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Product Details
PEP-144
Product Specifications
Species Reactivity
Rat
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
purified
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-144 is an 18 amino acid synthetic peptide whose sequence corresponds to residues 1-18 from rat rab 3D. The sequence of this peptide is (amino to carboxy terminus): M (1)-A-S-A-S-E-P-P-A-S-P-R-D-A-A-D-Q-N (18)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and rat rab 3D, catalog # PA1-773. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals. Rab 3D has been shown to be present, in part, in the tongue, pancreas, and liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein Rab-3D
Gene Aliases: Rab16; Rab3d
UniProt ID: (Rat) Q63942
Entrez Gene ID: (Rat) 140665
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