Product References
Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Nature
Hu C,Leche CA,Kiyatkin A,Yu Z,Stayrook SE,Ferguson KM,Lemmon MA
213-13 was used in Cell Culture to demonstrate how common extracellular glioblastoma multiforme (GBM) mutations prevent epidermal growth factor receptor (EGFR) from discriminating between its activating ligands.
Tue Feb 01 00:00:00 EST 2022
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
213-13 was used in Sample Preparation (FC/FACS) to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 EST 2022
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
The Journal of experimental medicine
Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T
Mon Jan 03 00:00:00 EST 2022
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
Blood advances
Xu JJ,Chalk AM,Nikolic I,Simpson KJ,Smeets MF,Walkley CR
Tue Apr 12 00:00:00 EDT 2022
The KRAS-G12D mutation induces metabolic vulnerability in B-cell acute lymphoblastic leukemia.
iScience
Xu Y,Fang H,Chen Y,Tang Y,Sun H,Kong Z,Yang F,Kirschner-Schwabe R,Zhu L,Toker A,Xiao N,Zhou BS,Li H
213-13 was used in Cell Culture to investigate RAS pathway mutations in acute lymphoblastic leukaemia.
Fri Mar 18 00:00:00 EDT 2022
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.
The Journal of biological chemistry
Koochaki SHJ,Słabicki M,Lumpkin R,Zou C,Belizaire R,Fischer ES,Ebert BL
213-13 was used in Cell Culture to identify the role and mechanisms of STUB1, an E3 ubiquitin ligase, and CHIC2 as regulators of CSF2RB ubiquitination and protein stability on IL-3, IL-5, and GM-CSF family of cytokine regulation.
Sat Oct 01 00:00:00 EDT 2022
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.
The Journal of biological chemistry
Koochaki SHJ,Słabicki M,Lumpkin R,Zou C,Belizaire R,Fischer ES,Ebert BL
213-13 was used in Cell Culture to identify the role and mechanisms of STUB1, an E3 ubiquitin ligase, and CHIC2 as regulators of CSF2RB ubiquitination and protein stability on IL-3, IL-5, and GM-CSF family of cytokine regulation.
Sat Oct 01 00:00:00 EDT 2022
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Cell
Lu SX,De Neef E,Thomas JD,Sabio E,Rousseau B,Gigoux M,Knorr DA,Greenbaum B,Elhanati Y,Hogg SJ,Chow A,Ghosh A,Xie A,Zamarin D,Cui D,Erickson C,Singer M,Cho H,Wang E,Lu B,Durham BH,Shah H,Chowell D,Gabel AM,Shen Y,Liu J,Jin J,Rhodes MC,Taylor RE,Molina H,Wolchok JD,Merghoub T,Diaz LA,Abdel-Wahab O,Bradley RK
213-13 was used in Cell Culture to investigate RNA splicing effects in antigen production in cancer.
Thu Jul 22 00:00:00 EDT 2021
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.
Cell
Zhang S,Edwards TN,Chaudhri VK,Wu J,Cohen JA,Hirai T,Rittenhouse N,Schmitz EG,Zhou PY,McNeil BD,Yang Y,Koerber HR,Sumpter TL,Poholek AC,Davis BM,Albers KM,Singh H,Kaplan DH
Thu Apr 15 00:00:00 EDT 2021
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
Immunity
Flommersfeld S,Böttcher JP,Ersching J,Flossdorf M,Meiser P,Pachmayr LO,Leube J,Hensel I,Jarosch S,Zhang Q,Chaudhry MZ,Andrae I,Schiemann M,Busch DH,Cicin-Sain L,Sun JC,Gasteiger G,Victora GD,Höfer T,Buchholz VR,Grassmann S
Tue Oct 12 00:00:00 EDT 2021
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Immunity
Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D
Tue Aug 10 00:00:00 EDT 2021
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Nature genetics
Yun H,Narayan N,Vohra S,Giotopoulos G,Mupo A,Madrigal P,Sasca D,Lara-Astiaso D,Horton SJ,Agrawal-Singh S,Meduri E,Basheer F,Marando L,Gozdecka M,Dovey OM,Castillo-Venzor A,Wang X,Gallipoli P,Müller-Tidow C,Osborne CS,Vassiliou GS,Huntly BJP
Fri Oct 01 00:00:00 EDT 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
213-13 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
Basophils balance healing after myocardial infarction via IL-4/IL-13.
The Journal of clinical investigation
Sicklinger F,Meyer IS,Li X,Radtke D,Dicks S,Kornadt MP,Mertens C,Meier JK,Lavine KJ,Zhang Y,Kuhn TC,Terzer T,Patel J,Boerries M,Schramm G,Frey N,Katus HA,Voehringer D,Leuschner F
Thu Jul 01 00:00:00 EDT 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
213-13 was used in Cell Culture to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 EDT 2021
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Molecular cell
Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI
213-13 was used in Cell Culture to conclude that METTL1-mediated tRNA modification drives oncogenic transformation through a remodeling of the mRNA translatome" to increase expression of growth-promoting proteins and represents a promising anti-cancer target."
Thu Aug 19 00:00:00 EDT 2021
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
The Journal of experimental medicine
Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S
Mon Oct 04 00:00:00 EDT 2021
ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
The Journal of experimental medicine
Nakajima T,Kanno T,Yokoyama S,Sasamoto S,Asou HK,Tumes DJ,Ohara O,Nakayama T,Endo Y
Mon Dec 06 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 EDT 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 EST 2021
Low-affinity but high-avidity interactions may offer an explanation for IgE-mediated allergen cross-reactivity.
Allergy
Chang X,Zha L,Wallimann A,Mohsen MO,Krenger P,Liu X,Vogel M,Bachmann MF
213-13 was used in In vitro experiments to suggest that the underlying mechanism of allergen cross-reactivity may be low-affinity but high-avidity binding between IgE antibodies and cross-reactive allergen.
Sun Aug 01 00:00:00 EDT 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 EDT 2021
Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine "matalafi".
Proceedings of the National Academy of Sciences of the United States of America
Molimau-Samasoni S,Woolner VH,Foliga ST,Robichon K,Patel V,Andreassend SK,Sheridan JP,Te Kawa T,Gresham D,Miller D,Sinclair DJ,La Flamme AC,Melnik AV,Aron A,Dorrestein PC,Atkinson PH,Keyzers RA,Munkacsi AB
Tue Nov 09 00:00:00 EST 2021
Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.
Journal of cachexia, sarcopenia and muscle
Widner DB,Liu C,Zhao Q,Sharp S,Eber MR,Park SH,Files DC,Shiozawa Y
Sun Aug 01 00:00:00 EDT 2021
Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia.
Journal of cachexia, sarcopenia and muscle
Widner DB,Liu C,Zhao Q,Sharp S,Eber MR,Park SH,Files DC,Shiozawa Y
Sun Aug 01 00:00:00 EDT 2021
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Blood advances
Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG
Tue Dec 14 00:00:00 EST 2021
IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.
Immunology
Drube S,Müller S,Weber F,Wegner P,Böttcher-Loschinski R,Gaestel M,Hutloff A,Kamradt T,Andreas N
Sat May 01 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
213-13 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Nov 10 00:00:00 EST 2021
Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Luo M,Lai W,He Z,Wu L
Wed Sep 15 00:00:00 EDT 2021
A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H
Mon Feb 01 00:00:00 EST 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
Mon Jan 11 00:00:00 EST 2021
Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway.
Cell death & disease
Baba T,Yoshida T,Tanabe Y,Nishimura T,Morishita S,Gotoh N,Hirao A,Hanayama R,Mukaida N
Fri Mar 26 00:00:00 EDT 2021
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs.
NPJ aging and mechanisms of disease
Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I
Tue Sep 21 00:00:00 EDT 2021
Engineering of a bona fide light-operated calcium channel.
Nature communications
He L,Wang L,Zeng H,Tan P,Ma G,Zheng S,Li Y,Sun L,Dou F,Siwko S,Huang Y,Wang Y,Zhou Y
Mon Jan 11 00:00:00 EST 2021
Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells.
STAR protocols
Qu J,Yang Z
213-13 was used in Cell Culture to demonstrate a modified protocol to overcome challenges associated with achieving high transduction efficiency in bone marrow cells in transplantation which enables reproducible and high-efficient retroviral transduction of hematopoietic stem and progenitor cells (HSPCs) for bone marrow transplantation (BMT).
Fri Jun 18 00:00:00 EDT 2021
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis.
iScience
Chatterjee S,Yabaji SM,Rukhlenko OS,Bhattacharya B,Waligurski E,Vallavoju N,Ray S,Kholodenko BN,Brown LE,Beeler AB,Ivanov AR,Kobzik L,Porco JA,Kramnik I
Fri Aug 20 00:00:00 EDT 2021
Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.
Cell reports
Dignum T,Varnum-Finney B,Srivatsan SR,Dozono S,Waltner O,Heck AM,Ishida T,Nourigat-McKay C,Jackson DL,Rafii S,Trapnell C,Bernstein ID,Hadland B
Tue Sep 14 00:00:00 EDT 2021
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Journal of experimental & clinical cancer research : CR
Wang F,Li Z,Zhou J,Wang G,Zhang W,Xu J,Liang A
213-13 was used in Cell Culture to investigate SIRT1 expression and function in T-cell acute lymphoblastic leukemia.
Wed Aug 18 00:00:00 EDT 2021
MEK inhibition exerts temporal and myeloid cell-specific effects in the pathogenesis of neurofibromatosis type 1 arteriopathy.
Scientific reports
Tritz R,Hudson FZ,Harris V,Ghoshal P,Singla B,Lin H,Csanyi G,Stansfield BK
Tue Dec 21 00:00:00 EST 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector.
Molecular therapy. Methods & clinical development
Dahl M,Smith EMK,Warsi S,Rothe M,Ferraz MJ,Aerts JMFG,Golipour A,Harper C,Pfeifer R,Pizzurro D,Schambach A,Mason C,Karlsson S
Fri Mar 12 00:00:00 EST 2021
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Nature communications
Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D
Thu Jun 17 00:00:00 EDT 2021
Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.
STAR protocols
Liang G,Huang B,Wang F,Liu F
213-13 was used in Flow cytometry/Cell sorting to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.
Fri Dec 17 00:00:00 EST 2021
Syngeneic leukemia models using lentiviral transgenics.
Cell death & disease
Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R
Thu Feb 18 00:00:00 EST 2021
Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.
iScience
Nguyen GT,Xu S,Adams W,Leong JM,Bunnell SC,Mansour MK,Sykes DB,Mecsas J
Fri Aug 20 00:00:00 EDT 2021
A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival.
Cell death & disease
Massett ME,Monaghan L,Patterson S,Mannion N,Bunschoten RP,Hoose A,Marmiroli S,Liskamp RMJ,Jørgensen HG,Vetrie D,Michie AM,Huang X
Thu Jun 03 00:00:00 EDT 2021
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.
Cell death & disease
Hu Q,Zhang Y,Lou H,Ou Z,Liu J,Duan W,Wang H,Ge Y,Min J,Wang F,Ju Z
Thu Jul 15 00:00:00 EDT 2021
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Nature communications
Khateb A,Deshpande A,Feng Y,Finlay D,Lee JS,Lazar I,Fabre B,Li Y,Fujita Y,Zhang T,Yin J,Pass I,Livneh I,Jeremias I,Burian C,Mason JR,Almog R,Horesh N,Ofran Y,Brown K,Vuori K,Jackson M,Ruppin E,Deshpande AJ,Ronai ZA
Mon Sep 13 00:00:00 EDT 2021
High-resolution characterization of gene function using single-cell CRISPR tiling screen.
Nature communications
Yang L,Chan AKN,Miyashita K,Delaney CD,Wang X,Li H,Pokharel SP,Li S,Li M,Xu X,Lu W,Liu Q,Mattson N,Chen KY,Wang J,Yuan YC,Horne D,Rosen ST,Soto-Feliciano Y,Feng Z,Hoshii T,Xiao G,Müschen M,Chen J,Armstrong SA,Chen CW
Thu Jul 01 00:00:00 EDT 2021
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Scientific reports
Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS
Fri Mar 05 00:00:00 EST 2021
TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.
iScience
Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C
213-13 was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.
Fri Dec 17 00:00:00 EST 2021
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
213-13 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
Tue Jul 13 00:00:00 EDT 2021
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System.
Stem cell reports
Jackson M,Fidanza A,Taylor AH,Rybtsov S,Axton R,Kydonaki M,Meek S,Burdon T,Medvinsky A,Forrester LM
Tue Apr 13 00:00:00 EDT 2021
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Nature communications
Supper E,Rudat S,Iyer V,Droop A,Wong K,Spinella JF,Thomas P,Sauvageau G,Adams DJ,Wong CC
Fri Apr 30 00:00:00 EDT 2021
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Mon May 11 00:00:00 EDT 2020
Vitamin B6 Addiction in Acute Myeloid Leukemia.
Cancer cell
Chen CC,Li B,Millman SE,Chen C,Li X,Morris JP,Mayle A,Ho YJ,Loizou E,Liu H,Qin W,Shah H,Violante S,Cross JR,Lowe SW,Zhang L
Mon Jan 13 00:00:00 EST 2020
SIRT1 is downregulated by autophagy in senescence and ageing.
Nature cell biology
Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL
213-13 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.
Thu Oct 01 00:00:00 EDT 2020
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Blood
Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG
Thu Oct 08 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
213-13 was used in In vitro experiments to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.
Cell stem cell
Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD
213-13 was used in In vitro experiments to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.
Thu Mar 05 00:00:00 EST 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 EST 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
Mon Mar 02 00:00:00 EST 2020
Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses.
The Journal of clinical investigation
Okunishi K,Wang H,Suzukawa M,Ishizaki R,Kobayashi E,Kihara M,Abe T,Miyazaki JI,Horie M,Saito A,Saito H,Nakae S,Izumi T
Wed Jul 01 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 EST 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.
The Journal of experimental medicine
Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z
Mon Feb 03 00:00:00 EST 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
Wed Feb 05 00:00:00 EST 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
Wed Feb 05 00:00:00 EST 2020
Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Duan C,Fukuda T,Isaji T,Qi F,Yang J,Wang Y,Takahashi S,Gu J
Sat Feb 01 00:00:00 EST 2020
Differentiation of c-Kit+ CD24+ natural killer cells into myeloid cells in a GATA-2-dependent manner.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Song B,Lee JM,Park YJ,Kim IK,Kim BS,Shin KS,Jeon I,Koh CH,Bae EA,Seo H,Byun Y,Kang CY
Sun Mar 01 00:00:00 EST 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 EST 2020
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.
Journal of immunology (Baltimore, Md. : 1950)
Yoshida K,Ito MA,Sato N,Obayashi K,Yamamoto K,Koizumi S,Tanaka S,Furuta K,Matsuoka I
Mon Jun 15 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
MALT1 Protease Plays a Dual Role in the Allergic Response by Acting in Both Mast Cells and Endothelial Cells.
Journal of immunology (Baltimore, Md. : 1950)
Alfano DN,Klei LR,Klei HB,Trotta M,Gough PJ,Foley KP,Bertin J,Sumpter TL,Lucas PC,McAllister-Lucas LM
Fri May 01 00:00:00 EDT 2020
Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.
Scientific reports
Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R
Tue Feb 04 00:00:00 EST 2020
GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.
Nature communications
Regan-Komito D,Swann JW,Demetriou P,Cohen ES,Horwood NJ,Sansom SN,Griseri T
Thu Jan 09 00:00:00 EST 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
213-13 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 EDT 2020
Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance.
Nature communications
Yabut JM,Desjardins EM,Chan EJ,Day EA,Leroux JM,Wang B,Crane ED,Wong W,Morrison KM,Crane JD,Khan WI,Steinberg GR
Thu Jan 23 00:00:00 EST 2020
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.
Nature communications
Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B
Mon Mar 16 00:00:00 EDT 2020
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nature communications
Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG
Fri Jul 03 00:00:00 EDT 2020
Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter.
