HPLC and UHPLC Columns
Quality columns you can rely on for quality results
Need a reliable column? With over 40 years as a leader in LC column technology, you can rely on the quality of Thermo Scientific™ HPLC and UHPLC columns. Our extensive family of products offers a variety of particle sizes and column designs to meet all separation needs, including improved resolution, enhanced sensitivity, faster analysis and consistent performance.
HPLC and UHPLC column categories
Have a biological sample? Get high resolution, high efficiency separations from our unique chemistries that are specially designed for proteins, peptides, carbohydrates, nucleic acids, oligonucleotides and more.
Need to maximize your productivity and flexibility in method development? We offer an array of RP chemistries to optimize separations and provide enhanced retention or changes in elution order.
Is your sample insoluble in mixtures of water and organic solvent? We manufacture a range of bonded and non-bonded normal phase columns that are ideal for the retention and separation of lipophilic compounds.
Have difficulty retaining polar hydrophilic compounds by RP chromatography? These columns strongly retain compounds that are unretained by conventional reversed phase, without the need for ion-pair additives.
Need a HILIC column for very polar analytes? These columns are well suited for separating hydrophilic molecules, including carbohydrates, glycans, and peptides.
Want to separate ionic and hydrophobic analytes in a single run? The multi-functionality of these columns can eliminate column switching, ion paring, or using columns in series.
Are your analytes ionizable or charged in solution? Our silica-based ion exchange columns are ideal for smaller water soluble compounds.
Need a column to separate carbohydrates using dilute acid mobile phase? These polymeric ligand exchange columns utilize a range of counter ions to deliver selectivity required.
Want high resolution separation of water soluble polymers? Our size exclusion columns (SEC) are available in tailored pore sizes to cover a broad range of molecular weight.
Designed for key pharmaceutical and environmental applications, these columns utilize novel and unique chemistries to provide superior resolution with ease of use.
Featured LC column videos
Access the latest version of our Chromatography Columns and Consumables Catalog to ensure that you're optimizing your applications! Our enhanced online version features a robust applications search tool, access to method development guides, application notebooks, and much more.
- An Objective Comparison of Solid Core HPLC Column Performance
- Mixed Mode HPLC Separations—What, Why and How
- How New Biopharmaceutical Sample Preparation and Bio-LC Column Technology Can Improve Your Results Quality and Workflow Efficiency
- Using Variations in Solid Core Particle Diameter and Pore Size to Improve UHPLC and HPLC Separations