The Thermo Scientific Talos L120C Transmission Electron Microscope (TEM) is a next-generation 120 kV imaging platform that includes a modular design and improved optical stability, yielding unmatched ease of use, productivity, operational comfort, and uptime. With its simple point-and-click imaging, it is ideal for entry-level cryo-studies. Additionally, it offers efficient tomography and single-particle-analysis (SPA) sample screening along with standalone options for energy-dispersive X-ray spectroscopy (EDS) and scanning transmission electron microscopy (STEM).

Transmission Electron Microscopes

Cryo EM Imaging for Life Science Research: Talos L120C TEM

Ideal 120 kV entry-level solution for cryo electron microscopy studies.


Key Features

Automation and ease of use

The Talos L120C TEM offers a high level of automation, allowing complete digital control over multiple microscope components, including the electron gun, optical elements, vacuum system and stage. With its easy-to-use software, operating on Windows™ 10, quick switching between TEM and STEM modes is possible. Additionally, the user interface allows for smart presets to save multiple operational conditions across many different applications.

Providing a single software solution, modular Thermo Scientific Maps Software allows for automated and unattended large-area acquisition at multiple scales, as well as image and data transfer between instruments (e.g. TEM, SEM, DualBeam and light microscopes). You can quickly and easily correlate data from multiple imaging platforms, preparing you for advanced visualization and analysis in Thermo Scientific Amira Software.

Versatile detectors

The Talos L120C TEM is an intuitive S/TEM system that includes the Thermo Scientifc Ceta 16MP Camera, and is available with the new, digital search-and-view Thermo Scientific SmartCam Camera, which allows users to remotely operate the microscope.

Ready for the future

With the potential to address multiple applications, the Talos L120C TEM is an ideal entry-level solution for imaging and tomography. It can be configured as a basic cryo-TEM imaging platform. Fully upgradeable and expandable as your research requirements and ambitions grow, the Talos L120C TEM will meet your needs, whether at cryogenic or room temperatures, in 2D or 3D imaging or with multi-modality imaging experiments.

Key Benefits

More stability

Robust system enclosure, constant power lenses, and remote operation allow consistent use.

Automation

Multiple auto-functions (auto-gun, auto-alignment) improve repeatability and reproducibility of results.

High-quality imaging

4k × 4K Thermo Scientific Ceta CMOS Camera provides a large field-of-view and live digital zooming with high sensitivity and high speed.

Quick sample exchange

Robust vacuum system provides a contamination-free environment and fast recovery after airlock.

Data correlation

Maps Software allows for automated and unattended large-area acquisition at multiple scales.

Cryo-imaging

Observe cryo-specimens with minimal ice growth and automate single particle analysis imaging with Thermo Scientific EPU Software.


Specifications

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TEM line resolution 0.16 nm
TEM point resolution < 0.37 nm
TEM magnification range 25 – 650 k×
TEM magnification range with camera 35 – 910 k×
TEM magnification range with camera 35 – 910 k×
Alpha tilt angle (with standard holders) -90° to +90°
STEM HAADF resolution with LaB6 ≤ 1.0 nm
STEM magnification range 200 – 2.2 M×
TEM magnification range with camera 35 – 910 k×
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Cryo TEM image of DNA origami particles
Negative stain image of DNA origami particles; sample courtesy of Thomas Martin, MRC LMB Cambridge. Magnification = 57,000x.
Cryo TEM image of DNA origami particles.
Negative stain image of DNA origami particles; sample courtesy of Thomas Martin, MRC LMB Cambridge. Magnification = 22,000x.
Cryo TEM (STEM) image of yeast cell cross-section
Low magnification STEM thick-section image of yeast cells; sample courtesy of Wanda Kukulski, MRC LMB Cambridge, UK.
Cryo TEM (STEM) image of yeast cell cross-section.
STEM thick-section image of yeast cells; sample courtesy of Wanda Kukulski, MRC LMB Cambridge, UK. Magnification = 35,000x.
Cryo TEM image of DNA origami particles
Negative stain image of DNA origami particles; sample courtesy of Thomas Martin, MRC LMB Cambridge. Magnification = 57,000x.
Cryo TEM image of DNA origami particles.
Negative stain image of DNA origami particles; sample courtesy of Thomas Martin, MRC LMB Cambridge. Magnification = 22,000x.
Cryo TEM (STEM) image of yeast cell cross-section
Low magnification STEM thick-section image of yeast cells; sample courtesy of Wanda Kukulski, MRC LMB Cambridge, UK.
Cryo TEM (STEM) image of yeast cell cross-section.
STEM thick-section image of yeast cells; sample courtesy of Wanda Kukulski, MRC LMB Cambridge, UK. Magnification = 35,000x.

Applications

Infectious_Disease_Research_App_w274x180

Infectious Disease Research

Cryo-EM techniques enable multiscale observations of 3D biological structures in their near-native states, informing faster, more efficient development of therapeutics.

Life_Sciences_Application_274x180_144DPI

Structural Biology Research

Cryo-electron microscopy enables the structural analysis of challenging biological targets such as large complexes, flexible species and membrane protein.

DrugDiscovery_Appl_274x180

Drug Discovery

Learn how to take advantage of rational drug design for many more major drug target classes, leading to best-in-class drugs.

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Plant Biology Research

Fundamental plant biology research is enabled by cryo electron microscopy, which provides information on proteins (with single particle analysis), to their cellular context (with tomography), all the way up to the overall structure of the plant (large volume analysis).

Pathology_Pancreas_274x180

Pathology Research

Transmission electron microscopy (TEM) is used when the nature of the disease cannot be established via alternative methods. With nano-biological imaging, TEM provides accurate and reliable insight for certain pathologies.

Single Particle Analysis

Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›

Single Particle Analysis

Single particle analysis (SPA) is a cryo electron microscopy technique that enables structural characterization at near-atomic resolutions, unraveling dynamic biological processes and the structure of biomolecular complexes/assemblies.

Learn more ›

Cryo-Tomography

Cryo electron tomography (cryo-ET) delivers both structural information about individual proteins as well as their spatial arrangements within the cell. This makes it a truly unique technique and also explains why the method has such an enormous potential for cell biology. Cryo-ET can bridge the gap between light microscopy and near-atomic-resolution techniques like single-particle analysis.

Learn more ›

MicroED

MicroED is an exciting new technique with applications in the structural determination of small molecules and protein. With this method, atomic details can be extracted from individual nanocrystals (<200 nm in size), even in a heterogeneous mixture.

Learn more ›


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