Cell reports
Eastman AE,Chen X,Hu X,Hartman AA,Pearlman Morales AM,Yang C,Lu J,Kueh HY,Guo S
213-13 was used in Cell Culture to describe a genetically encoded fluorescent reporter that captures live-cell cycle speed using a single measurement.
Tue Jun 23 00:00:00 EDT 2020
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
Communications biology
AhYoung AP,Eckard SC,Gogineni A,Xi H,Lin SJ,Gerhardy S,Cox C,Phung QT,Hackney JA,Katakam AK,Reichelt M,Caplazi P,Manzanillo P,Zhang J,Roose-Girma M,Tam LW,Newman RJ,Murthy A,Weimer RM,Lill JR,Lee WP,Grimbaldeston M,Kirchhofer D,van Lookeren Campagne M
Thu Nov 19 00:00:00 EST 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
Wed Jan 29 00:00:00 EST 2020
The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness.
Scientific reports
Mus LM,Lambertz I,Claeys S,Kumps C,Van Loocke W,Van Neste C,Umapathy G,Vaapil M,Bartenhagen C,Laureys G,De Wever O,Bexell D,Fischer M,Hallberg B,Schulte J,De Wilde B,Durinck K,Denecker G,De Preter K,Speleman F
Tue Jan 14 00:00:00 EST 2020
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.
Cell reports
Niederkorn M,Hueneman K,Choi K,Varney ME,Romano L,Pujato MA,Greis KD,Inoue JI,Meetei R,Starczynowski DT
213-13 was used in Cell Culture to study how forkhead-associated domain B (TIFAB) regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity using a combination of proteomic and genetic approaches to uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant hematopoietic stem/progenitor cells (HSPCs).
Tue Feb 25 00:00:00 EST 2020
Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells.
Frontiers in immunology
Kornstädt L,Pierre S,Weigert A,Ebersberger S,Schäufele TJ,Kolbinger A,Schmid T,Cohnen J,Thomas D,Ferreirós N,Brüne B,Ebersberger I,Scholich K
213-13 was used in Cell Culture to better understand the role of mast cells during the resolution phase of a local inflammation induced with the Toll-like receptor (TLR)-2 agonist zymosan.
Mon Jun 21 00:00:00 EDT 2021
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Science advances
Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS
213-13 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.
Sun Nov 01 00:00:00 EDT 2020
Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.
Nature communications
Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I
Tue Aug 18 00:00:00 EDT 2020
Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response.
The Journal of biological chemistry
Garg B,Mehta HM,Wang B,Kamel R,Horwitz MS,Corey SJ
Fri May 22 00:00:00 EDT 2020
Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.
Nature communications
Barbier V,Erbani J,Fiveash C,Davies JM,Tay J,Tallack MR,Lowe J,Magnani JL,Pattabiraman DR,Perkins AC,Lisle J,Rasko JEJ,Levesque JP,Winkler IG
Mon Apr 27 00:00:00 EDT 2020
A Requirement for Argonaute 4 in Mammalian Antiviral Defense.
Cell reports
Adiliaghdam F,Basavappa M,Saunders TL,Harjanto D,Prior JT,Cronkite DA,Papavasiliou N,Jeffrey KL
213-13 was used in Cell Culture to study the antiviral activity of Argonautes AGO1, AGO3 or AGO4 in interferon (IFN)-competent immune cells to demonstrate an essential role for AGO4 in mammalian antiviral defense.
Tue Feb 11 00:00:00 EST 2020
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.
Cell
Sanghvi VR,Leibold J,Mina M,Mohan P,Berishaj M,Li Z,Miele MM,Lailler N,Zhao C,de Stanchina E,Viale A,Akkari L,Lowe SW,Ciriello G,Hendrickson RC,Wendel HG
Thu Aug 08 00:00:00 EDT 2019
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Immunity
Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V
Tue Jul 16 00:00:00 EDT 2019
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.
Immunity
Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E
Tue Jun 18 00:00:00 EDT 2019
MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.
Immunity
Berrien-Elliott MM,Sun Y,Neal C,Ireland A,Trissal MC,Sullivan RP,Wagner JA,Leong JW,Wong P,Mah-Som AY,Wong TN,Schappe T,Keppel CR,Cortez VS,Stamatiades EG,Li MO,Colonna M,Link DC,French AR,Cooper MA,Wang WL,Boldin MP,Reddy P,Fehniger TA
Tue Sep 17 00:00:00 EDT 2019
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.
Immunity
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR
Tue Jun 18 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
Mon Apr 15 00:00:00 EDT 2019
Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.
Blood
Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS
Thu May 30 00:00:00 EDT 2019
A role for macrophages in hematopoiesis in the embryonic head.
Blood
Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E
Thu Nov 28 00:00:00 EST 2019
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.
Blood
Abdul-Aziz AM,Sun Y,Hellmich C,Marlein CR,Mistry J,Forde E,Piddock RE,Shafat MS,Morfakis A,Mehta T,Di Palma F,Macaulay I,Ingham CJ,Haestier A,Collins A,Campisi J,Bowles KM,Rushworth SA
Thu Jan 31 00:00:00 EST 2019
Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases.
Blood
Ramasz B,Krüger A,Reinhardt J,Sinha A,Gerlach M,Gerbaulet A,Reinhardt S,Dahl A,Chavakis T,Wielockx B,Grinenko T
Thu Sep 26 00:00:00 EDT 2019
Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.
Blood
Sasca D,Yun H,Giotopoulos G,Szybinski J,Evan T,Wilson NK,Gerstung M,Gallipoli P,Green AR,Hills R,Russell N,Osborne CS,Papaemmanuil E,Göttgens B,Campbell P,Huntly BJP
Thu Dec 12 00:00:00 EST 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity.
Blood
Weijenborg Campos L,Pini Zenatti P,Granato Pissinato L,Libanio Rodrigues GO,Artico LL,Rafael Guimarães T,Fröhlich Archangelo L,Martínez L,Brooks AJ,Yunes JA
Thu Mar 14 00:00:00 EDT 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
213-13 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
213-13 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.
Mon Feb 04 00:00:00 EST 2019
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
The Journal of experimental medicine
Weckbach LT,Grabmaier U,Uhl A,Gess S,Boehm F,Zehrer A,Pick R,Salvermoser M,Czermak T,Pircher J,Sorrelle N,Migliorini M,Strickland DK,Klingel K,Brinkmann V,Abu Abed U,Eriksson U,Massberg S,Brunner S,Walzog B
213-13 was used in Cell Culture to report the presence of neutrophil extracellular traps in cardiac tissue of patients and mice with myocarditis.
Mon Feb 04 00:00:00 EST 2019
CD97 is a critical regulator of acute myeloid leukemia stem cell function.
The Journal of experimental medicine
Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY
Mon Oct 07 00:00:00 EDT 2019
CD97 is a critical regulator of acute myeloid leukemia stem cell function.
The Journal of experimental medicine
Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY
Mon Oct 07 00:00:00 EDT 2019
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
The Journal of experimental medicine
Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK
Mon Feb 04 00:00:00 EST 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 EDT 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 EDT 2019
TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.
The Journal of experimental medicine
Albright AR,Kabat J,Li M,Raso F,Reboldi A,Muppidi JR
Mon Nov 04 00:00:00 EST 2019
Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.
The Journal of allergy and clinical immunology
Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R
213-13 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.
Tue Oct 01 00:00:00 EDT 2019
Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.
Developmental cell
Li H,Natarajan A,Ezike J,Barrasa MI,Le Y,Feder ZA,Yang H,Ma C,Markoulaki S,Lodish HF
213-13 was used in In vitro experiments to demonstrate a continuum of transcriptomic states in committed transit-amplifying erythropoietic progenitors, which correlates with a continuum of proliferative potentials in these cells.
Mon Apr 08 00:00:00 EDT 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
213-13 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 EDT 2019
Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.
EMBO reports
Schuler F,Afreen S,Manzl C,Häcker G,Erlacher M,Villunger A
Thu Aug 01 00:00:00 EDT 2019
Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.
Stem cells translational medicine
Kwon YW,Lee SJ,Heo SC,Lee TW,Park GT,Yoon JW,Kim SC,Shin HJ,Lee SC,Kim JH
Fri Mar 01 00:00:00 EST 2019
Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.
Cancer science
Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W
Mon Jul 01 00:00:00 EDT 2019
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.
Immunology and cell biology
McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC
Tue Jan 01 00:00:00 EST 2019
Chromosome Transplantation: Correction of the Chronic Granulomatous Disease Defect in Mouse Induced Pluripotent Stem Cells.
Stem cells (Dayton, Ohio)
Castelli A,Susani L,Menale C,Muggeo S,Caldana E,Strina D,Cassani B,Recordati C,Scanziani E,Ficara F,Villa A,Vezzoni P,Paulis M
Mon Jul 01 00:00:00 EDT 2019
Mast cell tetrahydrobiopterin contributes to itch in mice.
Journal of cellular and molecular medicine
Zschiebsch K,Fischer C,Wilken-Schmitz A,Geisslinger G,Channon K,Watschinger K,Tegeder I
Fri Feb 01 00:00:00 EST 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports
Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D
213-13 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.
Tue Jan 22 00:00:00 EST 2019
Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.
Frontiers in immunology
Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC
213-13 was used in In vitro experiments to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.
Tue Nov 17 00:00:00 EST 2020
Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection.
FEBS open bio
Lipok M,Szlachcic A,Kindela K,Czyrek A,Otlewski J
Wed May 01 00:00:00 EDT 2019
In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.
Cell death and differentiation
Dong L,Reljic B,Cheung JG,Ng ES,Lindqvist LM,Elefanty AG,Vaux DL,Tran H
213-13 was used in Cell Culture to show that Bax-/-Bak1-/- myeloid cells deprived of growth factor consume extracellular glucose to maintain long-term viability, without a requirement for Atg5-dependent autophagy.
Tue Oct 01 00:00:00 EDT 2019
Structural and functional consequences of the STAT5BN642H driver mutation.
Nature communications
de Araujo ED,Erdogan F,Neubauer HA,Meneksedag-Erol D,Manaswiyoungkul P,Eram MS,Seo HS,Qadree AK,Israelian J,Orlova A,Suske T,Pham HTT,Boersma A,Tangermann S,Kenner L,Rülicke T,Dong A,Ravichandran M,Brown PJ,Audette GF,Rauscher S,Dhe-Paganon S,Moriggl R,Gunning PT
Fri Jun 07 00:00:00 EDT 2019
Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells.
Scientific reports
Nishi K,Kanayama Y,Kim IH,Nakata A,Nishiwaki H,Sugahara T
Thu Nov 07 00:00:00 EST 2019
CXCR2 expression on granulocyte and macrophage progenitors under tumor conditions contributes to mo-MDSC generation via SAP18/ERK/STAT3.
Cell death & disease
Han X,Shi H,Sun Y,Shang C,Luan T,Wang D,Ba X,Zeng X
Thu Aug 08 00:00:00 EDT 2019
Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production.
Cell death discovery
Paivandy A,Eriksson J,Melo FR,Sellin ME,Pejler G
Thu Oct 01 00:00:00 EDT 2020
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 EST 2019
Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.
Scientific reports
Zhang Y,Hu N,Dong F
Thu Jan 24 00:00:00 EST 2019
Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.
Scientific reports
Dhakal H,Yang EJ,Lee S,Kim MJ,Baek MC,Lee B,Park PH,Kwon TK,Khang D,Song KS,Kim SH
Fri May 03 00:00:00 EDT 2019
Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin inflammatory diseases in NC/Nga mice.
Scientific reports
Lee MH,Lee YS,Kim HJ,Han CH,Kang SU,Kim CH
Wed Sep 18 00:00:00 EDT 2019
Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.
Scientific reports
Nakajima S,Ishimaru K,Kobayashi A,Yu G,Nakamura Y,Oh-Oka K,Suzuki-Inoue K,Kono K,Nakao A
Thu Dec 05 00:00:00 EST 2019
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
Nature communications
Jin N,Bi A,Lan X,Xu J,Wang X,Liu Y,Wang T,Tang S,Zeng H,Chen Z,Tan M,Ai J,Xie H,Zhang T,Liu D,Huang R,Song Y,Leung EL,Yao X,Ding J,Geng M,Lin SH,Huang M
Thu Jun 20 00:00:00 EDT 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 EST 2019
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells.
Scientific reports
Nakamura Y,Sasaki T,Mochizuki C,Ishimaru K,Koizumi S,Shinmori H,Suzuki-Inoue K,Nakao A
Mon Nov 04 00:00:00 EST 2019
Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation.
Nature communications
Wang N,Zheng J,Chen Z,Liu Y,Dura B,Kwak M,Xavier-Ferrucio J,Lu YC,Zhang M,Roden C,Cheng J,Krause DS,Ding Y,Fan R,Lu J
Wed Jan 09 00:00:00 EST 2019
Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.
Scientific reports
Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML
Wed Mar 20 00:00:00 EDT 2019
IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival.
Scientific reports
Wang Y,Richter L,Becker M,Amador C,Hyde RK
Mon Feb 11 00:00:00 EST 2019
Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.
Stem cell research & therapy
I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I
213-13 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.
Thu Oct 17 00:00:00 EDT 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
Thu Mar 01 00:00:00 EST 2018
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.
Nature
Shen Q,Zhang Q,Shi Y,Shi Q,Jiang Y,Gu Y,Li Z,Li X,Zhao K,Wang C,Li N,Cao X
Thu Feb 01 00:00:00 EST 2018
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.
Nature
Carrelha J,Meng Y,Kettyle LM,Luis TC,Norfo R,Alcolea V,Boukarabila H,Grasso F,Gambardella A,Grover A,Högstrand K,Lord AM,Sanjuan-Pla A,Woll PS,Nerlov C,Jacobsen SEW
Thu Feb 01 00:00:00 EST 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 EST 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
213-13 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 EDT 2018
Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting.
Cell
Cohen M,Giladi A,Gorki AD,Solodkin DG,Zada M,Hladik A,Miklosi A,Salame TM,Halpern KB,David E,Itzkovitz S,Harkany T,Knapp S,Amit I
Thu Nov 01 00:00:00 EDT 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
213-13 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.
Thu Sep 20 00:00:00 EDT 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 EDT 2018
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.
Immunity
Postat J,Olekhnovitch R,Lemaître F,Bousso P
Tue Oct 16 00:00:00 EDT 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
213-13 was used in Sample Preparation (FC/FACS) to investigate CD45, Ter119, and CD31 in hematopoietic cells.
Tue Oct 16 00:00:00 EDT 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 EDT 2018
Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors.
Immunity
Li Z,Liu S,Xu J,Zhang X,Han D,Liu J,Xia M,Yi L,Shen Q,Xu S,Lu L,Cao X
Tue Oct 16 00:00:00 EDT 2018
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Cancer cell
Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C
Mon Mar 12 00:00:00 EDT 2018
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy.
Cancer cell
Medler TR,Murugan D,Horton W,Kumar S,Cotechini T,Forsyth AM,Leyshock P,Leitenberger JJ,Kulesz-Martin M,Margolin AA,Werb Z,Coussens LM
Mon Oct 08 00:00:00 EDT 2018
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
Cancer cell
Yamauchi T,Masuda T,Canver MC,Seiler M,Semba Y,Shboul M,Al-Raqad M,Maeda M,Schoonenberg VAC,Cole MA,Macias-Trevino C,Ishikawa Y,Yao Q,Nakano M,Arai F,Orkin SH,Reversade B,Buonamici S,Pinello L,Akashi K,Bauer DE,Maeda T
Mon Mar 12 00:00:00 EDT 2018
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Cancer cell
Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH
Mon Jan 08 00:00:00 EST 2018
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J
Mon Aug 13 00:00:00 EDT 2018
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Cancer cell
Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ
Mon Feb 12 00:00:00 EST 2018
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Cancer cell
Kleppe M,Koche R,Zou L,van Galen P,Hill CE,Dong L,De Groote S,Papalexi E,Hanasoge Somasundara AV,Cordner K,Keller M,Farnoud N,Medina J,McGovern E,Reyes J,Roberts J,Witkin M,Rapaport F,Teruya-Feldstein J,Qi J,Rampal R,Bernstein BE,Bradner JE,Levine RL
Mon Jan 08 00:00:00 EST 2018
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Blood
Gallipoli P,Giotopoulos G,Tzelepis K,Costa ASH,Vohra S,Medina-Perez P,Basheer F,Marando L,Di Lisio L,Dias JML,Yun H,Sasca D,Horton SJ,Vassiliou G,Frezza C,Huntly BJP
Thu Apr 12 00:00:00 EDT 2018
A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.
