SCFD1 Proteins

Protein Information

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

Synonyms

3110021P21Rik; C14orf163; FKSG23; KIAA0917; Ra410; rSly1; Scfd1; Sec1 family domain containing 1; sec1 family domain-containing protein 1; Sly1; SLY1 homolog; Sly1p; STXBP1L2; Syntaxin-binding protein 1-like 2; vesicle transport-related protein; vesicle transport-related protein Ra410