We created this learning center to connect researchers around the world to the latest information on cryo-electron microscopy (cryo-EM). While cryo-EM has been perceived as complex and out of reach, dramatic advancements over the last decade have made this technology more accessible and cost-effective than ever before. With cryo-EM, molecular details can be seen at biologically relevant resolution, helping researchers understand protein function and disease mechanisms, and facilitating effective drug design.
This resource hub contains rich and reliable technical content designed for new and experienced researchers who are exploring the capabilities of cryo-EM. Learn about cryo-EM at your own pace. Our technical experts are here to support you every step of the way.
We have collaborated with researchers across the globe to develop content that can be consumed at any pace, from any place, free of charge!
Visit EM-learning.com to learn about the foundations of cryo-EM, including the single particle analysis (SPA) workflow, via step-by-step instructions, expert demonstrations, and theoretical lessons.
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Get to know some members of our scientific community and their latest work.
Cryo-EM is helping researchers unlock some of life’s greatest biological mysteries. Recent advancements to workflows and instruments enable scientists to expand their labs’ capabilities in a variety of therapeutic areas. Thermo Fisher Scientific offers monthly webinars to highlight the latest updates and insights from these cutting-edge techniques.
Date: November 17, 2022
Time: 8 a.m. PST | 11 a.m. EST | 5 p.m. CET
Speakers: Natalia de Val, Zuben Brown, Veer Bhatt
In this virtual workshop, join our experts for a demonstration of the EM workflow—from sample preparation to data collection—on the Thermo Scientific Tundra Cryo-TEM and see how easy and convenient is to get started with cryo-EM.
Date: December 6, 2022
Time: 8 a.m. PST | 11 a.m. EST | 5 p.m. CET
Speakers: Pascal Albanese, Edward Pryor, Albert Konijnenberg and Rosa Viner
Dr. Pascal Albanese discuss the characterization of a key enzyme of the central carbon metabolism of Pyrococcus furious, through an integrative approach combining structural mass spectrometry, cryo-electron microscopy, mass photometry and molecular modelling with molecular dynamics simulations. He will describe how his lab unveiled the structural organization of phosphoenolpyruvate synthase (PPSA).
Single particle analysis (SPA) is a cryo-EM technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.Watch now
Cryo-electron tomography (cryo-ET) delivers both structural information about individual proteins and their spatial arrangements within the cell. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis. Watch now to see how cryo-ET is opening literal windows into cells.See how
Micro electron diffraction (MicroED) is an exciting new technique with applications in the structural determination of small molecules and proteins. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture. Learn how MicroED is transforming structural determination.
Integrative structural biology uses structural and functional information from various techniques, including mass spectrometry and cryo-EM, to arrive faster at a more complete picture of the protein and its function. See how integrating data helps you to understand structure-function relationships.Learn more
Cryo-EM can determine structures of challenging proteins without the need for crystals and can provide insights into how these proteins function in a way that other methods simply cannot. Learn more about adopting cryo-EM and how it can advance your research.
Results from cryo-electron tomography are having profound effects on our understanding of cell biology, revealing native cellular architecture with molecular clarity. Explore a curated collection of publications highlighting the use of cryo-ET.
Cryo-EM is enhancing structural insights of drug targets to facilitate effective drug discovery and design. Download the eBook to discover how to bring cryo-EM in house.
Created specifically for pharmaceutical scientists, find a selection of case studies in drug discovery supported by cryo-EM.
Recent developments in cryo-EM facilitate profiling of the large filaments and plaques that are common to neurodegenerative diseases. Learn how cryo-EM helps classify tauopathies.
Cryo-EM helps researchers overcome challenges in virus purification and protein homogeneity. Read our eBook to find out how cryo-EM is revolutionizing antiviral drug discovery and drug design.
Leverage structural insights to better understand the conditions for cancer cell growth and identify new ways to treat cancer. Discover how cryo-EM is revolutionizing cancer research.
Cryo-electron microscopy (cryo-EM) describes an increasingly popular group of techniques including single particle analysis, micro-electron diffraction, and cryo-tomography. These techniques are performed on cryo-transmission electron microscopes (cryo-TEMs), which are specialized TEMs designed to operate at cryogenic temperatures. Cryo-EM has gained popularity in various research areas like structural biology, biochemistry, and cell biology due to the structural and functional insights it provides. With cryo-EM, molecular details can be seen at biologically relevant resolution, helping researchers understand protein function and disease mechanisms, and facilitating effective drug design.
|High resolution structural characterization|
|Reduced challenges during sample preparation|
|Near-native research conditions|
|Accelerate time to results|
|Cryo-TEMs are too expensive to purchase|
|Cryo-EM labs are too expensive to maintain|
|Cryo-EM labs require specific expertise and dedicated personnel|
|Cryo-EM sample prep takes too long and data collection is too slow|
Discover the facts behind the five most common misperceptions and learn how you can get started in cryo-EM.
We’ve made design improvements to our microscopes to address the need for a smaller footprint and easier access path. In many cases, this avoids the additional investment and unwanted lab downtime for significant modifications to an existing infrastructure or the need for a purposely built lab. See our Guidance for Planning a Cryo-EM Laboratory.
|Dimensions||Tundra Cryo-TEM||Glacios 2 Cryo-TEM||Krios G4 Cryo-TEM|
As the market leader in cryo-EM, we are uniquely positioned to help you and your team be successful at every stage of the adoption process, from financing, to guidance on facility requirements, to data processing and analysis. Learn about the accessible cryo-EM workflow and how to get started in cryo-EM.
When you are ready to take the next step, our experts can provide support and recommendations for funding your laboratory. We created the Electron Microscopy Funding Support Center where you will find more technical content, proposal writing tools, and financing information.
Our experts are here to support you and your team every step of the way. We can: