Basic life processes start in the cell, which is why biologists seek to understand how they function and respond to disease or genetic variations. Cellular biology explores individual cells and the ways in which they are organized into organs and tissues. Structural biology delves deeper into sub-cellular components, organelles and macromolecular structures. Electron microscopy (EM) is capable of providing insight at all these scales and more, revealing even atomic-level structural details for a range of biomolecules.
We’ve created this learning center to connect scientists around the world to the latest information on electron microscopy technology and to guide you to the best solution that will accelerate your next discovery or breakthrough.
Single particle analysis webinars
Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.
Micro electron diffraction (MicroED) is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. Watch now to see how
Integrative structural biology webinars
Integrative structural biology uses structural and functional information from various techniques, including mass spectrometry and cryo-EM, to arrive faster at a more complete picture of the protein and its function.
Customer and expert interviews
Watch these interviews to learn how our customers and products are impacting the latest life science research.
Dr. Erica Saphire on how cryo-EM is advancing her virus research
Prof. Erica Ollmann Saphire from La Jolla Institute for Immunology discusses how cryo-EM has been a winner to understand a range of virus structures from Ebola to SARS-CoV-2 leading to insights for drugs and vaccine development.
Sars-CoV-2 research at UT-Austin
Prof. Jason McLellan answers questions about spike protein structure, cryo-EM and vaccine trials with collaborators at NIH. Filmed in March 2020, video courtesy of The University of Texas at Austin.
Prof. Briegel and new discoveries in microbes with CryoET
Prof. Ariane Briegel from Leiden University was plenary speaker at ASM Microbe 2019. She discusses how cryo-electron tomography is overcoming research barriers faced in microbiology and gives her top tips for working with the technology.
New publications at the forefront of life science research
Learn cryo-EM essentials
Visit EM-learning.com to learn about the foundations of cryo-EM, including the single particle analysis (SPA) workflow, via step-by-step instructions, expert demonstrations and theoretical lessons—at any pace, from any place and free of charge.
Celebrating women in cryo-EM
Explore podcasts, interviews, and webinars featuring women in cryo-EM. Their stories from a variety of life science fields and locations all across the globe will inspire and encourage. Listen, discover, and set out to make your own mark in the cryo-EM movement.
Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insights into how these proteins function in a way that other methods simply cannot. Use cryo-EM to get a broader picture of how membrane proteins function and contribute to disease to drive your research and improve drug design. Learn more about adopting cryo-EM and how it can advance your research.
Access the inner workings of cells through 3D sample reconstruction at unprecedented nanoscale resolution. Results from this technique are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity. Explore a curated collection of publications highlighting the use of cryo-ET.
Cryo-EM technology is helping researchers overcome challenges related to virus purification and protein homogeneity and revolutionizing antiviral drug discovery and vaccine design. Learn more about how cryo-EM can help solve structural puzzles in virology.
Leverage structural insights to better understand the conditions for cancer-cell growth and identify new ways to treat cancer. Learn how cryo-EM is revolutionizing cancer research.
Get started with cryo-EM