Demystifying cryo-electron tomography: Exploring applications and workflow

March 6, 2024 | 2 p.m. EST | 11 a.m. PST | 8 p.m. CET

Cryo-electron tomography (cryo-ET) is a revolutionary technique that offers unprecedented insights into organelles and protein complexes in their physiological environments at nanometer resolution. By making it possible to observe intricate details of biological structures in their native state, cryo-ET helps scientists advance their drug discovery and disease research. 

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Demystifying cryo-electron tomography: Exploring applications and workflow

March 6, 2024 | 2 p.m. EST | 11 a.m. PST | 8 p.m. CET

Cryo-electron tomography (cryo-ET) is a revolutionary technique that offers unprecedented insights into organelles and protein complexes in their physiological environments at nanometer resolution. By making it possible to observe intricate details of biological structures in their native state, cryo-ET helps scientists advance their drug discovery and disease research. Ongoing advancements and streamlined workflows are now making cryo-ET more accessible across a range of life sciences disciplines.

 

In this webinar, Dr. Dorit Hanein and Dr. Sarah Shahmoradian will explore the cryo-ET workflow and discuss:

  • Diverse samples suitable for cryo-ET
  • The significance of cryo-ET in cellular and structural biology
  • How cryo-ET is transforming scientific exploration and commercial innovation
  • A streamlined cryo-ET workflow that includes everything from sample preparation to data insights

About the speakers

Natalie Young, PhD, Senior Product Specialist, Thermo Fisher Scientific

Natalie obtained her PhD in structural biology and biochemistry from the University of Colorado Anschutz Medical Campus, where she primarily used single particle electron microscopy to structurally characterize a large multi-subunit complex involved in RNA Polymerase II transcription. At Thermo Fisher, she covers all topics related to cryo-transmission electron microscopy.


Jessica Heebner, PhD, Applications Scientist, Thermo Fisher Scientific

Jessica completed her undergraduate degree in biology at the University of Alabama. She then worked as a veterinary oncology nurse for almost a decade before going back to school to complete her PhD in biomedical science at Penn State University. There, she researched cytoskeletal rearrangement in developing neurons using cryo-EM and helped pioneer workflows for using deep learning to perform high-throughput image analysis and segmentation of microscopy data.


Dorit Hanein, PhD, Professor, UC Santa Barbara Department of Chemistry and Biochemistry

Dorit received her PhD from the Weizmann Institute in Israel. She completed training as a Fulbright postdoctoral fellow at Brandeis University with Professor David DeRosier, one of the founding fathers of three-dimensional image reconstruction techniques via electron microscopy. Dorit holds a joint appointment with Institut Pasteur and the Scintillon Institute and is a PEW Innovation Fund Investigator. She holds a Habilitation à Diriger des Recherches (HDR, Accreditation to Direct Research) from Sorbonne University, France.


Sarah Shahmoradian, PhD, Assistant Professor, UT Southwestern Medical Center

Sarah received her PhD in molecular physiology and biophysics from the Baylor College of Medicine in 2013 working in the lab of Wah Chiu, where she used cryo-EM and cryo-ET to uncover new structural mechanisms and features of neurodegenerative-relevant proteins. She then completed her Roche Postdoctoral fellowship in the lab of Henning Stahlberg at the Biozentrum University of Basel. In 2021 Sarah joined UTSW, where her lab applies cryo-ET and correlative light and electron microscopy to study the macromolecular basis of protein aggregation and membrane remodeling in Parkinson's and Alzheimer's diseases within neuronal systems. Her group also develops and applies new interfaces, helping to push the boundaries of these techniques.