Product References
Intermittent cold exposure improves glucose homeostasis despite exacerbating diet-induced obesity in mice housed at thermoneutrality.
The Journal of physiology
McKie GL,Shamshoum H,Hunt KL,Thorpe HHA,Dibe HA,Khokhar JY,Doucette CA,Wright DC
450-31 was used in In vivo experiments to suggest that ICE, despite improving glucose tolerance, is not an effective obesity treatment in mice housed under humanized conditions.
Tue Feb 01 00:00:00 EST 2022
Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPKα and miR-33a levels to increase apoptosis in Panc-1 and MiaPaCa-2 cells.
Biotechnology and applied biochemistry
Rencuzogulları O,Yerlikaya PO,Gürkan AÇ,Arısan ED,Telci D
450-31 was used in Cell Culture to provide that a deeper understanding about possible interactions of cell cycle activity and reduction of FAs synthesis may facilitate the enhancement of cell death mechanisms in pancreatic cancer cells.
Tue Feb 01 00:00:00 EST 2022
Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells.
Journal of neurochemistry
Yoshida R,Margolskee RF,Ninomiya Y
450-31 was used in In vitro experiments to conclude that leptin suppresses sweet responses of T1R3-positive taste cells by activation of Ob-Rb-PI3K-KATP channel pathway.
Thu Jul 01 00:00:00 EDT 2021
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.
Cell reports
Heiss CN,Mannerås-Holm L,Lee YS,Serrano-Lobo J,Håkansson Gladh A,Seeley RJ,Drucker DJ,Bäckhed F,Olofsson LE
Tue May 25 00:00:00 EDT 2021
Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity.
Nature metabolism
Porniece Kumar M,Cremer AL,Klemm P,Steuernagel L,Sundaram S,Jais A,Hausen AC,Tao J,Secher A,Pedersen TÅ,Schwaninger M,Wunderlich FT,Lowell BB,Backes H,Brüning JC
Wed Dec 01 00:00:00 EST 2021
Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice.
Scientific reports
Takenaga K,Akimoto M,Koshikawa N,Nagase H
Wed Feb 03 00:00:00 EST 2021
MCH Neurons Regulate Permeability of the Median Eminence Barrier.
Neuron
Jiang H,Gallet S,Klemm P,Scholl P,Folz-Donahue K,Altmüller J,Alber J,Heilinger C,Kukat C,Loyens A,Müller-Fielitz H,Sundaram S,Schwaninger M,Prevot V,Brüning JC
Wed Jul 22 00:00:00 EDT 2020
Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring.
PLoS biology
Park S,Jang A,Bouret SG
450-31 was used in In vivo experiments to study the importance of early life endoplasmic reticulum (ER) stress in the nutritional programming of type II diabetes mellitus metabolic disease using a mouse model of maternal obesity.
Sun Mar 01 00:00:00 EST 2020
Sugar causes obesity and metabolic syndrome in mice independently of sweet taste.
American journal of physiology. Endocrinology and metabolism
Andres-Hernando A,Kuwabara M,Orlicky DJ,Vandenbeuch A,Cicerchi C,Kinnamon SC,Finger TE,Johnson RJ,Lanaspa MA
Sat Aug 01 00:00:00 EDT 2020
Identification of blood cell transcriptome-based biomarkers in adulthood predictive of increased risk to develop metabolic disorders using early life intervention rat models.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Szostaczuk N,van Schothorst EM,Sánchez J,Priego T,Palou M,Bekkenkamp-Grovenstein M,Faustmann G,Obermayer-Pietsch B,Tiran B,Roob JM,Winklhofer-Roob BM,Keijer J,Palou A,Picó C
Wed Jul 01 00:00:00 EDT 2020
Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
The Journal of cell biology
Casas M,Fadó R,Domínguez JL,Roig A,Kaku M,Chohnan S,Solé M,Unzeta M,Miñano-Molina AJ,Rodríguez-Álvarez J,Dickson EJ,Casals N
450-31 was used in Cell Culture to reveal that GluA1 trafficking is regulated by CPT1C sensing of malonyl-CoA and provide the first report of a SAC1 inhibitor.
Mon Oct 05 00:00:00 EDT 2020
Ruxolitinib can cause weight gain by blocking leptin signaling in the brain via JAK2/STAT3.
