For analyses that require more flexibility to accommodate all applications, Thermo Scientific Vanquish Flex UHPLC systems enable you to increase your productivity and drive innovation without compromising quality. Whether you need an LC or LC-MS solution, the flexibility of the Vanquish Flex systems with binary or quaternary solvent blending provides the most advanced performance through better separations, more results and easier interaction. Like all members of our Vanquish product line, Vanquish Flex UHPLC systems offer hardware precision, detector sensitivity, and simplicity of operation.
Thermo Scientific SmartFlow pumping technology includes automatic compensation for changes in eluent compressibility to ensure flow and gradient precision, independent of eluent composition and backpressure. The pump can operate up to 1000 bar and is available in binary, quaternary, and dual-gradient options.
Thermo Scientific Vanquish Split Sampler FT offers outstanding speed and injection precision using Thermo Scientific SmartInject technology. It has a default vial capacity of 216 samples, which can be extended up to 8832 samples with the Thermo Scientific Vanquish Charger sampler extension.
Two optional components are available to improve productivity, ensure compliance, and keep laboratories running smoothly. The Vanquish Solvent Monitor tracks solvent levels to prevent dry solvent channels and waste spills. Meanwhile, the touchscreen Vanquish User Interface provides visual monitoring of the system status.
A variety of detection options ensure you can collect the most information from your separation. Our portfolio includes diode array detection, near-universal charged aerosol detection, fluorescence detection, mass spectrometric detection and more.
The fluidic pathway of the Vanquish Flex UHPLC system is fully biocompatible and fitted with Thermo Scientific Viper fingertight fittings, which support near-zero dead volume connections and enable sharper peaks and tool-free setup.
The Vanquish Flex UHPLC system integrates with Thermo Scientific Chromeleon Chromatography Data System (CDS) with compliance tools, networking capabilities, automation, and data processing. We offer standard instrument integration (SII) packages to connect Thermo Scientific HPLC systems to other CDS and MS software programs.
The table below provides an overview of the Vanquish Flex UHPLC system specifications for a standard setup. Not all specifications are listed. Your specifications may differ based on the components of your system. Find the specification sheets for the system components in the Component specifications, below.
|Category||Vanquish Flex UHPLC Systems|
|System pressure, maximum||1000 bar|
|Flow range, maximum||0–8 mL/min|
|Pump options (default gradient delay volume)||
Binary (200 µL)
Quaternary (679 µL)
Delay volume dependent on pump(s) selected
|pH range||2–12, chloride concentration up to 1 mol/L|
|Touchscreen user interface display compatible (optional)||Yes|
|Solvent monitoring system compatible (optional)||Yes|
|Customizable gradient delay volume to simplify method transfer||Yes, with metering device|
|SmartInject technology for maximum injection precision and improved column lifetime||Yes|
|Injection volume range||
Standard: 0.01 - 25 µL
Optional: 0.01 - 100 µL
Sample capacity (standard)
Based on standard 12 mm OD vials (≤1.5 mL)
4 racks of 54 vials (≤ 1.5 mL) each, other rack formats available
+ capacity of 12 × 22.5 mm OD vials (≤10 mL) in the carousel
Sampler extension available (optional)
|Yes, with Vanquish Charger|
|Column compartment thermostatting||Yes, 5-120°C
Still air and forced air
|Column compartment pre-heater||Active and passive
|Column compartment post-column cooler||Yes|
Vanquish Charged Aerosol Detector
Vanquish Diode Array Detector
Vanquish Fluorescence Detector
Vanquish Multiple Wavelength Detector
Vanquish Variable Wavelength Detector
Refractive Index Detector
Standard Vanquish Flex UHPLC systems are made up of the following components. Download the associated specifications sheet for more detail on each component.
|Vanquish Flex Binary UHPLC||Vanquish Flex Quaternary UHPLC|
|Vanquish Binary Pump F||Vanquish Quaternary Pump F|
|Vanquish Split Sampler FT|
Extended sample capacity (optional)
|Vanquish Charger (optional)|
|Vanquish Column Compartment H|
Virtually zero dead volume system connections
|Viper UHPLC Fittings Kits|
|Visit our HPLC and UHPLC Detectors page|
|Optional components: Fraction Collector||Visit our Vanquish Fraction Collector FT page|
For Research Use Only. Not for use in diagnostic procedures.