Product References
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.
The European respiratory journal
Shu T,Zhang J,Zhou Y,Chen Z,Li J,Tang Q,Lei W,Xing Y,Wang J,Wang C
250-03 was used in Cell Culture to show that in PH development without external inflammatory stimulus, peripheral blood exhibits a low EOS level, in which EOS play a protective role through suppressing perivascular inflammation and maintaining PASMC homeostasis via 14/17-HDHA.
Wed Mar 01 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
250-03 was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 EST 2023
The constitutively active pSMAD2/3 relatively improves the proliferation of chicken primordial germ cells.
Molecular reproduction and development
Zare M,Mirhoseini SZ,Ghovvati S,Yakhkeshi S,Hesaraki M,Barati M,Sayyahpour FA,Baharvand H,Hassani SN
250-03 was used in Cell Culture to show that TGF-β signaling agonists (IDE1 and Activin-A) improved PGC proliferation to some extent while treatment with SB431542, the antagonist of TGF-β, disrupted PGCs' proliferation.
Thu Jun 01 00:00:00 EDT 2023
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Cancer discovery
Liu Y,Li Q,Alikarami F,Barrett DR,Mahdavi L,Li H,Tang S,Khan TA,Michino M,Hill C,Song L,Yang L,Li Y,Pokharel SP,Stamford AW,Liverton N,Renzetti LM,Taylor S,Watt GF,Ladduwahetty T,Kargman S,Meinke PT,Foley MA,Shi J,Li H,Carroll M,Chen CW,Gardini A,Maillard I,Huggins DJ,Bernt KM,Wan L
250-03 was used in Cell Culture to study the therapeutic potential of chromatin reader eleven-nineteen leukemia (ENL) dependency in acute myeloid leukemia (AML).
Wed Nov 02 00:00:00 EDT 2022
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
The Journal of experimental medicine
Liu M,Wu C,Luo S,Hua Q,Chen HT,Weng Y,Xu J,Lin H,Wang L,Li J,Zhu L,Guo Z,Zhuang SM,Kang T,Zheng L
250-03 was used in Sample Preparation (FC/FACS) to indicate that PERK-mediated HSPC preconditioning plays a crucial role in MDSC generation, suggesting novel spleen-targeting therapeutic opportunities for restraining the tumor-promoting myeloid response at its source.
Mon Apr 04 00:00:00 EDT 2022
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
The Journal of experimental medicine
Ahmed N,Etzrodt M,Dettinger P,Kull T,Loeffler D,Hoppe PS,Chavez JS,Zhang Y,Camargo Ortega G,Hilsenbeck O,Nakajima H,Pietras EM,Schroeder T
Mon Jan 03 00:00:00 EST 2022
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.
Blood advances
Xu JJ,Chalk AM,Nikolic I,Simpson KJ,Smeets MF,Walkley CR
Tue Apr 12 00:00:00 EDT 2022
Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Westermann S,Dietschmann A,Doehler D,Castiglione K,Bochner BS,Voehringer D,Radtke D
Tue Feb 01 00:00:00 EST 2022
OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
Frontiers in immunology
Xu L,Tian D,Zhou M,Ma J,Sun G,Jin H,Li M,Zhang D,Wu J
250-03 was used in Cell Culture to show that Ox40 deficiency dampened the Traf2/6-related NF-κB signaling pathway in eosinophils.
Tue Jun 21 00:00:00 EDT 2022
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Nature
Bielecki P,Riesenfeld SJ,Hütter JC,Torlai Triglia E,Kowalczyk MS,Ricardo-Gonzalez RR,Lian M,Amezcua Vesely MC,Kroehling L,Xu H,Slyper M,Muus C,Ludwig LS,Christian E,Tao L,Kedaigle AJ,Steach HR,York AG,Skadow MH,Yaghoubi P,Dionne D,Jarret A,McGee HM,Porter CBM,Licona-Limón P,Bailis W,Jackson R,Gagliani N,Gasteiger G,Locksley RM,Regev A,Flavell RA
250-03 was used in Sample Preparation (FC/FACS) to investigate cytokine production by tissue-resident innate lymphoid cells.
Thu Apr 01 00:00:00 EDT 2021
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis.
Cell
Zhang S,Edwards TN,Chaudhri VK,Wu J,Cohen JA,Hirai T,Rittenhouse N,Schmitz EG,Zhou PY,McNeil BD,Yang Y,Koerber HR,Sumpter TL,Poholek AC,Davis BM,Albers KM,Singh H,Kaplan DH
Thu Apr 15 00:00:00 EDT 2021
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.
Cell research
Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B
Fri Oct 01 00:00:00 EDT 2021
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection.
Immunity
Flommersfeld S,Böttcher JP,Ersching J,Flossdorf M,Meiser P,Pachmayr LO,Leube J,Hensel I,Jarosch S,Zhang Q,Chaudhry MZ,Andrae I,Schiemann M,Busch DH,Cicin-Sain L,Sun JC,Gasteiger G,Victora GD,Höfer T,Buchholz VR,Grassmann S
Tue Oct 12 00:00:00 EDT 2021
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Immunity
Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D
Tue Aug 10 00:00:00 EDT 2021
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression.
Nature genetics
Yun H,Narayan N,Vohra S,Giotopoulos G,Mupo A,Madrigal P,Sasca D,Lara-Astiaso D,Horton SJ,Agrawal-Singh S,Meduri E,Basheer F,Marando L,Gozdecka M,Dovey OM,Castillo-Venzor A,Wang X,Gallipoli P,Müller-Tidow C,Osborne CS,Vassiliou GS,Huntly BJP
Fri Oct 01 00:00:00 EDT 2021
The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.
Blood
Tu Z,Wang C,Davis AK,Hu M,Zhao C,Xin M,Lu QR,Zheng Y
Thu Jul 22 00:00:00 EDT 2021
Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging.
Cell stem cell
Kruta M,Sunshine MJ,Chua BA,Fu Y,Chawla A,Dillingham CH,Hidalgo San Jose L,De Jong B,Zhou FJ,Signer RAJ
Thu Nov 04 00:00:00 EDT 2021
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Cell stem cell
Leimkühler NB,Gleitz HFE,Ronghui L,Snoeren IAM,Fuchs SNR,Nagai JS,Banjanin B,Lam KH,Vogl T,Kuppe C,Stalmann USA,Büsche G,Kreipe H,Gütgemann I,Krebs P,Banz Y,Boor P,Tai EW,Brümmendorf TH,Koschmieder S,Crysandt M,Bindels E,Kramann R,Costa IG,Schneider RK
Thu Apr 01 00:00:00 EDT 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
250-03 was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.
Cellular & molecular immunology
Huang H,Wu X,Meng D,Feng Y,Zhou L,Liu Z,Tang S,Li X,Cao Y,He H,Xie Z,Zhang J,Chen Y,Zhao T,Wu Y,Zhou X
250-03 was used in Cell Culture to indicate that LXRβ functions as an important transcription factor upstream of IL-7Rα to promote the survival of SP thymocytes.
Sun Aug 01 00:00:00 EDT 2021
SRSF1 plays a critical role in invariant natural killer T cell development and function.
Cellular & molecular immunology
Liu J,You M,Yao Y,Ji C,Wang Z,Wang F,Wang D,Qi Z,Yu G,Sun Z,Guo W,Liu J,Li S,Jin Y,Zhao T,Xue HH,Xue Y,Yu S
Mon Nov 01 00:00:00 EDT 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
250-03 was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.
Mon Feb 15 00:00:00 EST 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
250-03 was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.
Mon Feb 15 00:00:00 EST 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
250-03 was used in Cell Culture to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 EDT 2021
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Molecular cell
Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI
250-03 was used in Cell Culture to conclude that METTL1-mediated tRNA modification drives oncogenic transformation through a remodeling of the mRNA translatome" to increase expression of growth-promoting proteins and represents a promising anti-cancer target."
Thu Aug 19 00:00:00 EDT 2021
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
The Journal of experimental medicine
Cova G,Taroni C,Deau MC,Cai Q,Mittelheisser V,Philipps M,Jung M,Cerciat M,Le Gras S,Thibault-Carpentier C,Jost B,Carlsson L,Thornton AM,Shevach EM,Kirstetter P,Kastner P,Chan S
Mon Oct 04 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 EDT 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 EST 2021
Low-affinity but high-avidity interactions may offer an explanation for IgE-mediated allergen cross-reactivity.
Allergy
Chang X,Zha L,Wallimann A,Mohsen MO,Krenger P,Liu X,Vogel M,Bachmann MF
250-03 was used in In vitro experiments to suggest that the underlying mechanism of allergen cross-reactivity may be low-affinity but high-avidity binding between IgE antibodies and cross-reactive allergen.
Sun Aug 01 00:00:00 EDT 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 EDT 2021
Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.
Haematologica
Xie M,Zhang S,Dong F,Zhang Q,Wang J,Wang C,Zhu C,Zhang S,Luo B,Wu P,Ema H
250-03 was used in Cell Culture to investigate whether granulocyte colony-stimulating factor directly stimulates hematopoietic stem cells to change their cell cycle state and fate.
Tue Jun 01 00:00:00 EDT 2021
C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis.
Aging cell
Shi Z,Diao D,Zhao Y,Luo Y,Li Y,Liu D,Zhang K,Qiu Y,Yu L,Song Z,Ju Z
250-03 was used in Cell Culture to show that C/EBP homologous protein (CHOP) has a significant role in supporting HSCs homesotasis and by reducing ATF3/ROS signalling, it promotes their regeneration.
Thu Jul 01 00:00:00 EDT 2021
The anti-parasitic drug miltefosine suppresses activation of human eosinophils and ameliorates allergic inflammation in mice.
British journal of pharmacology
Knuplez E,Kienzl M,Trakaki A,Schicho R,Heinemann A,Sturm EM,Marsche G
250-03 was used in Sample Preparation (FC/FACS) to underline the potential efficacy of miltefosine in the treatment of allergic diseases and other eosinophil-associated disorders and may raise important questions regarding the immunomodulatory effect of miltefosine in patients treated for leishmania infections.
Mon Mar 01 00:00:00 EST 2021
Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.
EMBO reports
Gutiérrez-Gutiérrez Ó,Felix DA,Salvetti A,Amro EM,Thems A,Pietsch S,Koeberle A,Rudolph KL,González-Estévez C
Wed Aug 04 00:00:00 EDT 2021
High-throughput screening in postimplantation haploid epiblast stem cells reveals Hs3st3b1 as a modulator for reprogramming.
Stem cells translational medicine
Gao Q,Zhang W,Zhao Y,Tian Y,Wang Y,Zhang J,Geng M,Xu M,Yao C,Wang H,Li L,Liu Y,Shuai L
Sat May 01 00:00:00 EDT 2021
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Blood advances
Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG
Tue Dec 14 00:00:00 EST 2021
5-Azacytidine depletes HSCs and synergizes with an anti-CD117 antibody to augment donor engraftment in immunocompetent mice.
Blood advances
Bankova AK,Pang WW,Velasco BJ,Long-Boyle JR,Shizuru JA
Tue Oct 12 00:00:00 EDT 2021
Oxidized mitochondrial DNA released after inflammasome activation is a disease biomarker for myelodysplastic syndromes.
Blood advances
Ward GA,McGraw KL,Abbas-Aghababazadeh F,Meyer BS,McLemore AF,Vincelette ND,Lam NB,Aldrich AL,Al Ali NH,Padron E,Pinilla-Ibarz J,Masala E,Santini V,Kosmider O,Fontenay M,Fenaux P,Johnson J,Fridley BL,List AF
Tue Apr 27 00:00:00 EDT 2021
IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction.
Immunology
Drube S,Müller S,Weber F,Wegner P,Böttcher-Loschinski R,Gaestel M,Hutloff A,Kamradt T,Andreas N
Sat May 01 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
250-03 was used in In vitro experiments to present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.
Wed Nov 10 00:00:00 EST 2021
Development of an Optimized Culture System for Generating Mouse Alveolar Macrophage-like Cells.
Journal of immunology (Baltimore, Md. : 1950)
Luo M,Lai W,He Z,Wu L
Wed Sep 15 00:00:00 EDT 2021
B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Strid T,Okuyama K,Tingvall-Gustafsson J,Kuruvilla J,Jensen CT,Lang S,Prasad M,Somasundaram R,Åhsberg J,Cristobal S,Soneji S,Ungerbäck J,Sigvardsson M
Tue Jun 01 00:00:00 EDT 2021
Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia.
Journal of immunology (Baltimore, Md. : 1950)
Sharma P,Sharma A,Ganga L,Satoeya N,Jha R,Srivastava M
Mon Feb 15 00:00:00 EST 2021
A Critical Role for Na+/H+ Exchanger Regulatory Factor 1 in Modulating FcεRI-Mediated Mast Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Kammala AK,Syed M,Yang C,Occhiuto CJ,Subramanian H
Mon Feb 01 00:00:00 EST 2021
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Xie B,Khoyratty TE,Abu-Shah E,F Cespedes P,MacLean AJ,Pirgova G,Hu Z,Ahmed AA,Dustin ML,Udalova IA,Arnon TI
Thu Apr 01 00:00:00 EDT 2021
Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.
Stem cell research
Hancock GV,Liu W,Peretz L,Chen D,Gell JJ,Collier AJ,Zamudio JR,Plath K,Clark AT
250-03 was used in Cell Culture to evaluate the role of KLF4 and TFCP2L1 in human primordial germ cell development.
Sun Aug 01 00:00:00 EDT 2021
Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells.
Nature communications
Jia W,Kong L,Kidoya H,Naito H,Muramatsu F,Hayashi Y,Hsieh HY,Yamakawa D,Hsu DK,Liu FT,Takakura N
Fri Apr 09 00:00:00 EDT 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
Mon Jan 11 00:00:00 EST 2021
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs.
NPJ aging and mechanisms of disease
Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I
Tue Sep 21 00:00:00 EDT 2021
Engineering of a bona fide light-operated calcium channel.
Nature communications
He L,Wang L,Zeng H,Tan P,Ma G,Zheng S,Li Y,Sun L,Dou F,Siwko S,Huang Y,Wang Y,Zhou Y
Mon Jan 11 00:00:00 EST 2021
Protocol to produce high-titer retrovirus for transduction of mouse bone marrow cells.
STAR protocols
Qu J,Yang Z
250-03 was used in Cell Culture to demonstrate a modified protocol to overcome challenges associated with achieving high transduction efficiency in bone marrow cells in transplantation which enables reproducible and high-efficient retroviral transduction of hematopoietic stem and progenitor cells (HSPCs) for bone marrow transplantation (BMT).
Fri Jun 18 00:00:00 EDT 2021
Multi-scale Dynamical Modeling of T Cell Development from an Early Thymic Progenitor State to Lineage Commitment.
Cell reports
Olariu V,Yui MA,Krupinski P,Zhou W,Deichmann J,Andersson E,Rothenberg EV,Peterson C
Tue Jan 12 00:00:00 EST 2021
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.
Cell reports
Kim SP,Srivatsan SN,Chavez M,Shirai CL,White BS,Ahmed T,Alberti MO,Shao J,Nunley R,White LS,Bednarski J,Pehrson JR,Walter MJ
Tue Aug 31 00:00:00 EDT 2021
Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo.
Cell reports
Dignum T,Varnum-Finney B,Srivatsan SR,Dozono S,Waltner O,Heck AM,Ishida T,Nourigat-McKay C,Jackson DL,Rafii S,Trapnell C,Bernstein ID,Hadland B
Tue Sep 14 00:00:00 EDT 2021
SIRT1 regulates the phosphorylation and degradation of P27 by deacetylating CDK2 to promote T-cell acute lymphoblastic leukemia progression.
Journal of experimental & clinical cancer research : CR
Wang F,Li Z,Zhou J,Wang G,Zhang W,Xu J,Liang A
250-03 was used in Cell Culture to investigate SIRT1 expression and function in T-cell acute lymphoblastic leukemia.
Wed Aug 18 00:00:00 EDT 2021
Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses.
Cell reports
Yu K,Hammerschmidt SI,Permanyer M,Galla M,Rothe M,Zheng X,Werth K,Martens R,Lueder Y,Janssen A,Friedrichsen M,Bernhardt G,Förster R
Tue Jun 22 00:00:00 EDT 2021
Correction of pathology in mice displaying Gaucher disease type 1 by a clinically-applicable lentiviral vector.
Molecular therapy. Methods & clinical development
Dahl M,Smith EMK,Warsi S,Rothe M,Ferraz MJ,Aerts JMFG,Golipour A,Harper C,Pfeifer R,Pizzurro D,Schambach A,Mason C,Karlsson S
Fri Mar 12 00:00:00 EST 2021
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Nature communications
Li J,Galbo PM,Gong W,Storey AJ,Tsai YH,Yu X,Ahn JH,Guo Y,Mackintosh SG,Edmondson RD,Byrum SD,Farrar JE,He S,Cai L,Jin J,Tackett AJ,Zheng D,Wang GG
Tue Feb 16 00:00:00 EST 2021
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.
Nature communications
Debackere K,Marcelis L,Demeyer S,Vanden Bempt M,Mentens N,Gielen O,Jacobs K,Broux M,Verhoef G,Michaux L,Graux C,Wlodarska I,Gaulard P,de Leval L,Tousseyn T,Cools J,Dierickx D
Thu Jun 17 00:00:00 EDT 2021
Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.
STAR protocols
Liang G,Huang B,Wang F,Liu F
250-03 was used in Flow cytometry/Cell sorting to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.
Fri Dec 17 00:00:00 EST 2021
Syngeneic leukemia models using lentiviral transgenics.
Cell death & disease
Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R
Thu Feb 18 00:00:00 EST 2021
GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis.
Cell death & disease
Hu Q,Zhang Y,Lou H,Ou Z,Liu J,Duan W,Wang H,Ge Y,Min J,Wang F,Ju Z
Thu Jul 15 00:00:00 EDT 2021
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Nature communications
Khateb A,Deshpande A,Feng Y,Finlay D,Lee JS,Lazar I,Fabre B,Li Y,Fujita Y,Zhang T,Yin J,Pass I,Livneh I,Jeremias I,Burian C,Mason JR,Almog R,Horesh N,Ofran Y,Brown K,Vuori K,Jackson M,Ruppin E,Deshpande AJ,Ronai ZA
Mon Sep 13 00:00:00 EDT 2021
High-resolution characterization of gene function using single-cell CRISPR tiling screen.
Nature communications
Yang L,Chan AKN,Miyashita K,Delaney CD,Wang X,Li H,Pokharel SP,Li S,Li M,Xu X,Lu W,Liu Q,Mattson N,Chen KY,Wang J,Yuan YC,Horne D,Rosen ST,Soto-Feliciano Y,Feng Z,Hoshii T,Xiao G,Müschen M,Chen J,Armstrong SA,Chen CW
Thu Jul 01 00:00:00 EDT 2021
Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory.
Scientific reports
Stahlhut M,Ha TC,Takmakova E,Morgan MA,Schwarzer A,Schaudien D,Eder M,Schambach A,Kustikova OS
Fri Mar 05 00:00:00 EST 2021
Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells.
Science advances
Pessoa Rodrigues C,Akhtar A
250-03 was used in Cell Culture to indicate H4K16ac as an important determinant for HSC heterogeneity, which is linked to the onset of monocytic disorders.
Sun Aug 01 00:00:00 EDT 2021
TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.
iScience
Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C
250-03 was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.
Fri Dec 17 00:00:00 EST 2021
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells.
eLife
Kiritsy MC,McCann K,Mott D,Holland SM,Behar SM,Sassetti CM,Olive AJ
250-03 was used in Cell Culture to study the metabolic dependencies of critical signals such as interferon gamma (IFNγ) for allowing antigen-presenting cells (APCs) to convey a wide array of functionally distinct signals to T cells. To demonstrate that IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I.
Tue Nov 02 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
Tue Jul 13 00:00:00 EDT 2021
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia.
Nature communications
Van Thillo Q,De Bie J,Seneviratne JA,Demeyer S,Omari S,Balachandran A,Zhai V,Tam WL,Sweron B,Geerdens E,Gielen O,Provost S,Segers H,Boeckx N,Marshall GM,Cheung BB,Isobe K,Kato I,Takita J,Amos TG,Deveson IW,McCalmont H,Lock RB,Oxley EP,Garwood MM,Dickins RA,Uyttebroeck A,Carter DR,Cools J,de Bock CE
Tue Jul 06 00:00:00 EDT 2021
Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.
Communications biology
Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R
Mon Jun 28 00:00:00 EDT 2021
Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner.
Cell reports
Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP
Tue Jan 12 00:00:00 EST 2021
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System.
Stem cell reports
Jackson M,Fidanza A,Taylor AH,Rybtsov S,Axton R,Kydonaki M,Meek S,Burdon T,Medvinsky A,Forrester LM
Tue Apr 13 00:00:00 EDT 2021
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Nature communications
Supper E,Rudat S,Iyer V,Droop A,Wong K,Spinella JF,Thomas P,Sauvageau G,Adams DJ,Wong CC
Fri Apr 30 00:00:00 EDT 2021
GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis.
Blood science (Baltimore, Md.)
Yang X,Cong T,He H,Wang J
250-03 was used in Cell Culture to reveal that GSDME modulates HSC function by coordinating pyroptosis and apoptosis.
Thu Apr 01 00:00:00 EDT 2021
Tunable, division-independent control of gene activation timing by a polycomb switch.
Cell reports
Pease NA,Nguyen PHB,Woodworth MA,Ng KKH,Irwin B,Vaughan JC,Kueh HY
Tue Mar 23 00:00:00 EDT 2021
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
Cell reports
Murakami K,Kurotaki D,Kawase W,Soma S,Fukuchi Y,Kunimoto H,Yoshimi R,Koide S,Oshima M,Hishiki T,Hayakawa N,Matsuura T,Oda M,Yanagisawa K,Kobayashi H,Haraguchi M,Atobe Y,Funakoshi K,Iwama A,Takubo K,Okamoto S,Tamura T,Nakajima H
Tue Jan 05 00:00:00 EST 2021
Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.
Molecular therapy. Methods & clinical development
Seymour BJ,Singh S,Certo HM,Sommer K,Sather BD,Khim S,Clough C,Hale M,Pangallo J,Ryu BY,Khan IF,Adair JE,Rawlings DJ
Fri Mar 12 00:00:00 EST 2021
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Immunity
Guendel F,Kofoed-Branzk M,Gronke K,Tizian C,Witkowski M,Cheng HW,Heinz GA,Heinrich F,Durek P,Norris PS,Ware CF,Ruedl C,Herold S,Pfeffer K,Hehlgans T,Waisman A,Becher B,Giannou AD,Brachs S,Ebert K,Tanriver Y,Ludewig B,Mashreghi MF,Kruglov AA,Diefenbach A
Tue Nov 17 00:00:00 EST 2020
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity.
Immunity
Kim S,Bagadia P,Anderson DA,Liu TT,Huang X,Theisen DJ,O'Connor KW,Ohara RA,Iwata A,Murphy TL,Murphy KM
Tue Oct 13 00:00:00 EDT 2020
In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors.
Immunity
Zeis P,Lian M,Fan X,Herman JS,Hernandez DC,Gentek R,Elias S,Symowski C,Knöpper K,Peltokangas N,Friedrich C,Doucet-Ladeveze R,Kabat AM,Locksley RM,Voehringer D,Bajenoff M,Rudensky AY,Romagnani C,Grün D,Gasteiger G
Tue Oct 13 00:00:00 EDT 2020
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I
Mon Jun 08 00:00:00 EDT 2020
C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.
Cancer cell
Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C
Mon May 11 00:00:00 EDT 2020
Vitamin B6 Addiction in Acute Myeloid Leukemia.
