Recombinant Rat MIP-1alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 3; H-MIP-1-alpha; LD78-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); Macrophage inflammatory protein 1-alpha; MIP-1-alpha; mip1 alpha; RP23-320E6.7; small inducible cytokine A3; Small-inducible cytokine A3
Gene Aliases: Ccl3; MIP-1a; Mip1a; Scya3
UniProt ID: (Rat) P50229
Entrez Gene ID: (Rat) 25542