The complex structures of biopharmaceutical therapeutic agents require greater selectivity and sensitivity, which drives the demand for powerful instrumentation and software for their data acquisition and analysis. Previously this required two software packages, one in Development and one in Quality Control (QC). Thermo Scientific Chromeleon 7.3.2 Chromatography Data System (CDS) comfortably operates in both areas and supports Mass Spectrometry (MS) instruments in a compliant enterprise environment, providing a seamless transition from Development to QC within a single software platform.
What are users saying?
"We use Chromeleon daily in my labs. Chromeleon report templates enable us to keep all the raw data, data manipulation, and lot recording in one file so submitting to our lab notebook software is super easy. All experiment details are in one place."
- Research Lab Manager, Genentech
Chromeleon CDS provides native control of MS and MS/MS instruments (for GC, HPLC, and IC front ends) with workflow support for targeted and non-targeted analysis, including lot release testing of intact and digested proteins, oligonucleotides analysis, and LC-MS/MS-based pharmaceutical bioanalysis.
Learn more about Chromeleon CDS features for mass spectrometry ›
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Chromeleon CDS is an integral part of the Thermo Scientific MAM 2.0 workflow. This powerful, high-resolution MS-based workflow delivers easy, compliance-ready characterization and monitoring of peptides and allows critical quality attributes to be monitored throughout every stage of the drug development process. The workflow leverages comprehensive compliance capabilities from data acquisition, to quality attribute quantitation, new peak detection, and customizable spreadsheet-based reporting.
Understanding your molecules is critical, and ensuring accuracy is paramount when it comes to DMPK studies. Chromeleon CDS provides a single software solution that is scalable,from a local standalone workstation to a multi-site enterprise system, with built-in features to simplify meeting compliance requirements. It provides robust and reliable control of the HPLC and MS with integrated MS/MS functionality for data acquisition and processing. A bi-directional gateway for the Watson LIMS provides complete end-to-end support.
From instrument control and data acquisition to automated data processing to customizable reports to streamlined data integrity reviews, Chromeleon CDS facilitates compliant-ready high resolution LC-MS analysis of modified and unmodified oligonucleotides. High throughput accurate molecular weight confirmation is streamlined with automated intact deconvolution processing. Chromeleon CDS provides enhanced easy electronic data reviews and secure organized data storage with the benefits of a scalable enterprise system for global collaboration.
Examine real-use cases of how a networked CDS is the best choice for data acquisition and processing for quantitative LC-MS analyses.
Discover the compliance-ready, enterprise MAM workflow that connects development and manufacturing.
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