Cancer cell
Chen CC,Li B,Millman SE,Chen C,Li X,Morris JP,Mayle A,Ho YJ,Loizou E,Liu H,Qin W,Shah H,Violante S,Cross JR,Lowe SW,Zhang L
Mon Jan 13 00:00:00 EST 2020
SIRT1 is downregulated by autophagy in senescence and ageing.
Nature cell biology
Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL
250-03 was used in In vitro experiments to investigate SIRT1 homeostasis in mammalian senescence and aging.
Thu Oct 01 00:00:00 EDT 2020
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Blood
Zambetti NA,Firestone AJ,Remsberg JR,Huang BJ,Wong JC,Long AM,Predovic M,Suciu RM,Inguva A,Kogan SC,Haigis KM,Cravatt BF,Shannon K
Thu May 14 00:00:00 EDT 2020
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.
Blood
Carmichael CL,Wang J,Nguyen T,Kolawole O,Benyoucef A,De Mazière C,Milne AR,Samuel S,Gillinder K,Hediyeh-Zadeh S,Vo ANQ,Huang Y,Knezevic K,McInnes WRL,Shields BJ,Mitchell H,Ritchie ME,Lammens T,Lintermans B,Van Vlierberghe P,Wong NC,Haigh K,Thoms JAI,Toulmin E,Curtis DJ,Oxley EP,Dickins RA,Beck D,Perkins A,McCormack MP,Davis MJ,Berx G,Zuber J,Pimanda JE,Kile BT,Goossens S,Haigh JJ
Thu Aug 20 00:00:00 EDT 2020
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Blood
Numata A,Kwok HS,Zhou QL,Li J,Tirado-Magallanes R,Angarica VE,Hannah R,Park J,Wang CQ,Krishnan V,Rajagopalan D,Zhang Y,Zhou S,Welner RS,Osato M,Jha S,Bohlander SK,Göttgens B,Yang H,Benoukraf T,Lough JW,Bararia D,Tenen DG
Thu Oct 08 00:00:00 EDT 2020
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Blood
He H,Xu P,Zhang X,Liao M,Dong Q,Cong T,Tang B,Yang X,Ye M,Chang Y,Liu W,Wang X,Ju Z,Wang J
Thu Jul 09 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
250-03 was used in In vitro experiments to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition.
Cell stem cell
Hinge A,He J,Bartram J,Javier J,Xu J,Fjellman E,Sesaki H,Li T,Yu J,Wunderlich M,Mulloy J,Kofron M,Salomonis N,Grimes HL,Filippi MD
250-03 was used in In vitro experiments to investigate the underlying role of mitochondria in hematopoietic stem cells (HSCs) to meet change of metabolic requirements during their cell cycle activity.
Thu Mar 05 00:00:00 EST 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
250-03 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 EST 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
250-03 was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 EST 2020
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.
The Journal of experimental medicine
Xiong Z,Xia P,Zhu X,Geng J,Wang S,Ye B,Qin X,Qu Y,He L,Fan D,Du Y,Tian Y,Fan Z
Mon Feb 03 00:00:00 EST 2020
Endothelial mTOR maintains hematopoiesis during aging.
The Journal of experimental medicine
Ramalingam P,Poulos MG,Gutkin MC,Katsnelson L,Freire AG,Lazzari E,Butler JM
Mon Jun 01 00:00:00 EDT 2020
The human fetal thymus generates invariant effector γδ T cells.
The Journal of experimental medicine
Tieppo P,Papadopoulou M,Gatti D,McGovern N,Chan JKY,Gosselin F,Goetgeluk G,Weening K,Ma L,Dauby N,Cogan A,Donner C,Ginhoux F,Vandekerckhove B,Vermijlen D
Mon Mar 02 00:00:00 EST 2020
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
The Journal of experimental medicine
Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A
Mon Dec 07 00:00:00 EST 2020
PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation.
Journal of biomedical science
Ju W,Lu W,Ding L,Bao Y,Hong F,Chen Y,Gao H,Xu X,Wang G,Wang W,Zhang X,Fu C,Qi K,Li Z,Xu K,Qiao J,Zeng L
250-03 was used in Cell Culture to investigate pigment epithelium-derived factor's effect on preconditioning induced damage of endothelial cells and hematopoietic reconstructioncon.
Tue Sep 01 00:00:00 EDT 2020
Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.
Cell systems
Arai F,Stumpf PS,Ikushima YM,Hosokawa K,Roch A,Lutolf MP,Suda T,MacArthur BD
250-03 was used in Cell Culture to indicate that the balance between intrinsic and extrinsic regulation of stem cell activity alters substantially with age and help explain why stem cell numbers increase through life, yet regenerative potency declines.
Wed Dec 16 00:00:00 EST 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
Wed Feb 05 00:00:00 EST 2020
Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells.
EMBO reports
Szade K,Zukowska M,Szade A,Nowak W,Skulimowska I,Ciesla M,Bukowska-Strakova K,Gulati GS,Kachamakova-Trojanowska N,Kusienicka A,Einwallner E,Kijowski J,Czauderna S,Esterbauer H,Benes V,L Weissman I,Dulak J,Jozkowicz A
Wed Feb 05 00:00:00 EST 2020
The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Journal of immunology (Baltimore, Md. : 1950)
Greenberg ZJ,Monlish DA,Bartnett RL,Yang Y,Shen G,Li W,Bednarski JJ,Schuettpelz LG
Wed Jan 01 00:00:00 EST 2020
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S
250-03 was used in Sample Preparation (FC/FACS) to show that fibrinogen is a specific trigger for cytolytic eosinophil degranulation with implications in human disease.
Wed Jan 15 00:00:00 EST 2020
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S
250-03 was used in Sample Preparation (FC/FACS) to show that fibrinogen is a specific trigger for cytolytic eosinophil degranulation with implications in human disease.
Wed Jan 15 00:00:00 EST 2020
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.
Journal of immunology (Baltimore, Md. : 1950)
Yoshida K,Ito MA,Sato N,Obayashi K,Yamamoto K,Koizumi S,Tanaka S,Furuta K,Matsuoka I
Mon Jun 15 00:00:00 EDT 2020
Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population.
Journal of immunology (Baltimore, Md. : 1950)
Daams R,Sime W,Leandersson K,Sitnicka E,Massoumi R
Thu Oct 01 00:00:00 EDT 2020
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Gene therapy
Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G
Tue Sep 01 00:00:00 EDT 2020
Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.
Integrative biology : quantitative biosciences from nano to macro
Gilchrist AE,Harley BAC
250-03 was used in Cell Culture to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.
Fri Jul 10 00:00:00 EDT 2020
Eosinophils improve cardiac function after myocardial infarction.
Nature communications
Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP
Wed Dec 16 00:00:00 EST 2020
Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.
Scientific reports
Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R
Tue Feb 04 00:00:00 EST 2020
GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis.
Nature communications
Regan-Komito D,Swann JW,Demetriou P,Cohen ES,Horwood NJ,Sansom SN,Griseri T
Thu Jan 09 00:00:00 EST 2020
Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Nature communications
Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J
Fri Jun 12 00:00:00 EDT 2020
Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Nature communications
Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J
Fri Jun 12 00:00:00 EDT 2020
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Nature communications
Tremblay CS,Chiu SK,Saw J,McCalmont H,Litalien V,Boyle J,Sonderegger SE,Chau N,Evans K,Cerruti L,Salmon JM,McCluskey A,Lock RB,Robinson PJ,Jane SM,Curtis DJ
250-03 was used in Cell Culture to study the inhibition of microenvironment signals as a strategy to target leukemia stem cells.
Fri Dec 04 00:00:00 EST 2020
IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils.
Oncoimmunology
Kienzl M,Hasenoehrl C,Valadez-Cosmes P,Maitz K,Sarsembayeva A,Sturm E,Heinemann A,Kargl J,Schicho R
250-03 was used in Sample Preparation (FC/FACS) to emphasize the potential use of IL-33 as an adjuvants in CRC immunotherapy.
Tue Jun 16 00:00:00 EDT 2020
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
Science advances
Pessoa Rodrigues C,Herman JS,Herquel B,Valsecchi CIK,Stehle T,Grün D,Akhtar A
250-03 was used in In vitro experiments to study the mechanism by which histone H4 lysine 16 acetyltransferase MOF regulates erythropoiesis.
Fri May 01 00:00:00 EDT 2020
Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.
FASEB bioAdvances
Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T
Sat Aug 01 00:00:00 EDT 2020
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.
Nature communications
Bank U,Deiser K,Plaza-Sirvent C,Osbelt L,Witte A,Knop L,Labrenz R,Jänsch R,Richter F,Biswas A,Zenclussen AC,Vivier E,Romagnani C,Kühl AA,Dunay IR,Strowig T,Schmitz I,Schüler T
Wed Feb 26 00:00:00 EST 2020
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.
Nature communications
Basilico S,Wang X,Kennedy A,Tzelepis K,Giotopoulos G,Kinston SJ,Quiros PM,Wong K,Adams DJ,Carnevalli LS,Huntly BJP,Vassiliou GS,Calero-Nieto FJ,Göttgens B
Mon Mar 16 00:00:00 EDT 2020
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nature communications
Zhang Y,Guo Y,Gough SM,Zhang J,Vann KR,Li K,Cai L,Shi X,Aplan PD,Wang GG,Kutateladze TG
Fri Jul 03 00:00:00 EDT 2020
An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure.
Stem cell reports
Gell JJ,Liu W,Sosa E,Chialastri A,Hancock G,Tao Y,Wamaitha SE,Bower G,Dey SS,Clark AT
Tue Mar 10 00:00:00 EDT 2020
BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis.
Blood science (Baltimore, Md.)
Yang X,Ge L,Wang J
250-03 was used in Cell Culture to investigate the role of Becn1 in hematopoietic stem cells.
Wed Jul 01 00:00:00 EDT 2020
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.
Scientific reports
Loffredo LF,Coden ME,Jeong BM,Walker MT,Anekalla KR,Doan TC,Rodriguez R,Browning M,Nam K,Lee JJ,Abdala-Valencia H,Berdnikovs S
Tue Mar 10 00:00:00 EDT 2020
MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia.
Nature communications
Itskovich SS,Gurunathan A,Clark J,Burwinkel M,Wunderlich M,Berger MR,Kulkarni A,Chetal K,Venkatasubramanian M,Salomonis N,Kumar AR,Lee LH
Tue May 12 00:00:00 EDT 2020
Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage.
Communications biology
AhYoung AP,Eckard SC,Gogineni A,Xi H,Lin SJ,Gerhardy S,Cox C,Phung QT,Hackney JA,Katakam AK,Reichelt M,Caplazi P,Manzanillo P,Zhang J,Roose-Girma M,Tam LW,Newman RJ,Murthy A,Weimer RM,Lill JR,Lee WP,Grimbaldeston M,Kirchhofer D,van Lookeren Campagne M
Thu Nov 19 00:00:00 EST 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
Wed Jan 29 00:00:00 EST 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
Wed Jan 29 00:00:00 EST 2020
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis.
Cell reports
Niederkorn M,Hueneman K,Choi K,Varney ME,Romano L,Pujato MA,Greis KD,Inoue JI,Meetei R,Starczynowski DT
250-03 was used in Cell Culture to study how forkhead-associated domain B (TIFAB) regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity using a combination of proteomic and genetic approaches to uncover a function of TIFAB as an effector of USP15 activity and rheostat of p53 signaling in stressed and malignant hematopoietic stem/progenitor cells (HSPCs).
Tue Feb 25 00:00:00 EST 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
Tue Oct 27 00:00:00 EDT 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
Tue Oct 27 00:00:00 EDT 2020
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Science advances
Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS
250-03 was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.
Sun Nov 01 00:00:00 EDT 2020
Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V.
Nature communications
Rai S,Tanaka H,Suzuki M,Espinoza JL,Kumode T,Tanimura A,Yokota T,Oritani K,Watanabe T,Kanakura Y,Matsumura I
Tue Aug 18 00:00:00 EDT 2020
Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1.
Immunity
Tyrkalska SD,Pérez-Oliva AB,Rodríguez-Ruiz L,Martínez-Morcillo FJ,Alcaraz-Pérez F,Martínez-Navarro FJ,Lachaud C,Ahmed N,Schroeder T,Pardo-Sánchez I,Candel S,López-Muñoz A,Choudhuri A,Rossmann MP,Zon LI,Cayuela ML,García-Moreno D,Mulero V
Tue Jul 16 00:00:00 EDT 2019
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.
Immunity
Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E
Tue Jun 18 00:00:00 EDT 2019
Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch.
Immunity
Meixiong J,Anderson M,Limjunyawong N,Sabbagh MF,Hu E,Mack MR,Oetjen LK,Wang F,Kim BS,Dong X
Tue May 21 00:00:00 EDT 2019
Distinct Surface Expression of Activating Receptor Ly49H Drives Differential Expansion of NK Cell Clones upon Murine Cytomegalovirus Infection.
Immunity
Grassmann S,Pachmayr LO,Leube J,Mihatsch L,Andrae I,Flommersfeld S,Oduro J,Cicin-Sain L,Schiemann M,Flossdorf M,Buchholz VR
Tue Jun 18 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
250-03 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell
Huang Y,Su R,Sheng Y,Dong L,Dong Z,Xu H,Ni T,Zhang ZS,Zhang T,Li C,Han L,Zhu Z,Lian F,Wei J,Deng Q,Wang Y,Wunderlich M,Gao Z,Pan G,Zhong D,Zhou H,Zhang N,Gan J,Jiang H,Mulloy JC,Qian Z,Chen J,Yang CG
250-03 was used in Cell Culture to show that FTO is a druggable target and that targeting FTO by small-molecule inhibitors holds potential to treat AML.
Mon Apr 15 00:00:00 EDT 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 EDT 2019
γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Luong-Gardiol N,Siddiqui I,Pizzitola I,Jeevan-Raj B,Charmoy M,Huang Y,Irmisch A,Curtet S,Angelov GS,Danilo M,Juilland M,Bornhauser B,Thome M,Hantschel O,Chalandon Y,Cazzaniga G,Bourquin JP,Huelsken J,Held W
Mon Apr 15 00:00:00 EDT 2019
Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.
Nature immunology
Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ
250-03 was used in Flow cytometry/Cell sorting to demonstrate that basophil-deficient mice exhibit reduced bacterial clearance and increased morbidity and mortality in the cecal ligation and puncture (CLP) model of sepsis.
Fri Feb 01 00:00:00 EST 2019
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Blood
McRae HM,Garnham AL,Hu Y,Witkowski MT,Corbett MA,Dixon MP,May RE,Sheikh BN,Chiang W,Kueh AJ,Nguyen TA,Man K,Gloury R,Aubrey BJ,Policheni A,Di Rago L,Alexander WS,Gray DHD,Strasser A,Hawkins ED,Wilcox S,Gécz J,Kallies A,McCormack MP,Smyth GK,Voss AK,Thomas T
Thu Apr 18 00:00:00 EDT 2019
Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program.
Blood
Mack EA,Stein SJ,Rome KS,Xu L,Wertheim GB,Melo RCN,Pear WS
Thu May 30 00:00:00 EDT 2019
A role for macrophages in hematopoiesis in the embryonic head.
Blood
Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E
Thu Nov 28 00:00:00 EST 2019
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.
Blood
Abdul-Aziz AM,Sun Y,Hellmich C,Marlein CR,Mistry J,Forde E,Piddock RE,Shafat MS,Morfakis A,Mehta T,Di Palma F,Macaulay I,Ingham CJ,Haestier A,Collins A,Campisi J,Bowles KM,Rushworth SA
Thu Jan 31 00:00:00 EST 2019
Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases.
Blood
Ramasz B,Krüger A,Reinhardt J,Sinha A,Gerlach M,Gerbaulet A,Reinhardt S,Dahl A,Chavakis T,Wielockx B,Grinenko T
Thu Sep 26 00:00:00 EDT 2019
Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.
Blood
Sasca D,Yun H,Giotopoulos G,Szybinski J,Evan T,Wilson NK,Gerstung M,Gallipoli P,Green AR,Hills R,Russell N,Osborne CS,Papaemmanuil E,Göttgens B,Campbell P,Huntly BJP
Thu Dec 12 00:00:00 EST 2019
IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.
Blood
González-García S,Mosquera M,Fuentes P,Palumbo T,Escudero A,Pérez-Martínez A,Ramírez M,Corcoran AE,Toribio ML
Thu Dec 12 00:00:00 EST 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
250-03 was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 EDT 2019
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.
Cell stem cell
Ho YH,Del Toro R,Rivera-Torres J,Rak J,Korn C,García-García A,Macías D,González-Gómez C,Del Monte A,Wittner M,Waller AK,Foster HR,López-Otín C,Johnson RS,Nerlov C,Ghevaert C,Vainchenker W,Louache F,Andrés V,Méndez-Ferrer S
250-03 was used in Cell Culture to show that the bone marrow microenvironment promotes myelopoiesis in premature/physiological aging.
Thu Sep 05 00:00:00 EDT 2019
Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
The Journal of experimental medicine
Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL
250-03 was used in In vitro experiments to determine hematopoietic stem cell function is limited by Rad21/cohesin-mediated NF-kB signaling during aging.
Mon Jan 07 00:00:00 EST 2019
CD97 is a critical regulator of acute myeloid leukemia stem cell function.
The Journal of experimental medicine
Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY
Mon Oct 07 00:00:00 EDT 2019
Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.
The Journal of experimental medicine
Abdulhay NJ,Fiorini C,Verboon JM,Ludwig LS,Ulirsch JC,Zieger B,Lareau CA,Mi X,Roy A,Obeng EA,Erlacher M,Gupta N,Gabriel SB,Ebert BL,Niemeyer CM,Khoriaty RN,Ancliff P,Gazda HT,Wlodarski MW,Sankaran VG
Mon May 06 00:00:00 EDT 2019
Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis.
The Journal of experimental medicine
Anzai A,Mindur JE,Halle L,Sano S,Choi JL,He S,McAlpine CS,Chan CT,Kahles F,Valet C,Fenn AM,Nairz M,Rattik S,Iwamoto Y,Fairweather D,Walsh K,Libby P,Nahrendorf M,Swirski FK
Mon Feb 04 00:00:00 EST 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 EDT 2019
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.
The Journal of experimental medicine
Basheer F,Giotopoulos G,Meduri E,Yun H,Mazan M,Sasca D,Gallipoli P,Marando L,Gozdecka M,Asby R,Sheppard O,Dudek M,Bullinger L,Döhner H,Dillon R,Freeman S,Ottmann O,Burnett A,Russell N,Papaemmanuil E,Hills R,Campbell P,Vassiliou GS,Huntly BJP
Mon Apr 01 00:00:00 EDT 2019
TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone.
The Journal of experimental medicine
Albright AR,Kabat J,Li M,Raso F,Reboldi A,Muppidi JR
Mon Nov 04 00:00:00 EST 2019
Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity.
The Journal of allergy and clinical immunology
Klein O,Krier-Burris RA,Lazki-Hagenbach P,Gorzalczany Y,Mei Y,Ji P,Bochner BS,Sagi-Eisenberg R
250-03 was used in Cell Culture to identify mDia1 as a novel regulator of MC response that coordinates MC chemotaxis and secretion through its actin-nucleating activity.
Tue Oct 01 00:00:00 EDT 2019
The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.
The EMBO journal
Sainz de Aja J,Menchero S,Rollan I,Barral A,Tiana M,Jawaid W,Cossio I,Alvarez A,Carreño-Tarragona G,Badia-Careaga C,Nichols J,Göttgens B,Isern J,Manzanares M
Mon Apr 01 00:00:00 EDT 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
250-03 was used in Cell Culture to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 EDT 2019
Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications.
Stem cells translational medicine
Kwon YW,Lee SJ,Heo SC,Lee TW,Park GT,Yoon JW,Kim SC,Shin HJ,Lee SC,Kim JH
Fri Mar 01 00:00:00 EST 2019
Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.
Antioxidants & redox signaling
Halvarsson C,Rörby E,Eliasson P,Lang S,Soneji S,Jönsson JI
250-03 was used in Cell Culture to investigate if HIF-1α protects hematopoietic stem cells against ROS.
Sat Jul 20 00:00:00 EDT 2019
Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia.
Cancer science
Chu Y,Chen Y,Li M,Shi D,Wang B,Lian Y,Cheng X,Wang X,Xu M,Cheng T,Shi J,Yuan W
Mon Jul 01 00:00:00 EDT 2019
IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3.
Immunology and cell biology
McCarthy PC,Phair IR,Greger C,Pardali K,McGuire VA,Clark AR,Gaestel M,Arthur JSC
Tue Jan 01 00:00:00 EST 2019
Mast cell tetrahydrobiopterin contributes to itch in mice.
Journal of cellular and molecular medicine
Zschiebsch K,Fischer C,Wilken-Schmitz A,Geisslinger G,Channon K,Watschinger K,Tegeder I
Fri Feb 01 00:00:00 EST 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports
Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D
250-03 was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.
Tue Jan 22 00:00:00 EST 2019
Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.
Frontiers in immunology
Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC
250-03 was used in In vitro experiments to show for the first time a role for mast cells in skin chronic graft-vs-host disease that may be targetable for preventive and therapeutic intervention in this disease.
Tue Nov 17 00:00:00 EST 2020
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.
Nature communications
Nayak RC,Hegde S,Althoff MJ,Wellendorf AM,Mohmoud F,Perentesis J,Reina-Campos M,Reynaud D,Zheng Y,Diaz-Meco MT,Moscat J,Cancelas JA
Fri Jan 04 00:00:00 EST 2019
Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells.
Scientific reports
Nishi K,Kanayama Y,Kim IH,Nakata A,Nishiwaki H,Sugahara T
Thu Nov 07 00:00:00 EST 2019
Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development.
Cell death & disease
Gong Z,Shang B,Chu Y,Chen X,Li Q,Liu K,Chen Y,Huang Y,Han Y,Shang Q,Zheng Z,Song L,Li Y,Liu R,Xu C,Zhang X,Liu B,Wang L,Shao C,Wang Y,Shi Y
Wed Jun 05 00:00:00 EDT 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 EST 2019
Functional Oocytes Derived from Granulosa Cells.
Cell reports
Tian C,Liu L,Ye X,Fu H,Sheng X,Wang L,Wang H,Heng D,Liu L
250-03 was used in Cell Culture to demonstrate that funtional oocytes posessing high genomic stability can be produced in vitro from somatic gPSCs through cellular reprogramming, facilitated by protonic sodium or acid - overall a safe and effective chemical induction technique.
Tue Dec 24 00:00:00 EST 2019
Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.
Cell stem cell
Masiuk KE,Laborada J,Roncarolo MG,Hollis RP,Kohn DB
250-03 was used in Cell Culture to demonstrate preclinical efficacy for the treatment of IPEX patients by autologous HSC transplant and may provide valuable insights into new cell therapies for autoimmunity.
Thu Feb 07 00:00:00 EST 2019
Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis.
Scientific reports
Zhang Y,Hu N,Dong F
Thu Jan 24 00:00:00 EST 2019
Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.
Scientific reports
Dhakal H,Yang EJ,Lee S,Kim MJ,Baek MC,Lee B,Park PH,Kwon TK,Khang D,Song KS,Kim SH
Fri May 03 00:00:00 EDT 2019
Non-thermal plasma inhibits mast cell activation and ameliorates allergic skin inflammatory diseases in NC/Nga mice.
Scientific reports
Lee MH,Lee YS,Kim HJ,Han CH,Kang SU,Kim CH
Wed Sep 18 00:00:00 EDT 2019
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Nature communications
Papaioannou D,Petri A,Dovey OM,Terreri S,Wang E,Collins FA,Woodward LA,Walker AE,Nicolet D,Pepe F,Kumchala P,Bill M,Walker CJ,Karunasiri M,Mrózek K,Gardner ML,Camilotto V,Zitzer N,Cooper JL,Cai X,Rong-Mullins X,Kohlschmidt J,Archer KJ,Freitas MA,Zheng Y,Lee RJ,Aifantis I,Vassiliou G,Singh G,Kauppinen S,Bloomfield CD,Dorrance AM,Garzon R
Mon Nov 25 00:00:00 EST 2019
Resveratrol inhibits IL-33-mediated mast cell activation by targeting the MK2/3-PI3K/Akt axis.
