Vanquish Flex UHPLC Systems

For analyses that require more flexibility to accommodate all applications, Thermo Scientific Vanquish Flex UHPLC systems enable you to increase your productivity and drive innovation without compromising quality. Whether you need an LC or LC-MS solution, the flexibility of the Vanquish Flex systems with binary or quaternary solvent blending provides the most advanced performance through better separations, more results and easier interaction. Like all members of our Vanquish product line, Vanquish Flex UHPLC systems offer hardware precision, detector sensitivity, and simplicity of operation.

Build your ideal HPLC or UHPLC with our step-by-step configurator


Separations with more flexibility

Thermo Scientific SmartFlow pumping technology includes automatic compensation for changes in eluent compressibility to ensure flow and gradient precision, independent of eluent composition and backpressure. The pump can operate up to 1000 bar and is available in binary, quaternary, and dual-gradient options.

Accurate sample handling

Thermo Scientific Vanquish Split Sampler FT offers outstanding speed and injection precision using Thermo Scientific SmartInject technology. It has a default vial capacity of 216 samples, which can be extended up to 8832 samples with the Thermo Scientific Vanquish Charger sampler extension.

Intelligent system tools

Two optional components are available to improve productivity, ensure compliance, and keep laboratories running smoothly. The Vanquish Solvent Monitor tracks solvent levels to prevent dry solvent channels and waste spills. Meanwhile, the touchscreen Vanquish User Interface provides visual monitoring of the system status.

Versatility in analyte detection

A variety of detection options ensure you can collect the most information from your separation. Our portfolio includes diode array detection, near-universal charged aerosol detection, fluorescence detection, mass spectrometric detection and more.

Biocompatible, easy and reliable tool-free connections

The fluidic pathway of the Vanquish Flex UHPLC system is fully biocompatible and fitted with Thermo Scientific Viper fingertight fittings, which support near-zero dead volume connections and enable sharper peaks and tool-free setup.

CDS software

The Vanquish Flex UHPLC system integrates with Thermo Scientific Chromeleon Chromatography Data System (CDS) with compliance tools, networking capabilities, automation, and data processing. We offer standard instrument integration (SII) packages to connect Thermo Scientific HPLC systems to other CDS and MS software programs.


System specifications

The table below provides an overview of the Vanquish Flex UHPLC system specifications for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.

Category Vanquish Flex UHPLC Systems
System pressure, maximum 1000 bar
Flow range, maximum 0–8 mL/min
Pump options (default gradient delay volume)

Binary (200 µL)

Quaternary (679 µL) 

Delay volume dependent on pump(s) selected

Biocompatibility Yes
pH range 2–12, chloride concentration up to 1 mol/L
System design Modular
Touchscreen user interface display compatible (optional) Yes
Solvent monitoring system compatible (optional) Yes
Customizable gradient delay volume to simplify method transfer Yes, with metering device
SmartInject technology for maximum injection precision and improved column lifetime Yes
Injection volume range

Standard: 0.01 - 25 µL

Optional: 0.01 - 100 µL

Sample cooling 4-40°C

Sample capacity (standard)

Based on standard 12 mm OD vials (≤1.5 mL)

4 racks of 54 vials (≤ 1.5 mL) each, other rack formats available

+ capacity of 12 × 22.5 mm OD vials (≤10 mL) in the carousel

Sampler extension available (optional)

Yes, with Vanquish Charger
Column compartment thermostatting Yes, 5-120°C 
Still air and forced air
Column compartment pre-heater Active and passive  
Column compartment post-column cooler Yes
Detector choices

Vanquish Charged Aerosol Detector

Vanquish Diode Array Detector

Vanquish Fluorescence Detector

Vanquish Multiple Wavelength Detector

Vanquish Variable Wavelength Detector

Refractive Index Detector

Mass Spectrometer

Component specifications

Standard Vanquish Flex UHPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component.

  Vanquish Flex Binary UHPLC Vanquish Flex Quaternary UHPLC



Download Specification Sheet

Vanquish Binary Pump F Vanquish Quaternary Pump F



Download Specification Sheet

Vanquish Split Sampler FT

Extended sample capacity (optional)


Download Specification Sheet

Vanquish Charger (optional)

Column compartment


Download Specification Sheet

Vanquish Column Compartment H

Virtually zero dead volume system connections


Download Specification Sheet

Viper UHPLC Fittings Kits



Visit our HPLC and UHPLC Detectors page
Optional components: Fraction Collector Visit our Vanquish Fraction Collector FT page

Contact us to get a quote or discuss an HPLC/UHPLC solution

For Research Use Only. Not for use in diagnostic procedures.