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          • Home
          • › Search Tool
          • › Search Results
          • › Hs00219132_m1
          See other TREM2 GE Assays ›
          Gene Symbol:
          TREM2
          Gene Name:
          triggering receptor expressed on myeloid cells 2
          Gene Aliases:
          AD17, PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c
          Chromosome Location:
          Chr.6: 41158508 - 41163116 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00219132_m1
          Best Coverage
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
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          • Genomic Map
          • Assay Details
          • More Information

          Genomic Map

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          Assay Details

          Gene Symbol: TREM2
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_001271821.2 NP_001258750.1 1 - 2 77 73
          NM_018965.4 NP_061838.1 1 - 2 77 73
          GenBank mRNA AB062787.1 - 1 - 2 147 73
          AF213457.1 - 1 - 2 137 73
          AK312215.1 - 1 - 2 120 73
          BC032362.1 - 1 - 2 64 73

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          More Information


          Updated Mapping Information

          This assay targets the same location as Clariom D transcript cluster(s) TC0600011771.hg.1
          This assay targets the same location as HTA transcript cluster(s) TC06001713.hg.1

          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Immune Tolerance Network Mammalian Gene Collection Recommended Assay Homo sapiens Inventoried Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene TREM2

          Gene Ontology Categories:

          Function(s) Process(es)

          microglial cell activation
          microglial cell activation involved in immune response
          T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
          positive regulation of antigen processing and presentation of peptide antigen via MHC class II
          negative regulation of inflammatory response to antigenic stimulus
          response to ischemia
          phagocytosis
          phagocytosis, recognition
          phagocytosis, engulfment
          immune response
          humoral immune response
          signal transduction
          cell surface receptor signaling pathway
          memory
          regulation of gene expression
          negative regulation of autophagy
          positive regulation of gene expression
          positive regulation of cholesterol efflux
          negative regulation of cholesterol storage
          negative regulation of sequestering of triglyceride
          positive regulation of high-density lipoprotein particle clearance
          regulation of lipid metabolic process
          osteoclast differentiation
          regulation of TOR signaling
          positive regulation of TOR signaling
          detection of lipopolysaccharide
          detection of peptidoglycan
          regulation of interleukin-6 production
          negative regulation of interleukin-1 beta production
          negative regulation of tumor necrosis factor production
          positive regulation of interleukin-10 production
          negative regulation of toll-like receptor 2 signaling pathway
          negative regulation of toll-like receptor 4 signaling pathway
          regulation of toll-like receptor 6 signaling pathway
          positive regulation of macrophage fusion
          negative regulation of glial cell apoptotic process
          social behavior
          CXCL12-activated CXCR4 signaling pathway
          defense response to bacterium
          negative regulation of apoptotic process
          negative regulation of I-kappaB kinase/NF-kappaB signaling
          positive regulation of potassium ion transport
          apoptotic cell clearance
          regulation of innate immune response
          positive regulation of osteoclast differentiation
          respiratory burst after phagocytosis
          positive regulation of complement activation, classical pathway
          astrocyte activation
          cell development
          response to axon injury
          positive regulation of protein secretion
          positive regulation of phagocytosis
          defense response to Gram-negative bacterium
          positive regulation of calcium-mediated signaling
          negative regulation of cell activation
          positive regulation of chemotaxis
          positive regulation of protein kinase B signaling
          negative regulation of protein kinase B signaling
          lipid homeostasis
          regulation of resting membrane potential
          positive regulation of phagocytosis, engulfment
          microglial cell proliferation
          negative regulation of astrocyte activation
          regulation of biological quality
          pyroptosis
          negative regulation of fat cell proliferation
          positive regulation of ERK1 and ERK2 cascade
          detection of lipoteichoic acid
          cellular response to lipoteichoic acid
          cellular response to peptidoglycan
          cellular response to glucose stimulus
          cellular response to lipid
          cellular response to lipoprotein particle stimulus
          cellular response to hypoxia
          semaphorin-plexin signaling pathway
          regulation of macrophage inflammatory protein 1 alpha production
          regulation of primary metabolic process
          dendritic cell differentiation
          dendritic spine maintenance
          beta-amyloid clearance
          import into cell
          regulation of hippocampal neuron apoptotic process
          regulation of plasma membrane bounded cell projection organization
          cellular response to oxidised low-density lipoprotein particle stimulus
          complement-mediated synapse pruning
          neuroinflammatory response
          positive regulation of neuroinflammatory response
          negative regulation of neuroinflammatory response
          amyloid-beta clearance by cellular catabolic process
          regulation of cytokine production involved in inflammatory response
          negative regulation of cytokine production involved in inflammatory response
          positive regulation of beta-amyloid clearance
          negative regulation of NLRP3 inflammasome complex assembly
          positive regulation of engulfment of apoptotic cell
          positive regulation of NIK/NF-kappaB signaling
          positive regulation of proteasomal protein catabolic process
          negative regulation of macrophage colony-stimulating factor signaling pathway
          positive regulation of intracellular signal transduction
          positive regulation of protein localization to plasma membrane
          positive regulation of C-C chemokine receptor CCR7 signaling pathway
          regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
          negative regulation of p38MAPK cascade
          positive regulation of microglial cell activation
          negative regulation of autophagic cell death
          positive regulation of microglial cell migration
          cellular response to beta-amyloid
          positive regulation of establishment of protein localization
          positive regulation of CAMKK-AMPK signaling cascade
          positive regulation of low-density lipoprotein particle clearance
          excitatory synapse pruning
          positive regulation of synapse pruning
          negative regulation of amyloid fibril formation
          positive regulation of CD40 signaling pathway
          positive regulation of ATP biosynthetic process
          lipopolysaccharide binding
          beta-amyloid binding
          phosphatidylserine binding
          transmembrane signaling receptor activity
          protein binding
          phospholipid binding
          beta-catenin binding
          high-density lipoprotein particle binding
          lipid binding
          phosphatidylethanolamine binding
          semaphorin receptor activity
          kinase activator activity
          low-density lipoprotein particle binding
          semaphorin receptor binding
          apolipoprotein binding
          apolipoprotein A-I binding
          very-low-density lipoprotein particle binding
          signaling receptor activity
          peptidoglycan binding
          macromolecular complex binding
          lipoteichoic acid binding
          lipoprotein particle binding
          scaffold protein binding
          carbohydrate derivative binding
          sulfatide binding
          protein tyrosine kinase binding

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000338469.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373113.7 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 ENST00000373122.8 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_001271821.1 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0600011771.hg.1 NM_018965.3 Refseq

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