TCF19 Proteins

Protein Information

TCF-19 (transcription factor 19), also known as SC1 or SC1-1, is a 345 amino acid protein that contains one FHA domain, a proline-rich domain and one PHD-type zinc finger. Localizing to the nucleus, TCF-19 is a growth regulated protein that is believed to function as a trans-activating factor with a role in the transcription of genes involved in the late stages of cell cycle progression (G1 to S transition or entry of cells into G2 and mitosis). TCF-19 is expressed preferentially in the G1-S phase of the cell cycle. The gene encoding TCF-19 localizes to a critical region on chromosome 6 that has been associated with psoriasis vulgaris, a disorder of the skin that is characterized by hyperproliferation of epidermal cells. This suggests that TCF-19, via its regulation of late cell cycle-specific genes, may play a role in the development of this disorder.

Synonyms

5730403J10Rik; AW495861; DAMA-213L4.5; SC 1; SC1; SC1 protein homolog; SC1(TCF19)-6; SC1(TCF19)-7; SC1-1; SCI(TCF19)-4; TCF 19; TCF19; TCF-19; Transcription factor 19; transcription factor 19-like protein; Transcription factor SC1