Blood
Dahlin JS,Hamey FK,Pijuan-Sala B,Shepherd M,Lau WWY,Nestorowa S,Weinreb C,Wolock S,Hannah R,Diamanti E,Kent DG,Göttgens B,Wilson NK
Thu May 24 00:00:00 EDT 2018
Extracellular vesicle-mediated transfer of constitutively active MyD88L265P engages MyD88wt and activates signaling.
Blood
Manček-Keber M,Lainšček D,Benčina M,Chen JG,Romih R,Hunter ZR,Treon SP,Jerala R
Thu Apr 12 00:00:00 EDT 2018
Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Blood
Shima H,Takamatsu-Ichihara E,Shino M,Yamagata K,Katsumoto T,Aikawa Y,Fujita S,Koseki H,Kitabayashi I
Thu Apr 19 00:00:00 EDT 2018
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
Blood
El Ashkar S,Schwaller J,Pieters T,Goossens S,Demeulemeester J,Christ F,Van Belle S,Juge S,Boeckx N,Engelman A,Van Vlierberghe P,Debyser Z,De Rijck J
Thu Jan 04 00:00:00 EST 2018
IGF-1 facilitates thrombopoiesis primarily through Akt activation.
Blood
Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J
Thu Jul 12 00:00:00 EDT 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
Tue Jan 02 00:00:00 EST 2018
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
The Journal of clinical investigation
Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J
Tue May 01 00:00:00 EDT 2018
Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
The Journal of clinical investigation
Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC
Mon Dec 03 00:00:00 EST 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
Fri Jun 01 00:00:00 EDT 2018
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.
The Journal of experimental medicine
Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F
Mon May 07 00:00:00 EDT 2018
Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
The Journal of experimental medicine
Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA
Mon Feb 05 00:00:00 EST 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 EDT 2018
Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.
Leukemia
Mingay M,Chaturvedi A,Bilenky M,Cao Q,Jackson L,Hui T,Moksa M,Heravi-Moussavi A,Humphries RK,Heuser M,Hirst M
Mon Jan 01 00:00:00 EST 2018
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Proceedings of the National Academy of Sciences of the United States of America
Das P,Veazey KJ,Van HT,Kaushik S,Lin K,Lu Y,Ishii M,Kikuta J,Ge K,Nussenzweig A,Santos MA
Tue Oct 23 00:00:00 EDT 2018
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America
Sharma S,Čermáková K,De Rijck J,Demeulemeester J,Fábry M,El Ashkar S,Van Belle S,Lepšík M,Tesina P,Duchoslav V,Novák P,Hubálek M,Srb P,Christ F,Řezáčová P,Hodges HC,Debyser Z,Veverka V
Tue Jul 24 00:00:00 EDT 2018
A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Zehrer A,Pick R,Salvermoser M,Boda A,Miller M,Stark K,Weckbach LT,Walzog B,Begandt D
Sat Sep 15 00:00:00 EDT 2018
Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.
Journal of immunology (Baltimore, Md. : 1950)
Lim TJF,Su IH
Sat Dec 15 00:00:00 EST 2018
Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.
Journal of immunology (Baltimore, Md. : 1950)
Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA
Thu Feb 01 00:00:00 EST 2018
Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Ocana JA,Romer E,Sahu R,Pawelzik SC,FitzGerald GA,Kaplan MH,Travers JB
Fri Jun 15 00:00:00 EDT 2018
Epithelial IL-15 Is a Critical Regulator of γδ Intraepithelial Lymphocyte Motility within the Intestinal Mucosa.
Journal of immunology (Baltimore, Md. : 1950)
Hu MD,Ethridge AD,Lipstein R,Kumar S,Wang Y,Jabri B,Turner JR,Edelblum KL
Sun Jul 15 00:00:00 EDT 2018
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Nature communications
Massara M,Bonavita O,Savino B,Caronni N,Mollica Poeta V,Sironi M,Setten E,Recordati C,Crisafulli L,Ficara F,Mantovani A,Locati M,Bonecchi R
Wed Feb 14 00:00:00 EST 2018
Ecrg4 peptide is the ligand of multiple scavenger receptors.
Scientific reports
Moriguchi T,Takeda S,Iwashita S,Enomoto K,Sawamura T,Koshimizu U,Kondo T
Tue Mar 06 00:00:00 EST 2018
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.
Scientific reports
Philp AR,Riquelme TT,Millar-Büchner P,González R,Sepúlveda FV,Cid LP,Flores CA
Mon Jun 18 00:00:00 EDT 2018
GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.
Scientific reports
Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S
Tue Apr 03 00:00:00 EDT 2018
MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.
Cell death & disease
Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G
Thu Jul 26 00:00:00 EDT 2018
Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells.
The Journal of biological chemistry
Gutierrez BA,Chavez MA,Rodarte AI,Ramos MA,Dominguez A,Petrova Y,Davalos AJ,Costa RM,Elizondo R,Tuvim MJ,Dickey BF,Burns AR,Heidelberger R,Adachi R
Fri May 11 00:00:00 EDT 2018
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
Tue May 15 00:00:00 EDT 2018
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
Stem cell reports
Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T
Tue Sep 11 00:00:00 EDT 2018
In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.
Stem cell reports
Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E
Tue Jan 09 00:00:00 EST 2018
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.
Nature communications
Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R
Wed Aug 29 00:00:00 EDT 2018
A malaria protein factor induces IL-4 production by dendritic cells via PI3K-Akt-NF-κB signaling independent of MyD88/TRIF and promotes Th2 response.
The Journal of biological chemistry
Wu X,Gowda NM,Kawasawa YI,Gowda DC
Fri Jul 06 00:00:00 EDT 2018
Honokiol is a FOXM1 antagonist.
Cell death & disease
Halasi M,Hitchinson B,Shah BN,Váraljai R,Khan I,Benevolenskaya EV,Gaponenko V,Arbiser JL,Gartel AL
Wed Jan 24 00:00:00 EST 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
213-13 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
213-13 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 EST 2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Nature communications
Su H,Hu J,Huang L,Yang Y,Thenoz M,Kuchmiy A,Hu Y,Li P,Feng H,Zhou Y,Taghon T,Van Vlierberghe P,Qing G,Chen Z,Liu H
Mon Oct 15 00:00:00 EDT 2018
The effect of PU.1 knockdown on gene expression and function of mast cells.
Scientific reports
Oda Y,Kasakura K,Fujigaki I,Kageyama A,Okumura K,Ogawa H,Yashiro T,Nishiyama C
Wed Jan 31 00:00:00 EST 2018
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
Nature communications
Ganuza M,Chabot A,Tang X,Bi W,Natarajan S,Carter R,Gawad C,Kang G,Cheng Y,McKinney-Freeman S
Thu Dec 20 00:00:00 EST 2018
Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.
Nature communications
Xu Y,Sun Y,Shen H,Dai Y,Liu H,Li R,Zhang H,Wu L,Zhu X,Liu X
Mon Sep 24 00:00:00 EDT 2018
Effects of the Th2-dominant milieu on allergic responses in Der f 1-activated mouse basophils and mast cells.
Scientific reports
Yi MH,Kim HP,Jeong KY,Kim JY,Lee IY,Yong TS
Wed May 16 00:00:00 EDT 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 EST 2018
IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.
Cell death & disease
Reinhart R,Kaufmann T
Mon Jun 18 00:00:00 EDT 2018
IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils.
Cell death & disease
Zellweger F,Buschor P,Hobi G,Brigger D,Dahinden CA,Villiger PM,Eggel A
Tue May 01 00:00:00 EDT 2018
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage.
The Journal of biological chemistry
Treutlein EM,Kern K,Weigert A,Tarighi N,Schuh CD,Nüsing RM,Schreiber Y,Ferreirós N,Brüne B,Geisslinger G,Pierre S,Scholich K
Fri Jun 22 00:00:00 EDT 2018
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.
Nature communications
Numata A,Kwok HS,Kawasaki A,Li J,Zhou QL,Kerry J,Benoukraf T,Bararia D,Li F,Ballabio E,Tapia M,Deshpande AJ,Welner RS,Delwel R,Yang H,Milne TA,Taneja R,Tenen DG
Tue Apr 24 00:00:00 EDT 2018
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
Tue Sep 11 00:00:00 EDT 2018
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Nature communications
Hyrenius-Wittsten A,Pilheden M,Sturesson H,Hansson J,Walsh MP,Song G,Kazi JU,Liu J,Ramakrishan R,Garcia-Ruiz C,Nance S,Gupta P,Zhang J,Rönnstrand L,Hultquist A,Downing JR,Lindkvist-Petersson K,Paulsson K,Järås M,Gruber TA,Ma J,Hagström-Andersson AK
Wed May 02 00:00:00 EDT 2018
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.
Cell death & disease
Schubert F,Rapp J,Brauns-Schubert P,Schlicher L,Stock K,Wissler M,Weiß M,Charvet C,Borner C,Maurer U
Tue May 01 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Tue Dec 11 00:00:00 EST 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nature communications
Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS
Wed Dec 19 00:00:00 EST 2018
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Nature
Barbieri I,Tzelepis K,Pandolfini L,Shi J,Millán-Zambrano G,Robson SC,Aspris D,Migliori V,Bannister AJ,Han N,De Braekeleer E,Ponstingl H,Hendrick A,Vakoc CR,Vassiliou GS,Kouzarides T
Thu Dec 07 00:00:00 EST 2017
Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.
Cell
Wang T,Yu H,Hughes NW,Liu B,Kendirli A,Klein K,Chen WW,Lander ES,Sabatini DM
Thu Feb 23 00:00:00 EST 2017
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
Burgess MR,Hwang E,Mroue R,Bielski CM,Wandler AM,Huang BJ,Firestone AJ,Young A,Lacap JA,Crocker L,Asthana S,Davis EM,Xu J,Akagi K,Le Beau MM,Li Q,Haley B,Stokoe D,Sampath D,Taylor BS,Evangelista M,Shannon K
Thu Feb 23 00:00:00 EST 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
213-13 was used in In vitro experiments to determine the role of TET2 deficiency in leukaemia stem cell maintenance.
Thu Sep 07 00:00:00 EDT 2017
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
213-13 was used in Cell Culture to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 EST 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
213-13 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 EST 2017
Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Immunity
Riffelmacher T,Clarke A,Richter FC,Stranks A,Pandey S,Danielli S,Hublitz P,Yu Z,Johnson E,Schwerd T,McCullagh J,Uhlig H,Jacobsen SEW,Simon AK
Tue Sep 19 00:00:00 EDT 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 EDT 2017
Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.
Cancer cell
Gu Y,Zhang J,Ma X,Kim BW,Wang H,Li J,Pan Y,Xu Y,Ding L,Yang L,Guo C,Wu X,Wu J,Wu K,Gan X,Li G,Li L,Forman SJ,Chan WC,Xu R,Huang W
Mon Jul 10 00:00:00 EDT 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
Mon Apr 10 00:00:00 EDT 2017
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood
Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T
Thu Mar 23 00:00:00 EDT 2017
Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin.
Blood
Seo A,Ben-Harosh M,Sirin M,Stein J,Dgany O,Kaplelushnik J,Hoenig M,Pannicke U,Lorenz M,Schwarz K,Stockklausner C,Walsh T,Gulsuner S,Lee MK,Sendamarai A,Sanchez-Bonilla M,King MC,Cario H,Kulozik AE,Debatin KM,Schulz A,Tamary H,Shimamura A
Thu Aug 17 00:00:00 EDT 2017
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.
Blood
Man N,Tan Y,Sun XJ,Liu F,Cheng G,Greenblatt SM,Martinez C,Karl DL,Ando K,Sun M,Hou D,Chen B,Xu M,Yang FC,Chen Z,Chen S,Nimer SD,Wang L
Thu May 18 00:00:00 EDT 2017
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Blood
Dovey OM,Cooper JL,Mupo A,Grove CS,Lynn C,Conte N,Andrews RM,Pacharne S,Tzelepis K,Vijayabaskar MS,Green P,Rad R,Arends M,Wright P,Yusa K,Bradley A,Varela I,Vassiliou GS
Thu Oct 26 00:00:00 EDT 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
Mon Dec 04 00:00:00 EST 2017
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
The Journal of experimental medicine
Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T
Mon Sep 04 00:00:00 EDT 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
Mon Dec 04 00:00:00 EST 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
213-13 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 EDT 2017
Preclinical modeling of myelodysplastic syndromes.
Leukemia
Rouault-Pierre K,Mian SA,Goulard M,Abarrategi A,Di Tulio A,Smith AE,Mohamedali A,Best S,Nloga AM,Kulasekararaj AG,Ades L,Chomienne C,Fenaux P,Dosquet C,Mufti GJ,Bonnet D
Fri Dec 01 00:00:00 EST 2017
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
Journal of immunology (Baltimore, Md. : 1950)
McCurdy S,Baumer Y,Toulmin E,Lee BH,Boisvert WA
Wed Nov 15 00:00:00 EST 2017
The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Drube S,Grimlowski R,Deppermann C,Fröbel J,Kraft F,Andreas N,Stegner D,Dudeck J,Weber F,Rödiger M,Göpfert C,Drube J,Reich D,Nieswandt B,Dudeck A,Kamradt T
Sun Oct 15 00:00:00 EDT 2017
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Journal of immunology (Baltimore, Md. : 1950)
Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI
Mon May 15 00:00:00 EDT 2017
TGF-β1 Suppresses IL-33-Induced Mast Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Ndaw VS,Abebayehu D,Spence AJ,Paez PA,Kolawole EM,Taruselli MT,Caslin HL,Chumanevich AP,Paranjape A,Baker B,Barnstein BO,Haque TT,Kiwanuka KN,Oskeritzian CA,Ryan JJ
Tue Aug 01 00:00:00 EDT 2017
The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
Molecular and cellular biology
Peraki I,Palis J,Mavrothalassitis G
213-13 was used in In vitro experiments to study how Erf is required in all three waves of embryonic hematopoiesis to show that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.
Sun Oct 01 00:00:00 EDT 2017
Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1).
The Journal of biological chemistry
Umezawa Y,Akiyama H,Okada K,Ishida S,Nogami A,Oshikawa G,Kurosu T,Miura O
Fri Dec 01 00:00:00 EST 2017
An unexpected protein interaction promotes drug resistance in leukemia.
Nature communications
Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD
Thu Nov 16 00:00:00 EST 2017
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.
Molecular therapy. Methods & clinical development
Lee S,Kivimäe S,Szoka FC
213-13 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.
Fri Dec 15 00:00:00 EST 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Fri Sep 29 00:00:00 EDT 2017
Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling.
The Journal of biological chemistry
Chehboun S,Labrecque-Carbonneau J,Pasquin S,Meliani Y,Meddah B,Ferlin W,Sharma M,Tormo A,Masson JF,Gauchat JF
Fri Apr 21 00:00:00 EDT 2017
Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.
The Journal of biological chemistry
Ueda F,Tago K,Tamura H,Funakoshi-Tago M
Fri Feb 03 00:00:00 EST 2017
Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.
The Journal of biological chemistry
Schultz V,Suflita M,Liu X,Zhang X,Yu Y,Li L,Green DE,Xu Y,Zhang F,DeAngelis PL,Liu J,Linhardt RJ
Fri Feb 10 00:00:00 EST 2017
Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).
Current protocols in pharmacology
Stubbs MC,Krivtsov AV
213-13 was used in In vitro experiments to define protocols which focus on bone marrow-derived models only, using one particular MLL fusion, MLL-AF9.