Scientific reports
Nakajima S,Ishimaru K,Kobayashi A,Yu G,Nakamura Y,Oh-Oka K,Suzuki-Inoue K,Kono K,Nakao A
Thu Dec 05 00:00:00 EST 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 EST 2019
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells.
Scientific reports
Nakamura Y,Sasaki T,Mochizuki C,Ishimaru K,Koizumi S,Shinmori H,Suzuki-Inoue K,Nakao A
Mon Nov 04 00:00:00 EST 2019
Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis.
Scientific reports
Lin CH,Wang Z,Duque-Afonso J,Wong SH,Demeter J,Loktev AV,Somervaille TCP,Jackson PK,Cleary ML
Wed Mar 20 00:00:00 EDT 2019
IL1RL1 is dynamically expressed on Cbfb-MYH11+ leukemia stem cells and promotes cell survival.
Scientific reports
Wang Y,Richter L,Becker M,Amador C,Hyde RK
Mon Feb 11 00:00:00 EST 2019
Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.
Stem cell research & therapy
I T,Sumita Y,Yoshida T,Honma R,Iwatake M,Raudales JLM,Shizuno T,Kuroshima S,Masuda H,Seki M,Tran SD,Asahara T,Asahina I
250-03 was used in Cell Culture to investigate methods conditioning peripheral blood mononuclear cells to regenerate salivary gland following head and neck cancer treatment.
Thu Oct 17 00:00:00 EDT 2019
Population snapshots predict early haematopoietic and erythroid hierarchies.
Nature
Tusi BK,Wolock SL,Weinreb C,Hwang Y,Hidalgo D,Zilionis R,Waisman A,Huh JR,Klein AM,Socolovsky M
250-03 was used in In vitro experiments to illustrate the utility of coupling population snapshots with predictive fate models, to gain in vivo insights of early hempatopoetic and erythroid lineage sorting.
Thu Mar 01 00:00:00 EST 2018
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.
Nature
Shen Q,Zhang Q,Shi Y,Shi Q,Jiang Y,Gu Y,Li Z,Li X,Zhao K,Wang C,Li N,Cao X
Thu Feb 01 00:00:00 EST 2018
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells.
Nature
Carrelha J,Meng Y,Kettyle LM,Luis TC,Norfo R,Alcolea V,Boukarabila H,Grasso F,Gambardella A,Grover A,Högstrand K,Lord AM,Sanjuan-Pla A,Woll PS,Nerlov C,Jacobsen SEW
Thu Feb 01 00:00:00 EST 2018
Senescence-associated reprogramming promotes cancer stemness.
Nature
Milanovic M,Fan DNY,Belenki D,Däbritz JHM,Zhao Z,Yu Y,Dörr JR,Dimitrova L,Lenze D,Monteiro Barbosa IA,Mendoza-Parra MA,Kanashova T,Metzner M,Pardon K,Reimann M,Trumpp A,Dörken B,Zuber J,Gronemeyer H,Hummel M,Dittmar G,Lee S,Schmitt CA
Thu Jan 04 00:00:00 EST 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 EST 2018
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
Nature biotechnology
Kosicki M,Tomberg K,Bradley A
Sat Sep 01 00:00:00 EDT 2018
Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.
Cell
Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T
Thu Jan 11 00:00:00 EST 2018
CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia.
Cell
Pulikkan JA,Hegde M,Ahmad HM,Belaghzal H,Illendula A,Yu J,O'Hagan K,Ou J,Muller-Tidow C,Wolfe SA,Zhu LJ,Dekker J,Bushweller JH,Castilla LH
250-03 was used in In vitro experiments to study the mechanism for the ways in which CBFβ-SMMHC drives leukemia maintenance and show that inhibitors targeting chromatin activity may prove effective in inv(16) leukemia therapy.
Thu Jun 28 00:00:00 EDT 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.
Cell
Minzel W,Venkatachalam A,Fink A,Hung E,Brachya G,Burstain I,Shaham M,Rivlin A,Omer I,Zinger A,Elias S,Winter E,Erdman PE,Sullivan RW,Fung L,Mercurio F,Li D,Vacca J,Kaushansky N,Shlush L,Oren M,Levine R,Pikarsky E,Snir-Alkalay I,Ben-Neriah Y
250-03 was used in In vitro experiments to demonstrate that the inhibitors abolish many SEs and preferentially suppress the transcription elongation of SE-driven oncogenes.
Thu Sep 20 00:00:00 EDT 2018
B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies.
Cell
Xiao G,Chan LN,Klemm L,Braas D,Chen Z,Geng H,Zhang QC,Aghajanirefah A,Cosgun KN,Sadras T,Lee J,Mirzapoiazova T,Salgia R,Ernst T,Hochhaus A,Jumaa H,Jiang X,Weinstock DM,Graeber TG,Müschen M
Thu Apr 05 00:00:00 EDT 2018
T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation.
Immunity
Tu E,Chia CPZ,Chen W,Zhang D,Park SA,Jin W,Wang D,Alegre ML,Zhang YE,Sun L,Chen W
Tue Apr 17 00:00:00 EDT 2018
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.
Immunity
Postat J,Olekhnovitch R,Lemaître F,Bousso P
Tue Oct 16 00:00:00 EDT 2018
Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding.
Immunity
Hosokawa H,Ungerbäck J,Wang X,Matsumoto M,Nakayama KI,Cohen SM,Tanaka T,Rothenberg EV
Tue Jun 19 00:00:00 EDT 2018
The Majority of CD45- Ter119- CD31- Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors.
Immunity
Boulais PE,Mizoguchi T,Zimmerman S,Nakahara F,Vivié J,Mar JC,van Oudenaarden A,Frenette PS
Tue Oct 16 00:00:00 EDT 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 EDT 2018
Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors.
Immunity
Li Z,Liu S,Xu J,Zhang X,Han D,Liu J,Xia M,Yi L,Shen Q,Xu S,Lu L,Cao X
Tue Oct 16 00:00:00 EDT 2018
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia.
Cancer cell
Maes T,Mascaró C,Tirapu I,Estiarte A,Ciceri F,Lunardi S,Guibourt N,Perdones A,Lufino MMP,Somervaille TCP,Wiseman DH,Duy C,Melnick A,Willekens C,Ortega A,Martinell M,Valls N,Kurz G,Fyfe M,Castro-Palomino JC,Buesa C
Mon Mar 12 00:00:00 EDT 2018
Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.
Cancer cell
Yamauchi T,Masuda T,Canver MC,Seiler M,Semba Y,Shboul M,Al-Raqad M,Maeda M,Schoonenberg VAC,Cole MA,Macias-Trevino C,Ishikawa Y,Yao Q,Nakano M,Arai F,Orkin SH,Reversade B,Buonamici S,Pinello L,Akashi K,Bauer DE,Maeda T
Mon Mar 12 00:00:00 EDT 2018
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
Cancer cell
Kunimoto H,Meydan C,Nazir A,Whitfield J,Shank K,Rapaport F,Maher R,Pronier E,Meyer SC,Garrett-Bakelman FE,Tallman M,Melnick A,Levine RL,Shih AH
Mon Jan 08 00:00:00 EST 2018
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Vanden Bempt M,Demeyer S,Broux M,De Bie J,Bornschein S,Mentens N,Vandepoel R,Geerdens E,Radaelli E,Bornhauser BC,Kulozik AE,Meijerink JP,Bourquin JP,de Bock CE,Cools J
Mon Aug 13 00:00:00 EDT 2018
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Cancer cell
Booth CAG,Barkas N,Neo WH,Boukarabila H,Soilleux EJ,Giotopoulos G,Farnoud N,Giustacchini A,Ashley N,Carrelha J,Jamieson L,Atkinson D,Bouriez-Jones T,Prinjha RK,Milne TA,Teachey DT,Papaemmanuil E,Huntly BJP,Jacobsen SEW,Mead AJ
Mon Feb 12 00:00:00 EST 2018
Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Cancer cell
Kleppe M,Koche R,Zou L,van Galen P,Hill CE,Dong L,De Groote S,Papalexi E,Hanasoge Somasundara AV,Cordner K,Keller M,Farnoud N,Medina J,McGovern E,Reyes J,Roberts J,Witkin M,Rapaport F,Teruya-Feldstein J,Qi J,Rampal R,Bernstein BE,Bradner JE,Levine RL
Mon Jan 08 00:00:00 EST 2018
Crbn I391V is sufficient to confer in vivo sensitivity to thalidomide and its derivatives in mice.
Blood
Fink EC,McConkey M,Adams DN,Haldar SD,Kennedy JA,Guirguis AA,Udeshi ND,Mani DR,Chen M,Liddicoat B,Svinkina T,Nguyen AT,Carr SA,Ebert BL
Thu Oct 04 00:00:00 EDT 2018
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.
Blood
Gallipoli P,Giotopoulos G,Tzelepis K,Costa ASH,Vohra S,Medina-Perez P,Basheer F,Marando L,Di Lisio L,Dias JML,Yun H,Sasca D,Horton SJ,Vassiliou G,Frezza C,Huntly BJP
Thu Apr 12 00:00:00 EDT 2018
A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.
Blood
Dahlin JS,Hamey FK,Pijuan-Sala B,Shepherd M,Lau WWY,Nestorowa S,Weinreb C,Wolock S,Hannah R,Diamanti E,Kent DG,Göttgens B,Wilson NK
Thu May 24 00:00:00 EDT 2018
Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.
Blood
Shima H,Takamatsu-Ichihara E,Shino M,Yamagata K,Katsumoto T,Aikawa Y,Fujita S,Koseki H,Kitabayashi I
Thu Apr 19 00:00:00 EDT 2018
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Blood
Jacquelin S,Straube J,Cooper L,Vu T,Song A,Bywater M,Baxter E,Heidecker M,Wackrow B,Porter A,Ling V,Green J,Austin R,Kazakoff S,Waddell N,Hesson LB,Pimanda JE,Stegelmann F,Bullinger L,Döhner K,Rampal RK,Heckl D,Hill GR,Lane SW
Thu Dec 27 00:00:00 EST 2018
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
Blood
El Ashkar S,Schwaller J,Pieters T,Goossens S,Demeulemeester J,Christ F,Van Belle S,Juge S,Boeckx N,Engelman A,Van Vlierberghe P,Debyser Z,De Rijck J
Thu Jan 04 00:00:00 EST 2018
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.
Cell stem cell
Duarte D,Hawkins ED,Akinduro O,Ang H,De Filippo K,Kong IY,Haltalli M,Ruivo N,Straszkowski L,Vervoort SJ,McLean C,Weber TS,Khorshed R,Pirillo C,Wei A,Ramasamy SK,Kusumbe AP,Duffy K,Adams RH,Purton LE,Carlin LM,Lo Celso C
250-03 was used in Cell Culture to suggest that preventing degradation of the endosteal vasculature may improve current paradigms for treating acute myeloid leukemia.
Thu Jan 04 00:00:00 EST 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
Tue Jan 02 00:00:00 EST 2018
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling.
The Journal of clinical investigation
Zhang Y,Xia F,Liu X,Yu Z,Xie L,Liu L,Chen C,Jiang H,Hao X,He X,Zhang F,Gu H,Zhu J,Bai H,Zhang CC,Chen GQ,Zheng J
Tue May 01 00:00:00 EDT 2018
Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy.
The Journal of clinical investigation
Zhang P,He F,Bai J,Yamamoto S,Chen S,Zhang L,Sheng M,Zhang L,Guo Y,Man N,Yang H,Wang S,Cheng T,Nimer SD,Zhou Y,Xu M,Wang QF,Yang FC
Mon Dec 03 00:00:00 EST 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
Fri Jun 01 00:00:00 EDT 2018
Kinetics of adult hematopoietic stem cell differentiation in vivo.
The Journal of experimental medicine
Upadhaya S,Sawai CM,Papalexi E,Rashidfarrokhi A,Jang G,Chattopadhyay P,Satija R,Reizis B
Mon Nov 05 00:00:00 EST 2018
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.
The Journal of experimental medicine
Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F
Mon May 07 00:00:00 EDT 2018
Altered compensatory cytokine signaling underlies the discrepancy between and mice.
The Journal of experimental medicine
Durai V,Bagadia P,Briseño CG,Theisen DJ,Iwata A,Davidson JT,Gargaro M,Fremont DH,Murphy TL,Murphy KM
Mon May 07 00:00:00 EDT 2018
Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
The Journal of experimental medicine
Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA
Mon Feb 05 00:00:00 EST 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 EDT 2018
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
The Journal of experimental medicine
Arnold IC,Artola-Borán M,Tallón de Lara P,Kyburz A,Taube C,Ottemann K,van den Broek M,Yousefi S,Simon HU,Müller A
Mon Aug 06 00:00:00 EDT 2018
Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
The Journal of experimental medicine
Khalil S,Delehanty L,Grado S,Holy M,White Z,Freeman K,Kurita R,Nakamura Y,Bullock G,Goldfarb A
Mon Feb 05 00:00:00 EST 2018
The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.
The Journal of allergy and clinical immunology
Li Y,Liu B,Harmacek L,Long Z,Liang J,Lukin K,Leach SM,O'Connor B,Gerber AN,Hagman J,Roers A,Finkelman FD,Huang H
250-03 was used in Cell Culture to conclude that the transcription factors GATA2 and MITF regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.
Mon Oct 01 00:00:00 EDT 2018
Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.
Leukemia
Mingay M,Chaturvedi A,Bilenky M,Cao Q,Jackson L,Hui T,Moksa M,Heravi-Moussavi A,Humphries RK,Heuser M,Hirst M
Mon Jan 01 00:00:00 EST 2018
Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Proceedings of the National Academy of Sciences of the United States of America
Das P,Veazey KJ,Van HT,Kaushik S,Lin K,Lu Y,Ishii M,Kikuta J,Ge K,Nussenzweig A,Santos MA
Tue Oct 23 00:00:00 EDT 2018
Revealing nascent proteomics in signaling pathways and cell differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Forester CM,Zhao Q,Phillips NJ,Urisman A,Chalkley RJ,Oses-Prieto JA,Zhang L,Ruggero D,Burlingame AL
Tue Mar 06 00:00:00 EST 2018
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America
Sharma S,Čermáková K,De Rijck J,Demeulemeester J,Fábry M,El Ashkar S,Van Belle S,Lepšík M,Tesina P,Duchoslav V,Novák P,Hubálek M,Srb P,Christ F,Řezáčová P,Hodges HC,Debyser Z,Veverka V
Tue Jul 24 00:00:00 EDT 2018
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.
Oncogene
Pinazza M,Ghisi M,Minuzzo S,Agnusdei V,Fossati G,Ciminale V,Pezzè L,Ciribilli Y,Pilotto G,Venturoli C,Amadori A,Indraccolo S
Sun Jul 01 00:00:00 EDT 2018
TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1.
Journal of immunology (Baltimore, Md. : 1950)
Shen ZJ,Hu J,Kashi V,Bochkov YA,Gern JE,Malter JS
Sat Dec 15 00:00:00 EST 2018
Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality.
Journal of immunology (Baltimore, Md. : 1950)
Lim TJF,Su IH
Sat Dec 15 00:00:00 EST 2018
Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.
Journal of immunology (Baltimore, Md. : 1950)
Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA
Thu Feb 01 00:00:00 EST 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
Thu Feb 15 00:00:00 EST 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
250-03 was used in Cell Culture to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity.
Nature communications
Massara M,Bonavita O,Savino B,Caronni N,Mollica Poeta V,Sironi M,Setten E,Recordati C,Crisafulli L,Ficara F,Mantovani A,Locati M,Bonecchi R
Wed Feb 14 00:00:00 EST 2018
Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.
Scientific reports
Philp AR,Riquelme TT,Millar-Büchner P,González R,Sepúlveda FV,Cid LP,Flores CA
Mon Jun 18 00:00:00 EDT 2018
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation.
Nature immunology
Cuartero S,Weiss FD,Dharmalingam G,Guo Y,Ing-Simmons E,Masella S,Robles-Rebollo I,Xiao X,Wang YF,Barozzi I,Djeghloul D,Amano MT,Niskanen H,Petretto E,Dowell RD,Tachibana K,Kaikkonen MU,Nasmyth KA,Lenhard B,Natoli G,Fisher AG,Merkenschlager M
250-03 was used in Cell Culture to show that cohesin is required for the core transcriptional response of primary macrophages to microbial signals, and for inducible enhancer activity that underpins inflammatory gene expression.
Sat Sep 01 00:00:00 EDT 2018
GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice.
Scientific reports
Chen C,Li X,Ge G,Liu J,Biju KC,Laing SD,Qian Y,Ballard C,He Z,Masliah E,Clark RA,O'Connor JC,Li S
Tue Apr 03 00:00:00 EDT 2018
Deficiency in Fpr2 results in reduced numbers of Lin-cKit+Sca1+ myeloid progenitor cells.
The Journal of biological chemistry
Chen K,Tang P,Bao Z,He T,Xiang Y,Gong W,Yoshimura T,Le Y,Tessarollo L,Chen X,Wang JM
Fri Aug 31 00:00:00 EDT 2018
MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.
Cell death & disease
Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G
Thu Jul 26 00:00:00 EDT 2018
Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.
Cell reports
Schmitt M,Schewe M,Sacchetti A,Feijtel D,van de Geer WS,Teeuwssen M,Sleddens HF,Joosten R,van Royen ME,van de Werken HJG,van Es J,Clevers H,Fodde R
250-03 was used in Cell Culture to show that acute inflammation of the mouse small intestine is followed by a dramatic loss of Lgr5+ stem cells.
Tue Aug 28 00:00:00 EDT 2018
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
Tue May 15 00:00:00 EDT 2018
The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.
Cell death & disease
Liu T,Kong WX,Tang XY,Xu M,Wang QH,Zhang B,Hu LD,Chen H
Thu Jun 07 00:00:00 EDT 2018
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
Stem cell reports
Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T
Tue Sep 11 00:00:00 EDT 2018
In Vitro Differentiation of Gata2 and Ly6a Reporter Embryonic Stem Cells Corresponds to In Vivo Waves of Hematopoietic Cell Generation.
Stem cell reports
Kauts ML,Rodriguez-Seoane C,Kaimakis P,Mendes SC,Cortés-Lavaud X,Hill U,Dzierzak E
Tue Jan 09 00:00:00 EST 2018
P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of Bim.
Nature communications
Hu P,Nebreda AR,Hanenberg H,Kinnebrew GH,Ivan M,Yoder MC,Filippi MD,Broxmeyer HE,Kapur R
Wed Aug 29 00:00:00 EDT 2018
Honokiol is a FOXM1 antagonist.
Cell death & disease
Halasi M,Hitchinson B,Shah BN,Váraljai R,Khan I,Benevolenskaya EV,Gaponenko V,Arbiser JL,Gartel AL
Wed Jan 24 00:00:00 EST 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
250-03 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
250-03 was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 EDT 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 EST 2018
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.
Nature communications
Calcinotto A,Brevi A,Chesi M,Ferrarese R,Garcia Perez L,Grioni M,Kumar S,Garbitt VM,Sharik ME,Henderson KJ,Tonon G,Tomura M,Miwa Y,Esplugues E,Flavell RA,Huber S,Canducci F,Rajkumar VS,Bergsagel PL,Bellone M
Mon Dec 03 00:00:00 EST 2018
SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival.
Nature communications
Su H,Hu J,Huang L,Yang Y,Thenoz M,Kuchmiy A,Hu Y,Li P,Feng H,Zhou Y,Taghon T,Van Vlierberghe P,Qing G,Chen Z,Liu H
Mon Oct 15 00:00:00 EDT 2018
mTOR complexes differentially orchestrates eosinophil development in allergy.
Scientific reports
Zhu C,Xia L,Li F,Zhou L,Weng Q,Li Z,Wu Y,Mao Y,Zhang C,Wu Y,Li M,Ying S,Chen Z,Shen H,Li W
Wed May 02 00:00:00 EDT 2018
Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume).
Scientific reports
Kono R,Nakamura M,Nomura S,Kitano N,Kagiya T,Okuno Y,Inada KI,Tokuda A,Utsunomiya H,Ueno M
Fri Aug 03 00:00:00 EDT 2018
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
Nature communications
Ganuza M,Chabot A,Tang X,Bi W,Natarajan S,Carter R,Gawad C,Kang G,Cheng Y,McKinney-Freeman S
Thu Dec 20 00:00:00 EST 2018
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell discovery
Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL
Thu Aug 17 00:00:00 EDT 2023
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 EST 2018
A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.
Nature communications
Brown JM,Roberts NA,Graham B,Waithe D,Lagerholm C,Telenius JM,De Ornellas S,Oudelaar AM,Scott C,Szczerbal I,Babbs C,Kassouf MT,Hughes JR,Higgs DR,Buckle VJ
Fri Sep 21 00:00:00 EDT 2018
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.
Nature communications
Numata A,Kwok HS,Kawasaki A,Li J,Zhou QL,Kerry J,Benoukraf T,Bararia D,Li F,Ballabio E,Tapia M,Deshpande AJ,Welner RS,Delwel R,Yang H,Milne TA,Taneja R,Tenen DG
Tue Apr 24 00:00:00 EDT 2018
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
Tue Sep 11 00:00:00 EDT 2018
De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.
Nature communications
Hyrenius-Wittsten A,Pilheden M,Sturesson H,Hansson J,Walsh MP,Song G,Kazi JU,Liu J,Ramakrishan R,Garcia-Ruiz C,Nance S,Gupta P,Zhang J,Rönnstrand L,Hultquist A,Downing JR,Lindkvist-Petersson K,Paulsson K,Järås M,Gruber TA,Ma J,Hagström-Andersson AK
Wed May 02 00:00:00 EDT 2018
Embryonic germ cell extracts erase imprinted genes and improve the efficiency of induced pluripotent stem cells.
Scientific reports
Hu J,Zhao Q,Feng Y,Li N,Gu Y,Sun R,Duan L,Wu Y,Shan Z,Lei L
Thu Jul 19 00:00:00 EDT 2018
Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.
Communications biology
Willetts L,Felix LC,Jacobsen EA,Puttagunta L,Condjella RM,Zellner KR,Ochkur SI,Kim JD,Luo H,Lee NA,Lee JJ,Moqbel R,Lacy P
Sat Jan 11 00:00:00 EST 2020
Generation of BMEC Lines and in vitro BMEC-HSPC Co-culture Assays.
Bio-protocol
Guo P,Rafii S
250-03 was used in Cell Culture to show that the BMEC-HSPC co-culture system serves as bioreactor prototype to generate scalable populations of the blood and immune systems.
Mon Nov 05 00:00:00 EST 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains.
Stem cell reports
Morales-Hernández A,Martinat A,Chabot A,Kang G,McKinney-Freeman S
Tue Aug 14 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Tue Dec 11 00:00:00 EST 2018
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Nature communications
Tzelepis K,De Braekeleer E,Aspris D,Barbieri I,Vijayabaskar MS,Liu WH,Gozdecka M,Metzakopian E,Toop HD,Dudek M,Robson SC,Hermida-Prado F,Yang YH,Babaei-Jadidi R,Garyfallos DA,Ponstingl H,Dias JML,Gallipoli P,Seiler M,Buonamici S,Vick B,Bannister AJ,Rad R,Prinjha RK,Marioni JC,Huntly B,Batson J,Morris JC,Pina C,Bradley A,Jeremias I,Bates DO,Yusa K,Kouzarides T,Vassiliou GS
Wed Dec 19 00:00:00 EST 2018
Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation.
