Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 14 amino acids from the middle of mouse TLR7.
PEP-0172 can be used as a blocking peptide with polyclonal antibody PA5-20053.
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: RP23-139P21.3; Toll-like receptor 7
Gene Aliases: Tlr7
UniProt ID: (Mouse) P58681
Entrez Gene ID: (Mouse) 170743
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