Electron Microscopy

Cancer Research with Cryo-EM

Cryo-electron microscopy enables structural analysis of oncology targets, guiding cancer research.

Seeing cancer in 3D

Cryo-EM is continuing to revolutionize our understanding of cancer and cancer treatments. Over the past several years, scientists are using cryo-EM in remarkable ways to uncover new cancer pathways, obtain atomic-level descriptions of key cancer proteins, and provide a framework for improving pharmaceutical interventions. Cryo-EM allows researchers to freeze biomolecules in their native conformations and visualize protein interactions. Scientists can use cryo-EM to capture different stages of biochemical reactions instead of just the pre-reaction and end states. With structural insights, researchers can better understand the conditions required for cancer cell growth and identify new ways to treat cancer.

Watch, read, or listen as we sit down with some of your peers using cryo-EM to discover how the technology is helping them gain a better understanding of cancer.



Lead identification: Who hits the target?


Harnessing the power of cryo-EM for discovery of cancer therapeutics: High-resolution structures of the human CDK-activating kinase bound to inhibitors.

How does cancer develop


Cryo-Electron Microscopy and the Complexity of Cancer
Dr. Simon Poepsel of UC Berkeley explains how single-particle cryo-electron microscopy enables us to gain insight into cancer development through the detailed analysis of molecular structure, covering both biology and methodology.


Understanding the Complexity of Cancer with Cryo-EM eBook

Interviews and research highlights from your peers in the cancer research field

Read the "Understanding the complexity of cancer with cryo-EM" eBook to explore:

  • How cryo-EM is helping to find the molecular drivers of cancer
  • Filling in the gaps: characterizing protein mechanisms for cancer research
  • P53 in its full structural glory

Download eBook: Understanding the complexity of cancer with Cryo-EM

3D atomic structure of active Janus Kinase (JAK)


Explore the cryo-EM instruments enabling cancer research


Thermo Scientific Krios G4 Cryo transmission electron microscope (TEM)

Krios G4 Cryo-TEM

Powerful & Productive

  • Ultimate productivity and image quality with an integrated workflow solution
  • Highest level of automation from sample vitrification to data analysis
  • Compact design fits in standard rooms without costly renovations

Thermo Scientific Glacios 2 Cryo-Transmission Electron Microscope

Glacios 2 Cryo-TEM

Capable & Versatile

  • Maximized ease of use and excellent performance to offer a complete package for introducing cryo-TEM into your research
  • Compact hardware footprint (minimizes installation requirements) at an affordable price

Thermo Scientific Tundra Cryo transmission electron microscope (TEM)

Tundra Cryo-TEM

Accessible & Smart

  • Easy, iterative loading and imaging for rapid sample-viability determination
  • AI-guided automation with results displayed progressively
  • Cost effective and space efficient
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To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.

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