Cell reports
Nakamura-Ishizu A,Matsumura T,Stumpf PS,Umemoto T,Takizawa H,Takihara Y,O'Neil A,Majeed ABBA,MacArthur BD,Suda T
250-03 was used in Cell Culture to report an important role for thrombopoietin in regulating rapid megakaryocyte-lineage commitment.
Tue Nov 13 00:00:00 EST 2018
In vitro improvement of quail primordial germ cell expansion through activation of TGF-beta signaling pathway.
Journal of cellular biochemistry
Yakhkeshi S,Rahimi S,Sharafi M,Hassani SN,Taleahmad S,Shahverdi A,Baharvand H
250-03 was used in In vitro experiments to suggest that the application of IDE1 small molecule into the culture of quail PGCs represented a step toward achieving efficient expansion of the avian PGCs.
Fri Jun 01 00:00:00 EDT 2018
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.
Nature
Barbieri I,Tzelepis K,Pandolfini L,Shi J,Millán-Zambrano G,Robson SC,Aspris D,Migliori V,Bannister AJ,Han N,De Braekeleer E,Ponstingl H,Hendrick A,Vakoc CR,Vassiliou GS,Kouzarides T
Thu Dec 07 00:00:00 EST 2017
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
Burgess MR,Hwang E,Mroue R,Bielski CM,Wandler AM,Huang BJ,Firestone AJ,Young A,Lacap JA,Crocker L,Asthana S,Davis EM,Xu J,Akagi K,Le Beau MM,Li Q,Haley B,Stokoe D,Sampath D,Taylor BS,Evangelista M,Shannon K
Thu Feb 23 00:00:00 EST 2017
Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.
Cell
Yu W,Goncalves KA,Li S,Kishikawa H,Sun G,Yang H,Vanli N,Wu Y,Jiang Y,Hu MG,Friedel RH,Hu GF
Thu Nov 02 00:00:00 EDT 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
250-03 was used in In vitro experiments to determine the role of TET2 deficiency in leukaemia stem cell maintenance.
Thu Sep 07 00:00:00 EDT 2017
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
Thu May 18 00:00:00 EDT 2017
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
250-03 was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 EST 2017
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Immunity
Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C
Tue May 16 00:00:00 EDT 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 EDT 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
Mon Apr 10 00:00:00 EDT 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
Mon Apr 10 00:00:00 EDT 2017
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood
Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T
Thu Mar 23 00:00:00 EDT 2017
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.
Blood
Ishizawa J,Sugihara E,Kuninaka S,Mogushi K,Kojima K,Benton CB,Zhao R,Chachad D,Hashimoto N,Jacamo RO,Qiu Y,Yoo SY,Okamoto S,Andreeff M,Kornblau SM,Saya H
Thu Apr 06 00:00:00 EDT 2017
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.
Blood
Man N,Tan Y,Sun XJ,Liu F,Cheng G,Greenblatt SM,Martinez C,Karl DL,Ando K,Sun M,Hou D,Chen B,Xu M,Yang FC,Chen Z,Chen S,Nimer SD,Wang L
Thu May 18 00:00:00 EDT 2017
NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.
Blood
Prince LR,Prosseda SD,Higgins K,Carlring J,Prestwich EC,Ogryzko NV,Rahman A,Basran A,Falciani F,Taylor P,Renshaw SA,Whyte MKB,Sabroe I
Thu Aug 24 00:00:00 EDT 2017
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.
Blood
Dovey OM,Cooper JL,Mupo A,Grove CS,Lynn C,Conte N,Andrews RM,Pacharne S,Tzelepis K,Vijayabaskar MS,Green P,Rad R,Arends M,Wright P,Yusa K,Bradley A,Varela I,Vassiliou GS
Thu Oct 26 00:00:00 EDT 2017
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.
The Journal of clinical investigation
Guo P,Poulos MG,Palikuqi B,Badwe CR,Lis R,Kunar B,Ding BS,Rabbany SY,Shido K,Butler JM,Rafii S
Fri Dec 01 00:00:00 EST 2017
Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.
The Journal of clinical investigation
Mitroulis I,Chen LS,Singh RP,Kourtzelis I,Economopoulou M,Kajikawa T,Troullinaki M,Ziogas A,Ruppova K,Hosur K,Maekawa T,Wang B,Subramanian P,Tonn T,Verginis P,von Bonin M,Wobus M,Bornhäuser M,Grinenko T,Di Scala M,Hidalgo A,Wielockx B,Hajishengallis G,Chavakis T
Mon Oct 02 00:00:00 EDT 2017
Histamine-releasing factor enhances food allergy.
The Journal of clinical investigation
Ando T,Kashiwakura JI,Itoh-Nagato N,Yamashita H,Baba M,Kawakami Y,Tsai SH,Inagaki N,Takeda K,Iwata T,Shimojo N,Fujisawa T,Nagao M,Matsumoto K,Kawakami Y,Kawakami T
Fri Dec 01 00:00:00 EST 2017
Endothelial transplantation rejuvenates aged hematopoietic stem cell function.
The Journal of clinical investigation
Poulos MG,Ramalingam P,Gutkin MC,Llanos P,Gilleran K,Rabbany SY,Butler JM
Wed Nov 01 00:00:00 EDT 2017
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.
Molecular cell
Jaco I,Annibaldi A,Lalaoui N,Wilson R,Tenev T,Laurien L,Kim C,Jamal K,Wicky John S,Liccardi G,Chau D,Murphy JM,Brumatti G,Feltham R,Pasparakis M,Silke J,Meier P
250-03 was used in Cell Culture to study how TNF induced activation of MK2 results in global RIPK1 phosphorylation which serves as a checkpoint within the TNF signaling pathway which integrates cell survival and cytokine production.
Thu Jun 01 00:00:00 EDT 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
Mon Dec 04 00:00:00 EST 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
Mon May 01 00:00:00 EDT 2017
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
The Journal of experimental medicine
Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T
Mon Sep 04 00:00:00 EDT 2017
Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.
The Journal of experimental medicine
Uderhardt S,Ackermann JA,Fillep T,Hammond VJ,Willeit J,Santer P,Mayr M,Biburger M,Miller M,Zellner KR,Stark K,Zarbock A,Rossaint J,Schubert I,Mielenz D,Dietel B,Raaz-Schrauder D,Ay C,Gremmel T,Thaler J,Heim C,Herrmann M,Collins PW,Schabbauer G,Mackman N,Voehringer D,Nadler JL,Lee JJ,Massberg S,Rauh M,Kiechl S,Schett G,O'Donnell VB,Krönke G
Mon Jul 03 00:00:00 EDT 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
Mon Dec 04 00:00:00 EST 2017
Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.
Autophagy
Chen X,Clark J,Wunderlich M,Fan C,Davis A,Chen S,Guan JL,Mulloy JC,Kumar A,Zheng Y
250-03 was used in Cell Culture to uncover anti-leukemic effects of choloroquine being independent of autophagy which can be enhanced via vesicular exocytotis inhibition, and autophagy being an insignificant target of MA9-AML therapy.
Thu May 04 00:00:00 EDT 2017
Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques.
Cancer research
Ishigaki H,Maeda T,Inoue H,Akagi T,Sasamura T,Ishida H,Inubushi T,Okahara J,Shiina T,Nakayama M,Itoh Y,Ogasawara K
250-03 was used in Cell Culture to demonstrate that autoantibodies can mitigate tumour growth in vitro and in vivo.
Wed Nov 01 00:00:00 EDT 2017
Preclinical modeling of myelodysplastic syndromes.
Leukemia
Rouault-Pierre K,Mian SA,Goulard M,Abarrategi A,Di Tulio A,Smith AE,Mohamedali A,Best S,Nloga AM,Kulasekararaj AG,Ades L,Chomienne C,Fenaux P,Dosquet C,Mufti GJ,Bonnet D
Fri Dec 01 00:00:00 EST 2017
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Gao X,Lee HY,Li W,Platt RJ,Barrasa MI,Ma Q,Elmes RR,Rosenfeld MG,Lodish HF
Tue Sep 19 00:00:00 EDT 2017
Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2-/- mice.
Mucosal immunology
Verma AH,Bueter CL,Rothenberg ME,Deepe GS
Sun Jan 01 00:00:00 EST 2017
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.
Journal of immunology (Baltimore, Md. : 1950)
Falahee PC,Anderson LS,Reynolds MB,Pirir M,McLaughlin BE,Dillen CA,Cheung AL,Miller LS,Simon SI
Fri Sep 01 00:00:00 EDT 2017
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
Journal of immunology (Baltimore, Md. : 1950)
McCurdy S,Baumer Y,Toulmin E,Lee BH,Boisvert WA
Wed Nov 15 00:00:00 EST 2017
The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Drube S,Grimlowski R,Deppermann C,Fröbel J,Kraft F,Andreas N,Stegner D,Dudeck J,Weber F,Rödiger M,Göpfert C,Drube J,Reich D,Nieswandt B,Dudeck A,Kamradt T
Sun Oct 15 00:00:00 EDT 2017
The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production.
Journal of immunology (Baltimore, Md. : 1950)
Netherby CS,Messmer MN,Burkard-Mandel L,Colligan S,Miller A,Cortes Gomez E,Wang J,Nemeth MJ,Abrams SI
Mon May 15 00:00:00 EDT 2017
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y
Sun Oct 15 00:00:00 EDT 2017
TGF-β1 Suppresses IL-33-Induced Mast Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Ndaw VS,Abebayehu D,Spence AJ,Paez PA,Kolawole EM,Taruselli MT,Caslin HL,Chumanevich AP,Paranjape A,Baker B,Barnstein BO,Haque TT,Kiwanuka KN,Oskeritzian CA,Ryan JJ
Tue Aug 01 00:00:00 EDT 2017
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Nature communications
Hinge A,Xu J,Javier J,Mose E,Kumar S,Kapur R,Srour EF,Malik P,Aronow BJ,Filippi MD
Wed Feb 08 00:00:00 EST 2017
An unexpected protein interaction promotes drug resistance in leukemia.
Nature communications
Pitre A,Ge Y,Lin W,Wang Y,Fukuda Y,Temirov J,Phillips AH,Peters JL,Fan Y,Ma J,Nourse A,Sinha C,Lin H,Kriwacki R,Downing JR,Gruber TA,Centonze VE,Naren AP,Chen T,Schuetz JD
Thu Nov 16 00:00:00 EST 2017
Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice.
Molecular therapy. Methods & clinical development
Lee S,Kivimäe S,Szoka FC
250-03 was used in In vitro experiments to generate Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow cells with a constitutively expressed Hoxb8 flanked by loxP. HDPs proliferate indefinitely and differentiate into MΦ when Hoxb8 is removed by a tamoxifen-inducible Cre.
Fri Dec 15 00:00:00 EST 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Fri Sep 29 00:00:00 EDT 2017
PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.
Nature communications
Yu M,Chen Y,Zeng H,Zheng Y,Fu G,Zhu W,Broeckel U,Aggarwal P,Turner A,Neale G,Guy C,Zhu N,Chi H,Wen R,Wang D
Mon Nov 13 00:00:00 EST 2017
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
The Journal of biological chemistry
Nadeau SA,An W,Mohapatra BC,Mushtaq I,Bielecki TA,Luan H,Zutshi N,Ahmad G,Storck MD,Sanada M,Ogawa S,Band V,Band H
Fri Mar 03 00:00:00 EST 2017
Murine Retrovirally-Transduced Bone Marrow Engraftment Models of MLL-Fusion-Driven Acute Myelogenous Leukemias (AML).
Current protocols in pharmacology
Stubbs MC,Krivtsov AV
250-03 was used in In vitro experiments to define protocols which focus on bone marrow-derived models only, using one particular MLL fusion, MLL-AF9.
Mon Sep 11 00:00:00 EDT 2017
Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells.
Nature communications
Ranjan S,Goihl A,Kohli S,Gadi I,Pierau M,Shahzad K,Gupta D,Bock F,Wang H,Shaikh H,Kähne T,Reinhold D,Bank U,Zenclussen AC,Niemz J,Schnöder TM,Brunner-Weinzierl M,Fischer T,Kalinski T,Schraven B,Luft T,Huehn J,Naumann M,Heidel FH,Isermann B
Mon Aug 21 00:00:00 EDT 2017
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.
Nature communications
Liu B,Ye B,Zhu X,Huang G,Yang L,Zhu P,Du Y,Wu J,Meng S,Tian Y,Fan Z
Thu Aug 10 00:00:00 EDT 2017
CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.
Scientific reports
Rozenberg P,Reichman H,Zab-Bar I,Itan M,Pasmanik-Chor M,Bouffi C,Qimron U,Bachelet I,Fulkerson PC,Rothenberg ME,Munitz A
Wed Jul 19 00:00:00 EDT 2017
Role of Mast Cells in clearance of Leishmania through extracellular trap formation.
Scientific reports
Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N
Mon Oct 16 00:00:00 EDT 2017
Role of Mast Cells in clearance of Leishmania through extracellular trap formation.
Scientific reports
Naqvi N,Ahuja K,Selvapandiyan A,Dey R,Nakhasi H,Puri N
Mon Oct 16 00:00:00 EDT 2017
TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.
Scientific reports
Pike KA,Hatzihristidis T,Bussières-Marmen S,Robert F,Desai N,Miranda-Saavedra D,Pelletier J,Tremblay ML
Mon Oct 16 00:00:00 EDT 2017
IL-7 and immobilized Kit-ligand stimulate serum- and stromal cell-free cultures of precursor B-cell lines and clones.
European journal of immunology
Kawano Y,Petkau G,Wolf I,Tornack J,Melchers F
250-03 was used in Cell Culture to describe a novel serum-free, stromal cell-free culture system, which allows us to establish and maintain pre-B cells not only from fetal liver, but also from bone marrow with practically identical efficiencies in proliferation, cloning and differentiation.
Sun Jan 01 00:00:00 EST 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
250-03 was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 EDT 2016
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.
Cell
Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL
Thu Apr 07 00:00:00 EDT 2016
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.
Cell
Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I
Thu Dec 15 00:00:00 EST 2016
Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.
Immunity
Kristiansen TA,Jaensson Gyllenbäck E,Zriwil A,Björklund T,Daniel JA,Sitnicka E,Soneji S,Bryder D,Yuan J
Tue Aug 16 00:00:00 EDT 2016
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Cell metabolism
Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC
250-03 was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.
Tue Apr 12 00:00:00 EDT 2016
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification.
Blood
Kokkaliaris KD,Drew E,Endele M,Loeffler D,Hoppe PS,Hilsenbeck O,Schauberger B,Hinzen C,Skylaki S,Theodorou M,Kieslinger M,Lemischka I,Moore K,Schroeder T
Thu Sep 01 00:00:00 EDT 2016
EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.
Blood
Gnanapragasam MN,McGrath KE,Catherman S,Xue L,Palis J,Bieker JJ
Thu Sep 22 00:00:00 EDT 2016
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Blood
Schulze I,Rohde C,Scheller-Wendorff M,Bäumer N,Krause A,Herbst F,Riemke P,Hebestreit K,Tschanter P,Lin Q,Linhart H,Godley LA,Glimm H,Dugas M,Wagner W,Berdel WE,Rosenbauer F,Müller-Tidow C
Thu Mar 24 00:00:00 EDT 2016
Developing HSCs become Notch independent by the end of maturation in the AGM region.
Blood
Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A
Thu Sep 22 00:00:00 EDT 2016
MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.
Blood
Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH
Thu Oct 27 00:00:00 EDT 2016
MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.
Blood
Baba T,Tanabe Y,Yoshikawa S,Yamanishi Y,Morishita S,Komatsu N,Karasuyama H,Hirao A,Mukaida N
Thu May 26 00:00:00 EDT 2016
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood
Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B
Thu Aug 25 00:00:00 EDT 2016
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood
Dhahri D,Sato-Kusubata K,Ohki-Koizumi M,Nishida C,Tashiro Y,Munakata S,Shimazu H,Salama Y,Eiamboonsert S,Nakauchi H,Hattori K,Heissig B
Thu Aug 25 00:00:00 EDT 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
Fri Apr 01 00:00:00 EDT 2016
FGF23 signaling impairs neutrophil recruitment and host defense during CKD.
The Journal of clinical investigation
Rossaint J,Oehmichen J,Van Aken H,Reuter S,Pavenstädt HJ,Meersch M,Unruh M,Zarbock A
Tue Mar 01 00:00:00 EST 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
Fri Jan 01 00:00:00 EST 2016
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis.
The Journal of clinical investigation
Gu H,Chen C,Hao X,Wang C,Zhang X,Li Z,Shao H,Zeng H,Yu Z,Xie L,Xia F,Zhang F,Liu X,Zhang Y,Jiang H,Zhu J,Wan J,Wang C,Weng W,Xie J,Tao M,Zhang CC,Liu J,Chen GQ,Zheng J
Thu Dec 01 00:00:00 EST 2016
Functional screen identifies regulators of murine hematopoietic stem cell repopulation.
The Journal of experimental medicine
Holmfeldt P,Ganuza M,Marathe H,He B,Hall T,Kang G,Moen J,Pardieck J,Saulsberry AC,Cico A,Gaut L,McGoldrick D,Finkelstein D,Tan K,McKinney-Freeman S
Mon Mar 07 00:00:00 EST 2016
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
The Journal of experimental medicine
Hatlen MA,Arora K,Vacic V,Grabowska EA,Liao W,Riley-Gillis B,Oschwald DM,Wang L,Joergens JE,Shih AH,Rapaport F,Gu S,Voza F,Asai T,Neel BG,Kharas MG,Gonen M,Levine RL,Nimer SD
Mon Jan 11 00:00:00 EST 2016
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
The Journal of experimental medicine
Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ
Mon Oct 17 00:00:00 EDT 2016
Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses.
The Journal of experimental medicine
Bannard O,McGowan SJ,Ersching J,Ishido S,Victora GD,Shin JS,Cyster JG
Mon May 30 00:00:00 EDT 2016
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 EDT 2016
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.
The Journal of experimental medicine
Ishida T,Takahashi S,Lai CY,Nojima M,Yamamoto R,Takeuchi E,Takeuchi Y,Higashihara M,Nakauchi H,Otsu M
Mon Aug 22 00:00:00 EDT 2016
Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis.
The Journal of experimental medicine
Shimizu T,Kubovcakova L,Nienhold R,Zmajkovic J,Meyer SC,Hao-Shen H,Geier F,Dirnhofer S,Guglielmelli P,Vannucchi AM,Feenstra JD,Kralovics R,Orkin SH,Skoda RC
Mon Jul 25 00:00:00 EDT 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival.
Stem cells (Dayton, Ohio)
Wingert S,Thalheimer FB,Haetscher N,Rehage M,Schroeder T,Rieger MA
Tue Mar 01 00:00:00 EST 2016
AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.
Stem cells (Dayton, Ohio)
Singh S,Moirangthem RD,Vaidya A,Jalnapurkar S,Limaye L,Kale V
Thu Sep 01 00:00:00 EDT 2016
CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.
Stem cells (Dayton, Ohio)
Ahmed T,Tsuji-Tamura K,Ogawa M
Thu Dec 01 00:00:00 EST 2016
SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.
Stem cells (Dayton, Ohio)
Du W,Amarachintha S,Wilson AF,Pang Q
Fri Apr 01 00:00:00 EDT 2016
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity.
Stem cells (Dayton, Ohio)
Frame JM,Fegan KH,Conway SJ,McGrath KE,Palis J
Mon Feb 01 00:00:00 EST 2016
MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Drube S,Kraft F,Dudeck J,Müller AL,Weber F,Göpfert C,Meininger I,Beyer M,Irmler I,Häfner N,Schütz D,Stumm R,Yakovleva T,Gaestel M,Dudeck A,Kamradt T
Tue Nov 01 00:00:00 EDT 2016
Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth.
Journal of immunology (Baltimore, Md. : 1950)
Kim J,Kim W,Moon UJ,Kim HJ,Choi HJ,Sin JI,Park NH,Cho HR,Kwon B
Tue Mar 01 00:00:00 EST 2016
Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Sertorio M,Amarachintha S,Wilson A,Pang Q
Fri Apr 01 00:00:00 EDT 2016
Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation.
Journal of immunology (Baltimore, Md. : 1950)
Malu K,Garhwal R,Pelletier MG,Gotur D,Halene S,Zwerger M,Yang ZF,Rosmarin AG,Gaines P
Mon Aug 01 00:00:00 EDT 2016
IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Polukort SH,Rovatti J,Carlson L,Thompson C,Ser-Dolansky J,Kinney SR,Schneider SS,Mathias CB
Wed Jun 15 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Tue Aug 09 00:00:00 EDT 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
Tue Mar 08 00:00:00 EST 2016
Atg5-dependent autophagy contributes to the development of acute myeloid leukemia in an MLL-AF9-driven mouse model.
Cell death & disease
Liu Q,Chen L,Atkinson JM,Claxton DF,Wang HG
Thu Sep 08 00:00:00 EDT 2016
Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells.
Nature communications
George J,Uyar A,Young K,Kuffler L,Waldron-Francis K,Marquez E,Ucar D,Trowbridge JJ
Mon Jul 11 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
Human GV oocytes generated by mitotically active germ cells obtained from follicular aspirates.
Scientific reports
Ding X,Liu G,Xu B,Wu C,Hui N,Ni X,Wang J,Du M,Teng X,Wu J
Thu Jun 30 00:00:00 EDT 2016
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Nature communications
Ding X,Ray Chaudhuri A,Callen E,Pang Y,Biswas K,Klarmann KD,Martin BK,Burkett S,Cleveland L,Stauffer S,Sullivan T,Dewan A,Marks H,Tubbs AT,Wong N,Buehler E,Akagi K,Martin SE,Keller JR,Nussenzweig A,Sharan SK
Mon Aug 08 00:00:00 EDT 2016
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.
Nature communications
Poulos MG,Ramalingam P,Gutkin MC,Kleppe M,Ginsberg M,Crowley MJP,Elemento O,Levine RL,Rafii S,Kitajewski J,Greenblatt MB,Shim JH,Butler JM
Wed Dec 21 00:00:00 EST 2016
Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.
Cell death & disease
Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH
Thu Apr 07 00:00:00 EDT 2016
Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.
Stem cell reports
Huang K,Gao J,Du J,Ma N,Zhu Y,Wu P,Zhang T,Wang W,Li Y,Chen Q,Hutchins AP,Yang Z,Zheng Y,Zhang J,Shan Y,Li X,Liao B,Liu J,Wang J,Liu B,Pan G
Tue Nov 08 00:00:00 EST 2016
B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.
The Journal of biological chemistry
Imoto N,Hayakawa F,Kurahashi S,Morishita T,Kojima Y,Yasuda T,Sugimoto K,Tsuzuki S,Naoe T,Kiyoi H
Fri Feb 26 00:00:00 EST 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
250-03 was used in In vitro experiments to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 EDT 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
250-03 was used in In vitro experiments to identify EphrinB2 as an essential regulator of adult haematopoiesis but not generation of endothelial cells.
Thu Jun 02 00:00:00 EDT 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
Tue Aug 02 00:00:00 EDT 2016
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling.
Nature communications
Gamrekelashvili J,Giagnorio R,Jussofie J,Soehnlein O,Duchene J,Briseño CG,Ramasamy SK,Krishnasamy K,Limbourg A,Kapanadze T,Ishifune C,Hinkel R,Radtke F,Strobl LJ,Zimber-Strobl U,Napp LC,Bauersachs J,Haller H,Yasutomo K,Kupatt C,Murphy KM,Adams RH,Weber C,Limbourg FP
Wed Aug 31 00:00:00 EDT 2016
Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research.
Methods in molecular biology (Clifton, N.J.)