Blood
Mollé N,Krichevsky S,Kermani P,Silver RT,Ritchie E,Scandura JM
Thu Mar 26 00:00:00 EDT 2020
Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice.
Scientific reports
Wang J,Ortiz C,Fontenot L,Mukhopadhyay R,Xie Y,Law IKM,Shih DQ,Mattai SA,Li Z,Koon HW
Thu Jul 30 00:00:00 EDT 2020
Sex-specific effects of leptin administration to pregnant mice on the placentae and the metabolic phenotypes of offspring.
FEBS open bio
Denisova EI,Kozhevnikova VV,Bazhan NM,Makarova EN
Wed Jan 01 00:00:00 EST 2020
Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice.
Journal of lipid research
Miralpeix C,Fosch A,Casas J,Baena M,Herrero L,Serra D,Rodríguez-Rodríguez R,Casals N
Mon Jul 01 00:00:00 EDT 2019
Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues.
Scientific reports
Pereira S,O'Dwyer SM,Webber TD,Baker RK,So V,Ellis CE,Yoon JS,Mojibian M,Glavas MM,Karunakaran S,Clee SM,Covey SD,Kieffer TJ
Fri Mar 01 00:00:00 EST 2019
Tanycyte-Independent Control of Hypothalamic Leptin Signaling.
Frontiers in neuroscience
Yoo S,Cha D,Kim DW,Hoang TV,Blackshaw S
450-31 was used in In vivo experiments to analyse the expression and function of the tanycytic leptin receptor in mice.
Wed Sep 30 00:00:00 EDT 2020
Attenuation of Inflammation and Leptin Resistance by Pyrogallol-Phloroglucinol-6,6-Bieckol on in the Brain of Obese Animal Models.
Nutrients
Son M,Oh S,Choi J,Jang JT,Choi CH,Park KY,Son KH,Byun K
450-31 was used in In vivo experiments to evaluate the effects of PPB effect M1 polarization and inflammation and its ability to restore the effects of leptin, such as a decrease in appetite and body weight.
Thu Nov 14 00:00:00 EST 2019
Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C.
International journal of obesity (2005)
Becerril S,Rodríguez A,Catalán V,Méndez-Giménez L,Ramírez B,Sáinz N,Llorente M,Unamuno X,Gómez-Ambrosi J,Frühbeck G
Wed Aug 01 00:00:00 EDT 2018
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling.
Nature communications
Zhang L,Ip CK,Lee IJ,Qi Y,Reed F,Karl T,Low JK,Enriquez RF,Lee NJ,Baldock PA,Herzog H
Fri Nov 09 00:00:00 EST 2018
The LepR-mediated leptin transport across brain barriers controls food reward.
Molecular metabolism
Di Spiezio A,Sandin ES,Dore R,Müller-Fielitz H,Storck SE,Bernau M,Mier W,Oster H,Jöhren O,Pietrzik CU,Lehnert H,Schwaninger M
450-31 was used in In vivo experiments to study which of the central effects of leptin has to penetrate brain barriers and the mechanism mediating the transport across barriers.
Thu Feb 01 00:00:00 EST 2018
Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for Leptin Alleviating Inflammation in Adipose Tissue.
Frontiers in immunology
Gan L,Liu Z,Luo D,Ren Q,Wu H,Li C,Sun C
450-31 was used in Sample Preparation(ELISA) to identify a new potential means for intervention of autophagy to prevent or treat obese caused metabolic syndrome of mammals.
Wed Nov 20 00:00:00 EST 2019
Perinatal Exposure to Low-Dose Bisphenol-A Disrupts the Structural and Functional Development of the Hypothalamic Feeding Circuitry.
Endocrinology
MacKay H,Patterson ZR,Abizaid A
450-31 was used in In vivo experiments to investigate bisphenol-A in obesity.
Sat Apr 01 00:00:00 EDT 2017
Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation.
Scientific reports
Desai HR,Sivasubramaniyam T,Revelo XS,Schroer SA,Luk CT,Rikkala PR,Metherel AH,Dodington DW,Park YJ,Kim MJ,Rapps JA,Besla R,Robbins CS,Wagner KU,Bazinet RP,Winer DA,Woo M
450-31 was used in Cell Culture to show that macrophage JAK2 deficiency improves systemic insulin sensitivity and reduces inflammation in VAT and liver in response to metabolic stress.
Wed Aug 09 00:00:00 EDT 2017
Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906.
