mRNA Bioprocessing Solutions

Fueling your mRNA innovation

Accelerate each step of mRNA development

We’re ready to help you transform your mRNA production process. Thermo Fisher Scientific works with you to develop an effective production strategy and provides expert professional support to help accelerate commercialization of your mRNA vaccine or therapeutic. Our high-performance products are proven to meet critical process, scale, quality, and regulatory requirements.


Plasmid production

Plasmids are the building blocks needed to manufacture mRNA therapeutics. Plasmid production takes place in a microbial fermentation process, and our product solutions are designed to scale up the production from development to commercial phase.

Purpose-built to pioneer the single-use technology market by delivering a unique and rigorous solution for microbial fermentation applications while offering the flexibility, ease of use, and efficiency found in single-use systems.

Chemically-defined, animal origin free, dry powder medium designed to support high cell density cultures of Escherichia coli.

Support upstream process intensification with a range of optimized nutritional benefits for plasmid DNA production with the industry’s first commercially available chemically-defined media for microbial fermentation, enabling lot-to-lot consistency and an optimized workflow.


Plasmid purification and analytics

Achieve fast process development with our product solutions designed to scale production whilst isolating, purifying, and extracting high quality plasmid DNA.

Ideally suited for the purification of larger molecules such as plasmids and will help you overcome the common challenges of plasmid purification.

Streamline process liquid/buffer manufacturing workflows by leveraging ready-to-hydrate dry powder chemicals and ready-to-use process liquids.

Highly sensitive, rapid, and reliable PCR-based quantitation system for the detection of host cell DNA from E. coli.


mRNA production

We offer a comprehensive portfolio of nucleotide, enzymes, and single-use equipment for mRNA production designed for seamless progression from preclinical development to commercial manufacturing.

Discover the advantages of consistently scalable bioreactors from process development to cGMP manufacturing.

Streamline process control and data management from research to production scale applications.

Specifically designed to facilitate the development of mRNA vaccines and therapeutics.


mRNA purification

Simplify your purification process with our innovative chromatography solutions specifically designed to improve the downstream purification of mRNA molecules.

Designed for efficient, scalable purification of mRNA of in vitro transcription manufacturing processes.

Removal of dsRNA and uncapped DNA from the final product and removal of secondary RNA structures, if needed.

Streamline process liquid/buffer manufacturing workflows by leveraging ready-to-hydrate dry powder chemicals and ready-to-use process liquids.


Analytics, fill, and finish

Detection of impurities and contaminants is critical in the therapeutics manufacturing process. We provide rapid analytical assays with total workflow solutions to align with regulatory requirements. Thermo Fisher Scientific provides drug product fill, finish, and storage solutions, including sterile container systems for therapy delivery.

Access a portfolio of market-leading chemical brands for use in cGMP manufacturing, as well as services specific to sourcing, supplier management, and second sourcing assistance.

Access a portfolio of market-leading chemical brands for use in cGMP manufacturing, as well as services specific to sourcing, supplier management, and second sourcing assistance.

Think beyond sterile with Nalgene Platinum Certified Clean Bottles and Carboys, enabling on-time delivery of high-quality product.


White Paper: Streamlining the upstream workflow for plasmid DNA manufacturing

Learn more about upstream solutions that enable efficient large-scale production of plasmid DNA.

Video: Key lessons for cell and gene therapy and mRNA therapeutic development from COVID-19 mRNA vaccine approvals

Watch experts from mRNA vaccine spheres discuss the lessons they have learned.

Application Note: Production of therapeutic plasmid DNA in single-use fermentors

Learn how single-use production facilities are being used to efficiently meet the growing demand for plasmid DNA.


Additional resources

Enhance your bioprocessing knowledge with educational content to help you understand issues, solve problems, and make solid decisions.

Deep dive into a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing.

Learn, evaluate, connect. 

Connect with a Bioprocessing representative or request more info.


Thermo Fisher Bioprocessing Portfolio

Upstream bioprocessing

Develop and scale biomanufacturing processes efficiently with trusted technologies and full-service support.

Downstream bioprocessing

Streamline downstream biomanufacturing and improve product quality with innovative technologies and outsourcing services to drive efficiency.

Assurance of supply

We strive to support industry growth by investing in capacity and quality systems for a reliable supply of critical materials.


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