Basic life processes start in the cell, which is why biologists seek to understand how they function and respond to disease or genetic variations. Cellular biology explores individual cells and the ways in which they are organized into organs and tissues. Structural biology delves deeper into sub-cellular components, organelles and macromolecular structures. Electron microscopy (EM) is capable of providing insight at all these scales and more, revealing even atomic-level structural details for a range of biomolecules.
We’ve created this learning center to connect scientists around the world to the latest information on electron microscopy technology and to guide you to the best solution that will accelerate your next discovery or breakthrough.
Visit Electron Microscopy for the Life Sciences to learn more.
Learn from the experts
Single particle analysis webinars
Single particle analysis (SPA) is a cryo-electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.
Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.
Micro electron diffraction (MicroED) is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. Watch now to see how
Customer and expert interviews
Watch these interviews to learn how our customers and products are impacting the latest life science research.
Sars-CoV-2 research at UT-Austin
Prof. Jason McLellan answers questions about spike protein structure, cryo-EM and vaccine trials with collaborators at NIH. Filmed in March 2020, video courtesy of The University of Texas at Austin.
Prof. Briegel and new discoveries in microbes with CryoET
Prof. Ariane Briegel from Leiden University was plenary speaker at ASM Microbe 2019. She discusses how cryo-electron tomography is overcoming research barriers faced in microbiology and gives her top tips for working with the technology.
Prof. Villa and role of cryoET in Parkinson's research
Prof. Elizabeth Villa from UCSD describes the role of cryo-tomography which brings structural biology to cell biology in order to look at structure and function of key proteins for better understanding of disease mechanisms.
New publications at the forefront of life science research
Hervas, R. et al. Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila.
Science 367, 1230 (2020). DOI: 10.1126/science.aba3526
Hurdiss, D. L. et al. Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans.
bioRxiv (2020). DOI: 10.1101/2020.03.25.998963
Liang, Y.-L. et al. Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
ACS Pharmacol. Transl. Sci. (2020). DOI: 10.1021/acsptsci.9b00080
Learn cryo-EM essentials
Visit EM-learning.com to learn about the foundations of cryo-EM, including the single particle analysis (SPA) workflow, via step-by-step instructions, expert demonstrations and theoretical lessons—at any pace, from any place and free of charge.
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