Scientific reports
Tajima K,Shirakawa J,Togashi Y,Yamazaki S,Okuyama T,Kyohara M,Konishi H,Terauchi Y
Fri Jun 23 00:00:00 EDT 2017
Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β2-adrenergic receptor but not by AMPK.
Scientific reports
Shiuchi T,Toda C,Okamoto S,Coutinho EA,Saito K,Miura S,Ezaki O,Minokoshi Y
Thu Nov 09 00:00:00 EST 2017
p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.
Scientific reports
Litwak SA,Loh K,Stanley WJ,Pappas EG,Wali JA,Selck C,Strasser A,Thomas HE,Gurzov EN
Fri Apr 01 00:00:00 EDT 2016
Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis.
Scientific reports
Kessoku T,Imajo K,Honda Y,Kato T,Ogawa Y,Tomeno W,Kato S,Mawatari H,Fujita K,Yoneda M,Nagashima Y,Saito S,Wada K,Nakajima A
Thu Feb 25 00:00:00 EST 2016
Developmental Responses of the Lateral Hypothalamus to Leptin in Neonatal Rats, and its Implications for the Development of Functional Connections with the Ventral Tegmental Area.
Journal of neuroendocrinology
Gjerde E,Long H,Richard D,Walker CD
450-31 was used in Tissue/organ culture to test whether phenotypically identified neurones of the LH that respond to leptin project to ventral tegmental area (VTA) neurones.
Tue Mar 01 00:00:00 EST 2016
Leptin and insulin act on POMC neurons to promote the browning of white fat.
Cell
Dodd GT,Decherf S,Loh K,Simonds SE,Wiede F,Balland E,Merry TL,Münzberg H,Zhang ZY,Kahn BB,Neel BG,Bence KK,Andrews ZB,Cowley MA,Tiganis T
Thu Jan 15 00:00:00 EST 2015
Neonatal ghrelin programs development of hypothalamic feeding circuits.
The Journal of clinical investigation
Steculorum SM,Collden G,Coupe B,Croizier S,Lockie S,Andrews ZB,Jarosch F,Klussmann S,Bouret SG
Sun Feb 01 00:00:00 EST 2015
Neonatal ghrelin programs development of hypothalamic feeding circuits.
The Journal of clinical investigation
Steculorum SM,Collden G,Coupe B,Croizier S,Lockie S,Andrews ZB,Jarosch F,Klussmann S,Bouret SG
Sun Feb 01 00:00:00 EST 2015
Dual action of leptin on rest-firing and stimulated catecholamine release via phosphoinositide 3-kinase-driven BK channel up-regulation in mouse chromaffin cells.
The Journal of physiology
Gavello D,Vandael D,Gosso S,Carbone E,Carabelli V
450-31 was used in In vitro experiments to investigate cellular effects of leptin in mice.
Sun Nov 15 00:00:00 EST 2015
Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice.
Scientific reports
Rodríguez A,Moreno NR,Balaguer I,Méndez-Giménez L,Becerril S,Catalán V,Gómez-Ambrosi J,Portincasa P,Calamita G,Soveral G,Malagón MM,Frühbeck G
Fri Jul 10 00:00:00 EDT 2015
Blood cell transcriptomic-based early biomarkers of adverse programming effects of gestational calorie restriction and their reversibility by leptin supplementation.
Scientific reports
Konieczna J,Sánchez J,Palou M,Picó C,Palou A
Fri Mar 13 00:00:00 EDT 2015
Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction.
The Journal of clinical investigation
Bellefontaine N,Chachlaki K,Parkash J,Vanacker C,Colledge W,d'Anglemont de Tassigny X,Garthwaite J,Bouret SG,Prevot V
Sun Jun 01 00:00:00 EDT 2014
PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding.
The Journal of clinical investigation
Long L,Toda C,Jeong JK,Horvath TL,Diano S
Mon Sep 01 00:00:00 EDT 2014
Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits.
Hypertension (Dallas, Tex. : 1979)
Lim K,Burke SL,Head GA
450-31 was used in In vivo experiments to analyse the contribution of leptin and insulin in promoting hypertension and raising RSNA after a high-fat diet. Findings highlight leptin as the key modulator, while insulin is only a secondry contributor with a activity in raising blood pressure only.
