Counter Ion Analysis

Effectively assay pharmaceutical anions and cations

Accelerate the determination and quantification of inorganic anions and cations in pharmaceutical formulations. Approximately half of all drugs are formulated and administered as salts. A broad selection of inorganic and organic ions can be used as drug substance counterions, with different ions being used to alter the biological and physicochemical properties such as solubility, stability, and dissolution rate. Screening and assaying of a broad variety of counterions and active pharmaceutical ingredients (APIs) is crucial for quality control (QC) of pharmaceutical salts to confirm identity of salt form and mass balance of the API.

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Versatile UHPLC for counterion determination

Detect and quantify counterions with increased separation speed and resolution using the Thermo Scientific Vanquish UHPLC system with near-universal detection capabilities of the Vanquish Charged Aerosol Detector (CAD). With enhanced linear dynamic range and accurate, consistent response, this detector can measure low-level impurities, counterions and APIs simultaneously, regardless of chemical structure. One can measure virtually any non-volatile and most semi-volatile analytes with sub-nanogram sensitivity. The charged aerosol detector expands the capabilities for discovery and is a powerful addition to any chromatography lab.

Ultimate performance and flexibility

The Dionex ICS-6000 Hybrid HPIC System is a top-of-the-line ion chromatography (IC) system capable of addressing a full range of counterion assays. This high-performance Reagent-Free IC (RFIC) system can operate at pressures up to 5000 psi. This high-pressure capability gives you the flexibility to use small-particle columns in standard lengths for higher resolution without sacrificing speed, or to use shorter (150mm) columns for higher flow rates and high throughput, to meet the demands of the pharmaceutical laboratory.

Pharma QC primer on new regulatory guidelines