Peng C,Li S
250-03 was used in Cell Culture to describe how we utilize this triple gene system to prove the function of Pten as a tumor suppressor in leukemogenesis.
Mon Dec 18 00:00:00 EST 2017
Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.
Nature communications
Jung H,Kim DO,Byun JE,Kim WS,Kim MJ,Song HY,Kim YK,Kang DK,Park YJ,Kim TD,Yoon SR,Lee HG,Choi EJ,Min SH,Choi I
250-03 was used in Sample Preparation (FC/FACS) to study the rejuvenation of stem cells and report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated protein kinase (p38) axis regulates the ageing of haematopoietic stem cells (HSCs), by causing a higher frequency of long-term HSCs, lineage skewing, a decrease in engraftment, an increase in reactive oxygen species and loss of Cdc42 polarity.
Thu Dec 08 00:00:00 EST 2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature communications
Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG
Tue Nov 08 00:00:00 EST 2016
CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress.
Scientific reports
Zhang Y,Dépond M,He L,Foudi A,Kwarteng EO,Lauret E,Plo I,Desterke C,Dessen P,Fujii N,Opolon P,Herault O,Solary E,Vainchenker W,Joulin V,Louache F,Wittner M
Fri Nov 25 00:00:00 EST 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 EDT 2016
USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.
Stem cell reports
Higuchi M,Kawamura H,Matsuki H,Hara T,Takahashi M,Saito S,Saito K,Jiang S,Naito M,Kiyonari H,Fujii M
Tue Dec 13 00:00:00 EST 2016
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Nature communications
White Y,Bagchi A,Van Ziffle J,Inguva A,Bollag G,Zhang C,Carias H,Dickens D,Loh M,Shannon K,Firestone AJ
Mon Feb 08 00:00:00 EST 2016
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.
Nature communications
Bahal R,Ali McNeer N,Quijano E,Liu Y,Sulkowski P,Turchick A,Lu YC,Bhunia DC,Manna A,Greiner DL,Brehm MA,Cheng CJ,López-Giráldez F,Ricciardi A,Beloor J,Krause DS,Kumar P,Gallagher PG,Braddock DT,Mark Saltzman W,Ly DH,Glazer PM
250-03 was used in Sample Preparation (FC/FACS) to demonstrate that iplex-forming peptide nucleic acids (PNAs) substituted at the γ position plus stimulation of the stem cell factor (SCF)/c-Kit pathway yields high levels of gene editing in haematopoietic stem cells (HSCs) in a mouse model of human β-thalassaemia.
Wed Oct 26 00:00:00 EDT 2016
Induction of Chronic Myeloid Leukemia in Mice.
Methods in molecular biology (Clifton, N.J.)
Zhang H,Li S
250-03 was used in In vitro experiments to describe methods for induction of CML in mice with BCR-ABL.
Fri Jan 26 00:00:00 EST 2018
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Nature
Chen Z,Shojaee S,Buchner M,Geng H,Lee JW,Klemm L,Titz B,Graeber TG,Park E,Tan YX,Satterthwaite A,Paietta E,Hunger SP,Willman CL,Melnick A,Loh ML,Jung JU,Coligan JE,Bolland S,Mak TW,Limnander A,Jumaa H,Reth M,Weiss A,Lowell CA,Müschen M
Thu May 21 00:00:00 EDT 2015
IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.
Blood
Siegemund S,Rigaud S,Conche C,Broaten B,Schaffer L,Westernberg L,Head SR,Sauer K
Thu Apr 30 00:00:00 EDT 2015
T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
Blood
Iriguchi S,Kikuchi N,Kaneko S,Noguchi E,Morishima Y,Matsuyama M,Yoh K,Takahashi S,Nakauchi H,Ishii Y
Thu Jan 08 00:00:00 EST 2015
Morgana acts as an oncosuppressor in chronic myeloid leukemia.
Blood
Di Savino A,Panuzzo C,Rocca S,Familiari U,Piazza R,Crivellaro S,Carrà G,Ferretti R,Fusella F,Giugliano E,Camporeale A,Franco I,Miniscalco B,Cutrin JC,Turco E,Silengo L,Hirsch E,Rege-Cambrin G,Gambacorti-Passerini C,Pandolfi PP,Papotti M,Saglio G,Tarone G,Morotti A,Brancaccio M
Thu Apr 02 00:00:00 EDT 2015
MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.
Blood
Roychoudhury J,Clark JP,Gracia-Maldonado G,Unnisa Z,Wunderlich M,Link KA,Dasgupta N,Aronow B,Huang G,Mulloy JC,Kumar AR
Thu Apr 16 00:00:00 EDT 2015
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Blood
Xiao N,Laha S,Das SP,Morlock K,Jesneck JL,Raffel GD
Thu Feb 05 00:00:00 EST 2015
MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.
Blood
Shaham L,Vendramini E,Ge Y,Goren Y,Birger Y,Tijssen MR,McNulty M,Geron I,Schwartzman O,Goldberg L,Chou ST,Pitman H,Weiss MJ,Michaeli S,Sredni B,Göttgens B,Crispino JD,Taub JW,Izraeli S
Thu Feb 19 00:00:00 EST 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 EST 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 EST 2015
Coordinate expression of heme and globin is essential for effective erythropoiesis.
The Journal of clinical investigation
Doty RT,Phelps SR,Shadle C,Sanchez-Bonilla M,Keel SB,Abkowitz JL
Tue Dec 01 00:00:00 EST 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
Fri May 01 00:00:00 EDT 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 EDT 2015
A single glycan on IgE is indispensable for initiation of anaphylaxis.
The Journal of experimental medicine
Shade KT,Platzer B,Washburn N,Mani V,Bartsch YC,Conroy M,Pagan JD,Bosques C,Mempel TR,Fiebiger E,Anthony RM
Mon Apr 06 00:00:00 EDT 2015
Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.
The Journal of experimental medicine
Ungerbäck J,Åhsberg J,Strid T,Somasundaram R,Sigvardsson M
Mon Jun 29 00:00:00 EDT 2015
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
The Journal of experimental medicine
Diaz MF,Li N,Lee HJ,Adamo L,Evans SM,Willey HE,Arora N,Torisawa YS,Vickers DA,Morris SA,Naveiras O,Murthy SK,Ingber DE,Daley GQ,García-Cardeña G,Wenzel PL
Mon May 04 00:00:00 EDT 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 EST 2015
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
The Journal of experimental medicine
Yu Y,Wang C,Clare S,Wang J,Lee SC,Brandt C,Burke S,Lu L,He D,Jenkins NA,Copeland NG,Dougan G,Liu P
Mon Jun 01 00:00:00 EDT 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
250-03 was used in Sample Preparation (FC/FACS) to represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.
Mon Oct 19 00:00:00 EDT 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
250-03 was used in Sample Preparation (FC/FACS) to represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.
Mon Oct 19 00:00:00 EDT 2015
DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3.
The Journal of experimental medicine
Thompson BJ,Bhansali R,Diebold L,Cook DE,Stolzenburg L,Casagrande AS,Besson T,Leblond B,Désiré L,Malinge S,Crispino JD
Mon Jun 01 00:00:00 EDT 2015
Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America
Smith DJ,Liu S,Ji S,Li B,McLaughlin J,Cheng D,Witte ON,Yang L
Tue Feb 03 00:00:00 EST 2015
Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Godec J,Cowley GS,Barnitz RA,Alkan O,Root DE,Sharpe AH,Haining WN
Tue Jan 13 00:00:00 EST 2015
Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.
British journal of haematology
Sjögren SE,Siva K,Soneji S,George AJ,Winkler M,Jaako P,Wlodarski M,Karlsson S,Hannan RD,Flygare J
Sun Nov 01 00:00:00 EDT 2015
MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.
Oncogenesis
Wenge DV,Felipe-Fumero E,Angenendt L,Schliemann C,Schmidt E,Schmidt LH,Thiede C,Ehninger G,Berdel WE,Arteaga MF,Mikesch JH
Mon Dec 21 00:00:00 EST 2015
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio)
Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW
Fri May 01 00:00:00 EDT 2015
Bmi1 promotes erythroid development through regulating ribosome biogenesis.
Stem cells (Dayton, Ohio)
Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y
Sun Mar 01 00:00:00 EST 2015
Bmi1 promotes erythroid development through regulating ribosome biogenesis.
Stem cells (Dayton, Ohio)
Gao R,Chen S,Kobayashi M,Yu H,Zhang Y,Wan Y,Young SK,Soltis A,Yu M,Vemula S,Fraenkel E,Cantor A,Antipin Y,Xu Y,Yoder MC,Wek RC,Ellis SR,Kapur R,Zhu X,Liu Y
Sun Mar 01 00:00:00 EST 2015
The orphan nuclear receptor NR4A1 specifies a distinct subpopulation of quiescent myeloid-biased long-term HSCs.
Stem cells (Dayton, Ohio)
Land RH,Rayne AK,Vanderbeck AN,Barlowe TS,Manjunath S,Gross M,Eiger S,Klein PS,Cunningham NR,Huang J,Emerson SG,Punt JA
Thu Jan 01 00:00:00 EST 2015
Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.
Stem cells (Dayton, Ohio)
Fleenor CJ,Rozhok AI,Zaberezhnyy V,Mathew D,Kim J,Tan AC,Bernstein ID,DeGregori J
Wed Apr 01 00:00:00 EDT 2015
Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Journal of immunology (Baltimore, Md. : 1950)
Krishnamoorthy V,Carr T,de Pooter RF,Emanuelle AO,Gounari F,Kee BL
Wed Apr 01 00:00:00 EDT 2015
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Xiao Y,Qiao G,Tang J,Tang R,Guo H,Warwar S,Langdon WY,Tao L,Zhang J
Sun Nov 01 00:00:00 EDT 2015
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.
Journal of immunology (Baltimore, Md. : 1950)
Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT
Sun Mar 15 00:00:00 EDT 2015
The T Cell Repertoire-Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens.
Journal of immunology (Baltimore, Md. : 1950)
Viret C,Mahiddine K,Baker RL,Haskins K,Guerder S
Tue Sep 01 00:00:00 EDT 2015
Heme exporter FLVCR is required for T cell development and peripheral survival.
Journal of immunology (Baltimore, Md. : 1950)
Philip M,Funkhouser SA,Chiu EY,Phelps SR,Delrow JJ,Cox J,Fink PJ,Abkowitz JL
Sun Feb 15 00:00:00 EST 2015
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
Journal of immunology (Baltimore, Md. : 1950)
Ottina E,Lyberg K,Sochalska M,Villunger A,Nilsson GP
Sun Feb 01 00:00:00 EST 2015
Microtubule nucleation in mouse bone marrow-derived mast cells is regulated by the concerted action of GIT1/βPIX proteins and calcium.
Journal of immunology (Baltimore, Md. : 1950)
Sulimenko V,Hájková Z,Černohorská M,Sulimenko T,Sládková V,Dráberová L,Vinopal S,Dráberová E,Dráber P
Fri May 01 00:00:00 EDT 2015
Identification of a New Exo-Endocytic Mechanism Triggered by Corticotropin-Releasing Hormone in Mast Cells.
Journal of immunology (Baltimore, Md. : 1950)
Balseiro-Gomez S,Flores JA,Acosta J,Ramirez-Ponce MP,Ales E
Tue Sep 01 00:00:00 EDT 2015
Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.
Journal of immunology (Baltimore, Md. : 1950)
Eddens T,Elsegeiny W,Nelson MP,Horne W,Campfield BT,Steele C,Kolls JK
Wed Jul 01 00:00:00 EDT 2015
IFN-γ regulates CD8+ memory T cell differentiation and survival in response to weak, but not strong, TCR signals.
Journal of immunology (Baltimore, Md. : 1950)
Stoycheva D,Deiser K,Stärck L,Nishanth G,Schlüter D,Uckert W,Schüler T
Thu Jan 15 00:00:00 EST 2015
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.
Molecular therapy. Methods & clinical development
Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A
Wed Oct 28 00:00:00 EDT 2015
Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.
Molecular therapy. Methods & clinical development
Wielgosz MM,Kim YS,Carney GG,Zhan J,Reddivari M,Coop T,Heath RJ,Brown SA,Nienhuis AW
250-03 was used in In vitro experiments to show that the producer cell line and the specific monoclonal antibody will facilitate the development of a clinical protocol for gene transfer into WAS protein deficient stem cells.
Mon Jun 08 00:00:00 EDT 2015
CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis.
Nature communications
Murayama MA,Kakuta S,Inoue A,Umeda N,Yonezawa T,Maruhashi T,Tateishi K,Ishigame H,Yabe R,Ikeda S,Seno A,Chi HH,Hashiguchi Y,Kurata R,Tada T,Kubo S,Sato N,Liu Y,Hattori M,Saijo S,Matsushita M,Fujita T,Sumida T,Iwakura Y
Fri Sep 25 00:00:00 EDT 2015
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.
Nature communications
Buchner M,Park E,Geng H,Klemm L,Flach J,Passegué E,Schjerven H,Melnick A,Paietta E,Kopanja D,Raychaudhuri P,Müschen M
Tue Mar 10 00:00:00 EDT 2015
In Vitro Derivation of Melanocytes from Embryonic Neural Crest Stem Cells.
Methods in molecular biology (Clifton, N.J.)
Shakhova O,Sommer L
250-03 was used in Cell Culture to investigate the differentiation of multipotent embryonic neural crest stem cells into differentiated pigmented melanocytes.
Sun Dec 13 00:00:00 EST 2015
Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.
Nature communications
Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A
Mon Jun 22 00:00:00 EDT 2015
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Tue Oct 13 00:00:00 EDT 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 EST 2015
Fancb deficiency impairs hematopoietic stem cell function.
Scientific reports
Du W,Amarachintha S,Erden O,Wilson A,Meetei AR,Andreassen PR,Namekawa SH,Pang Q
Fri Dec 11 00:00:00 EST 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 EDT 2015
Amelioration of murine sickle cell disease by nonablative conditioning and γ-globin gene-corrected bone marrow cells.
Molecular therapy. Methods & clinical development
Pestina TI,Hargrove PW,Zhao H,Mead PE,Smeltzer MP,Weiss MJ,Wilber A,Persons DA
Tue Dec 15 00:00:00 EST 2015
Defective repair of uracil causes telomere defects in mouse hematopoietic cells.
The Journal of biological chemistry
Vallabhaneni H,Zhou F,Maul RW,Sarkar J,Yin J,Lei M,Harrington L,Gearhart PJ,Liu Y
Fri Feb 27 00:00:00 EST 2015
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Stem cell reports
Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH
Tue Oct 13 00:00:00 EDT 2015
STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.
Nature communications
Haetscher N,Feuermann Y,Wingert S,Rehage M,Thalheimer FB,Weiser C,Bohnenberger H,Jung K,Schroeder T,Serve H,Oellerich T,Hennighausen L,Rieger MA
Wed Nov 25 00:00:00 EST 2015
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Nature
Nakada D,Oguro H,Levi BP,Ryan N,Kitano A,Saitoh Y,Takeichi M,Wendt GR,Morrison SJ
Thu Jan 23 00:00:00 EST 2014
Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.
Cell
Cunningham JT,Moreno MV,Lodi A,Ronen SM,Ruggero D
Thu May 22 00:00:00 EDT 2014
Nonstochastic reprogramming from a privileged somatic cell state.
Cell
Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J
Thu Feb 13 00:00:00 EST 2014
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Immunity
Nabekura T,Kanaya M,Shibuya A,Fu G,Gascoigne NR,Lanier LL
Thu Feb 20 00:00:00 EST 2014
Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice.
Blood
Komeno Y,Yan M,Matsuura S,Lam K,Lo MC,Huang YJ,Tenen DG,Downing JR,Zhang DE
Thu Jun 12 00:00:00 EDT 2014
Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.
Blood
Wang C,Sashida G,Saraya A,Ishiga R,Koide S,Oshima M,Isono K,Koseki H,Iwama A
Thu May 22 00:00:00 EDT 2014
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.
Blood
Kobayashi CI,Takubo K,Kobayashi H,Nakamura-Ishizu A,Honda H,Kataoka K,Kumano K,Akiyama H,Sudo T,Kurokawa M,Suda T
Thu Apr 17 00:00:00 EDT 2014
miRNA-130a regulates C/EBP-ε expression during granulopoiesis.
Blood
Larsen MT,Häger M,Glenthøj A,Asmar F,Clemmensen SN,Mora-Jensen H,Borregaard N,Cowland JB
Thu Feb 13 00:00:00 EST 2014
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA
Thu Dec 18 00:00:00 EST 2014
JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.
Blood
Degryse S,de Bock CE,Cox L,Demeyer S,Gielen O,Mentens N,Jacobs K,Geerdens E,Gianfelici V,Hulselmans G,Fiers M,Aerts S,Meijerink JP,Tousseyn T,Cools J
Thu Nov 13 00:00:00 EST 2014
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Blood
de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F
Thu Jan 23 00:00:00 EST 2014
Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation.
Blood
Lan Y,He W,Li Z,Wang Y,Wang J,Gao J,Wang W,Cheng T,Liu B,Yang X
Thu Apr 03 00:00:00 EDT 2014
Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.
Blood
Pawlikowska P,Fouchet P,Vainchenker W,Rosselli F,Naim V
Thu Dec 04 00:00:00 EST 2014
Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation.
The Journal of clinical investigation
Wegiel B,Larsen R,Gallo D,Chin BY,Harris C,Mannam P,Kaczmarek E,Lee PJ,Zuckerbraun BS,Flavell R,Soares MP,Otterbein LE
Sat Nov 01 00:00:00 EDT 2014
Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis.
The Journal of clinical investigation
Dahdah A,Gautier G,Attout T,Fiore F,Lebourdais E,Msallam R,Daëron M,Monteiro RC,Benhamou M,Charles N,Davoust J,Blank U,Malissen B,Launay P
Wed Oct 01 00:00:00 EDT 2014
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation.
The Journal of clinical investigation
Jones M,Osawa G,Regal JA,Weinberg DN,Taggart J,Kocak H,Friedman A,Ferguson DO,Keegan CE,Maillard I
Wed Jan 01 00:00:00 EST 2014
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
The Journal of clinical investigation
Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP
250-03 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.
Tue Apr 01 00:00:00 EDT 2014
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.
The Journal of clinical investigation
Wu J,Yang J,Yang K,Wang H,Gorentla B,Shin J,Qiu Y,Que LG,Foster WM,Xia Z,Chi H,Zhong XP
250-03 was used in Cell Culture to study how invariant NKT (iNKT) terminal maturation is regulated and what factors mediate the predominance of iNKT-1 compared with iNKT-17 to indicate that tumor suppressor tuberous sclerosis 1 (TSC1)-dependent control of mTORC1 is crucial for terminal iNKT maturation and effector lineage decisions.
Tue Apr 01 00:00:00 EDT 2014
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.
The Journal of clinical investigation
Sungalee S,Mamessier E,Morgado E,Grégoire E,Brohawn PZ,Morehouse CA,Jouve N,Monvoisin C,Menard C,Debroas G,Faroudi M,Mechin V,Navarro JM,Drevet C,Eberle FC,Chasson L,Baudimont F,Mancini SJ,Tellier J,Picquenot JM,Kelly R,Vineis P,Ruminy P,Chetaille B,Jaffe ES,Schiff C,Hardwigsen J,Tice DA,Higgs BW,Tarte K,Nadel B,Roulland S
Mon Dec 01 00:00:00 EST 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
Mon Sep 01 00:00:00 EDT 2014
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
The Journal of clinical investigation
Smeets MF,DeLuca E,Wall M,Quach JM,Chalk AM,Deans AJ,Heierhorst J,Purton LE,Izon DJ,Walkley CR
Fri Aug 01 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
Mon Apr 07 00:00:00 EDT 2014
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 EDT 2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
The Journal of experimental medicine
Beck TC,Gomes AC,Cyster JG,Pereira JP
Mon Dec 15 00:00:00 EST 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 EST 2014
Initiation of MLL-rearranged AML is dependent on C/EBPα.
The Journal of experimental medicine
Ohlsson E,Hasemann MS,Willer A,Lauridsen FK,Rapin N,Jendholm J,Porse BT
Mon Jan 13 00:00:00 EST 2014
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
Mon Apr 07 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 EDT 2014
Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.
The Journal of experimental medicine
Wang D,Zheng M,Qiu Y,Guo C,Ji J,Lei L,Zhang X,Liang J,Lou J,Huang W,Dong B,Wu S,Wang J,Ke Y,Cao X,Zhou YT,Lu L
Mon Dec 15 00:00:00 EST 2014
Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
The Journal of experimental medicine
Gazit R,Mandal PK,Ebina W,Ben-Zvi A,Nombela-Arrieta C,Silberstein LE,Rossi DJ
Mon Jun 30 00:00:00 EDT 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 EST 2014
IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.
EMBO molecular medicine
Wang J,Lindholt JS,Sukhova GK,Shi MA,Xia M,Chen H,Xiang M,He A,Wang Y,Xiong N,Libby P,Wang JA,Shi GP
Tue Jul 01 00:00:00 EDT 2014
Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.
Proceedings of the National Academy of Sciences of the United States of America
Shi J,Kundrat L,Pishesha N,Bilate A,Theile C,Maruyama T,Dougan SK,Ploegh HL,Lodish HF
Tue Jul 15 00:00:00 EDT 2014
IL-33/ST2 axis promotes mast cell survival via BCLXL.
Proceedings of the National Academy of Sciences of the United States of America
Wang JX,Kaieda S,Ameri S,Fishgal N,Dwyer D,Dellinger A,Kepley CL,Gurish MF,Nigrovic PA
Tue Jul 15 00:00:00 EDT 2014
PDK1 regulates B cell differentiation and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Baracho GV,Cato MH,Zhu Z,Jaren OR,Hobeika E,Reth M,Rickert RC
Tue Jul 01 00:00:00 EDT 2014
Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.
Blood cancer journal
Sprissler C,Belenki D,Maurer H,Aumann K,Pfeifer D,Klein C,Müller TA,Kissel S,Hülsdünker J,Alexandrovski J,Brummer T,Jumaa H,Duyster J,Dierks C
Fri Aug 22 00:00:00 EDT 2014
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood cancer journal
Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K
Fri Jan 10 00:00:00 EST 2014
Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.
Stem cell reports
Inlay MA,Serwold T,Mosley A,Fathman JW,Dimov IK,Seita J,Weissman IL
250-03 was used in Sample Preparation (FC/FACS) to develop a single-cell multipotency assay which can be used to identify when and where clonal multilineage potential arises during embryogenesis.
Tue Apr 08 00:00:00 EDT 2014
Dendritic cell development requires histone deacetylase activity.
European journal of immunology
Chauvistré H,Küstermann C,Rehage N,Klisch T,Mitzka S,Felker P,Rose-John S,Zenke M,Seré KM
Fri Aug 01 00:00:00 EDT 2014
Twist-1, a novel regulator of hematopoietic stem cell self-renewal and myeloid lineage development.
Stem cells (Dayton, Ohio)
Dong CY,Liu XY,Wang N,Wang LN,Yang BX,Ren Q,Liang HY,Ma XT
Mon Dec 01 00:00:00 EST 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
Wed Jan 01 00:00:00 EST 2014
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming.
Stem cells (Dayton, Ohio)
Zdzieblo D,Li X,Lin Q,Zenke M,Illich DJ,Becker M,Müller AM
Mon Dec 01 00:00:00 EST 2014
Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.
Journal of immunology (Baltimore, Md. : 1950)
Wen T,Mingler MK,Wahl B,Khorki ME,Pabst O,Zimmermann N,Rothenberg ME
Sun Jun 15 00:00:00 EDT 2014
Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Azouz NP,Zur N,Efergan A,Ohbayashi N,Fukuda M,Amihai D,Hammel I,Rothenberg ME,Sagi-Eisenberg R
Thu May 01 00:00:00 EDT 2014
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sun Jun 15 00:00:00 EDT 2014
Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling.