Mon Sep 11 00:00:00 EDT 2017
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nature communications
Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B
Mon Aug 21 00:00:00 EDT 2017
Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2.
Scientific reports
MacNicol MC,Cragle CE,McDaniel FK,Hardy LL,Wang Y,Arumugam K,Rahmatallah Y,Glazko GV,Wilczynska A,Childs GV,Zhou D,MacNicol AM
Thu Sep 14 00:00:00 EDT 2017
Hematopoietic pannexin 1 function is critical for neuropathic pain.
Scientific reports
Weaver JL,Arandjelovic S,Brown G,K Mendu S,S Schappe M,Buckley MW,Chiu YH,Shu S,Kim JK,Chung J,Krupa J,Jevtovic-Todorovic V,Desai BN,Ravichandran KS,Bayliss DA
Tue Feb 14 00:00:00 EST 2017
Role of Mast Cells in clearance of Leishmania through extracellular trap formation.
Scientific reports
Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N
Mon Oct 16 00:00:00 EDT 2017
Role of Mast Cells in clearance of Leishmania through extracellular trap formation.
Scientific reports
Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N
Mon Oct 16 00:00:00 EDT 2017
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.
Scientific reports
Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML
Mon Oct 16 00:00:00 EDT 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
213-13 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 EDT 2016
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Cell
Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I
Thu Dec 15 00:00:00 EST 2016
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Cell
Sykes DB,Kfoury YS,Mercier FE,Wawer MJ,Law JM,Haynes MK,Lewis TA,Schajnovitz A,Jain E,Lee D,Meyer H,Pierce KA,Tolliday NJ,Waller A,Ferrara SJ,Eheim AL,Stoeckigt D,Maxcy KL,Cobert JM,Bachand J,Szekely BA,Mukherjee S,Sklar LA,Kotz JD,Clish CB,Sadreyev RI,Clemons PA,Janzer A,Schreiber SL,Scadden DT
Thu Sep 22 00:00:00 EDT 2016
Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.
Immunity
Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J
Tue Aug 16 00:00:00 EDT 2016
Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.
Immunity
Matthews SP,McMillan SJ,Colbert JD,Lawrence RA,Watts C
Tue Apr 19 00:00:00 EDT 2016
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Cell metabolism
Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC
213-13 was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.
Tue Apr 12 00:00:00 EDT 2016
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Blood
Schulze I,Rohde C,Scheller-Wendorff M,Bäumer N,Krause A,Herbst F,Riemke P,Hebestreit K,Tschanter P,Lin Q,Linhart H,Godley LA,Glimm H,Dugas M,Wagner W,Berdel WE,Rosenbauer F,Müller-Tidow C
Thu Mar 24 00:00:00 EDT 2016
Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.
Blood
Mascarenhas MI,Bacon WA,Kapeni C,Fitch SR,Kimber G,Cheng SW,Li J,Green AR,Ottersbach K
Thu May 12 00:00:00 EDT 2016
Developing HSCs become Notch independent by the end of maturation in the AGM region.
Blood
Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A
Thu Sep 22 00:00:00 EDT 2016
MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.
Blood
Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH
Thu Oct 27 00:00:00 EDT 2016
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Blood
Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N
Thu May 26 00:00:00 EDT 2016
Reprogramming Müller glia via in vivo cell fusion regenerates murine photoreceptors.
The Journal of clinical investigation
Sanges D,Simonte G,Di Vicino U,Romo N,Pinilla I,Nicolás M,Cosma MP
Mon Aug 01 00:00:00 EDT 2016
FGF23 signaling impairs neutrophil recruitment and host defense during CKD.
The Journal of clinical investigation
Rossaint J,Oehmichen J,Van Aken H,Reuter S,Pavenstädt HJ,Meersch M,Unruh M,Zarbock A
Tue Mar 01 00:00:00 EST 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
Fri Jan 01 00:00:00 EST 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
The Journal of experimental medicine
Hatlen MA,Arora K,Vacic V,Grabowska EA,Liao W,Riley-Gillis B,Oschwald DM,Wang L,Joergens JE,Shih AH,Rapaport F,Gu S,Voza F,Asai T,Neel BG,Kharas MG,Gonen M,Levine RL,Nimer SD
Mon Jan 11 00:00:00 EST 2016
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
The Journal of experimental medicine
Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ
Mon Oct 17 00:00:00 EDT 2016
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
The Journal of experimental medicine
Bannard O,McGowan SJ,Ersching J,Ishido S,Victora GD,Shin JS,Cyster JG
Mon May 30 00:00:00 EDT 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 EDT 2016
TLR9-mediated inflammation drives a Ccr2-independent peripheral monocytosis through enhanced extramedullary monocytopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Weaver LK,Chu N,Behrens EM
Tue Sep 27 00:00:00 EDT 2016
Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.
Mucosal immunology
Patel KR,Aven L,Shao F,Krishnamoorthy N,Duvall MG,Levy BD,Ai X
213-13 was used in Sample Preparation (FC/FACS) to identify a essential role of mast cells in mediating airway smooth muscle hyperinnervation following early-life insults by producing neurotrophin 4.
Tue Nov 01 00:00:00 EDT 2016
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.
Stem cells translational medicine
Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM
213-13 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.
Mon Aug 01 00:00:00 EDT 2016
Rel B-modified dendritic cells possess tolerogenic phenotype and functions on lupus splenic lymphocytes in vitro.
Immunology
Wu H,Lo Y,Chan A,Law KS,Mok MY
Thu Sep 01 00:00:00 EDT 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.
Stem cells (Dayton, Ohio)
Singh S,Moirangthem RD,Vaidya A,Jalnapurkar S,Limaye L,Kale V
Thu Sep 01 00:00:00 EDT 2016
CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.
Stem cells (Dayton, Ohio)
Ahmed T,Tsuji-Tamura K,Ogawa M
Thu Dec 01 00:00:00 EST 2016
TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.
Journal of immunology (Baltimore, Md. : 1950)
Nagashima H,Okuyama Y,Hayashi T,Ishii N,So T
Sun May 15 00:00:00 EDT 2016
Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.
Journal of immunology (Baltimore, Md. : 1950)
Efergan A,Azouz NP,Klein O,Noguchi K,Rothenberg ME,Fukuda M,Sagi-Eisenberg R
Mon Feb 01 00:00:00 EST 2016
Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P
Mon Aug 01 00:00:00 EDT 2016
IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Polukort SH,Rovatti J,Carlson L,Thompson C,Ser-Dolansky J,Kinney SR,Schneider SS,Mathias CB
Wed Jun 15 00:00:00 EDT 2016
Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion.
Journal of immunology (Baltimore, Md. : 1950)
Martín-Ávila A,Medina-Tamayo J,Ibarra-Sánchez A,Vázquez-Victorio G,Castillo-Arellano JI,Hernández-Mondragón AC,Rivera J,Madera-Salcedo IK,Blank U,Macías-Silva M,González-Espinosa C
Wed Jun 15 00:00:00 EDT 2016
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
Journal of pharmaceutical sciences
Xia X,Kumru OS,Blaber SI,Middaugh CR,Li L,Ornitz DM,Sutherland MA,Tenorio CA,Blaber M
Fri Apr 01 00:00:00 EDT 2016
An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.
Journal of pharmaceutical sciences
Xia X,Kumru OS,Blaber SI,Middaugh CR,Li L,Ornitz DM,Suh JM,Atkins AR,Downes M,Evans RM,Tenorio CA,Bienkiewicz E,Blaber M
Thu Dec 01 00:00:00 EST 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Tue Aug 09 00:00:00 EDT 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
Tue Mar 08 00:00:00 EST 2016
RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity.
Blood cancer journal
Chin DW,Sakurai M,Nah GS,Du L,Jacob B,Yokomizo T,Matsumura T,Suda T,Huang G,Fu XY,Ito Y,Nakajima H,Osato M
Fri Jan 08 00:00:00 EST 2016
Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.
Cell death & disease
Liu Q,Chen L,Atkinson JM,Claxton DF,Wang HG
Thu Sep 08 00:00:00 EDT 2016
Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.
Nature communications
George J,Uyar A,Young K,Kuffler L,Waldron-Francis K,Marquez E,Ucar D,Trowbridge JJ
Mon Jul 11 00:00:00 EDT 2016
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.
Nature communications
Grover A,Sanjuan-Pla A,Thongjuea S,Carrelha J,Giustacchini A,Gambardella A,Macaulay I,Mancini E,Luis TC,Mead A,Jacobsen SE,Nerlov C
Thu Mar 24 00:00:00 EDT 2016
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Nature communications
Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK
Mon Aug 08 00:00:00 EDT 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 EDT 2016
An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.
Molecular & cellular proteomics : MCP
Bigenzahn JW,Fauster A,Rebsamen M,Kandasamy RK,Scorzoni S,Vladimer GI,Müller AC,Gstaiger M,Zuber J,Bennett KL,Superti-Furga G
Tue Mar 01 00:00:00 EST 2016
A Molecular Chipper technology for CRISPR sgRNA library generation and functional mapping of noncoding regions.
Nature communications
Cheng J,Roden CA,Pan W,Zhu S,Baccei A,Pan X,Jiang T,Kluger Y,Weissman SM,Guo S,Flavell RA,Ding Y,Lu J
Wed Mar 30 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 EDT 2016
Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.
Methods in molecular biology (Clifton, N.J.)
Peng C,Li S
213-13 was used in Cell Culture to describe how we utilize this triple gene system to prove the function of Pten as a tumor suppressor in leukemogenesis.
Mon Dec 18 00:00:00 EST 2017
Activated mast cells promote differentiation of B cells into effector cells.
Scientific reports
Palm AK,Garcia-Faroldi G,Lundberg M,Pejler G,Kleinau S
Fri Feb 05 00:00:00 EST 2016
NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.
Cell discovery
Yuzugullu H,Von T,Thorpe LM,Walker SR,Roberts TM,Frank DA,Zhao JJ
Tue Sep 27 00:00:00 EDT 2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature communications
Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG
Tue Nov 08 00:00:00 EST 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem cell reports
Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M
Tue Dec 13 00:00:00 EST 2016
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Nature communications
White Y,Bagchi A,Van Ziffle J,Inguva A,Bollag G,Zhang C,Carias H,Dickens D,Loh M,Shannon K,Firestone AJ
Mon Feb 08 00:00:00 EST 2016
Induction of Chronic Myeloid Leukemia in Mice.
Methods in molecular biology (Clifton, N.J.)
Zhang H,Li S
213-13 was used in In vitro experiments to describe methods for induction of CML in mice with BCR-ABL.
Fri Jan 26 00:00:00 EST 2018
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Nature
Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M
Thu May 21 00:00:00 EDT 2015
T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
Blood
Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y
Thu Jan 08 00:00:00 EST 2015
Morgana acts as an oncosuppressor in chronic myeloid leukemia.
Blood
Di Savino A,Panuzzo C,Rocca S,Familiari U,Piazza R,Crivellaro S,Carrà G,Ferretti R,Fusella F,Giugliano E,Camporeale A,Franco I,Miniscalco B,Cutrin JC,Turco E,Silengo L,Hirsch E,Rege-Cambrin G,Gambacorti-Passerini C,Pandolfi PP,Papotti M,Saglio G,Tarone G,Morotti A,Brancaccio M
Thu Apr 02 00:00:00 EDT 2015
Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN.
Blood
Grisouard J,Shimizu T,Duek A,Kubovcakova L,Hao-Shen H,Dirnhofer S,Skoda RC
Thu Mar 26 00:00:00 EDT 2015
MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
Blood
Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR
Thu Apr 16 00:00:00 EDT 2015
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.
Blood
Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J
Thu May 07 00:00:00 EDT 2015
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Blood
Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD
Thu Feb 05 00:00:00 EST 2015
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Blood
Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS
Thu Feb 26 00:00:00 EST 2015
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
The Journal of clinical investigation
Millet A,Martin KR,Bonnefoy F,Saas P,Mocek J,Alkan M,Terrier B,Kerstein A,Tamassia N,Satyanarayanan SK,Ariel A,Ribeil JA,Guillevin L,Cassatella MA,Mueller A,Thieblemont N,Lamprecht P,Mouthon L,Perruche S,Witko-Sarsat V
Mon Nov 02 00:00:00 EST 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 EST 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 EST 2015
Coordinate expression of heme and globin is essential for effective erythropoiesis.
The Journal of clinical investigation
Doty RT,Phelps SR,Shadle C,Sanchez-Bonilla M,Keel SB,Abkowitz JL
Tue Dec 01 00:00:00 EST 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
Fri May 01 00:00:00 EDT 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 EDT 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 EST 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
Mon Oct 19 00:00:00 EDT 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
Mon Oct 19 00:00:00 EDT 2015
Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America
Smith DJ,Liu S,Ji S,Li B,McLaughlin J,Cheng D,Witte ON,Yang L
Tue Feb 03 00:00:00 EST 2015
MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.
Oncogenesis
Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH
Mon Dec 21 00:00:00 EST 2015
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio)
Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW
Fri May 01 00:00:00 EDT 2015
Bmi1 promotes erythroid development through regulating ribosome biogenesis.
Stem cells (Dayton, Ohio)
Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y
Sun Mar 01 00:00:00 EST 2015
IL-4-Producing Dendritic Cells Induced during Schistosoma japonica Infection Promote Th2 Cells via IL-4-Dependent Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Ma YL,Huang FJ,Cong L,Gong WC,Bai HM,Li J,Chen CX,Zhou NY,Jiang XL,Yin L,Chen XP
Thu Oct 15 00:00:00 EDT 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
Wed Jul 01 00:00:00 EDT 2015
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Xiao Y,Qiao G,Tang J,Tang R,Guo H,Warwar S,Langdon WY,Tao L,Zhang J
Sun Nov 01 00:00:00 EDT 2015
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.
Journal of immunology (Baltimore, Md. : 1950)
Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT
Sun Mar 15 00:00:00 EDT 2015
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.
Journal of immunology (Baltimore, Md. : 1950)
Viret C,Mahiddine K,Baker RL,Haskins K,Guerder S
Tue Sep 01 00:00:00 EDT 2015
Heme exporter FLVCR is required for T cell development and peripheral survival.
Journal of immunology (Baltimore, Md. : 1950)
Philip M,Funkhouser SA,Chiu EY,Phelps SR,Delrow JJ,Cox J,Fink PJ,Abkowitz JL
Sun Feb 15 00:00:00 EST 2015
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP
Sun Feb 01 00:00:00 EST 2015
Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.
Journal of immunology (Baltimore, Md. : 1950)
Sulimenko V,Hájková Z,Černohorská M,Sulimenko T,Sládková V,Dráberová L,Vinopal S,Dráberová E,Dráber P
Fri May 01 00:00:00 EDT 2015
Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells.
Journal of immunology (Baltimore, Md. : 1950)
Balseiro-Gomez S,Flores JA,Acosta J,Ramirez-Ponce MP,Ales E
Tue Sep 01 00:00:00 EDT 2015
IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals.
Journal of immunology (Baltimore, Md. : 1950)
Stoycheva D,Deiser K,Stärck L,Nishanth G,Schlüter D,Uckert W,Schüler T
Thu Jan 15 00:00:00 EST 2015
Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β Activation.
Journal of immunology (Baltimore, Md. : 1950)
Orlowski GM,Colbert JD,Sharma S,Bogyo M,Robertson SA,Rock KL
Sat Aug 15 00:00:00 EDT 2015
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.
Molecular therapy. Methods & clinical development
Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A
Wed Oct 28 00:00:00 EDT 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
213-13 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
Nature communications
Buchner M,Park E,Geng H,Klemm L,Flach J,Passegué E,Schjerven H,Melnick A,Paietta E,Kopanja D,Raychaudhuri P,Müschen M
Tue Mar 10 00:00:00 EDT 2015
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.
Nature communications
Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A
Mon Jun 22 00:00:00 EDT 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 EDT 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
Fancb deficiency impairs hematopoietic stem cell function.
Scientific reports
Du W,Amarachintha S,Erden O,Wilson A,Meetei AR,Andreassen PR,Namekawa SH,Pang Q
Fri Dec 11 00:00:00 EST 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 EDT 2015
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Stem cell reports
Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH
Tue Oct 13 00:00:00 EDT 2015
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature communications
Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA
Wed Nov 25 00:00:00 EST 2015
Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.