Fri Mar 01 00:00:00 EST 2013
Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lee SJ,Verma S,Simonds SE,Kirigiti MA,Kievit P,Lindsley SR,Loche A,Smith MS,Cowley MA,Grove KL
450-31 was used in In vivo experiments to suggest that during the progression of DIO, there is an unknown signal that drives the expression of the orexigenic NPY signal within the DMH, and that the chronic hyperleptinemia increases the activity of these NPY/CART neurons.
Wed Sep 18 00:00:00 EDT 2013
Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Haan N,Goodman T,Najdi-Samiei A,Stratford CM,Rice R,El Agha E,Bellusci S,Hajihosseini MK
Wed Apr 03 00:00:00 EDT 2013
Energy budget, behavior and leptin in striped hamsters subjected to food restriction and refeeding.
PloS one
Zhao ZJ,Zhu QX,Chen KX,Wang YK,Cao J
Mon Jul 22 00:00:00 EDT 2013
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors.
Nature neuroscience
Dietrich MO,Bober J,Ferreira JG,Tellez LA,Mineur YS,Souza DO,Gao XB,Picciotto MR,Araújo I,Liu ZW,Horvath TL
450-31 was used in Sample Preparation to find that impairment of Agouti-related protein (AgRP) circuitry by either Sirt1 knockdown in AgRP-expressing neurons or early postnatal ablation of these neurons increased exploratory behavior and enhanced responses to cocaine.
Sun Jun 24 00:00:00 EDT 2012
Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study.
PloS one
Gavello D,Rojo-Ruiz J,Marcantoni A,Franchino C,Carbone E,Carabelli V
Mon Mar 11 00:00:00 EDT 2013
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
PloS one
Cao Y,Nakata M,Okamoto S,Takano E,Yada T,Minokoshi Y,Hirata Y,Nakajima K,Iskandar K,Hayashi Y,Ogawa W,Barsh GS,Hosoda H,Kangawa K,Itoh H,Noda T,Kasuga M,Nakae J
Wed Oct 12 00:00:00 EDT 2011
Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1.
Proceedings of the National Academy of Sciences of the United States of America
Lam QL,Wang S,Ko OK,Kincade PW,Lu L
Tue Aug 03 00:00:00 EDT 2010
ENU mutagenesis identifies mice with morbid obesity and severe hyperinsulinemia caused by a novel mutation in leptin.
PloS one
Hong CJ,Tsai PJ,Cheng CY,Chou CK,Jheng HF,Chuang YC,Yang CN,Lin YT,Hsu CW,Cheng IH,Chen SY,Tsai SJ,Liou YJ,Tsai YS
Thu Dec 09 00:00:00 EST 2010
Mechanism of attenuation of leptin signaling under chronic ligand stimulation.
BMC biochemistry
Knobelspies H,Zeidler J,Hekerman P,Bamberg-Lemper S,Becker W
Fri Jan 08 00:00:00 EST 2010
Mechanism of attenuation of leptin signaling under chronic ligand stimulation.
BMC biochemistry
Knobelspies H,Zeidler J,Hekerman P,Bamberg-Lemper S,Becker W
Fri Jan 08 00:00:00 EST 2010
Leptin increases maternal investment.
Proceedings. Biological sciences
French SS,Greives TJ,Zysling DA,Chester EM,Demas GE
Sun Nov 22 00:00:00 EST 2009
Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents.
PloS one
Sakar Y,Nazaret C,Lettéron P,Ait Omar A,Avenati M,Viollet B,Ducroc R,Bado A
Mon Nov 30 00:00:00 EST 2009
Endogenous prolactin-releasing peptide regulates food intake in rodents.
The Journal of clinical investigation
Takayanagi Y,Matsumoto H,Nakata M,Mera T,Fukusumi S,Hinuma S,Ueta Y,Yada T,Leng G,Onaka T
Mon Dec 01 00:00:00 EST 2008
Food intake-induced leptin secretion modulates hypothalamo-pituitary-adrenal axis response and hypothalamic Ob-Rb expression to insulin administration.
Neuroendocrinology
Giovambattista A,Chisari AN,Gaillard RC,Spinedi E
450-31 was used in In vivo experiments to suggest an inhibitory effect of endogenous leptin on insulin-induced HPA axis response, an interaction relevant to the physiological adaptation to starvation and caloric excess, and further supports the pivotal role played by the hypothalamus in restoring homeostasis in different allostatic states.
Fri Dec 01 00:00:00 EST 2000