Journal of immunology (Baltimore, Md. : 1950)
Balmer ML,Schürch CM,Saito Y,Geuking MB,Li H,Cuenca M,Kovtonyuk LV,McCoy KD,Hapfelmeier S,Ochsenbein AF,Manz MG,Slack E,Macpherson AJ
Sat Nov 15 00:00:00 EST 2014
SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3ζ interactions.
Journal of immunology (Baltimore, Md. : 1950)
Chu C,Wang Y,Zhang X,Ni X,Cao J,Xu W,Dong Z,Yuan P,Wei W,Ma Y,Zhang L,Wu L,Qi H
Wed Oct 15 00:00:00 EDT 2014
Munc18-2 and syntaxin 3 control distinct essential steps in mast cell degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Brochetta C,Suzuki R,Vita F,Soranzo MR,Claver J,Madjene LC,Attout T,Vitte J,Varin-Blank N,Zabucchi G,Rivera J,Blank U
Wed Jan 01 00:00:00 EST 2014
SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis.
Journal of immunology (Baltimore, Md. : 1950)
Sharma N,Everingham S,Ramdas B,Kapur R,Craig AW
Thu May 15 00:00:00 EDT 2014
Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Journal of immunology (Baltimore, Md. : 1950)
Stärck L,Popp K,Pircher H,Uckert W
Wed Jan 01 00:00:00 EST 2014
Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.
Stem cells international
Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED
250-03 was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.
Thu Jan 22 00:00:00 EST 2015
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
Nature communications
Piunti A,Rossi A,Cerutti A,Albert M,Jammula S,Scelfo A,Cedrone L,Fragola G,Olsson L,Koseki H,Testa G,Casola S,Helin K,d'Adda di Fagagna F,Pasini D
Mon Apr 14 00:00:00 EDT 2014
Bone Marrow Derived Eosinophil Cultures.
Bio-protocol
Lu TX,Rothenberg ME
250-03 was used in Cell Culture to describe how bone marrow derived eosinophils are fully differentiated at the end of a 14 day culture based on morphology and expression of molecular markers.
Fri Jun 20 00:00:00 EDT 2014
The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.
Cell death & disease
Becker MS,Schmezer P,Breuer R,Haas SF,Essers MA,Krammer PH,Li-Weber M
Thu Jan 16 00:00:00 EST 2014
Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.
Nature communications
Obata Y,Toyoshima S,Wakamatsu E,Suzuki S,Ogawa S,Esumi H,Abe R
Wed Dec 10 00:00:00 EST 2014
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.
Cell death & disease
Lu H,Fang EF,Sykora P,Kulikowicz T,Zhang Y,Becker KG,Croteau DL,Bohr VA
Thu May 15 00:00:00 EDT 2014
Regulation of Fc∈RI signaling in mast cells by G protein-coupled receptor kinase 2 and its RH domain.
The Journal of biological chemistry
Subramanian H,Gupta K,Parameswaran N,Ali H
Fri Jul 25 00:00:00 EDT 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 EST 2013
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
Cancer cell
Arteaga MF,Mikesch JH,Qiu J,Christensen J,Helin K,Kogan SC,Dong S,So CW
Mon Mar 18 00:00:00 EDT 2013
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Blood
Conway AE,Scotland PB,Lavau CP,Wechsler DS
Thu Jun 06 00:00:00 EDT 2013
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Blood
Malinge S,Thiollier C,Chlon TM,Doré LC,Diebold L,Bluteau O,Mabialah V,Vainchenker W,Dessen P,Winandy S,Mercher T,Crispino JD
Thu Mar 28 00:00:00 EDT 2013
Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.
Blood
Holmfeldt P,Pardieck J,Saulsberry AC,Nandakumar SK,Finkelstein D,Gray JT,Persons DA,McKinney-Freeman S
Thu Oct 24 00:00:00 EDT 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 EDT 2013
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
Blood
May RM,Okumura M,Hsu CJ,Bassiri H,Yang E,Rak G,Mace EM,Philip NH,Zhang W,Baumgart T,Orange JS,Nichols KE,Kambayashi T
Thu Apr 18 00:00:00 EDT 2013
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Blood
Santoro F,Botrugno OA,Dal Zuffo R,Pallavicini I,Matthews GM,Cluse L,Barozzi I,Senese S,Fornasari L,Moretti S,Altucci L,Pelicci PG,Chiocca S,Johnstone RW,Minucci S
Thu Apr 25 00:00:00 EDT 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 EDT 2013
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
Blood
Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A
Thu Oct 03 00:00:00 EDT 2013
Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression.
Blood
Laperrousaz B,Jeanpierre S,Sagorny K,Voeltzel T,Ramas S,Kaniewski B,Ffrench M,Salesse S,Nicolini FE,Maguer-Satta V
Thu Nov 28 00:00:00 EST 2013
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.
Blood
Wahlestedt M,Norddahl GL,Sten G,Ugale A,Frisk MA,Mattsson R,Deierborg T,Sigvardsson M,Bryder D
Thu May 23 00:00:00 EDT 2013
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk.
The Journal of clinical investigation
Staser K,Park SJ,Rhodes SD,Zeng Y,He YZ,Shew MA,Gehlhausen JR,Cerabona D,Menon K,Chen S,Sun Z,Yuan J,Ingram DA,Nalepa G,Yang FC,Clapp DW
Tue Jan 01 00:00:00 EST 2013
Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica.
The Journal of clinical investigation
Zhang H,Verkman AS
Wed May 01 00:00:00 EDT 2013
GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.
The Journal of clinical investigation
Lapid K,Itkin T,D'Uva G,Ovadya Y,Ludin A,Caglio G,Kalinkovich A,Golan K,Porat Z,Zollo M,Lapidot T
Mon Apr 01 00:00:00 EDT 2013
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
The Journal of clinical investigation
Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R
Tue Oct 01 00:00:00 EDT 2013
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells.
The Journal of experimental medicine
Yi Z,Stunz LL,Bishop GA
Mon Jun 03 00:00:00 EDT 2013
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance.
The Journal of experimental medicine
Singh SK,Williams CA,Klarmann K,Burkett SS,Keller JR,Oberdoerffer P
Mon May 06 00:00:00 EDT 2013
Notch pathway activation targets AML-initiating cell homeostasis and differentiation.
The Journal of experimental medicine
Lobry C,Ntziachristos P,Ndiaye-Lobry D,Oh P,Cimmino L,Zhu N,Araldi E,Hu W,Freund J,Abdel-Wahab O,Ibrahim S,Skokos D,Armstrong SA,Levine RL,Park CY,Aifantis I
Mon Feb 11 00:00:00 EST 2013
SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
Leukemia
Hansen N,Ågerstam H,Wahlestedt M,Landberg N,Askmyr M,Ehinger M,Rissler M,Lilljebjörn H,Johnels P,Ishiko J,Melo JV,Alexander WS,Bryder D,Järås M,Fioretos T
Tue Jan 01 00:00:00 EST 2013
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling.
Proceedings of the National Academy of Sciences of the United States of America
Jin HS,Liao L,Park Y,Liu YC
Tue Jan 08 00:00:00 EST 2013
CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Arndt K,Grinenko T,Mende N,Reichert D,Portz M,Ripich T,Carmeliet P,Corbeil D,Waskow C
Tue Apr 02 00:00:00 EDT 2013
Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Wen T,Besse JA,Mingler MK,Fulkerson PC,Rothenberg ME
Tue Apr 09 00:00:00 EDT 2013
Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.
Proceedings of the National Academy of Sciences of the United States of America
Chan CK,Lindau P,Jiang W,Chen JY,Zhang LF,Chen CC,Seita J,Sahoo D,Kim JB,Lee A,Park S,Nag D,Gong Y,Kulkarni S,Luppen CA,Theologis AA,Wan DC,DeBoer A,Seo EY,Vincent-Tompkins JD,Loh K,Walmsley GG,Kraft DL,Wu JC,Longaker MT,Weissman IL
Tue Jul 30 00:00:00 EDT 2013
Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity.
Blood cancer journal
Pannucci NL,Li D,Sahay S,Thomas EK,Chen R,Tala I,Hu T,Ciccarelli BT,Megjugorac NJ,Adams Iii HC,Rodriguez PL,Fitzpatrick ER,Lagunoff D,Williams DA,Whitehead IP
Fri Aug 16 00:00:00 EDT 2013
Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.
Oncogenesis
Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y
Mon Nov 04 00:00:00 EST 2013
Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.
Stem cells (Dayton, Ohio)
Porter RL,Georger MA,Bromberg O,McGrath KE,Frisch BJ,Becker MW,Calvi LM
Fri Feb 01 00:00:00 EST 2013
p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity.
Stem cells (Dayton, Ohio)
Tornillo G,Elia AR,Castellano I,Spadaro M,Bernabei P,Bisaro B,Camacho-Leal Mdel P,Pincini A,Provero P,Sapino A,Turco E,Defilippi P,Cabodi S
Mon Jul 01 00:00:00 EDT 2013
The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.
Journal of immunology (Baltimore, Md. : 1950)
Sesti-Costa R,Silva GK,Proença-Módena JL,Carlos D,Silva ML,Alves-Filho JC,Arruda E,Liew FY,Silva JS
Mon Jul 01 00:00:00 EDT 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 EDT 2013
Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.
Journal of immunology (Baltimore, Md. : 1950)
Fernando J,Faber TW,Pullen NA,Falanga YT,Kolawole EM,Oskeritzian CA,Barnstein BO,Bandara G,Li G,Schwartz LB,Spiegel S,Straus DB,Conrad DH,Bunting KD,Ryan JJ
Fri Nov 01 00:00:00 EDT 2013
Mast cell FcεRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration.
Journal of immunology (Baltimore, Md. : 1950)
Wu Z,Macneil AJ,Junkins R,Li B,Berman JN,Lin TJ
Wed May 01 00:00:00 EDT 2013
MiR-223 deficiency increases eosinophil progenitor proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Lu TX,Lim EJ,Besse JA,Itskovich S,Plassard AJ,Fulkerson PC,Aronow BJ,Rothenberg ME
Fri Feb 15 00:00:00 EST 2013
Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Wu Z,Li Y,MacNeil AJ,Junkins RD,Berman JN,Lin TJ
Sun Dec 15 00:00:00 EST 2013
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.
Journal of immunology (Baltimore, Md. : 1950)
Bouffi C,Rochman M,Zust CB,Stucke EM,Kartashov A,Fulkerson PC,Barski A,Rothenberg ME
Tue Oct 15 00:00:00 EDT 2013
Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.
Journal of immunology (Baltimore, Md. : 1950)
Graham AC,Hilmer KM,Zickovich JM,Obar JJ
Wed May 01 00:00:00 EDT 2013
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Paster W,Brockmeyer C,Fu G,Simister PC,de Wet B,Martinez-Riaño A,Hoerter JA,Feller SM,Wülfing C,Gascoigne NR,Acuto O
Mon Apr 01 00:00:00 EDT 2013
Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex.
Journal of immunology (Baltimore, Md. : 1950)
Madera-Salcedo IK,Cruz SL,Gonzalez-Espinosa C
Sun Sep 15 00:00:00 EDT 2013
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined.
Journal of immunology (Baltimore, Md. : 1950)
Dillahunt SE,Sargent JL,Suzuki R,Proia RL,Gilfillan A,Rivera J,Olivera A
Fri Mar 01 00:00:00 EST 2013
The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics.
The Journal of biological chemistry
Chacón-Martínez CA,Kiessling N,Winterhoff M,Faix J,Müller-Reichert T,Jessberger R
Fri Oct 04 00:00:00 EDT 2013
Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.
The Journal of biological chemistry
Kosoff R,Chow HY,Radu M,Chernoff J
Fri Jan 11 00:00:00 EST 2013
Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.
The Journal of biological chemistry
Anower-E-Khuda MF,Habuchi H,Nagai N,Habuchi O,Yokochi T,Kimata K
Fri Feb 08 00:00:00 EST 2013
Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.
PloS one
Coutinho AE,Brown JK,Yang F,Brownstein DG,Gray M,Seckl JR,Savill JS,Chapman KE
Fri Jul 19 00:00:00 EDT 2013
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one
Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M
Fri Sep 27 00:00:00 EDT 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 EST 2013
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 EDT 2012
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Cancer cell
Gruber TA,Larson Gedman A,Zhang J,Koss CS,Marada S,Ta HQ,Chen SC,Su X,Ogden SK,Dang J,Wu G,Gupta V,Andersson AK,Pounds S,Shi L,Easton J,Barbato MI,Mulder HL,Manne J,Wang J,Rusch M,Ranade S,Ganti R,Parker M,Ma J,Radtke I,Ding L,Cazzaniga G,Biondi A,Kornblau SM,Ravandi F,Kantarjian H,Nimer SD,Döhner K,Döhner H,Ley TJ,Ballerini P,Shurtleff S,Tomizawa D,Adachi S,Hayashi Y,Tawa A,Shih LY,Liang DC,Rubnitz JE,Pui CH,Mardis ER,Wilson RK,Downing JR
Tue Nov 13 00:00:00 EST 2012
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.
Blood
Tanaka S,Miyagi S,Sashida G,Chiba T,Yuan J,Mochizuki-Kashio M,Suzuki Y,Sugano S,Nakaseko C,Yokote K,Koseki H,Iwama A
Thu Aug 02 00:00:00 EDT 2012
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
Blood
Lin DC,Yin T,Koren-Michowitz M,Ding LW,Gueller S,Gery S,Tabayashi T,Bergholz U,Kazi JU,Rönnstrand L,Stocking C,Koeffler HP
Thu Oct 18 00:00:00 EDT 2012
EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress.
Blood
Peslak SA,Wenger J,Bemis JC,Kingsley PD,Koniski AD,McGrath KE,Palis J
Thu Sep 20 00:00:00 EDT 2012
The tumor suppressor p15Ink4b regulates the differentiation and maturation of conventional dendritic cells.
Blood
Fares J,Koller R,Humeniuk R,Wolff L,Bies J
Thu May 24 00:00:00 EDT 2012
Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.
Blood
Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E
Thu Jul 05 00:00:00 EDT 2012
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis.
Blood
Yuan H,Wang Z,Li L,Zhang H,Modi H,Horne D,Bhatia R,Chen W
Thu Feb 23 00:00:00 EST 2012
Activated expression of the chemokine Mig after chemotherapy contributes to chemotherapy-induced bone marrow suppression and lethal toxicity.
Blood
Lu H,Zhu S,Qian L,Xiang D,Zhang W,Nie A,Gao J,Wu M,Gao J,Lu B,Yu Y,Han W,Moldenhauer A
Thu May 24 00:00:00 EDT 2012
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.
Blood
Reddy PN,Sargin B,Choudhary C,Stein S,Grez M,Müller-Tidow C,Berdel WE,Serve H,Brandts CH
Thu Aug 23 00:00:00 EDT 2012
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood
Mérino D,Khaw SL,Glaser SP,Anderson DJ,Belmont LD,Wong C,Yue P,Robati M,Phipson B,Fairlie WD,Lee EF,Campbell KJ,Vandenberg CJ,Cory S,Roberts AW,Ludlam MJ,Huang DC,Bouillet P
Thu Jun 14 00:00:00 EDT 2012
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
Blood
Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F
Thu May 03 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
Thu Feb 09 00:00:00 EST 2012
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood
Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G
Thu Aug 02 00:00:00 EDT 2012
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis.
Blood
Krishnan S,Mali RS,Ramdas B,Sims E,Ma P,Ghosh J,Munugalavadla V,Hanneman P,Beane JD,Kapur R
Thu Apr 26 00:00:00 EDT 2012
TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.
Blood
Spranger S,Jeremias I,Wilde S,Leisegang M,Stärck L,Mosetter B,Uckert W,Heemskerk MH,Schendel DJ,Frankenberger B
Thu Apr 12 00:00:00 EDT 2012
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.
Blood
Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D
Thu Mar 01 00:00:00 EST 2012
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Blood
Zhao L,Melenhorst JJ,Alemu L,Kirby M,Anderson S,Kench M,Hoogstraten-Miller S,Brinster L,Kamikubo Y,Gilliland DG,Liu PP
Thu Feb 09 00:00:00 EST 2012
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.
Blood
Cai M,Langer EM,Gill JG,Satpathy AT,Albring JC,KC W,Murphy TL,Murphy KM
Thu Jul 12 00:00:00 EDT 2012
Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.
Blood
Guo H,Ma O,Speck NA,Friedman AD
Thu May 10 00:00:00 EDT 2012
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 EDT 2012
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.
Blood
Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T
Thu Aug 30 00:00:00 EDT 2012
FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.
Blood
Itkin T,Ludin A,Gradus B,Gur-Cohen S,Kalinkovich A,Schajnovitz A,Ovadya Y,Kollet O,Canaani J,Shezen E,Coffin DJ,Enikolopov GN,Berg T,Piacibello W,Hornstein E,Lapidot T
Thu Aug 30 00:00:00 EDT 2012
Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.
Blood
Greenblatt S,Li L,Slape C,Nguyen B,Novak R,Duffield A,Huso D,Desiderio S,Borowitz MJ,Aplan P,Small D
Thu Mar 22 00:00:00 EDT 2012
Critical role of P1-Runx1 in mouse basophil development.
Blood
Mukai K,BenBarak MJ,Tachibana M,Nishida K,Karasuyama H,Taniuchi I,Galli SJ
Thu Jul 05 00:00:00 EDT 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
Thu Oct 11 00:00:00 EDT 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 EST 2012
Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.
Blood
Asai T,Liu Y,Di Giandomenico S,Bae N,Ndiaye-Lobry D,Deblasio A,Menendez S,Antipin Y,Reva B,Wevrick R,Nimer SD
Thu Aug 23 00:00:00 EDT 2012
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2.
Blood
Sathyanarayana P,Dev A,Pradeep A,Ufkin M,Licht JD,Wojchowski DM
Thu Jun 07 00:00:00 EDT 2012
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Blood
Chang KH,Sanchez-Aguilera A,Shen S,Sengupta A,Madhu MN,Ficker AM,Dunn SK,Kuenzi AM,Arnett JL,Santho RA,Agirre X,Perentesis JP,Deininger MW,Zheng Y,Bustelo XR,Williams DA,Cancelas JA
Thu Jul 26 00:00:00 EDT 2012
Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells.
Blood
Gerrits A,Walasek MA,Olthof S,Weersing E,Ritsema M,Zwart E,van Os R,Bystrykh LV,de Haan G
Thu Jan 12 00:00:00 EST 2012
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells.
The Journal of clinical investigation
Jiang J,Balcerek J,Rozenova K,Cheng Y,Bersenev A,Wu C,Song Y,Tong W
Fri Jun 01 00:00:00 EDT 2012
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation
Sugimoto K,Kudo M,Sundaram A,Ren X,Huang K,Bernstein X,Wang Y,Raymond WW,Erle DJ,Abrink M,Caughey GH,Huang X,Sheppard D
Wed Feb 01 00:00:00 EST 2012
Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.
The Journal of clinical investigation
Schoppy DW,Ragland RL,Gilad O,Shastri N,Peters AA,Murga M,Fernandez-Capetillo O,Diehl JA,Brown EJ
Sun Jan 01 00:00:00 EST 2012
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
The Journal of experimental medicine
Block H,Herter JM,Rossaint J,Stadtmann A,Kliche S,Lowell CA,Zarbock A
Mon Feb 13 00:00:00 EST 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 EDT 2012
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
The Journal of experimental medicine
Oguro H,Yuan J,Tanaka S,Miyagi S,Mochizuki-Kashio M,Ichikawa H,Yamazaki S,Koseki H,Nakauchi H,Iwama A
Mon Mar 12 00:00:00 EDT 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
Mon Apr 09 00:00:00 EDT 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
Mon Oct 22 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
Mon Jan 16 00:00:00 EST 2012
Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.
Proceedings of the National Academy of Sciences of the United States of America
Taniguchi Ishikawa E,Gonzalez-Nieto D,Ghiaur G,Dunn SK,Ficker AM,Murali B,Madhu M,Gutstein DE,Fishman GI,Barrio LC,Cancelas JA
Tue Jun 05 00:00:00 EDT 2012
p85β phosphoinositide 3-kinase subunit regulates tumor progression.
Proceedings of the National Academy of Sciences of the United States of America
Cortés I,Sánchez-Ruíz J,Zuluaga S,Calvanese V,Marqués M,Hernández C,Rivera T,Kremer L,González-García A,Carrera AC
Tue Jul 10 00:00:00 EDT 2012
Early ontogenic origin of the hematopoietic stem cell lineage.
Proceedings of the National Academy of Sciences of the United States of America
Tanaka Y,Hayashi M,Kubota Y,Nagai H,Sheng G,Nishikawa S,Samokhvalov IM
Tue Mar 20 00:00:00 EDT 2012
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M
Tue Sep 25 00:00:00 EDT 2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Proceedings of the National Academy of Sciences of the United States of America
Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J
Tue Oct 09 00:00:00 EDT 2012
Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
Proceedings of the National Academy of Sciences of the United States of America
Oyoshi MK,He R,Kanaoka Y,ElKhal A,Kawamoto S,Lewis CN,Austen KF,Geha RS
Tue Mar 27 00:00:00 EDT 2012
Spontaneous mutation of the Dock2 gene in Irf5-/- mice complicates interpretation of type I interferon production and antibody responses.
Proceedings of the National Academy of Sciences of the United States of America
Purtha WE,Swiecki M,Colonna M,Diamond MS,Bhattacharya D
Tue Apr 10 00:00:00 EDT 2012
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America
Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P
Tue Sep 04 00:00:00 EDT 2012
Induced transgene expression for the treatment of solid tumors by hematopoietic stem cell-based gene therapy.
Cancer gene therapy
Noyan F,Díez IA,Hapke M,Klein C,Dewey RA
Tue May 01 00:00:00 EDT 2012
Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages.
Stem cells (Dayton, Ohio)
Megías J,Yáñez A,Moriano S,O'Connor JE,Gozalbo D,Gil ML
Sun Jul 01 00:00:00 EDT 2012
Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53.
Stem cells (Dayton, Ohio)
Hegde S,Hankey P,Paulson RF
Wed Feb 01 00:00:00 EST 2012
Amniotic fluid stem cells restore the muscle cell niche in a HSA-Cre, Smn(F7/F7) mouse model.
Stem cells (Dayton, Ohio)
Piccoli M,Franzin C,Bertin E,Urbani L,Blaauw B,Repele A,Taschin E,Cenedese A,Zanon GF,André-Schmutz I,Rosato A,Melki J,Cavazzana-Calvo M,Pozzobon M,De Coppi P
Wed Aug 01 00:00:00 EDT 2012
The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L.
Journal of immunology (Baltimore, Md. : 1950)
Nunomura S,Kawakami Y,Kawakami T,Ra C
Sun Apr 15 00:00:00 EDT 2012
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Morita H,Nambu A,Arae K,Shimura E,Shibui A,Yamaguchi S,Suzukawa K,Nakanishi W,Oboki K,Kajiwara N,Ohno T,Ishii A,Körner H,Cua DJ,Suto H,Yoshimoto T,Iwakura Y,Yamasoba T,Ohta K,Sudo K,Saito H,Okumura K,Broide DH,Matsumoto K,Nakae S
Mon Oct 01 00:00:00 EDT 2012
NLRP3 inflammasome activity is negatively controlled by miR-223.