The Journal of biological chemistry
Zhang J,Ranheim EA,Du J,Liu Y,Wang J,Kong G,Zhang J
Fri Jul 31 00:00:00 EDT 2015
Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.
The Journal of biological chemistry
Hu N,Qiu Y,Dong F
Fri Oct 02 00:00:00 EDT 2015
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Cell
Cunningham JT,Moreno MV,Lodi A,Ronen SM,Ruggero D
Thu May 22 00:00:00 EDT 2014
Dissecting engineered cell types and enhancing cell fate conversion via CellNet.
Cell
Morris SA,Cahan P,Li H,Zhao AM,San Roman AK,Shivdasani RA,Collins JJ,Daley GQ
Thu Aug 14 00:00:00 EDT 2014
Nonstochastic reprogramming from a privileged somatic cell state.
Cell
Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J
Thu Feb 13 00:00:00 EST 2014
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Immunity
Nabekura T,Kanaya M,Shibuya A,Fu G,Gascoigne NR,Lanier LL
Thu Feb 20 00:00:00 EST 2014
Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.
Blood
Komeno Y,Yan M,Matsuura S,Lam K,Lo MC,Huang YJ,Tenen DG,Downing JR,Zhang DE
Thu Jun 12 00:00:00 EDT 2014
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.
Blood
Kobayashi CI,Takubo K,Kobayashi H,Nakamura-Ishizu A,Honda H,Kataoka K,Kumano K,Akiyama H,Sudo T,Kurokawa M,Suda T
Thu Apr 17 00:00:00 EDT 2014
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA
Thu Dec 18 00:00:00 EST 2014
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Blood
Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J
Thu Nov 13 00:00:00 EST 2014
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Blood
de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F
Thu Jan 23 00:00:00 EST 2014
Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.
Blood
Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X
Thu Apr 03 00:00:00 EDT 2014
Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.
Blood
Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V
Thu Dec 04 00:00:00 EST 2014
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.
The Journal of clinical investigation
Wegiel B,Larsen R,Gallo D,Chin BY,Harris C,Mannam P,Kaczmarek E,Lee PJ,Zuckerbraun BS,Flavell R,Soares MP,Otterbein LE
Sat Nov 01 00:00:00 EDT 2014
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.
The Journal of clinical investigation
Dahdah A,Gautier G,Attout T,Fiore F,Lebourdais E,Msallam R,Daëron M,Monteiro RC,Benhamou M,Charles N,Davoust J,Blank U,Malissen B,Launay P
Wed Oct 01 00:00:00 EDT 2014
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.
The Journal of clinical investigation
Jones M,Osawa G,Regal JA,Weinberg DN,Taggart J,Kocak H,Friedman A,Ferguson DO,Keegan CE,Maillard I
Wed Jan 01 00:00:00 EST 2014
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
The Journal of clinical investigation
Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP
213-13 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.
Tue Apr 01 00:00:00 EDT 2014
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
The Journal of clinical investigation
Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP
213-13 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.
Tue Apr 01 00:00:00 EDT 2014
Serum IgE clearance is facilitated by human FcεRI internalization.
The Journal of clinical investigation
Greer AM,Wu N,Putnam AL,Woodruff PG,Wolters P,Kinet JP,Shin JS
Sat Mar 01 00:00:00 EST 2014
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
The Journal of clinical investigation
Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR
Fri Aug 01 00:00:00 EDT 2014
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 EDT 2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
The Journal of experimental medicine
Beck TC,Gomes AC,Cyster JG,Pereira JP
Mon Dec 15 00:00:00 EST 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 EST 2014
DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.
The Journal of experimental medicine
Ogawa K,Tanaka Y,Uruno T,Duan X,Harada Y,Sanematsu F,Yamamura K,Terasawa M,Nishikimi A,Côté JF,Fukui Y
Mon Jun 30 00:00:00 EDT 2014
Initiation of MLL-rearranged AML is dependent on C/EBPα.
The Journal of experimental medicine
Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT
Mon Jan 13 00:00:00 EST 2014
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
Mon Apr 07 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 EDT 2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
The Journal of experimental medicine
Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L
Mon Dec 15 00:00:00 EST 2014
Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
The Journal of experimental medicine
Gazit R,Mandal PK,Ebina W,Ben-Zvi A,Nombela-Arrieta C,Silberstein LE,Rossi DJ
Mon Jun 30 00:00:00 EDT 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 EST 2014
IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.
EMBO molecular medicine
Wang J,Lindholt JS,Sukhova GK,Shi MA,Xia M,Chen H,Xiang M,He A,Wang Y,Xiong N,Libby P,Wang JA,Shi GP
Tue Jul 01 00:00:00 EDT 2014
Key regulators control distinct transcriptional programmes in blood progenitor and mast cells.
The EMBO journal
Calero-Nieto FJ,Ng FS,Wilson NK,Hannah R,Moignard V,Leal-Cervantes AI,Jimenez-Madrid I,Diamanti E,Wernisch L,Göttgens B
Mon Jun 02 00:00:00 EDT 2014
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.
Proceedings of the National Academy of Sciences of the United States of America
Shi J,Kundrat L,Pishesha N,Bilate A,Theile C,Maruyama T,Dougan SK,Ploegh HL,Lodish HF
Tue Jul 15 00:00:00 EDT 2014
IL-33/ST2 axis promotes mast cell survival via BCLXL.
Proceedings of the National Academy of Sciences of the United States of America
Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA
Tue Jul 15 00:00:00 EDT 2014
JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms.
Proceedings of the National Academy of Sciences of the United States of America
Etheridge SL,Roh ME,Cosgrove ME,Sangkhae V,Fox NE,Chen J,López JA,Kaushansky K,Hitchcock IS
Tue Feb 11 00:00:00 EST 2014
K-RasV14I recapitulates Noonan syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America
Hernández-Porras I,Fabbiano S,Schuhmacher AJ,Aicher A,Cañamero M,Cámara JA,Cussó L,Desco M,Heeschen C,Mulero F,Bustelo XR,Guerra C,Barbacid M
Tue Nov 18 00:00:00 EST 2014
Signaling pathways activated by a protease allergen in basophils.
Proceedings of the National Academy of Sciences of the United States of America
Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R
Tue Nov 18 00:00:00 EST 2014
Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.
Blood cancer journal
Sprissler C,Belenki D,Maurer H,Aumann K,Pfeifer D,Klein C,Müller TA,Kissel S,Hülsdünker J,Alexandrovski J,Brummer T,Jumaa H,Duyster J,Dierks C
Fri Aug 22 00:00:00 EDT 2014
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood cancer journal
Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K
Fri Jan 10 00:00:00 EST 2014
Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.
Stem cells (Dayton, Ohio)
Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT
Mon Dec 01 00:00:00 EST 2014
Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities.
Journal of immunology (Baltimore, Md. : 1950)
Deho' L,Leoni C,Brodie TM,Montagner S,De Simone M,Polletti S,Barozzi I,Natoli G,Monticelli S
Mon Sep 01 00:00:00 EDT 2014
Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Azouz NP,Zur N,Efergan A,Ohbayashi N,Fukuda M,Amihai D,Hammel I,Rothenberg ME,Sagi-Eisenberg R
Thu May 01 00:00:00 EDT 2014
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sun Jun 15 00:00:00 EDT 2014
Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.
Journal of immunology (Baltimore, Md. : 1950)
Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ
Sat Nov 15 00:00:00 EST 2014
SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.
Journal of immunology (Baltimore, Md. : 1950)
Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H
Wed Oct 15 00:00:00 EDT 2014
Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Brochetta C,Suzuki R,Vita F,Soranzo MR,Claver J,Madjene LC,Attout T,Vitte J,Varin-Blank N,Zabucchi G,Rivera J,Blank U
Wed Jan 01 00:00:00 EST 2014
Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Journal of immunology (Baltimore, Md. : 1950)
Stärck L,Popp K,Pircher H,Uckert W
Wed Jan 01 00:00:00 EST 2014
RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage.
Cell death & disease
Nugues AL,El Bouazzati H,Hétuin D,Berthon C,Loyens A,Bertrand E,Jouy N,Idziorek T,Quesnel B
Thu Aug 21 00:00:00 EDT 2014
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
Nature communications
Piunti A,Rossi A,Cerutti A,Albert M,Jammula S,Scelfo A,Cedrone L,Fragola G,Olsson L,Koseki H,Testa G,Casola S,Helin K,d'Adda di Fagagna F,Pasini D
Mon Apr 14 00:00:00 EDT 2014
The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.
Oncotarget
Saurabh K,Scherzer MT,Shah PP,Mims AS,Lockwood WW,Kraft AS,Beverly LJ
213-13 was used in Cell Culture to assess the comparative signalling and oncogenic potential of three PIM kinases.
Tue Sep 30 00:00:00 EDT 2014
Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.
The Journal of biological chemistry
Subramanian H,Gupta K,Parameswaran N,Ali H
Fri Jul 25 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 EST 2013
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell
Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW
Mon Mar 18 00:00:00 EDT 2013
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Blood
Chen Y,Aardema J,Kale S,Whichard ZL,Awomolo A,Blanchard E,Chang B,Myers DR,Ju L,Tran R,Reece D,Christensen H,Boukour S,Debili N,Strom TS,Rawlings D,Vázquez FX,Voth GA,Zhu C,Kahr WH,Lam WA,Corey SJ
Thu Sep 05 00:00:00 EDT 2013
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Blood
Conway AE,Scotland PB,Lavau CP,Wechsler DS
Thu Jun 06 00:00:00 EDT 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 EDT 2013
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Blood
May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T
Thu Apr 18 00:00:00 EDT 2013
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Blood
Santoro F,Botrugno OA,Dal Zuffo R,Pallavicini I,Matthews GM,Cluse L,Barozzi I,Senese S,Fornasari L,Moretti S,Altucci L,Pelicci PG,Chiocca S,Johnstone RW,Minucci S
Thu Apr 25 00:00:00 EDT 2013
Ikaros limits basophil development by suppressing C/EBP-α expression.
Blood
Rao KN,Smuda C,Gregory GD,Min B,Brown MA
Thu Oct 10 00:00:00 EDT 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 EDT 2013
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
Blood
Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A
Thu Oct 03 00:00:00 EDT 2013
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Blood
Sportoletti P,Varasano E,Rossi R,Bereshchenko O,Cecchini D,Gionfriddo I,Bolli N,Tiacci E,Intermesoli T,Zanghì P,Masciulli A,Martelli MP,Falzetti F,Martelli MF,Falini B
Thu Apr 25 00:00:00 EDT 2013
The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation.
Blood
Sakai Y,Tanaka Y,Yanagihara T,Watanabe M,Duan X,Terasawa M,Nishikimi A,Sanematsu F,Fukui Y
Thu Jul 18 00:00:00 EDT 2013
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.
Blood
Wahlestedt M,Norddahl GL,Sten G,Ugale A,Frisk MA,Mattsson R,Deierborg T,Sigvardsson M,Bryder D
Thu May 23 00:00:00 EDT 2013
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.
The Journal of clinical investigation
Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW
Tue Jan 01 00:00:00 EST 2013
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
The Journal of clinical investigation
Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R
Tue Oct 01 00:00:00 EDT 2013
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
The Journal of experimental medicine
Yi Z,Stunz LL,Bishop GA
Mon Jun 03 00:00:00 EDT 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 EST 2013
SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
Leukemia
Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T
Tue Jan 01 00:00:00 EST 2013
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.
Proceedings of the National Academy of Sciences of the United States of America
Jin HS,Liao L,Park Y,Liu YC
Tue Jan 08 00:00:00 EST 2013
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C
Tue Apr 02 00:00:00 EDT 2013
Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America
Kurokawa M,Ito T,Yang CS,Zhao C,Macintyre AN,Rizzieri DA,Rathmell JC,Deininger MW,Reya T,Kornbluth S
Tue Feb 05 00:00:00 EST 2013
Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.
Stem cells (Dayton, Ohio)
Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM
Fri Feb 01 00:00:00 EST 2013
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.
Stem cells (Dayton, Ohio)
Pfaff N,Lachmann N,Ackermann M,Kohlscheen S,Brendel C,Maetzig T,Niemann H,Antoniou MN,Grez M,Schambach A,Cantz T,Moritz T
Fri Mar 01 00:00:00 EST 2013
The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.
Journal of immunology (Baltimore, Md. : 1950)
Sesti-Costa R,Silva GK,Proença-Módena JL,Carlos D,Silva ML,Alves-Filho JC,Arruda E,Liew FY,Silva JS
Mon Jul 01 00:00:00 EDT 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 EDT 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 EDT 2013
TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis.
Journal of immunology (Baltimore, Md. : 1950)
Oh MH,Oh SY,Lu J,Lou H,Myers AC,Zhu Z,Zheng T
Sun Dec 01 00:00:00 EST 2013
β-Defensins activate human mast cells via Mas-related gene X2.
Journal of immunology (Baltimore, Md. : 1950)
Subramanian H,Gupta K,Lee D,Bayir AK,Ahn H,Ali H
Mon Jul 01 00:00:00 EDT 2013
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kamijo S,Takeda H,Tokura T,Suzuki M,Inui K,Hara M,Matsuda H,Matsuda A,Oboki K,Ohno T,Saito H,Nakae S,Sudo K,Suto H,Ichikawa S,Ogawa H,Okumura K,Takai T
Wed May 01 00:00:00 EDT 2013
Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.
Journal of immunology (Baltimore, Md. : 1950)
Graham AC,Hilmer KM,Zickovich JM,Obar JJ
Wed May 01 00:00:00 EDT 2013
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Paster W,Brockmeyer C,Fu G,Simister PC,de Wet B,Martinez-Riaño A,Hoerter JA,Feller SM,Wülfing C,Gascoigne NR,Acuto O
Mon Apr 01 00:00:00 EDT 2013
Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex.
Journal of immunology (Baltimore, Md. : 1950)
Madera-Salcedo IK,Cruz SL,Gonzalez-Espinosa C
Sun Sep 15 00:00:00 EDT 2013
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.
Journal of immunology (Baltimore, Md. : 1950)
Dillahunt SE,Sargent JL,Suzuki R,Proia RL,Gilfillan A,Rivera J,Olivera A
Fri Mar 01 00:00:00 EST 2013
The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Kraft S,Jouvin MH,Kulkarni N,Kissing S,Morgan ES,Dvorak AM,Schröder B,Saftig P,Kinet JP
Sun Sep 15 00:00:00 EDT 2013
Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.
The Journal of biological chemistry
Kosoff R,Chow HY,Radu M,Chernoff J
Fri Jan 11 00:00:00 EST 2013
Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.
PloS one
Coutinho AE,Brown JK,Yang F,Brownstein DG,Gray M,Seckl JR,Savill JS,Chapman KE
Fri Jul 19 00:00:00 EDT 2013
Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
PloS one
Funakoshi-Tago M,Sumi K,Kasahara T,Tago K
Tue Aug 20 00:00:00 EDT 2013
Critical roles of Myc-ODC axis in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 V617F mutant.
PloS one
Funakoshi-Tago M,Sumi K,Kasahara T,Tago K
Tue Aug 20 00:00:00 EDT 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 EST 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 EDT 2012
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell
Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,Ma J,Radtke I,Ding L,Cazzaniga G,Biondi A,Kornblau SM,Ravandi F,Kantarjian H,Nimer SD,Döhner K,Döhner H,Ley TJ,Ballerini P,Shurtleff S,Tomizawa D,Adachi S,Hayashi Y,Tawa A,Shih LY,Liang DC,Rubnitz JE,Pui CH,Mardis ER,Wilson RK,Downing JR
Tue Nov 13 00:00:00 EST 2012
EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.
Blood
Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J
Thu Sep 20 00:00:00 EDT 2012
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood
Fares J,Koller R,Humeniuk R,Wolff L,Bies J
Thu May 24 00:00:00 EDT 2012
Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia.
