Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Single particle cryo-electron microscopy (cryo-EM) uses the particles extracted from thousands of images to reconstruct 3D structures of macromolecules. The yield of an acquisition session at the microscope depends on the time needed to set up the run and the speed of the acquisition itself. Thermo Scientific Smart EPU Software is an innovative, easy-to-use data acquisition solution for single particle analysis that focuses on automation and user guidance to increase throughput and deliver reproducible results. Available on all our transmission electron microscopy (TEM) platforms, Smart EPU Software allows you to focus more on your research and make efficient use of your microscope.
Smart EPU Software is an ecosystem of multiple interactive software components that work together to drive automation of the data acquisition steps. The software enables advanced AI-guided decisions.
EPU presets, microscope traffic lights, and smart automation benefit from artificial intelligence that captures the decisions of cryo-EM specialists in its algorithms.
Fast set-up time with EPU Multigrid Software for more efficient microscope usage, combined with throughput- and quality-enhancing automation and real-time feedback when intervention is needed during acquisition.
The use of automation algorithms and AI-guided decisions reduces operator variability, making outcomes more predictable.
We are committed to continuously improving the EPU experience through regular updates. Smart EPU Software is supported by our service organization and application specialists.
View our 45-minute webcast in which we introduce the Smart EPU ecosystem, to understand how:
EPU 3 Software has been reimagined to allow both new and experienced microscopists to set up their experiments more quickly and easily. Features include:
EPU Multigrid Software allows users to take full advantage of their autoloader by enabling them to setup and queue multiple data acquisition experiments to run unattended and overnight. Features include:
Get an overview of Smart EPU Software and its components for scheduling, data acquisition, and decision algorithms.
EPU Quality Monitor (EQM) Software analyzes and visualizes images on-the-fly, enabling users to judge image quality of running or completed acquisitions remotely. The combination of EPU Software, EQM Software, and smart plugins helps to generate high-quality results quickly and with confidence. Features of EQM Software include:
Smart plug-ins either dynamically adjust EPU Software settings based on real-time image analysis software (EPU Quality Monitor Software or Embedded CryoSPARC Live^™) output; use image-based AI to suggest the operator make changes; or even make decisions in acquisition strategy. The first plugins to be released with Smart EPU Software include:
The Smart EPU ecosystem, through its open API, allows you to develop plug-ins that interact with Smart EPU Software. User-developed plugins can take advantage of artificial intelligence/machine learning to evaluate microscope output and adjust microscope settings on the fly.
Demonstrate how to use Discovery Viewer to identify grid areas for high-quality data acquisition.
Get an overview of Smart EPU Software and its components for scheduling, data acquisition, and decision algorithms.
This tutorial demonstrates how to use Smart Filter, Fast Screening and Auto-create sessions to facilitate sample screening in single particle analysis.
In this Ask the Experts webinar, we reviewed the capabilities that have since been added to Smart EPU Software. Our panel also discusses how these improvements and features help them streamline their cryo-EM single particle analysis (SPA) workflow.
This tutorial demonstrates the latest features of Smart EPU Software for SPA included: TIFF LZW output for Falcon-4i cameras, guided Image Shift Calibration, and clean up functions.
This tutorial demonstrates how to get started with Smart EPU Software with Embedded CryoSPARC Live. This software enables users processes images on the fly to assess sample quality and accelerate structural determination.
This tutorial demonstrates how to get started with Smart EPU Software (EPU 3.6) with Embedded CryoSPARC Live. This software enables users processes images on the fly to assess sample quality and accelerate structural determination.
This tutorial demonstrates the latest features of Smart EPU Software including the new Athena selection window, Smart Selection of grid squares, and automatic placement of the autofocus area.
We ensure seamless integration of Smart EPU Software into your on-site environment, allowing you to optimize your infrastructure investments.
Our experts are dedicated to helping you shorten your learning curve to be your most productive with Smart EPU Software.
Our worldwide customer support team is ready to assist you and answer all your questions about Smart EPU, any time you need it.
To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and certified spare parts.