Journal of immunology (Baltimore, Md. : 1950)
Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V
Mon Oct 15 00:00:00 EDT 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 EDT 2012
The SWI/SNF-like BAF complex is essential for early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH
Sun Apr 15 00:00:00 EDT 2012
Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bahaie NS,Hosseinkhani MR,Ge XN,Kang BN,Ha SG,Blumenthal MS,Jessberger R,Rao SP,Sriramarao P
Wed Feb 01 00:00:00 EST 2012
Stem cell factor programs the mast cell activation phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Ito T,Smrž D,Jung MY,Bandara G,Desai A,Smržová Š,Kuehn HS,Beaven MA,Metcalfe DD,Gilfillan AM
Fri Jun 01 00:00:00 EDT 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
Sun Jan 01 00:00:00 EST 2012
CD11c+ cells are required for antigen-induced increase of mast cells in the lung.
Journal of immunology (Baltimore, Md. : 1950)
Dahlin JS,Feinstein R,Cui Y,Heyman B,Hallgren J
Mon Oct 15 00:00:00 EDT 2012
Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice.
Evidence-based complementary and alternative medicine : eCAM
Wang X,Kageyama-Yahara N,Hayashi S,Yamamoto T,Kadowaki M
Thu Aug 23 00:00:00 EDT 2012
Tcf7 is an important regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line.
PLoS genetics
Wu JQ,Seay M,Schulz VP,Hariharan M,Tuck D,Lian J,Du J,Shi M,Ye Z,Gerstein M,Snyder MP,Weissman S
Tue Sep 04 00:00:00 EDT 2012
Interleukin-33 primes mast cells for activation by IgG immune complexes.
PloS one
Kaieda S,Wang JX,Shnayder R,Fishgal N,Hei H,Lee RT,Stevens RL,Nigrovic PA
Thu Apr 04 00:00:00 EDT 2013
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
The Journal of biological chemistry
Pullen NA,Barnstein BO,Falanga YT,Wang Z,Suzuki R,Tamang TD,Khurana MC,Harry EA,Draber P,Bunting KD,Mizuno K,Wilson BS,Ryan JJ
Fri Jan 13 00:00:00 EST 2012
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
PloS one
Laranjeiro R,Alcobia I,Neves H,Gomes AC,Saavedra P,Carvalho CC,Duarte A,Cidadão A,Parreira L
Thu Aug 30 00:00:00 EDT 2012
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications
Matsumura T,Ato M,Ikebe T,Ohnishi M,Watanabe H,Kobayashi K
Tue Feb 14 00:00:00 EST 2012
TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms.
PloS one
Takaesu G,Inagaki M,Takubo K,Mishina Y,Hess PR,Dean GA,Yoshimura A,Matsumoto K,Suda T,Ninomiya-Tsuji J
Tue May 28 00:00:00 EDT 2013
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PloS one
Nakamura S,Oshima M,Yuan J,Saraya A,Miyagi S,Konuma T,Yamazaki S,Osawa M,Nakauchi H,Koseki H,Iwama A
Tue Oct 16 00:00:00 EDT 2012
Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.
The Journal of biological chemistry
Hu P,Carlesso N,Xu M,Liu Y,Nebreda AR,Takemoto C,Kapur R
Fri Jun 08 00:00:00 EDT 2012
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions.
The Journal of biological chemistry
Eylenstein A,Schmidt S,Gu S,Yang W,Schmid E,Schmidt EM,Alesutan I,Szteyn K,Regel I,Shumilina E,Lang F
Fri Jan 20 00:00:00 EST 2012
The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.
PloS one
Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD
Mon Oct 22 00:00:00 EDT 2012
FcεR1-mediated mast cell reactivity is amplified through prolonged Toll-like receptor-ligand treatment.
PloS one
Saluja R,Delin I,Nilsson GP,Adner M
Wed Jan 16 00:00:00 EST 2013
Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model.
Clinical and molecular allergy : CMA
Banerjee ER,Henderson WR
Wed Jan 04 00:00:00 EST 2012
IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.
PloS one
Heller NM,Gwinn WM,Donnelly RP,Constant SL,Keegan AD
Fri Jan 04 00:00:00 EST 2013
A microRNA encoded by Kaposi sarcoma-associated herpesvirus promotes B-cell expansion in vivo.
PloS one
Dahlke C,Maul K,Christalla T,Walz N,Schult P,Stocking C,Grundhoff A
Wed May 22 00:00:00 EDT 2013
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 EST 2013
The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression.
The Journal of biological chemistry
Haining EJ,Yang J,Bailey RL,Khan K,Collier R,Tsai S,Watson SP,Frampton J,Garcia P,Tomlinson MG
Fri Nov 16 00:00:00 EST 2012
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 EST 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 EST 2013
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Cancer cell
Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M
Tue Apr 12 00:00:00 EDT 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 EDT 2011
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.
Blood
Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR
Thu May 26 00:00:00 EDT 2011
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.
Blood
Mazharian A,Ghevaert C,Zhang L,Massberg S,Watson SP
Thu May 12 00:00:00 EDT 2011
Macrophage development from HSCs requires PU.1-coordinated microRNA expression.
Blood
Ghani S,Riemke P,Schönheit J,Lenze D,Stumm J,Hoogenkamp M,Lagendijk A,Heinz S,Bonifer C,Bakkers J,Abdelilah-Seyfried S,Hummel M,Rosenbauer F
Thu Aug 25 00:00:00 EDT 2011
HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal.
Blood
Flygare J,Rayon Estrada V,Shin C,Gupta S,Lodish HF
Thu Mar 24 00:00:00 EDT 2011
DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis.
Blood
Nguyen AT,Taranova O,He J,Zhang Y
Thu Jun 23 00:00:00 EDT 2011
PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability.
Blood
Furumoto Y,Charles N,Olivera A,Leung WH,Dillahunt S,Sargent JL,Tinsley K,Odom S,Scott E,Wilson TM,Ghoreschi K,Kneilling M,Chen M,Lee DM,Bolland S,Rivera J
Thu Nov 17 00:00:00 EST 2011
Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.
Blood
Maetzig T,Brugman MH,Bartels S,Heinz N,Kustikova OS,Modlich U,Li Z,Galla M,Schiedlmeier B,Schambach A,Baum C
Thu Mar 17 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
Thu Feb 24 00:00:00 EST 2011
Specificity for the tumor-associated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination.
Blood
Pospori C,Xue SA,Holler A,Voisine C,Perro M,King J,Fallah-Arani F,Flutter B,Chakraverty R,Stauss HJ,Morris EC
Thu Jun 23 00:00:00 EDT 2011
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Blood
Cornejo MG,Mabialah V,Sykes SM,Khandan T,Lo Celso C,Lopez CK,Rivera-Muñoz P,Rameau P,Tothova Z,Aster JC,DePinho RA,Scadden DT,Gilliland DG,Mercher T
Thu Aug 04 00:00:00 EDT 2011
Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.
Blood
Zhang L,Magli A,Catanese J,Xu Z,Kyba M,Perlingeiro RC
Thu Jul 07 00:00:00 EDT 2011
Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
Blood
Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A
Thu Sep 08 00:00:00 EDT 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 EST 2011
Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
Blood
Aue G,Du Y,Cleveland SM,Smith SB,Davé UP,Liu D,Weniger MA,Metais JY,Jenkins NA,Copeland NG,Dunbar CE
Thu Oct 27 00:00:00 EDT 2011
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Blood
Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M
Thu Aug 04 00:00:00 EDT 2011
E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.
Blood
Yang Q,Esplin B,Borghesi L
Thu Mar 31 00:00:00 EDT 2011
The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.
Blood
Ma P,Mali RS,Munugalavadla V,Krishnan S,Ramdas B,Sims E,Martin H,Ghosh J,Li S,Chan RJ,Krystal G,Craig AW,Takemoto C,Kapur R
Thu Sep 29 00:00:00 EDT 2011
Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
Blood
Jaako P,Flygare J,Olsson K,Quere R,Ehinger M,Henson A,Ellis S,Schambach A,Baum C,Richter J,Larsson J,Bryder D,Karlsson S
Thu Dec 01 00:00:00 EST 2011
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
Blood
Kharazi S,Mead AJ,Mansour A,Hultquist A,Böiers C,Luc S,Buza-Vidas N,Ma Z,Ferry H,Atkinson D,Reckzeh K,Masson K,Cammenga J,Rönnstrand L,Arai F,Suda T,Nerlov C,Sitnicka E,Jacobsen SE
Thu Sep 29 00:00:00 EDT 2011
AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Blood
Steffen B,Knop M,Bergholz U,Vakhrusheva O,Rode M,Köhler G,Henrichs MP,Bulk E,Hehn S,Stehling M,Dugas M,Bäumer N,Tschanter P,Brandts C,Koschmieder S,Berdel WE,Serve H,Stocking C,Müller-Tidow C
Thu Apr 21 00:00:00 EDT 2011
Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice.
Blood
Hegde S,Kaushal N,Ravindra KC,Chiaro C,Hafer KT,Gandhi UH,Thompson JT,van den Heuvel JP,Kennett MJ,Hankey P,Paulson RF,Prabhu KS
Thu Dec 22 00:00:00 EST 2011
The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal.
Blood
Wang J,Han F,Wu J,Lee SW,Chan CH,Wu CY,Yang WL,Gao Y,Zhang X,Jeong YS,Moten A,Samaniego F,Huang P,Liu Q,Zeng YX,Lin HK
Thu Nov 17 00:00:00 EST 2011
SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.
Blood
Zhang L,Friedman AD
Thu Aug 25 00:00:00 EDT 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 EST 2011
Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.
Blood
Sakata-Yanagimoto M,Sakai T,Miyake Y,Saito TI,Maruyama H,Morishita Y,Nakagami-Yamaguchi E,Kumano K,Yagita H,Fukayama M,Ogawa S,Kurokawa M,Yasutomo K,Chiba S
Thu Jan 06 00:00:00 EST 2011
A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.
Blood
McGrath KE,Frame JM,Fromm GJ,Koniski AD,Kingsley PD,Little J,Bulger M,Palis J
Thu Apr 28 00:00:00 EDT 2011
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane.
Blood
Nanua S,Murakami M,Xia J,Grenda DS,Woloszynek J,Strand M,Link DC
Thu Mar 31 00:00:00 EDT 2011
Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.
Blood
England SJ,McGrath KE,Frame JM,Palis J
Thu Mar 03 00:00:00 EST 2011
Correction of murine β-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion.
Blood
Negre O,Fusil F,Colomb C,Roth S,Gillet-Legrand B,Henri A,Beuzard Y,Bushman F,Leboulch P,Payen E
Thu May 19 00:00:00 EDT 2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Blood
Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS
Thu Apr 21 00:00:00 EDT 2011
Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution.
Blood
Li N,Matte-Martone C,Zheng H,Cui W,Venkatesan S,Tan HS,McNiff J,Demetris AJ,Roopenian D,Kaech S,Shlomchik WD
Thu Nov 24 00:00:00 EST 2011
Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
The Journal of clinical investigation
Kreisel D,Sugimoto S,Tietjens J,Zhu J,Yamamoto S,Krupnick AS,Carmody RJ,Gelman AE
Sat Jan 01 00:00:00 EST 2011
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
The Journal of clinical investigation
Weber C,Meiler S,Döring Y,Koch M,Drechsler M,Megens RT,Rowinska Z,Bidzhekov K,Fecher C,Ribechini E,van Zandvoort MA,Binder CJ,Jelinek I,Hristov M,Boon L,Jung S,Korn T,Lutz MB,Förster I,Zenke M,Hieronymus T,Junt T,Zernecke A
Fri Jul 01 00:00:00 EDT 2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine
Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA
Mon Jun 06 00:00:00 EDT 2011
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
The Journal of experimental medicine
Hurtz C,Hatzi K,Cerchietti L,Braig M,Park E,Kim YM,Herzog S,Ramezani-Rad P,Jumaa H,Müller MC,Hofmann WK,Hochhaus A,Ye BH,Agarwal A,Druker BJ,Shah NP,Melnick AM,Müschen M
Mon Oct 24 00:00:00 EDT 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
Mon Jun 06 00:00:00 EDT 2011
Complex interactions in EML cell stimulation by stem cell factor and IL-3.
Proceedings of the National Academy of Sciences of the United States of America
Ye ZJ,Gulcicek E,Stone K,Lam T,Schulz V,Weissman SM
Tue Mar 22 00:00:00 EDT 2011
Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.
Proceedings of the National Academy of Sciences of the United States of America
Calderón L,Boehm T
Tue May 03 00:00:00 EDT 2011
Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.
Stem cells (Dayton, Ohio)
Heffner GC,Clutter MR,Nolan GP,Weissman IL
Tue Nov 01 00:00:00 EDT 2011
Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Luna-Gomes T,Magalhães KG,Mesquita-Santos FP,Bakker-Abreu I,Samico RF,Molinaro R,Calheiros AS,Diaz BL,Bozza PT,Weller PF,Bandeira-Melo C
Thu Dec 15 00:00:00 EST 2011
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950)
Grenningloh R,Tai TS,Frahm N,Hongo TC,Chicoine AT,Brander C,Kaufmann DE,Ho IC
Sat Jan 15 00:00:00 EST 2011
STIM1-directed reorganization of microtubules in activated mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Hájková Z,Bugajev V,Dráberová E,Vinopal S,Dráberová L,Janáček J,Dráber P,Dráber P
Sat Jan 15 00:00:00 EST 2011
Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Cantor J,Slepak M,Ege N,Chang JT,Ginsberg MH
Fri Jul 15 00:00:00 EDT 2011
Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Li H,Nourbakhsh B,Safavi F,Li K,Xu H,Cullimore M,Zhou F,Zhang G,Rostami A
Fri Jul 01 00:00:00 EDT 2011
SIRPα/CD172a regulates eosinophil homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Verjan Garcia N,Umemoto E,Saito Y,Yamasaki M,Hata E,Matozaki T,Murakami M,Jung YJ,Woo SY,Seoh JY,Jang MH,Aozasa K,Miyasaka M
Thu Sep 01 00:00:00 EDT 2011
Mast cell-derived IL-10 suppresses germinal center formation by affecting T follicular helper cell function.
Journal of immunology (Baltimore, Md. : 1950)
Chacón-Salinas R,Limón-Flores AY,Chávez-Blanco AD,Gonzalez-Estrada A,Ullrich SE
Sat Jan 01 00:00:00 EST 2011
Graft-versus-leukemia (GVL) against mouse blast-crisis chronic myelogenous leukemia (BC-CML) and chronic-phase chronic myelogenous leukemia (CP-CML): shared mechanisms of T cell killing, but programmed death ligands render CP-CML and not BC-CML GVL resistant.
Journal of immunology (Baltimore, Md. : 1950)
Matte-Martone C,Venkatesan S,Tan HS,Athanasiadis I,Chang J,Pavisic J,Shlomchik WD
Mon Aug 15 00:00:00 EDT 2011
Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.
PloS one
Sutherland RE,Xu X,Kim SS,Seeley EJ,Caughey GH,Wolters PJ
Mon Mar 26 00:00:00 EDT 2012
Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.
The Journal of biological chemistry
Guo H,Friedman AD
Fri Jan 07 00:00:00 EST 2011
Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis.
BMC genomics
Dutta P,Koch A,Breyer B,Schneider H,Dittrich-Breiholz O,Kracht M,Tamura T
Mon Apr 18 00:00:00 EDT 2011
Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.
PloS one
Persson J,Beyer I,Yumul R,Li Z,Kiem HP,Roffler S,Lieber A
Tue Nov 15 00:00:00 EST 2011
Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.
PloS one
Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML
Tue Feb 28 00:00:00 EST 2012
ISG15 modulates development of the erythroid lineage.
PloS one
Maragno AL,Pironin M,Alcalde H,Cong X,Knobeloch KP,Tangy F,Zhang DE,Ghysdael J,Quang CT
Fri Feb 17 00:00:00 EST 2012
MiR-221 influences effector functions and actin cytoskeleton in mast cells.
PloS one
Mayoral RJ,Deho L,Rusca N,Bartonicek N,Saini HK,Enright AJ,Monticelli S
Fri Feb 17 00:00:00 EST 2012
Triple selectin knockout (ELP-/-) mice fail to develop OVA-induced acute asthma phenotype.
Journal of inflammation (London, England)
Banerjee ER
Thu Aug 11 00:00:00 EDT 2011
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
The Journal of biological chemistry
Liu Z,Yang A,Wang Z,Bunting KD,Davuluri G,Green MR,Devireddy LR
Fri Jun 10 00:00:00 EDT 2011
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.
PloS one
Otsuka A,Kubo M,Honda T,Egawa G,Nakajima S,Tanizaki H,Kim B,Matsuoka S,Watanabe T,Nakae S,Miyachi Y,Kabashima K
Thu Jan 26 00:00:00 EST 2012
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
The Journal of biological chemistry
Dagälv A,Holmborn K,Kjellén L,Abrink M
Fri Dec 30 00:00:00 EST 2011
Magnetic resonance imaging of bone marrow cell-mediated interleukin-10 gene therapy of atherosclerosis.
PloS one
Sun J,Li X,Feng H,Gu H,Blair T,Li J,Soriano S,Meng Y,Zhang F,Feng Q,Yang X
Tue Feb 14 00:00:00 EST 2012
IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.
PloS one
Dahlin JS,Ivarsson MA,Heyman B,Hallgren J
Mon Oct 17 00:00:00 EDT 2011
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis.
BMC immunology
Arumugam M,Ahrens R,Osterfeld H,Kottyan LC,Shang X,Maclennan JA,Zimmermann N,Zheng Y,Finkelman FD,Hogan SP
Thu Feb 03 00:00:00 EST 2011
Stem cell factor and granulocyte colony-stimulating factor reduce β-amyloid deposits in the brains of APP/PS1 transgenic mice.
Alzheimer's research & therapy
Li B,Gonzalez-Toledo ME,Piao CS,Gu A,Kelley RE,Zhao LR
Tue Mar 15 00:00:00 EDT 2011
Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils.
PloS one
Zhang J,Alcaide P,Liu L,Sun J,He A,Luscinskas FW,Shi GP
Fri Jan 14 00:00:00 EST 2011
Differential Secondary Reconstitution of In Vivo-Selected Human SCID-Repopulating Cells in NOD/SCID versus NOD/SCID/γ chain Mice.
Bone marrow research
Cai S,Wang H,Bailey B,Hartwell JR,Silver JM,Juliar BE,Sinn AL,Baluyut AR,Pollok KE
Thu Nov 10 00:00:00 EST 2011
Single cell analysis facilitates staging of Blimp1-dependent primordial germ cells derived from mouse embryonic stem cells.
PloS one
Vincent JJ,Li Z,Lee SA,Liu X,Etter MO,Diaz-Perez SV,Taylor SK,Gkountela S,Lindgren AG,Clark AT
Mon Aug 27 00:00:00 EDT 2012
Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.
The Journal of biological chemistry
Chaix A,Lopez S,Voisset E,Gros L,Dubreuil P,De Sepulveda P
Fri Feb 25 00:00:00 EST 2011
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.
PloS one
Heinonen KM,Vanegas JR,Lew D,Krosl J,Perreault C
Tue Apr 26 00:00:00 EDT 2011
Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations.
The Journal of biological chemistry
Nörenberg W,Hempel C,Urban N,Sobottka H,Illes P,Schaefer M
Fri Apr 01 00:00:00 EDT 2011
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.
Nature
Nakada D,Saunders TL,Morrison SJ
Thu Dec 02 00:00:00 EST 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 EST 2010
Single-gene transgenic mouse strains for reprogramming adult somatic cells.
Nature methods
Carey BW,Markoulaki S,Beard C,Hanna J,Jaenisch R
Fri Jan 01 00:00:00 EST 2010
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
Immunity
Vonarbourg C,Mortha A,Bui VL,Hernandez PP,Kiss EA,Hoyler T,Flach M,Bengsch B,Thimme R,Hölscher C,Hönig M,Pannicke U,Schwarz K,Ware CF,Finke D,Diefenbach A
Wed Nov 24 00:00:00 EST 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 EST 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 EST 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.
Blood
Keeshan K,Bailis W,Dedhia PH,Vega ME,Shestova O,Xu L,Toscano K,Uljon SN,Blacklow SC,Pear WS
Thu Dec 02 00:00:00 EST 2010
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
Thu Jun 10 00:00:00 EDT 2010
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Blood
Qiu JJ,Lu X,Zeisig BB,Ma Z,Cai X,Chen S,Gronemeyer H,Tweardy DJ,So CW,Dong S
Thu Jan 21 00:00:00 EST 2010
Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia.
Blood
Dedhia PH,Keeshan K,Uljon S,Xu L,Vega ME,Shestova O,Zaks-Zilberman M,Romany C,Blacklow SC,Pear WS
Thu Aug 26 00:00:00 EDT 2010
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood
Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT
Thu Dec 23 00:00:00 EST 2010
During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool.
Blood
Dev A,Fang J,Sathyanarayana P,Pradeep A,Emerson C,Wojchowski DM
Thu Dec 09 00:00:00 EST 2010
Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.
Blood
Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E
Thu Jul 15 00:00:00 EDT 2010
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells.
Blood
Hosokawa K,Arai F,Yoshihara H,Iwasaki H,Nakamura Y,Gomei Y,Suda T
Thu Jul 29 00:00:00 EDT 2010
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Blood
Juntilla MM,Patil VD,Calamito M,Joshi RP,Birnbaum MJ,Koretzky GA
Thu May 20 00:00:00 EDT 2010
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood
Kerns HM,Ryu BY,Stirling BV,Sather BD,Astrakhan A,Humblet-Baron S,Liggitt D,Rawlings DJ
Thu Mar 18 00:00:00 EDT 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 EST 2010
Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.
Blood
Agrawal-Singh S,Koschmieder S,Gelsing S,Stocking C,Stehling M,Thiede C,Thoennissen NH,Köhler G,Valk PJ,Delwel R,Mills K,Bäumer N,Tickenbrock L,Hansen K,Berdel WE,Müller-Tidow C,Serve H
Thu Jun 03 00:00:00 EDT 2010
W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis.
Blood
Jansson L,Larsson J
Thu Jan 07 00:00:00 EST 2010
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
Thu Jun 17 00:00:00 EDT 2010
Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.
Blood
Mazharian A,Thomas SG,Dhanjal TS,Buckley CD,Watson SP
Thu Aug 05 00:00:00 EDT 2010
A key role for ATF3 in regulating mast cell survival and mediator release.
Blood
Gilchrist M,Henderson WR,Morotti A,Johnson CD,Nachman A,Schmitz F,Smith KD,Aderem A
Thu Jun 10 00:00:00 EDT 2010
Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors.
Blood
Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP
Thu Nov 18 00:00:00 EST 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 EST 2010
Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Blood
Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F
Thu Dec 02 00:00:00 EST 2010
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.
Blood
Li J,Spensberger D,Ahn JS,Anand S,Beer PA,Ghevaert C,Chen E,Forrai A,Scott LM,Ferreira R,Campbell PJ,Watson SP,Liu P,Erber WN,Huntly BJ,Ottersbach K,Green AR
Thu Sep 02 00:00:00 EDT 2010
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
Blood
Pulliam-Leath AC,Ciccone SL,Nalepa G,Li X,Si Y,Miravalle L,Smith D,Yuan J,Li J,Anur P,Orazi A,Vance GH,Yang FC,Hanenberg H,Bagby GC,Clapp DW
Thu Oct 21 00:00:00 EDT 2010
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Blood
de Bruin AM,Buitenhuis M,van der Sluijs KF,van Gisbergen KP,Boon L,Nolte MA
Thu Oct 07 00:00:00 EDT 2010
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Blood
Li G,Miskimen KL,Wang Z,Xie XY,Brenzovich J,Ryan JJ,Tse W,Moriggl R,Bunting KD
Thu Feb 18 00:00:00 EST 2010
Early mammalian erythropoiesis requires the Dot1L methyltransferase.
Blood
Feng Y,Yang Y,Ortega MM,Copeland JN,Zhang M,Jacob JB,Fields TA,Vivian JL,Fields PE
Thu Nov 25 00:00:00 EST 2010
Leukemogenic transformation by HOXA cluster genes.