Blood
Matsuura S,Yan M,Lo MC,Ahn EY,Weng S,Dangoor D,Matin M,Higashi T,Feng GS,Zhang DE
Thu Mar 29 00:00:00 EDT 2012
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.
Blood
Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W
Thu Feb 23 00:00:00 EST 2012
Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.
Blood
Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A
Thu May 24 00:00:00 EDT 2012
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.
Blood
Reddy PN,Sargin B,Choudhary C,Stein S,Grez M,Müller-Tidow C,Berdel WE,Serve H,Brandts CH
Thu Aug 23 00:00:00 EDT 2012
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood
Mérino D,Khaw SL,Glaser SP,Anderson DJ,Belmont LD,Wong C,Yue P,Robati M,Phipson B,Fairlie WD,Lee EF,Campbell KJ,Vandenberg CJ,Cory S,Roberts AW,Ludlam MJ,Huang DC,Bouillet P
Thu Jun 14 00:00:00 EDT 2012
Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
Blood
Godfrey R,Arora D,Bauer R,Stopp S,Müller JP,Heinrich T,Böhmer SA,Dagnell M,Schnetzke U,Scholl S,Östman A,Böhmer FD
Thu May 10 00:00:00 EDT 2012
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood
Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G
Thu Aug 02 00:00:00 EDT 2012
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.
Blood
Krishnan S,Mali RS,Ramdas B,Sims E,Ma P,Ghosh J,Munugalavadla V,Hanneman P,Beane JD,Kapur R
Thu Apr 26 00:00:00 EDT 2012
Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration.
Blood
Kostyak JC,Naik MU,Naik UP
Thu Jan 19 00:00:00 EST 2012
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Blood
Spranger S,Jeremias I,Wilde S,Leisegang M,Stärck L,Mosetter B,Uckert W,Heemskerk MH,Schendel DJ,Frankenberger B
Thu Apr 12 00:00:00 EDT 2012
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.
Blood
Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D
Thu Mar 01 00:00:00 EST 2012
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.
Blood
Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM
Thu Jul 12 00:00:00 EDT 2012
Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.
Blood
Guo H,Ma O,Speck NA,Friedman AD
Thu May 10 00:00:00 EDT 2012
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 EDT 2012
Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
Blood
Sun K,Alvarez M,Ames E,Barao I,Chen M,Longo DL,Redelman D,Murphy WJ
Thu Feb 09 00:00:00 EST 2012
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood
Ottina E,Grespi F,Tischner D,Soratroi C,Geley S,Ploner A,Reichardt HM,Villunger A,Herold MJ
Thu Jun 21 00:00:00 EDT 2012
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood
Greenblatt S,Li L,Slape C,Nguyen B,Novak R,Duffield A,Huso D,Desiderio S,Borowitz MJ,Aplan P,Small D
Thu Mar 22 00:00:00 EDT 2012
Critical role of P1-Runx1 in mouse basophil development.
Blood
Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ
Thu Jul 05 00:00:00 EDT 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
Thu Oct 11 00:00:00 EDT 2012
Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.
Blood
Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD
Thu Aug 23 00:00:00 EDT 2012
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.
The Journal of clinical investigation
Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W
Fri Jun 01 00:00:00 EDT 2012
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.
The Journal of clinical investigation
Schoppy DW,Ragland RL,Gilad O,Shastri N,Peters AA,Murga M,Fernandez-Capetillo O,Diehl JA,Brown EJ
Sun Jan 01 00:00:00 EST 2012
Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
Nucleic acids research
Rodríguez-Ubreva J,Ciudad L,Gómez-Cabrero D,Parra M,Bussmann LH,di Tullio A,Kallin EM,Tegnér J,Graf T,Ballestar E
Thu Mar 01 00:00:00 EST 2012
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.
The Journal of experimental medicine
Kaufmann KB,Gründer A,Hadlich T,Wehrle J,Gothwal M,Bogeska R,Seeger TS,Kayser S,Pham KB,Jutzi JS,Ganzenmüller L,Steinemann D,Schlegelberger B,Wagner JM,Jung M,Will B,Steidl U,Aumann K,Werner M,Günther T,Schüle R,Rambaldi A,Pahl HL
Mon Jan 16 00:00:00 EST 2012
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
The Journal of experimental medicine
Block H,Herter JM,Rossaint J,Stadtmann A,Kliche S,Lowell CA,Zarbock A
Mon Feb 13 00:00:00 EST 2012
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
The Journal of experimental medicine
Oguro H,Yuan J,Tanaka S,Miyagi S,Mochizuki-Kashio M,Ichikawa H,Yamazaki S,Koseki H,Nakauchi H,Iwama A
Mon Mar 12 00:00:00 EDT 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
Mon Oct 22 00:00:00 EDT 2012
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
The Journal of experimental medicine
Fang TC,Schaefer U,Mecklenbrauker I,Stienen A,Dewell S,Chen MS,Rioja I,Parravicini V,Prinjha RK,Chandwani R,MacDonald MR,Lee K,Rice CM,Tarakhovsky A
Mon Apr 09 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
Mon Jan 16 00:00:00 EST 2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Proceedings of the National Academy of Sciences of the United States of America
Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J
Tue Oct 09 00:00:00 EDT 2012
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Roche O,Xu C,Moriyama EH,Heir P,Chung J,Roos FC,Chen Y,Finak G,Milosevic M,Wilson BC,Teh BT,Park M,Irwin MS,Ohh M
Tue Mar 27 00:00:00 EDT 2012
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America
Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P
Tue Sep 04 00:00:00 EDT 2012
GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
Oncogene
Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T
Thu Mar 15 00:00:00 EDT 2012
Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.
Cancer gene therapy
Noyan F,Díez IA,Hapke M,Klein C,Dewey RA
Tue May 01 00:00:00 EDT 2012
Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53.
Stem cells (Dayton, Ohio)
Hegde S,Hankey P,Paulson RF
Wed Feb 01 00:00:00 EST 2012
The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.
Journal of immunology (Baltimore, Md. : 1950)
Nunomura S,Kawakami Y,Kawakami T,Ra C
Sun Apr 15 00:00:00 EDT 2012
NLRP3 inflammasome activity is negatively controlled by miR-223.
Journal of immunology (Baltimore, Md. : 1950)
Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V
Mon Oct 15 00:00:00 EDT 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 EDT 2012
The SWI/SNF-like BAF complex is essential for early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH
Sun Apr 15 00:00:00 EDT 2012
The IL-1-dependent sterile inflammatory response has a substantial caspase-1-independent component that requires cathepsin C.
Journal of immunology (Baltimore, Md. : 1950)
Kono H,Orlowski GM,Patel Z,Rock KL
Mon Oct 01 00:00:00 EDT 2012
Stem cell factor programs the mast cell activation phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Ito T,Smrž D,Jung MY,Bandara G,Desai A,Smržová Š,Kuehn HS,Beaven MA,Metcalfe DD,Gilfillan AM
Fri Jun 01 00:00:00 EDT 2012
Cutting edge: persistence of increased mast cell numbers in tissues links dermatitis to enhanced airway disease in a mouse model of atopy.
Journal of immunology (Baltimore, Md. : 1950)
Hershko AY,Charles N,Olivera A,Alvarez-Errico D,Rivera J
Sun Jan 15 00:00:00 EST 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
Sun Jan 01 00:00:00 EST 2012
Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Falanga YT,Chaimowitz NS,Charles N,Finkelman FD,Pullen NA,Barbour S,Dholaria K,Faber T,Kolawole M,Huang B,Odom S,Rivera J,Carlyon J,Conrad DH,Spiegel S,Oskeritzian CA,Ryan JJ
Tue May 01 00:00:00 EDT 2012
Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.
Evidence-based complementary and alternative medicine : eCAM
Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M
Thu Aug 23 00:00:00 EDT 2012
Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.
The Journal of biological chemistry
Khanna-Gupta A,Abayasekara N,Levine M,Sun H,Virgilio M,Nia N,Halene S,Sportoletti P,Jeong JY,Pandolfi PP,Berliner N
Fri Sep 21 00:00:00 EDT 2012
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Cell communication and signaling : CCS
Arora D,Köthe S,van den Eijnden M,Hooft van Huijsduijnen R,Heidel F,Fischer T,Scholl S,Tölle B,Böhmer SA,Lennartsson J,Isken F,Müller-Tidow C,Böhmer FD
Wed Jul 11 00:00:00 EDT 2012
Cytosolic Bax: does it require binding proteins to keep its pro-apoptotic activity in check?
The Journal of biological chemistry
Vogel S,Raulf N,Bregenhorn S,Biniossek ML,Maurer U,Czabotar P,Borner C
Fri Mar 16 00:00:00 EDT 2012
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
The Journal of biological chemistry
Pullen NA,Barnstein BO,Falanga YT,Wang Z,Suzuki R,Tamang TD,Khurana MC,Harry EA,Draber P,Bunting KD,Mizuno K,Wilson BS,Ryan JJ
Fri Jan 13 00:00:00 EST 2012
γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
PloS one
Vinopal S,Cernohorská M,Sulimenko V,Sulimenko T,Vosecká V,Flemr M,Dráberová E,Dráber P
Mon May 14 00:00:00 EDT 2012
Type II-activated murine macrophages produce IL-4.
PloS one
La Flamme AC,Kharkrang M,Stone S,Mirmoeini S,Chuluundorj D,Kyle R
Wed May 01 00:00:00 EDT 2013
Evidence that formation of vimentin mitogen-activated protein kinase (MAPK) complex mediates mast cell activation following FcεRI/CC chemokine receptor 1 cross-talk.
The Journal of biological chemistry
Toda M,Kuo CH,Borman SK,Richardson RM,Inoko A,Inagaki M,Collins A,Schneider K,Ono SJ
Fri Jul 13 00:00:00 EDT 2012
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PloS one
Nakamura S,Oshima M,Yuan J,Saraya A,Miyagi S,Konuma T,Yamazaki S,Osawa M,Nakauchi H,Koseki H,Iwama A
Tue Oct 16 00:00:00 EDT 2012
Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.
The Journal of biological chemistry
Hu P,Carlesso N,Xu M,Liu Y,Nebreda AR,Takemoto C,Kapur R
Fri Jun 08 00:00:00 EDT 2012
Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor.
PloS one
Drechsler J,Grötzinger J,Hermanns HM
Thu Apr 25 00:00:00 EDT 2013
The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.
PloS one
Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD
Mon Oct 22 00:00:00 EDT 2012
A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.
PloS one
Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A
Wed May 22 00:00:00 EDT 2013
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 EST 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 EST 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 EST 2013
Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions.
PloS one
Shen H,de Almeida PE,Kang KH,Yao P,Chan CW
Thu May 16 00:00:00 EDT 2013
Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Nature
Anthony RM,Kobayashi T,Wermeling F,Ravetch JV
Sun Jun 19 00:00:00 EDT 2011
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Cancer cell
Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M
Tue Apr 12 00:00:00 EDT 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.
Blood
Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR
Thu May 26 00:00:00 EDT 2011
The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.
Blood
Nelson EA,Walker SR,Weisberg E,Bar-Natan M,Barrett R,Gashin LB,Terrell S,Klitgaard JL,Santo L,Addorio MR,Ebert BL,Griffin JD,Frank DA
Thu Mar 24 00:00:00 EDT 2011
HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Blood
Flygare J,Rayon Estrada V,Shin C,Gupta S,Lodish HF
Thu Mar 24 00:00:00 EDT 2011
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.
Blood
Nguyen AT,Taranova O,He J,Zhang Y
Thu Jun 23 00:00:00 EDT 2011
PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.
Blood
Furumoto Y,Charles N,Olivera A,Leung WH,Dillahunt S,Sargent JL,Tinsley K,Odom S,Scott E,Wilson TM,Ghoreschi K,Kneilling M,Chen M,Lee DM,Bolland S,Rivera J
Thu Nov 17 00:00:00 EST 2011
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood
Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C
Thu Mar 17 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
Thu Feb 24 00:00:00 EST 2011
Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.
Blood
Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC
Thu Jun 23 00:00:00 EDT 2011
C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes.
Blood
Paz-Priel I,Houng S,Dooher J,Friedman AD
Thu Apr 14 00:00:00 EDT 2011
Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
Blood
Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A
Thu Sep 08 00:00:00 EDT 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Blood
Aue G,Du Y,Cleveland SM,Smith SB,Davé UP,Liu D,Weniger MA,Metais JY,Jenkins NA,Copeland NG,Dunbar CE
Thu Oct 27 00:00:00 EDT 2011
E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.
Blood
Yang Q,Esplin B,Borghesi L
Thu Mar 31 00:00:00 EDT 2011
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.
Blood
Ma P,Mali RS,Munugalavadla V,Krishnan S,Ramdas B,Sims E,Martin H,Ghosh J,Li S,Chan RJ,Krystal G,Craig AW,Takemoto C,Kapur R
Thu Sep 29 00:00:00 EDT 2011
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Blood
Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S
Thu Dec 01 00:00:00 EST 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
Thu Sep 29 00:00:00 EDT 2011
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Blood
Steffen B,Knop M,Bergholz U,Vakhrusheva O,Rode M,Köhler G,Henrichs MP,Bulk E,Hehn S,Stehling M,Dugas M,Bäumer N,Tschanter P,Brandts C,Koschmieder S,Berdel WE,Serve H,Stocking C,Müller-Tidow C
Thu Apr 21 00:00:00 EDT 2011
TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms.
Blood
Fleischman AG,Aichberger KJ,Luty SB,Bumm TG,Petersen CL,Doratotaj S,Vasudevan KB,LaTocha DH,Yang F,Press RD,Loriaux MM,Pahl HL,Silver RT,Agarwal A,O'Hare T,Druker BJ,Bagby GC,Deininger MW
Thu Dec 08 00:00:00 EST 2011
SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.
Blood
Zhang L,Friedman AD
Thu Aug 25 00:00:00 EDT 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 EST 2011
Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.
Blood
Sakata-Yanagimoto M,Sakai T,Miyake Y,Saito TI,Maruyama H,Morishita Y,Nakagami-Yamaguchi E,Kumano K,Yagita H,Fukayama M,Ogawa S,Kurokawa M,Yasutomo K,Chiba S
Thu Jan 06 00:00:00 EST 2011
Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.
Blood
Negre O,Fusil F,Colomb C,Roth S,Gillet-Legrand B,Henri A,Beuzard Y,Bushman F,Leboulch P,Payen E
Thu May 19 00:00:00 EDT 2011
G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
Blood
Futami M,Zhu QS,Whichard ZL,Xia L,Ke Y,Neel BG,Feng GS,Corey SJ
Thu Jul 28 00:00:00 EDT 2011
PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia.
Blood
Kleppe M,Soulier J,Asnafi V,Mentens N,Hornakova T,Knoops L,Constantinescu S,Sigaux F,Meijerink JP,Vandenberghe P,Tartaglia M,Foa R,Macintyre E,Haferlach T,Cools J
Thu Jun 30 00:00:00 EDT 2011
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.
Blood
Li N,Matte-Martone C,Zheng H,Cui W,Venkatesan S,Tan HS,McNiff J,Demetris AJ,Roopenian D,Kaech S,Shlomchik WD
Thu Nov 24 00:00:00 EST 2011
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation
Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE
Sat Jan 01 00:00:00 EST 2011
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
The Journal of experimental medicine
Hurtz C,Hatzi K,Cerchietti L,Braig M,Park E,Kim YM,Herzog S,Ramezani-Rad P,Jumaa H,Müller MC,Hofmann WK,Hochhaus A,Ye BH,Agarwal A,Druker BJ,Shah NP,Melnick AM,Müschen M
Mon Oct 24 00:00:00 EDT 2011
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors.
The Journal of experimental medicine
Pronk CJ,Veiby OP,Bryder D,Jacobsen SE
Mon Aug 01 00:00:00 EDT 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
Mon Jun 06 00:00:00 EDT 2011
Complex interactions in EML cell stimulation by stem cell factor and IL-3.
Proceedings of the National Academy of Sciences of the United States of America
Ye ZJ,Gulcicek E,Stone K,Lam T,Schulz V,Weissman SM
Tue Mar 22 00:00:00 EDT 2011
Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression.
