NCoR1 Proteins

Protein Information

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.

Synonyms

5730405M06Rik; A230020K14Rik; h KIAA1047; hCIT529I10; hN-CoR; KIAA1047; MGC104216; mKIAA1047; NCoR; N-CoR; N-Cor/SMRT corepressor Rip13; N-Cor/SMRT corepressor, Rip13; NCOR1; N-CoR1; nuclear receptor corepressor; nuclear receptor corepressor 1; nuclear receptor co-repressor 1; PPP1R109; protein phosphatase 1, regulatory subunit 109; retinoid X receptor interacting protein 13; retinoid X receptor-interacting protein 13; RIP13; Rxrip13; thyroid hormone- and retinoic acid receptor-associated corepressor 1; TRAC1