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Discover resources for the Glacios 3 Cryo-TEM
The Thermo Scientific Glacios 3 Cryo-Transmission Electron Microscope is transforming high-performance cryo-EM, bringing together advanced 200 kV optics, powerful AI-driven workflows, and robust automation to facilitate single particle analysis, cryo-ET, and microED at exceptional resolution and throughput.
This page features user experiences with the Glacios Cryo-TEM along with webinars and downloadable materials that highlight the capabilities of this instrument. Learn how the Glacios 3 Cryo-TEM is empowering teams to push the boundaries of biological discovery and structure-based drug design.
Glacios Cryo-TEM webinar
User spotlights in drug discovery and biological research
“Cryo-EM used to be this bespoke technology that was only available to a few labs around the world. Thermo Fisher has now democratized this, bringing cryo-EM to thousands of lives across the world. And I think the collaboration with Schrödinger is essentially bringing two essential components of structure-based drug design together so that people can learn not just how to get these highly accurate structures but also how to apply these predictive methods to those structures to accelerate drug design.”
Karen Akinsanya
President of R&D, Therapeutics Group, Schrödinger
“For cryo-EM in particular, we feel like there’s a significant advantage to be gained in having total internal control over the entire gene to structure pipeline.”
“We’re now able to collect enough high-quality data in just a day or two on a 200 kV Glacios [Cryo-TEM] and turn around a sub three angstrom structure in a matter of just days to a few weeks, enabling the confident modeling of small molecules in a surrounding protein environment at a speed that keeps up with drug discovery programs.”
Zach Johnson
Director of Cryo-EM, Therapeutics Group, Schrödinger
“This partnership of physician-identified targets solved at the atomic level resolution by structural biologists, now becomes a team. Working together with the other modalities to fully understand not only the structure, but the functionality of those structures. And that’s the power of having multiple modalities. And cryo-EM, it really was the final piece that I think we were missing that is now here.”
Gustavo Leon
Director, Medical College of Wisconsin Cancer Center
"Using the Thermo Scientific Glacios Cryo-TEM, we developed a workflow that enables us to determine structures of small, asymmetric protein complexes at high-resolution and at high-speed. These structures allowed us to derive a mechanism for target selectivity in kinase inhibitors that may allow us to design new cancer therapeutics.”
Basil Greber
Team Leader, Institute of Cancer Research, London
How the Glacios Cryo-TEM is transforming research at the University of California, Santa Cruz
“The Glacios 200 kV Cryo-TEM provides outstanding performance and throughput, proving that a lower kV microscope can achieve near-atomic resolution with remarkable efficiency. Combined with Smart EPU and Tomography 5 Software, it has enabled seamless workflows and helped transform UCSC into an international center for cryo-EM research and training.”
Vitor Hugo Balasco Serrão
Director, Biomolecular Cryo-Electron Microscopy Facility, University of California, Santa Cruz
“We have one microscope, a 200 kV Glacios [Cryo-TEM] equipped with a state-of-the-art detector, a Falcon 4 [Detector], and it is equipped with a Selectris Energy Filter. No one would have thought it... people were skeptical... but we are getting 2.2 Å structures of previously unknown complexes. The technology, the Selectris [Energy Filter], it works. It is really helping us achieve resolutions at 200 kV.”
Elizabeth Wasmuth
Assistant Professor, Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San Antonio
Additional resources
For Research Use Only. Not for use in diagnostic procedures.