Cell death and differentiation
Guitart AV,Debeissat C,Hermitte F,Villacreces A,Ivanovic Z,Boeuf H,Praloran V
213-13 was used in In vitro experiments to show that culture of the murine hematopoietic nonleukemic factor-dependent cell Paterson (FDCP)-Mix cell line under hypoxic conditions induced hypophosphorylation of pRb and increased the expression of p27(KIP1).
Sat Jan 01 00:00:00 EST 2011
IL-21 reduces immediate hypersensitivity reactions in mouse skin by suppressing mast cell activation or IgE production.
The Journal of investigative dermatology
Tamagawa-Mineoka R,Kishida T,Mazda O,Katoh N
Fri Jul 01 00:00:00 EDT 2011
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.
Stem cells (Dayton, Ohio)
Heffner GC,Clutter MR,Nolan GP,Weissman IL
Tue Nov 01 00:00:00 EDT 2011
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950)
Grenningloh R,Tai TS,Frahm N,Hongo TC,Chicoine AT,Brander C,Kaufmann DE,Ho IC
Sat Jan 15 00:00:00 EST 2011
Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.
Journal of immunology (Baltimore, Md. : 1950)
Bonnefoy F,Perruche S,Couturier M,Sedrati A,Sun Y,Tiberghien P,Gaugler B,Saas P
Sun May 15 00:00:00 EDT 2011
Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1-/- mice.
Journal of immunology (Baltimore, Md. : 1950)
Maxwell MJ,Duan M,Armes JE,Anderson GP,Tarlinton DM,Hibbs ML
Wed Jun 15 00:00:00 EDT 2011
STIM1-directed reorganization of microtubules in activated mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Hájková Z,Bugajev V,Dráberová E,Vinopal S,Dráberová L,Janáček J,Dráber P,Dráber P
Sat Jan 15 00:00:00 EST 2011
Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Cantor J,Slepak M,Ege N,Chang JT,Ginsberg MH
Fri Jul 15 00:00:00 EDT 2011
Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Li H,Nourbakhsh B,Safavi F,Li K,Xu H,Cullimore M,Zhou F,Zhang G,Rostami A
Fri Jul 01 00:00:00 EDT 2011
Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function.
Journal of immunology (Baltimore, Md. : 1950)
Chacón-Salinas R,Limón-Flores AY,Chávez-Blanco AD,Gonzalez-Estrada A,Ullrich SE
Sat Jan 01 00:00:00 EST 2011
TGF-beta-exposed plasmacytoid dendritic cells participate in Th17 commitment.
Journal of immunology (Baltimore, Md. : 1950)
Bonnefoy F,Couturier M,Clauzon A,Rémy-Martin JP,Gaugler B,Tiberghien P,Chen W,Saas P,Perruche S
Wed Jun 01 00:00:00 EDT 2011
Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.
Journal of immunology (Baltimore, Md. : 1950)
Matte-Martone C,Venkatesan S,Tan HS,Athanasiadis I,Chang J,Pavisic J,Shlomchik WD
Mon Aug 15 00:00:00 EDT 2011
Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Journal of immunology (Baltimore, Md. : 1950)
Pascual-García M,Carbó JM,León T,Matalonga J,Out R,Van Berkel T,Sarrias MR,Lozano F,Celada A,Valledor AF
Fri Apr 15 00:00:00 EDT 2011
Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.
PloS one
Sutherland RE,Xu X,Kim SS,Seeley EJ,Caughey GH,Wolters PJ
Mon Mar 26 00:00:00 EDT 2012
Differential but competitive binding of Nogo protein and class i major histocompatibility complex (MHCI) to the PIR-B ectodomain provides an inhibition of cells.
The Journal of biological chemistry
Matsushita H,Endo S,Kobayashi E,Sakamoto Y,Kobayashi K,Kitaguchi K,Kuroki K,Söderhäll A,Maenaka K,Nakamura A,Strittmatter SM,Takai T
Fri Jul 22 00:00:00 EDT 2011
Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.
The Journal of biological chemistry
Guo H,Friedman AD
Fri Jan 07 00:00:00 EST 2011
Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release.
The Journal of biological chemistry
Kuehn HS,Jung MY,Beaven MA,Metcalfe DD,Gilfillan AM
Fri Jan 07 00:00:00 EST 2011
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
PloS one
Reichel CA,Lerchenberger M,Uhl B,Rehberg M,Berberich N,Zahler S,Wymann MP,Krombach F
Tue Feb 22 00:00:00 EST 2011
R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.
The Journal of biological chemistry
Shang X,Cancelas JA,Li L,Guo F,Liu W,Johnson JF,Ficker A,Daria D,Geiger H,Ratner N,Zheng Y
Fri Jul 08 00:00:00 EDT 2011
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
The Journal of biological chemistry
Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR
Fri Jun 10 00:00:00 EDT 2011
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.
PloS one
Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K
Thu Jan 26 00:00:00 EST 2012
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
The Journal of biological chemistry
Dagälv A,Holmborn K,Kjellén L,Abrink M
Fri Dec 30 00:00:00 EST 2011
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.
BMC immunology
Arumugam M,Ahrens R,Osterfeld H,Kottyan LC,Shang X,Maclennan JA,Zimmermann N,Zheng Y,Finkelman FD,Hogan SP
Thu Feb 03 00:00:00 EST 2011
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.
PloS one
Zhang J,Alcaide P,Liu L,Sun J,He A,Luscinskas FW,Shi GP
Fri Jan 14 00:00:00 EST 2011
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PloS one
Ohno T,Oboki K,Morita H,Kajiwara N,Arae K,Tanaka S,Ikeda M,Iikura M,Akiyama T,Inoue J,Matsumoto K,Sudo K,Azuma M,Okumura K,Kamradt T,Saito H,Nakae S
Mon Apr 11 00:00:00 EDT 2011
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
The Journal of biological chemistry
Coloff JL,Mason EF,Altman BJ,Gerriets VA,Liu T,Nichols AN,Zhao Y,Wofford JA,Jacobs SR,Ilkayeva O,Garrison SP,Zambetti GP,Rathmell JC
Fri Feb 18 00:00:00 EST 2011
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
The Journal of biological chemistry
Arora D,Stopp S,Böhmer SA,Schons J,Godfrey R,Masson K,Razumovskaya E,Rönnstrand L,Tänzer S,Bauer R,Böhmer FD,Müller JP
Fri Apr 01 00:00:00 EDT 2011
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.
PloS one
Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C
Tue Apr 26 00:00:00 EDT 2011
Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
The Journal of biological chemistry
Nörenberg W,Hempel C,Urban N,Sobottka H,Illes P,Schaefer M
Fri Apr 01 00:00:00 EDT 2011
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
Nature
Nakada D,Saunders TL,Morrison SJ
Thu Dec 02 00:00:00 EST 2010
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 EDT 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 EST 2010
Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.
Blood
van der Poel CE,Karssemeijer RA,Boross P,van der Linden JA,Blokland M,van de Winkel JG,Leusen JH
Thu Dec 09 00:00:00 EST 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 EST 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 EST 2010
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Blood
Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S
Thu Jan 21 00:00:00 EST 2010
Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development.
Blood
Li H,Ji M,Klarmann KD,Keller JR
Thu Aug 19 00:00:00 EDT 2010
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
Blood
Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS
Thu Aug 26 00:00:00 EDT 2010
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.
Blood
Singbrant S,Karlsson G,Ehinger M,Olsson K,Jaako P,Miharada K,Stadtfeld M,Graf T,Karlsson S
Thu Jun 10 00:00:00 EDT 2010
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood
Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT
Thu Dec 23 00:00:00 EST 2010
The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells.
Blood
Drube S,Heink S,Walter S,Löhn T,Grusser M,Gerbaulet A,Berod L,Schons J,Dudeck A,Freitag J,Grotha S,Reich D,Rudeschko O,Norgauer J,Hartmann K,Roers A,Kamradt T
Thu May 13 00:00:00 EDT 2010
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Blood
Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA
Thu May 20 00:00:00 EDT 2010
Downstream targets of HOXB4 in a cell line model of primitive hematopoietic progenitor cells.
Blood
Lee HM,Zhang H,Schulz V,Tuck DP,Forget BG
Thu Aug 05 00:00:00 EDT 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 EST 2010
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.
Blood
de la Luz Sierra M,Sakakibara S,Gasperini P,Salvucci O,Jiang K,McCormick PJ,Segarra M,Stone J,Maric D,Zhu J,Qian X,Lowy DR,Tosato G
Thu May 13 00:00:00 EDT 2010
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Blood
Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H
Thu Jun 03 00:00:00 EDT 2010
Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells.
Blood
Heaney NB,Pellicano F,Zhang B,Crawford L,Chu S,Kazmi SM,Allan EK,Jorgensen HG,Irvine AE,Bhatia R,Holyoake TL
Thu Mar 18 00:00:00 EDT 2010
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
Thu Jun 17 00:00:00 EDT 2010
A key role for ATF3 in regulating mast cell survival and mediator release.
Blood
Gilchrist M,Henderson WR,Morotti A,Johnson CD,Nachman A,Schmitz F,Smith KD,Aderem A
Thu Jun 10 00:00:00 EDT 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
Blood
Vemula S,Shi J,Hanneman P,Wei L,Kapur R
Thu Mar 04 00:00:00 EST 2010
Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Blood
Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F
Thu Dec 02 00:00:00 EST 2010
Serum response factor is an essential transcription factor in megakaryocytic maturation.
Blood
Halene S,Gao Y,Hahn K,Massaro S,Italiano JE,Schulz V,Lin S,Kupfer GM,Krause DS
Thu Sep 16 00:00:00 EDT 2010
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
Blood
Pulliam-Leath AC,Ciccone SL,Nalepa G,Li X,Si Y,Miravalle L,Smith D,Yuan J,Li J,Anur P,Orazi A,Vance GH,Yang FC,Hanenberg H,Bagby GC,Clapp DW
Thu Oct 21 00:00:00 EDT 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
Thu Oct 07 00:00:00 EDT 2010
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Blood
Li G,Miskimen KL,Wang Z,Xie XY,Brenzovich J,Ryan JJ,Tse W,Moriggl R,Bunting KD
Thu Feb 18 00:00:00 EST 2010
Leukemogenic transformation by HOXA cluster genes.
Blood
Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK
Thu Apr 08 00:00:00 EDT 2010
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts.
The Journal of clinical investigation
Liao CH,Akazawa H,Tamagawa M,Ito K,Yasuda N,Kudo Y,Yamamoto R,Ozasa Y,Fujimoto M,Wang P,Nakauchi H,Nakaya H,Komuro I
Fri Jan 01 00:00:00 EST 2010
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
The Journal of clinical investigation
Si Y,Tsou CL,Croft K,Charo IF
Thu Apr 01 00:00:00 EDT 2010
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
The Journal of experimental medicine
Morita Y,Ema H,Nakauchi H
Mon Jun 07 00:00:00 EDT 2010
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.
The Journal of experimental medicine
Yu L,Ji W,Zhang H,Renda MJ,He Y,Lin S,Cheng EC,Chen H,Krause DS,Min W
Mon Jun 07 00:00:00 EDT 2010
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
The Journal of experimental medicine
Henderson RB,Grys K,Vehlow A,de Bettignies C,Zachacz A,Henley T,Turner M,Batista F,Tybulewicz VL
Mon Apr 12 00:00:00 EDT 2010
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
The Journal of experimental medicine
Lauterbach H,Bathke B,Gilles S,Traidl-Hoffmann C,Luber CA,Fejer G,Freudenberg MA,Davey GM,Vremec D,Kallies A,Wu L,Shortman K,Chaplin P,Suter M,O'Keeffe M,Hochrein H
Mon Nov 22 00:00:00 EST 2010
Sulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.
The Journal of experimental medicine
Buono M,Visigalli I,Bergamasco R,Biffi A,Cosma MP
Mon Aug 02 00:00:00 EDT 2010
NIP45 controls the magnitude of the type 2 T helper cell response.
Proceedings of the National Academy of Sciences of the United States of America
Fathman JW,Gurish MF,Hemmers S,Bonham K,Friend DS,Grusby MJ,Glimcher LH,Mowen KA
Tue Feb 23 00:00:00 EST 2010
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
Proceedings of the National Academy of Sciences of the United States of America
Foukas LC,Berenjeno IM,Gray A,Khwaja A,Vanhaesebroeck B
Tue Jun 22 00:00:00 EDT 2010
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Naramura M,Nandwani N,Gu H,Band V,Band H
Tue Sep 14 00:00:00 EDT 2010
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.
Haematologica
Kalfa TA,Pushkaran S,Zhang X,Johnson JF,Pan D,Daria D,Geiger H,Cancelas JA,Williams DA,Zheng Y
Fri Jan 01 00:00:00 EST 2010
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.
PLoS biology
Pop R,Shearstone JR,Shen Q,Liu Y,Hallstrom K,Koulnis M,Gribnau J,Socolovsky M
Tue Sep 21 00:00:00 EDT 2010
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis.
PLoS pathogens
Garrison SP,Thornton JA,Häcker H,Webby R,Rehg JE,Parganas E,Zambetti GP,Tuomanen EI
Thu Dec 23 00:00:00 EST 2010
Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.
Stem cells (Dayton, Ohio)
Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G
Sat May 01 00:00:00 EDT 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 EDT 2010
Basophils support the survival of plasma cells in mice.
Journal of immunology (Baltimore, Md. : 1950)
Rodriguez Gomez M,Talke Y,Goebel N,Hermann F,Reich B,Mack M
Wed Dec 15 00:00:00 EST 2010
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950)
Scandiuzzi L,Beghdadi W,Daugas E,Abrink M,Tiwari N,Brochetta C,Claver J,Arouche N,Zang X,Pretolani M,Monteiro RC,Pejler G,Blank U
Thu Jul 01 00:00:00 EDT 2010
Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Alvarez-Errico D,Yamashita Y,Suzuki R,Odom S,Furumoto Y,Yamashita T,Rivera J
Sat May 01 00:00:00 EDT 2010
A critical role for mast cells and mast cell-derived IL-6 in TLR2-mediated inhibition of tumor growth.
Journal of immunology (Baltimore, Md. : 1950)
Oldford SA,Haidl ID,Howatt MA,Leiva CA,Johnston B,Marshall JS
Wed Dec 01 00:00:00 EST 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
Thu Jul 01 00:00:00 EDT 2010
PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Samayawardhena LA,Pallen CJ
Mon Nov 15 00:00:00 EST 2010
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Wrzesinski C,Paulos CM,Kaiser A,Muranski P,Palmer DC,Gattinoni L,Yu Z,Rosenberg SA,Restifo NP
Fri Jan 01 00:00:00 EST 2010
Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.
Gene therapy
Maetzig T,Galla M,Brugman MH,Loew R,Baum C,Schambach A
Mon Mar 01 00:00:00 EST 2010
Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model.
PloS one
Yang Z,Zhang B,Li D,Lv M,Huang C,Shen GX,Huang B
Wed Jan 27 00:00:00 EST 2010
Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.
The Journal of biological chemistry
Zhang Y,Tang W,Jones MC,Xu W,Halene S,Wu D
Fri Aug 06 00:00:00 EDT 2010
Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.
Virology journal
Fratini P,Strauss BE
Fri Jan 22 00:00:00 EST 2010
STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.
The Journal of biological chemistry
Funakoshi-Tago M,Tago K,Abe M,Sonoda Y,Kasahara T
Fri Feb 19 00:00:00 EST 2010
Hepatocyte nuclear factor-4alpha induces transdifferentiation of hematopoietic cells into hepatocytes.
The Journal of biological chemistry
Khurana S,Jaiswal AK,Mukhopadhyay A
Fri Feb 12 00:00:00 EST 2010
Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.
The Journal of biological chemistry
Ohtake-Niimi S,Kondo S,Ito T,Kakehi S,Ohta T,Habuchi H,Kimata K,Habuchi O
Fri Jul 02 00:00:00 EDT 2010
Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts.