Blood
Bach C,Buhl S,Mueller D,García-Cuéllar MP,Maethner E,Slany RK
Thu Apr 08 00:00:00 EDT 2010
Lnk constrains myeloproliferative diseases in mice.
The Journal of clinical investigation
Bersenev A,Wu C,Balcerek J,Jing J,Kundu M,Blobel GA,Chikwava KR,Tong W
Tue Jun 01 00:00:00 EDT 2010
CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
The Journal of clinical investigation
Si Y,Tsou CL,Croft K,Charo IF
Thu Apr 01 00:00:00 EDT 2010
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
The Journal of experimental medicine
Morita Y,Ema H,Nakauchi H
Mon Jun 07 00:00:00 EDT 2010
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.
The Journal of experimental medicine
Yu L,Ji W,Zhang H,Renda MJ,He Y,Lin S,Cheng EC,Chen H,Krause DS,Min W
Mon Jun 07 00:00:00 EDT 2010
A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
The Journal of experimental medicine
Henderson RB,Grys K,Vehlow A,de Bettignies C,Zachacz A,Henley T,Turner M,Batista F,Tybulewicz VL
Mon Apr 12 00:00:00 EDT 2010
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Chou S,Lodish HF
Tue Apr 27 00:00:00 EDT 2010
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Naramura M,Nandwani N,Gu H,Band V,Band H
Tue Sep 14 00:00:00 EDT 2010
Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.
Haematologica
Kalfa TA,Pushkaran S,Zhang X,Johnson JF,Pan D,Daria D,Geiger H,Cancelas JA,Williams DA,Zheng Y
Fri Jan 01 00:00:00 EST 2010
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression.
PLoS biology
Pop R,Shearstone JR,Shen Q,Liu Y,Hallstrom K,Koulnis M,Gribnau J,Socolovsky M
Tue Sep 21 00:00:00 EDT 2010
Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.
Stem cells (Dayton, Ohio)
Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G
Sat May 01 00:00:00 EDT 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 EDT 2010
Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.
Journal of immunology (Baltimore, Md. : 1950)
Scandiuzzi L,Beghdadi W,Daugas E,Abrink M,Tiwari N,Brochetta C,Claver J,Arouche N,Zang X,Pretolani M,Monteiro RC,Pejler G,Blank U
Thu Jul 01 00:00:00 EDT 2010
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Journal of immunology (Baltimore, Md. : 1950)
Dyer KD,Percopo CM,Xie Z,Yang Z,Kim JD,Davoine F,Lacy P,Druey KM,Moqbel R,Rosenberg HF
Tue Jun 01 00:00:00 EDT 2010
The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Collington SJ,Hallgren J,Pease JE,Jones TG,Rollins BJ,Westwick J,Austen KF,Williams TJ,Gurish MF,Weller CL
Tue Jun 01 00:00:00 EDT 2010
Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Alvarez-Errico D,Yamashita Y,Suzuki R,Odom S,Furumoto Y,Yamashita T,Rivera J
Sat May 01 00:00:00 EDT 2010
Kit ligand and Il7 differentially regulate Peyer's patch and lymph node development.
Journal of immunology (Baltimore, Md. : 1950)
Chappaz S,Gärtner C,Rodewald HR,Finke D
Wed Sep 15 00:00:00 EDT 2010
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M
Mon Nov 01 00:00:00 EDT 2010
IL-33 induces IL-13-dependent cutaneous fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Rankin AL,Mumm JB,Murphy E,Turner S,Yu N,McClanahan TK,Bourne PA,Pierce RH,Kastelein R,Pflanz S
Mon Feb 01 00:00:00 EST 2010
Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Wrzesinski C,Paulos CM,Kaiser A,Muranski P,Palmer DC,Gattinoni L,Yu Z,Rosenberg SA,Restifo NP
Fri Jan 01 00:00:00 EST 2010
Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis.
Cell death & disease
Karlberg M,Ekoff M,Labi V,Strasser A,Huang D,Nilsson G
Thu May 13 00:00:00 EDT 2010
Mast cells mobilize myeloid-derived suppressor cells and Treg cells in tumor microenvironment via IL-17 pathway in murine hepatocarcinoma model.
PloS one
Yang Z,Zhang B,Li D,Lv M,Huang C,Shen GX,Huang B
Wed Jan 27 00:00:00 EST 2010
Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.
The Journal of biological chemistry
Zhang Y,Tang W,Jones MC,Xu W,Halene S,Wu D
Fri Aug 06 00:00:00 EDT 2010
Characterization of oxidative guanine damage and repair in mammalian telomeres.
PLoS genetics
Wang Z,Rhee DB,Lu J,Bohr CT,Zhou F,Vallabhaneni H,de Souza-Pinto NC,Liu Y
Thu May 13 00:00:00 EDT 2010
c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.
The Journal of biological chemistry
Jiao X,Katiyar S,Willmarth NE,Liu M,Ma X,Flomenberg N,Lisanti MP,Pestell RG
Fri Mar 12 00:00:00 EST 2010
Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector.
Virology journal
Fratini P,Strauss BE
Fri Jan 22 00:00:00 EST 2010
Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.
The Journal of biological chemistry
Ohtake-Niimi S,Kondo S,Ito T,Kakehi S,Ohta T,Habuchi H,Kimata K,Habuchi O
Fri Jul 02 00:00:00 EDT 2010
Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts.
The Journal of biological chemistry
Heneberg P,Dráberová L,Bambousková M,Pompach P,Dráber P
Fri Apr 23 00:00:00 EDT 2010
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).
The Journal of biological chemistry
Kaieda S,Shin K,Nigrovic PA,Seki K,Lee RT,Stevens RL,Lee DM
Fri Jul 09 00:00:00 EDT 2010
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.
Nature
Gu Y,Harley IT,Henderson LB,Aronow BJ,Vietor I,Huber LA,Harley JB,Kilpatrick JR,Langefeld CD,Williams AH,Jegga AG,Chen J,Wills-Karp M,Arshad SH,Ewart SL,Thio CL,Flick LM,Filippi MD,Grimes HL,Drumm ML,Cutting GR,Knowles MR,Karp CL
Thu Apr 23 00:00:00 EDT 2009
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
Nature
Yanai H,Ban T,Wang Z,Choi MK,Kawamura T,Negishi H,Nakasato M,Lu Y,Hangai S,Koshiba R,Savitsky D,Ronfani L,Akira S,Bianchi ME,Honda K,Tamura T,Kodama T,Taniguchi T
Thu Nov 05 00:00:00 EST 2009
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.
Nature
Viale A,De Franco F,Orleth A,Cambiaghi V,Giuliani V,Bossi D,Ronchini C,Ronzoni S,Muradore I,Monestiroli S,Gobbi A,Alcalay M,Minucci S,Pelicci PG
Thu Jan 01 00:00:00 EST 2009
A role for Lin28 in primordial germ-cell development and germ-cell malignancy.
Nature
West JA,Viswanathan SR,Yabuuchi A,Cunniff K,Takeuchi A,Park IH,Sero JE,Zhu H,Perez-Atayde A,Frazier AL,Surani MA,Daley GQ
Thu Aug 13 00:00:00 EDT 2009
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature
Sanada M,Suzuki T,Shih LY,Otsu M,Kato M,Yamazaki S,Tamura A,Honda H,Sakata-Yanagimoto M,Kumano K,Oda H,Yamagata T,Takita J,Gotoh N,Nakazaki K,Kawamata N,Onodera M,Nobuyoshi M,Hayashi Y,Harada H,Kurokawa M,Chiba S,Mori H,Ozawa K,Omine M,Hirai H,Nakauchi H,Koeffler HP,Ogawa S
Thu Aug 13 00:00:00 EDT 2009
Direct cell reprogramming is a stochastic process amenable to acceleration.
Nature
Hanna J,Saha K,Pando B,van Zon J,Lengner CJ,Creyghton MP,van Oudenaarden A,Jaenisch R
Thu Dec 03 00:00:00 EST 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 EDT 2009
Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.
Nature immunology
Stehling-Sun S,Dade J,Nutt SL,DeKoter RP,Camargo FD
Sun Mar 01 00:00:00 EST 2009
Intraclonal competition limits the fate determination of regulatory T cells in the thymus.
Nature immunology
Bautista JL,Lio CW,Lathrop SK,Forbush K,Liang Y,Luo J,Rudensky AY,Hsieh CS
Mon Jun 01 00:00:00 EDT 2009
Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy.
Blood
Laje P,Shang D,Cao W,Niiya M,Endo M,Radu A,DeRogatis N,Scheiflinger F,Zoltick PW,Flake AW,Zheng XL
Thu Mar 05 00:00:00 EST 2009
Amelioration of murine beta-thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT drug-resistance gene.
Blood
Zhao H,Pestina TI,Nasimuzzaman M,Mehta P,Hargrove PW,Persons DA
Thu Jun 04 00:00:00 EDT 2009
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Blood
Horman SR,Velu CS,Chaubey A,Bourdeau T,Zhu J,Paul WE,Gebelein B,Grimes HL
Thu May 28 00:00:00 EDT 2009
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.
Blood
Praetor A,McBride JM,Chiu H,Rangell L,Cabote L,Lee WP,Cupp J,Danilenko DM,Fong S
Thu Feb 26 00:00:00 EST 2009
Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.
Blood
Cochrane SW,Zhao Y,Welner RS,Sun XH
Thu Jan 29 00:00:00 EST 2009
Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo.
Blood
Li Y,Chen S,Yuan J,Yang Y,Li J,Ma J,Wu X,Freund M,Pollok K,Hanenberg H,Goebel WS,Yang FC
Thu Mar 05 00:00:00 EST 2009
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
Blood
Rice KL,Hormaeche I,Doulatov S,Flatow JM,Grimwade D,Mills KI,Leiva M,Ablain J,Ambardekar C,McConnell MJ,Dick JE,Licht JD
Thu Dec 24 00:00:00 EST 2009
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Blood
Bandi SR,Brandts C,Rensinghoff M,Grundler R,Tickenbrock L,Köhler G,Duyster J,Berdel WE,Müller-Tidow C,Serve H,Sargin B
Thu Nov 05 00:00:00 EST 2009
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.
Blood
King IL,Dickendesher TL,Segal BM
Thu Apr 02 00:00:00 EDT 2009
Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist.
Blood
Blue R,Kowalska MA,Hirsch J,Murcia M,Janczak CA,Harrington A,Jirouskova M,Li J,Fuentes R,Thornton MA,Filizola M,Poncz M,Coller BS
Thu Jul 02 00:00:00 EDT 2009
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.
Blood
Kuo YH,Zaidi SK,Gornostaeva S,Komori T,Stein GS,Castilla LH
Thu Apr 02 00:00:00 EDT 2009
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Blood
Chan G,Kalaitzidis D,Usenko T,Kutok JL,Yang W,Mohi MG,Neel BG
Thu Apr 30 00:00:00 EDT 2009
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.
Blood
Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,Moorman AV,Morrison H,Rand V,Strefford JC,Schwab C,Tönnies H,Dyer MJ,Siebert R,Harrison CJ
Thu Sep 24 00:00:00 EDT 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 EDT 2009
Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis.
Blood
Saadatzadeh MR,Bijangi-Vishehsaraei K,Kapur R,Haneline LS
Thu Mar 19 00:00:00 EDT 2009
Negative regulation of activated alpha-2 integrins during thrombopoiesis.
Blood
Zou Z,Schmaier AA,Cheng L,Mericko P,Dickeson SK,Stricker TP,Santoro SA,Kahn ML
Thu Jun 18 00:00:00 EDT 2009
Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model.
Blood
Hu X,Shen H,Tian C,Yu H,Zheng G,XuFeng R,Ju Z,Xu J,Wang J,Cheng T
Thu Oct 29 00:00:00 EDT 2009
Gfi1 regulates miR-21 and miR-196b to control myelopoiesis.
Blood
Velu CS,Baktula AM,Grimes HL
Thu May 07 00:00:00 EDT 2009
p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.
Blood
Allen JD,Jaffer ZM,Park SJ,Burgin S,Hofmann C,Sells MA,Chen S,Derr-Yellin E,Michels EG,McDaniel A,Bessler WK,Ingram DA,Atkinson SJ,Travers JB,Chernoff J,Clapp DW
Thu Mar 19 00:00:00 EDT 2009
Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.
Blood
Schwieger M,Schüler A,Forster M,Engelmann A,Arnold MA,Delwel R,Valk PJ,Löhler J,Slany RK,Olson EN,Stocking C
Thu Sep 17 00:00:00 EDT 2009
Critical role of class IA PI3K for c-Rel expression in B lymphocytes.
Blood
Matsuda S,Mikami Y,Ohtani M,Fujiwara M,Hirata Y,Minowa A,Terauchi Y,Kadowaki T,Koyasu S
Thu Jan 29 00:00:00 EST 2009
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood
Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD
Thu Oct 22 00:00:00 EDT 2009
Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.
Blood
Horton SJ,Walf-Vorderwülbecke V,Chatters SJ,Sebire NJ,de Boer J,Williams O
Thu May 14 00:00:00 EDT 2009
Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6.
Blood
Dyer KD,Percopo CM,Fischer ER,Gabryszewski SJ,Rosenberg HF
Thu Sep 24 00:00:00 EDT 2009
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation
Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L
Wed Apr 01 00:00:00 EDT 2009
Niche recycling through division-independent egress of hematopoietic stem cells.
The Journal of experimental medicine
Bhattacharya D,Czechowicz A,Ooi AG,Rossi DJ,Bryder D,Weissman IL
Mon Nov 23 00:00:00 EST 2009
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
The Journal of experimental medicine
Fukui R,Saitoh S,Matsumoto F,Kozuka-Hata H,Oyama M,Tabeta K,Beutler B,Miyake K
Mon Jun 08 00:00:00 EDT 2009
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.
The EMBO journal
Schwermann J,Rathinam C,Schubert M,Schumacher S,Noyan F,Koseki H,Kotlyarov A,Klein C,Gaestel M
Wed May 20 00:00:00 EDT 2009
Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Bosticardo M,Ghosh A,Du Y,Jenkins NA,Copeland NG,Candotti F
Sun Nov 01 00:00:00 EDT 2009
Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
Molecular therapy : the journal of the American Society of Gene Therapy
Pestina TI,Hargrove PW,Jay D,Gray JT,Boyd KM,Persons DA
Sun Feb 01 00:00:00 EST 2009
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.
Proceedings of the National Academy of Sciences of the United States of America
XuFeng R,Boyer MJ,Shen H,Li Y,Yu H,Gao Y,Yang Q,Wang Q,Cheng T
Tue Oct 20 00:00:00 EDT 2009
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.
Proceedings of the National Academy of Sciences of the United States of America
Schmaier AA,Zou Z,Kazlauskas A,Emert-Sedlak L,Fong KP,Neeves KB,Maloney SF,Diamond SL,Kunapuli SP,Ware J,Brass LF,Smithgall TE,Saksela K,Kahn ML
Tue Dec 15 00:00:00 EST 2009
Misguided transcriptional elongation causes mixed lineage leukemia.
PLoS biology
Mueller D,García-Cuéllar MP,Bach C,Buhl S,Maethner E,Slany RK
Sun Nov 01 00:00:00 EDT 2009
The role of stem cell factor and granulocyte-colony stimulating factor in brain repair during chronic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Piao CS,Gonzalez-Toledo ME,Xue YQ,Duan WM,Terao S,Granger DN,Kelley RE,Zhao LR
Wed Apr 01 00:00:00 EDT 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 EST 2009
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Ogaeri T,Eto K,Otsu M,Ema H,Nakauchi H
Fri May 01 00:00:00 EDT 2009
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R
Sun Feb 15 00:00:00 EST 2009
Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Kambayashi T,Allenspach EJ,Chang JT,Zou T,Shoag JE,Reiner SL,Caton AJ,Koretzky GA
Wed Apr 15 00:00:00 EDT 2009
FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee JH,Wang C,Kim CH
Sun Nov 15 00:00:00 EST 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
Sun Nov 01 00:00:00 EDT 2009
NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.
Journal of immunology (Baltimore, Md. : 1950)
Wang D,Paz-Priel I,Friedman AD
Fri May 01 00:00:00 EDT 2009
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hundt M,Harada Y,De Giorgio L,Tanimura N,Zhang W,Altman A
Sat Aug 01 00:00:00 EDT 2009
Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Zheng H,Matte-Martone C,Jain D,McNiff J,Shlomchik WD
Fri May 15 00:00:00 EDT 2009
Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
Journal of immunology (Baltimore, Md. : 1950)
Duelli A,Rönnberg E,Waern I,Ringvall M,Kolset SO,Pejler G
Tue Dec 01 00:00:00 EST 2009
Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1.
Journal of immunology (Baltimore, Md. : 1950)
Sobiesiak M,Shumilina E,Lam RS,Wölbing F,Matzner N,Kaesler S,Zemtsova IM,Lupescu A,Zahir N,Kuhl D,Schaller M,Biedermann T,Lang F
Thu Oct 01 00:00:00 EDT 2009
An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kool M,van Nimwegen M,Willart MA,Muskens F,Boon L,Smit JJ,Coyle A,Clausen BE,Hoogsteden HC,Lambrecht BN,Hammad H
Wed Jul 15 00:00:00 EDT 2009
Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
Journal of immunology (Baltimore, Md. : 1950)
Carlens J,Wahl B,Ballmaier M,Bulfone-Paus S,Förster R,Pabst O
Sun Nov 01 00:00:00 EDT 2009
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Journal of immunology (Baltimore, Md. : 1950)
Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I
Sat Aug 15 00:00:00 EDT 2009
IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Mathias CB,Freyschmidt EJ,Caplan B,Jones T,Poddighe D,Xing W,Harrison KL,Gurish MF,Oettgen HC
Sun Feb 15 00:00:00 EST 2009
MicroRNA-221-222 regulate the cell cycle in mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Mayoral RJ,Pipkin ME,Pachkov M,van Nimwegen E,Rao A,Monticelli S
Thu Jan 01 00:00:00 EST 2009
Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.
Journal of immunology (Baltimore, Md. : 1950)
Tagen M,Elorza A,Kempuraj D,Boucher W,Kepley CL,Shirihai OS,Theoharides TC
Sun Nov 15 00:00:00 EST 2009
Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.
Experimental hematology
Mazharian A,Watson SP,Séverin S
Thu Oct 01 00:00:00 EDT 2009
cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis.
PloS one
Aicher A,Heeschen C,Feil S,Hofmann F,Mendelsohn ME,Feil R,Dimmeler S
Thu May 28 00:00:00 EDT 2009
Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.
PloS one
Aguilar S,Scotton CJ,McNulty K,Nye E,Stamp G,Laurent G,Bonnet D,Janes SM
Tue Nov 24 00:00:00 EST 2009
A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.
The Journal of biological chemistry
Zhao L,Dong H,Zhang CC,Kinch L,Osawa M,Iacovino M,Grishin NV,Kyba M,Huang LJ
Fri Sep 25 00:00:00 EDT 2009
Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.
PloS one
Miletic AV,Graham DB,Sakata-Sogawa K,Hiroshima M,Hamann MJ,Cemerski S,Kloeppel T,Billadeau DD,Kanagawa O,Tokunaga M,Swat W
Wed Aug 12 00:00:00 EDT 2009
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
PloS one
Johnson KJ,Griswold IJ,O'Hare T,Corbin AS,Loriaux M,Deininger MW,Druker BJ
Tue Oct 13 00:00:00 EDT 2009
FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.
The Journal of biological chemistry
Fukushima K,Matsumura I,Ezoe S,Tokunaga M,Yasumi M,Satoh Y,Shibayama H,Tanaka H,Iwama A,Kanakura Y
Fri Mar 20 00:00:00 EDT 2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry
Lin IJ,Zhou Z,Crusselle-Davis VJ,Moghimi B,Gandhi K,Anantharaman A,Pantic D,Huang S,Jayandharan G,Zhong L,Srivastava A,Bungert J
Fri Jul 24 00:00:00 EDT 2009
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell
Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA
Tue Nov 04 00:00:00 EST 2008
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Blood
Seita J,Asakawa M,Ooehara J,Takayanagi S,Morita Y,Watanabe N,Fujita K,Kudo M,Mizuguchi J,Ema H,Nakauchi H,Yoshimoto T
Fri Feb 15 00:00:00 EST 2008
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes.
Blood
Crist SA,Sprague DL,Ratliff TL
Tue Apr 01 00:00:00 EDT 2008
IRF8 regulates B-cell lineage specification, commitment, and differentiation.
Blood
Wang H,Lee CH,Qi C,Tailor P,Feng J,Abbasi S,Atsumi T,Morse HC
Sat Nov 15 00:00:00 EST 2008
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.
Blood
Zhou Y,Du W,Koretsky T,Bagby GC,Pang Q
Mon Sep 15 00:00:00 EDT 2008
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America
Gan B,Sahin E,Jiang S,Sanchez-Aguilera A,Scott KL,Chin L,Williams DA,Kwiatkowski DJ,DePinho RA
Tue Dec 09 00:00:00 EST 2008
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
Stem cells (Dayton, Ohio)
Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR
Sun Jun 01 00:00:00 EDT 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
Sat Nov 01 00:00:00 EDT 2008
Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils.
Journal of immunology (Baltimore, Md. : 1950)
Watanabe M,Satoh T,Yamamoto Y,Kanai Y,Karasuyama H,Yokozeki H
Wed Oct 15 00:00:00 EDT 2008
IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma.
Journal of immunology (Baltimore, Md. : 1950)
Song C,Luo L,Lei Z,Li B,Liang Z,Liu G,Li D,Zhang G,Huang B,Feng ZH
Sat Nov 01 00:00:00 EDT 2008
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.
The Journal of biological chemistry
Bogacheva O,Bogachev O,Menon M,Dev A,Houde E,Valoret EI,Prosser HM,Creasy CL,Pickering SJ,Grau E,Rance K,Livi GP,Karur V,Erickson-Miller CL,Wojchowski DM
Fri Dec 26 00:00:00 EST 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 EST 2009
Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC immunology
Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD
Thu Aug 07 00:00:00 EDT 2008
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Blood
Yang L,Wang L,Kalfa TA,Cancelas JA,Shang X,Pushkaran S,Mo J,Williams DA,Zheng Y
Sat Dec 01 00:00:00 EST 2007
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
Blood
Wu Y,Welte T,Michaud M,Madri JA
Wed Aug 01 00:00:00 EDT 2007
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 EDT 2007
FcepsilonRI aggregation promotes survival of connective tissue-like mast cells but not mucosal-like mast cells.
Journal of immunology (Baltimore, Md. : 1950)
Ekoff M,Strasser A,Nilsson G
Sun Apr 01 00:00:00 EDT 2007
Lyn kinase promotes erythroblast expansion and late-stage development.
Blood
Karur VG,Lowell CA,Besmer P,Agosti V,Wojchowski DM
Fri Sep 01 00:00:00 EDT 2006
Coordination of erythropoiesis by the transcription factor c-Myb.
Blood
Vegiopoulos A,García P,Emambokus N,Frampton J
Thu Jun 15 00:00:00 EDT 2006
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 EDT 2005
Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs.
Blood
Xie X,Chan RJ,Johnson SA,Starr M,McCarthy J,Kapur R,Yoder MC
Sat Feb 15 00:00:00 EST 2003
A role for thrombopoietin in hemangioblast development.
Stem cells (Dayton, Ohio)
Perlingeiro RC,Kyba M,Bodie S,Daley GQ
Fri Feb 27 00:00:00 EST 2004
Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.
Blood
Nakajima T,Inagaki N,Tanaka H,Tanaka A,Yoshikawa M,Tamari M,Hasegawa K,Matsumoto K,Tachimoto H,Ebisawa M,Tsujimoto G,Matsuda H,Nagai H,Saito H
Sun Dec 01 00:00:00 EST 2002
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 EST 2003