JC,Kanno Y,Yao ZJ,Bream JH,O'Shea JJ,Strober W
Mon Mar 20 00:00:00 UTC 2006
Notch signaling is an important regulator of type 2 immunity.
The Journal of experimental medicine
Tu L,Fang TC,Artis D,Shestova O,Pross SE,Maillard I,Pear WS
Mon Oct 17 00:00:00 UTC 2005
Thymus-dependent memory phenotype CD8 T cells in naive B6.H-2Kb-/-Db-/- animals mediate an antigen-specific response against Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Su J,Berg RE,Murray S,Forman J
Tue Nov 15 00:00:00 UTC 2005
Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.
Journal of immunology (Baltimore, Md. : 1950)
Yu CR,Mahdi RM,Ebong S,Vistica BP,Chen J,Guo Y,Gery I,Egwuagu CE
Thu Jul 15 00:00:00 UTC 2004
Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen.
The Journal of experimental medicine
Berg RE,Crossley E,Murray S,Forman J
Mon Nov 17 00:00:00 UTC 2003
CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.
European journal of immunology
Nansen A,Marker O,Bartholdy C,Thomsen AR
210-12 was used in Cell Culture to correlate the expression of multiple chemokine and CC chemokine receptor (CCR) genes during the course of intracerebral (i.c.) infection with lymphocytic choriomeningitis virus (LCMV) and vesicular stomatitis virus (VSV), which are prototypic of a noncytopathic and a cytopathic virus, respectively.
Sat Jul 01 00:00:00 UTC 2000