The Journal of biological chemistry
Heneberg P,Dráberová L,Bambousková M,Pompach P,Dráber P
Fri Apr 23 00:00:00 EDT 2010
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).
The Journal of biological chemistry
Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM
Fri Jul 09 00:00:00 EDT 2010
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
Nature
Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T
Thu Nov 05 00:00:00 EST 2009
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG
Thu Jan 01 00:00:00 EST 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 EDT 2009
Intraclonal competition limits the fate determination of regulatory T cells in the thymus.
Nature immunology
Bautista JL,Lio CW,Lathrop SK,Forbush K,Liang Y,Luo J,Rudensky AY,Hsieh CS
Mon Jun 01 00:00:00 EDT 2009
Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression.
Blood
Fromm G,de Vries C,Byron R,Fields J,Fiering S,Groudine M,Bender MA,Palis J,Bulger M
Thu Oct 15 00:00:00 EDT 2009
Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.
Blood
Piconese S,Gri G,Tripodo C,Musio S,Gorzanelli A,Frossi B,Pedotti R,Pucillo CE,Colombo MP
Thu Sep 24 00:00:00 EDT 2009
HOXA9 is required for survival in human MLL-rearranged acute leukemias.
Blood
Faber J,Krivtsov AV,Stubbs MC,Wright R,Davis TN,van den Heuvel-Eibrink M,Zwaan CM,Kung AL,Armstrong SA
Thu Mar 12 00:00:00 EDT 2009
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood
Nordigården A,Kraft M,Eliasson P,Labi V,Lam EW,Villunger A,Jönsson JI
Thu Mar 05 00:00:00 EST 2009
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Blood
Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL
Thu May 28 00:00:00 EDT 2009
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.
Blood
Praetor A,McBride JM,Chiu H,Rangell L,Cabote L,Lee WP,Cupp J,Danilenko DM,Fong S
Thu Feb 26 00:00:00 EST 2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Blood
Cochrane SW,Zhao Y,Welner RS,Sun XH
Thu Jan 29 00:00:00 EST 2009
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.
Blood
Li Y,Chen S,Yuan J,Yang Y,Li J,Ma J,Wu X,Freund M,Pollok K,Hanenberg H,Goebel WS,Yang FC
Thu Mar 05 00:00:00 EST 2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Blood
Rice KL,Hormaeche I,Doulatov S,Flatow JM,Grimwade D,Mills KI,Leiva M,Ablain J,Ambardekar C,McConnell MJ,Dick JE,Licht JD
Thu Dec 24 00:00:00 EST 2009
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Blood
Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B
Thu Nov 05 00:00:00 EST 2009
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.
Blood
Blue R,Kowalska MA,Hirsch J,Murcia M,Janczak CA,Harrington A,Jirouskova M,Li J,Fuentes R,Thornton MA,Filizola M,Poncz M,Coller BS
Thu Jul 02 00:00:00 EDT 2009
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality.
Blood
Schmidt-Arras D,Böhmer SA,Koch S,Müller JP,Blei L,Cornils H,Bauer R,Korasikha S,Thiede C,Böhmer FD
Thu Apr 09 00:00:00 EDT 2009
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Blood
Lannutti BJ,Epp A,Roy J,Chen J,Josephson NC
Thu Feb 19 00:00:00 EST 2009
Role for MKL1 in megakaryocytic maturation.
Blood
Cheng EC,Luo Q,Bruscia EM,Renda MJ,Troy JA,Massaro SA,Tuck D,Schulz V,Mane SM,Berliner N,Sun Y,Morris SW,Qiu C,Krause DS
Thu Mar 19 00:00:00 EDT 2009
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.
Blood
Kuo YH,Zaidi SK,Gornostaeva S,Komori T,Stein GS,Castilla LH
Thu Apr 02 00:00:00 EDT 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 EDT 2009
Negative regulation of activated alpha-2 integrins during thrombopoiesis.
Blood
Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML
Thu Jun 18 00:00:00 EDT 2009
Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model.
Blood
Hu X,Shen H,Tian C,Yu H,Zheng G,XuFeng R,Ju Z,Xu J,Wang J,Cheng T
Thu Oct 29 00:00:00 EDT 2009
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.
Blood
Velu CS,Baktula AM,Grimes HL
Thu May 07 00:00:00 EDT 2009
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Blood
Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW
Thu Mar 19 00:00:00 EDT 2009
Critical role of class IA PI3K for c-Rel expression in B lymphocytes.
Blood
Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S
Thu Jan 29 00:00:00 EST 2009
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood
Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD
Thu Oct 22 00:00:00 EDT 2009
Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.
Blood
Milsom MD,Schiedlmeier B,Bailey J,Kim MO,Li D,Jansen M,Ali AM,Kirby M,Baum C,Fairbairn LJ,Williams DA
Thu May 21 00:00:00 EDT 2009
Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.
Blood
Horton SJ,Walf-Vorderwülbecke V,Chatters SJ,Sebire NJ,de Boer J,Williams O
Thu May 14 00:00:00 EDT 2009
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation
Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L
Wed Apr 01 00:00:00 EDT 2009
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
Mon Nov 23 00:00:00 EST 2009
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
The Journal of experimental medicine
Fukui R,Saitoh S,Matsumoto F,Kozuka-Hata H,Oyama M,Tabeta K,Beutler B,Miyake K
Mon Jun 08 00:00:00 EDT 2009
Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.
The EMBO journal
Sheng Z,Wang SZ,Green MR
Wed Apr 08 00:00:00 EDT 2009
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.
Molecular therapy : the journal of the American Society of Gene Therapy
Modlich U,Navarro S,Zychlinski D,Maetzig T,Knoess S,Brugman MH,Schambach A,Charrier S,Galy A,Thrasher AJ,Bueren J,Baum C
Sun Nov 01 00:00:00 EDT 2009
Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes.
Leukemia
Kozuma Y,Yuki S,Ninomiya H,Nagasawa T,Kojima H
Mon Jun 01 00:00:00 EDT 2009
CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients.
Leukemia
Pardanani A,Lasho T,Smith G,Burns CJ,Fantino E,Tefferi A
Sat Aug 01 00:00:00 EDT 2009
Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America
Groschwitz KR,Ahrens R,Osterfeld H,Gurish MF,Han X,Abrink M,Finkelman FD,Pejler G,Hogan SP
Tue Dec 29 00:00:00 EST 2009
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Proceedings of the National Academy of Sciences of the United States of America
Schmaier AA,Zou Z,Kazlauskas A,Emert-Sedlak L,Fong KP,Neeves KB,Maloney SF,Diamond SL,Kunapuli SP,Ware J,Brass LF,Smithgall TE,Saksela K,Kahn ML
Tue Dec 15 00:00:00 EST 2009
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America
Mathas S,Kreher S,Meaburn KJ,Jöhrens K,Lamprecht B,Assaf C,Sterry W,Kadin ME,Daibata M,Joos S,Hummel M,Stein H,Janz M,Anagnostopoulos I,Schrock E,Misteli T,Dörken B
Tue Apr 07 00:00:00 EDT 2009
Misguided transcriptional elongation causes mixed lineage leukemia.
PLoS biology
Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK
Sun Nov 01 00:00:00 EDT 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 EST 2009
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Ogaeri T,Eto K,Otsu M,Ema H,Nakauchi H
Fri May 01 00:00:00 EDT 2009
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Ohno T,Oboki K,Kajiwara N,Morii E,Aozasa K,Flavell RA,Okumura K,Saito H,Nakae S
Tue Dec 15 00:00:00 EST 2009
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R
Sun Feb 15 00:00:00 EST 2009
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA
Wed Apr 15 00:00:00 EDT 2009
Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties.
Journal of immunology (Baltimore, Md. : 1950)
Smith TR,Tang X,Maricic I,Garcia Z,Fanchiang S,Kumar V
Mon Jun 01 00:00:00 EDT 2009
14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Ajjappala BS,Kim YS,Kim MS,Lee MY,Lee KY,Ki HY,Cha DH,Baek KH
Thu Jan 15 00:00:00 EST 2009
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A
Sat Aug 01 00:00:00 EDT 2009
Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Zheng H,Matte-Martone C,Jain D,McNiff J,Shlomchik WD
Fri May 15 00:00:00 EDT 2009
Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes.
Journal of immunology (Baltimore, Md. : 1950)
Kim S,Shen T,Min B
Tue Sep 01 00:00:00 EDT 2009
Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
Journal of immunology (Baltimore, Md. : 1950)
Duelli A,Rönnberg E,Waern I,Ringvall M,Kolset SO,Pejler G
Tue Dec 01 00:00:00 EST 2009
Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
Journal of immunology (Baltimore, Md. : 1950)
Carlens J,Wahl B,Ballmaier M,Bulfone-Paus S,Förster R,Pabst O
Sun Nov 01 00:00:00 EDT 2009
Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.
Journal of immunology (Baltimore, Md. : 1950)
Tagen M,Elorza A,Kempuraj D,Boucher W,Kepley CL,Shirihai OS,Theoharides TC
Sun Nov 15 00:00:00 EST 2009
A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.
The Journal of biological chemistry
Zhao L,Dong H,Zhang CC,Kinch L,Osawa M,Iacovino M,Grishin NV,Kyba M,Huang LJ
Fri Sep 25 00:00:00 EDT 2009
IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.
PloS one
Ernst J,Ghanem L,Bar-Joseph Z,McNamara M,Brown J,Steinman RA
Thu Oct 15 00:00:00 EDT 2009
Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.
The Journal of biological chemistry
Gao Y,Howard A,Ban K,Chandra J
Fri Mar 13 00:00:00 EDT 2009
Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.
The Journal of biological chemistry
Marty C,Chaligné R,Lacout C,Constantinescu SN,Vainchenker W,Villeval JL
Fri May 01 00:00:00 EDT 2009
Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.
PloS one
Miletic AV,Graham DB,Sakata-Sogawa K,Hiroshima M,Hamann MJ,Cemerski S,Kloeppel T,Billadeau DD,Kanagawa O,Tokunaga M,Swat W
Wed Aug 12 00:00:00 EDT 2009
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
PloS one
Johnson KJ,Griswold IJ,O'Hare T,Corbin AS,Loriaux M,Deininger MW,Druker BJ
Tue Oct 13 00:00:00 EDT 2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry
Lin IJ,Zhou Z,Crusselle-Davis VJ,Moghimi B,Gandhi K,Anantharaman A,Pantic D,Huang S,Jayandharan G,Zhong L,Srivastava A,Bungert J
Fri Jul 24 00:00:00 EDT 2009
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell
Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA
Tue Nov 04 00:00:00 EST 2008
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Blood
Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T
Fri Feb 15 00:00:00 EST 2008
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.
Blood
Crist SA,Sprague DL,Ratliff TL
Tue Apr 01 00:00:00 EDT 2008
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America
Gan B,Sahin E,Jiang S,Sanchez-Aguilera A,Scott KL,Chin L,Williams DA,Kwiatkowski DJ,DePinho RA
Tue Dec 09 00:00:00 EST 2008
Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo.
Stem cells (Dayton, Ohio)
Kobune M,Kato J,Kawano Y,Sasaki K,Uchida H,Takada K,Takahashi S,Takimoto R,Niitsu Y
Fri Feb 01 00:00:00 EST 2008
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
Stem cells (Dayton, Ohio)
Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR
Sun Jun 01 00:00:00 EDT 2008
Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.
Journal of immunology (Baltimore, Md. : 1950)
Watanabe M,Satoh T,Yamamoto Y,Kanai Y,Karasuyama H,Yokozeki H
Wed Oct 15 00:00:00 EDT 2008
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuehn HS,Swindle EJ,Kim MS,Beaven MA,Metcalfe DD,Gilfillan AM
Mon Dec 01 00:00:00 EST 2008
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Journal of immunology (Baltimore, Md. : 1950)
Song C,Luo L,Lei Z,Li B,Liang Z,Liu G,Li D,Zhang G,Huang B,Feng ZH
Sat Nov 01 00:00:00 EDT 2008
Instant conditional transgenesis in the mouse hematopoietic compartment.
Journal of immunological methods
Csikós T,Reijmers RM,Uren AG,Spaargaren M,Pals ST
Wed Dec 31 00:00:00 EST 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 EST 2009
Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC immunology
Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD
Thu Aug 07 00:00:00 EDT 2008
Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPepsilon gene.
Blood
Khanna-Gupta A,Sun H,Zibello T,Lee HM,Dahl R,Boxer LA,Berliner N
Tue May 15 00:00:00 EDT 2007
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Blood
Yang L,Wang L,Kalfa TA,Cancelas JA,Shang X,Pushkaran S,Mo J,Williams DA,Zheng Y
Sat Dec 01 00:00:00 EST 2007
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
Blood
Wu Y,Welte T,Michaud M,Madri JA
Wed Aug 01 00:00:00 EDT 2007
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 EDT 2007
Mast cells are essential intermediaries in regulatory T-cell tolerance.
Nature
Lu LF,Lind EF,Gondek DC,Bennett KA,Gleeson MW,Pino-Lagos K,Scott ZA,Coyle AJ,Reed JL,Van Snick J,Strom TB,Zheng XX,Noelle RJ
Thu Aug 31 00:00:00 EDT 2006
The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.
Blood
Trudel S,Stewart AK,Rom E,Wei E,Li ZH,Kotzer S,Chumakov I,Singer Y,Chang H,Liang SB,Yayon A
Mon May 15 00:00:00 EDT 2006
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
The Journal of biological chemistry
Zhang X,Ibrahimi OA,Olsen SK,Umemori H,Mohammadi M,Ornitz DM
Fri Jun 09 00:00:00 EDT 2006
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry
McDowell LM,Frazier BA,Studelska DR,Giljum K,Chen J,Liu J,Yu K,Ornitz DM,Zhang L
Fri Mar 17 00:00:00 EST 2006
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 EDT 2005
Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23.
Endocrinology
Yu X,Ibrahimi OA,Goetz R,Zhang F,Davis SI,Garringer HJ,Linhardt RJ,Ornitz DM,Mohammadi M,White KE
Tue Nov 01 00:00:00 EST 2005
Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.
The Journal of biological chemistry
Yamauchi A,Marchal CC,Molitoris J,Pech N,Knaus U,Towe J,Atkinson SJ,Dinauer MC
Fri Jan 14 00:00:00 EST 2005
Basophils initiate IL-4 production during a memory T-dependent response.
The Journal of experimental medicine
Khodoun MV,Orekhova T,Potter C,Morris S,Finkelman FD
Mon Oct 04 00:00:00 EDT 2004
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Blood
Xie X,Chan RJ,Johnson SA,Starr M,McCarthy J,Kapur R,Yoder MC
Sat Feb 15 00:00:00 EST 2003
A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.
Blood
Chandra S,Kapur R,Chuzhanova N,Summey V,Prentice D,Barker J,Cooper DN,Williams DA
Sat Nov 15 00:00:00 EST 2003
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 EST 2003
Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.
Cancer research
Kobune M,Xu Y,Baum C,Kelley MR,Williams DA
Sun Jul 01 00:00:00 EDT 2001
TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation.
Journal of immunology (Baltimore, Md. : 1950)
Rovida E,Paccagnini A,Del Rosso M,Peschon J,Dello Sbarba P
213-13 was used in Cell Culture to study how M-CSFR is shed from macrophage surface and identify the protease responsible for M-CSFR cleavage and down-modulation and demonstrate how the proTNF-converting enzyme (TACE) protease is responsible for M-CSFR shedding and down-modulation in mononuclear phagocytes undergoing activation.
Thu Feb 01 00:00:00 EST 2001
The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation.
Blood
Peled A,Gonzalo JA,Lloyd C,Gutierrez-Ramos JC
Sun Mar 15 00:00:00 EST 1998
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 EDT 1998
Studies of thiamine metabolism in man; thiamine and pyrimidine excretion with special reference to the relationship between injected and excreted thiamine in normal and abnormal subjects.
The Journal of clinical investigation
ALEXANDER B,LANDWEHR G,MITCHELL F
Wed May 01 00:00:00 EDT 1946